Basic study on the network of mRNA maturation process by analyzing diversified mRNA exporter.
| Project/Area Number |
23380059
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied biochemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
MASUDA Seiji 京都大学, 生命科学研究科, 准教授 (20260614)
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| Co-Investigator(Kenkyū-buntansha) |
OKUMURA Katsuzumi 三重大学, 大学院・生物資源学研究科, 教授 (30177183)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Keywords | mRNA / 核外輸送 / 輸送体 / 複合体 / mRNA輸送体 / 複合体形成 |
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| Research Abstract |
Messenger RNA exporter regulates the mRNA processing. In human, mRNA exporter is diversified. Here, I am focusing on the mechanism of the complex formation of TREX and AREX as functional mRNA exporters.
The analysis using chimera mutants and point-mutated proteins, I have shown that TREX and AREX complex formation by UAP56 and URH49 are regulated by single amino acid exchange. This indicates that UAP56 and URH49 were diversified from the common ancestor and obtained the specific function through forming specific complex.
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Report
(4 results)
Research Products
(59 results)
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[Journal Article] Identification of 6-octadecynoic acid from a methanol extract of Marrubium vulgare L. as a peroxisome proliferator-activated receptor γ agonist2013
Author(s)
Ohtera, A., Miyamae, Y., Nakai, N., Kawachi, A., Kawada, K., Han, J., Isoda, H., Neffati, M., Akita, T., Maejima, K., Masuda, S., Kambe, T., Mori, N., Irie, K. and Nagao, M
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Journal Title
Biochem. Biophys. Res. Commun
Volume: 440
Issue: 2
Pages: 204-209
DOI
Related Report
Peer Reviewed
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[Journal Article] Establishment of the monitoring system which detects the inhibition of mRNA processing2012
Author(s)
Fujita, K., Okamura, M., Nishimoto, S., Kurihara, T., Momma, K., Miyamae, Y., Kambe, T., Nagao, M., Narita, H. and Masuda, S
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Journal Title
Biosci. Biotechnol. Biochem
Volume: 76
Pages: 1248-1251
URL
Related Report
Peer Reviewed
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[Journal Article] Establishment of the monitoring system which detects the inhibition of mRNA processing.2012
Author(s)
Fujita, K., Okamura, M., Nishimoto, S., Kurihara, T., Momma, K., Miyamae, Y., Kambe, T., Nagao, M., Narita, H. and Masuda, S.
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Journal Title
Biosci. Biotechnol. Biochem.
Volume: 76
Pages: 1248-1251
Related Report
Peer Reviewed
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[Journal Article] Tissue nonspecific alkaline phosphatase is activated via a two-step mechanism by zinc transport complexes in the early secretory pathway2011
Author(s)
Fukunaka, A., Kurokawa, Y., Teranishi, F., Sekler, I., Oda, K., Ackland, ML., Faundez, V., Hiromura, M., Masuda, S., Nagao, M., Enomoto, S. and Kambe, T
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Journal Title
J Biol Chem
Volume: 286
Issue: 18
Pages: 16363-16373
DOI
Related Report
Peer Reviewed
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