Research Project
Grant-in-Aid for Scientific Research (B)
Messenger RNA exporter regulates the mRNA processing. In human, mRNA exporter is diversified. Here, I am focusing on the mechanism of the complex formation of TREX and AREX as functional mRNA exporters.The analysis using chimera mutants and point-mutated proteins, I have shown that TREX and AREX complex formation by UAP56 and URH49 are regulated by single amino acid exchange. This indicates that UAP56 and URH49 were diversified from the common ancestor and obtained the specific function through forming specific complex.
All 2014 2013 2012 2011 Other
All Journal Article (9 results) (of which Peer Reviewed: 7 results) Presentation (38 results) Book (5 results) Remarks (5 results) Patent(Industrial Property Rights) (2 results)
PLOS ONE
Volume: 8 Issue: 10 Pages: e77445-e77445
10.1371/journal.pone.0077445
Biochem. Biophys. Res. Commun
Volume: 440 Issue: 2 Pages: 204-209
10.1016/j.bbrc.2013.09.003
Nucleus
Volume: 4 Issue: 4 Pages: 326-40
10.4161/nucl.26052
バイオサイエンスとインダストリー
Volume: 70 Pages: 373-375
10031003447
http://www.jba.or.jp/pc/bi/
Biosci. Biotechnol. Biochem
Volume: 76 Pages: 1248-1251
https://www.jstage.jst.go.jp/article/bbb/76/6/76_120226/_article
化学と生物
Volume: 50 Pages: 9-11
http://www.jsbba.or.jp/pub/journal_kasei/
Biosci. Biotechnol. Biochem.
J Biotechnol
Volume: 153 Issue: 3-4 Pages: 86-91
10.1016/j.jbiotec.2011.03.024
120003072129
J Biol Chem
Volume: 286 Issue: 18 Pages: 16363-16373
10.1074/jbc.m111.227173
http://www.lif.kyoto-u.ac.jp/labs/bunshioutou/
http://www.lif.kyoto-u.ac.jp/j/modules/education/content0040.html