| Project/Area Number |
23380055
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HIGASHIDA Haruhiho 金沢大学, 医学系, 教授 (30093066)
ONAKA Tatushi 自治医科大学, 医学部, 准教授 (90177254)
SAKAMOTO Hirotaka 岡山大学, 自然科学研究科, 教授 (20363971)
KURODA Kumi 独立行政法人理化学研究所, 脳科学総合研究センター, 研究ユニット長 (90391945)
YAO Hiromu 東北大学, 生命科学研究科, 教授 (00144353)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Keywords | 情報伝達 / オキシトシン受容体 / オキシトシン / 社会行動 / 自閉症スペクトラム / 母性行動 / 扁桃体内側核 / セロトニン / グリア細胞 / 向社会行動 / 自閉症 / 外側中隔 / 体温制御 |
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| Research Abstract |
Central oxytocin and its receptor Oxtr have a regulatory function to control social behaviors in mammals, including human. Also, application of oxytocin to Autism patients have been started and reports describing positive cure effects have been accumulated. In this study, we analyzed the mechanism controlling social behaviors by neurons expressing Oxtr in brain First, by crossing fx-type Oxtr KO mice with ePet-Cre mice, we generated mice having 5-HT neurons-specific deletion of Oxtr genes. This line didn't show any impairment in their social memory. In contrast, rescue experiment was carried out by injection of AAV-Cre viral vector to mice brains to induce MeA-specific deletion of Oxtr gene, and it revealed that Oxtr expressing in MeA were essential for social memory. In addition, we found that the glutamatergic neurons expressing Oxtr in rRPa regulated body temperature. We forwarded study of type I taste cells expressing Oxtr, and obtained novel characteristics of these populations.
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