Sensing mechanism of growing environment and survival strategy in bacterial cells.
| Project/Area Number |
23380052
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Tokyo University of Agriculture |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Keywords | 遺伝子発現 / 機能ネットワーク / 微生物 / 細胞分裂 / 細胞分化 / 脂質合成 / 定常期 / 生長戦略 |
|---|
| Research Abstract |
Bacterial cells possess sensing mechanism of environmental changes at the end of logarithmic growth phase. We focused on two key enzymes, PlsX and OdhB, and found that these are global regulatory factors connecting several cellular functional networks. Most important finding is that PlsX, an essential lipid synthetic enzyme, has crucial role in cell division machinery and regulating the localization of FtsZ that is a critical protein of division septa. Moreover, PlsX also has functions on stringent control through RelA, an enzyme for ppGpp synthesis and degradation. Alternatively, a TCA cycle enzyme, OdhB, has most significant function in energy production and this aspect has fundamental function on sporulation in Bacillus subtilis. These results demonstrate cooperative networks of bacterial cells responding and dealing with the environmental changes.
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Report
(4 results)
Research Products
(81 results)
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[Journal Article] Single mutations introduced in the essential ribosomal protein L3 and S10 cause a sporulation defect in Bacillus subtilis.2013
Author(s)
Genki Akanuma, Shota Suzuki, Koichi Yano, Hideaki Nanamiya, Yousuke Natori, Eri Namba, Kazuya Watanabe, Kazumi Tagami, Takuya Takeda, Yuka Iizuka, Ako Kobayashi, Morio Ishizuka, Hirofumi Yoshikawa, and Fujio Kawamura
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Journal Title
J Gen Appl Microbiol.
Volume: 59
Pages: 105-107
NAID
Related Report
Peer Reviewed
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[Journal Article] Multiple rRNA operons are essential for efficient cell growth and sporulation as well as outgrowth in Bacillus subtilis.2013
Author(s)
Koichi Yano, Tetsuya Wada, Shota Suzuki, Kazumi Tagami, Takashi Matsumoto, Yuh Shiwa, Taichiro Ishige, Yasuhiro Kawaguchi, Kenta Masuda, Genki Akanuma, Hideaki Nanamiya, Hironori Niki, Hirofumi Yoshikawa and Fujio Kawamura.
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Journal Title
Microbiology
Volume: 159
Issue: Pt_11
Pages: 2225-2236
DOI
Related Report
Peer Reviewed
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