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Synthesis of complex-type glycan containing LacdiNAc structure and its application to the glycoprotein synthesis

Research Project

Project/Area Number 23380065
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Bioproduction chemistry/Bioorganic chemistry
Research InstitutionOsaka University (2013)
Tokai University (2011-2012)

Principal Investigator

HOJO Hironobu  大阪大学, たんぱく質研究所, 教授 (00209214)

Co-Investigator(Renkei-kenkyūsha) KATAYAMA Hidekazu  東海大学, 工学部, 講師 (30580857)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Keywords糖タンパク質 / グライコデリン / 糖ペプチドチオエステル / セグメント縮合法 / LacdiNAc / glycodelin / ペプチドチオエステル / 化学合成
Research Abstract

Glycodelin A (GdA), a glycoprotein of 162 amino acid residues, has unusual carbohydrate structures composed of GalNAc-GlcNAc (LacdiNAc), and is engaged in important biological processes, such as fertilization. To promote the functional analysis of GdA as well as LacdiNAc-containing glycan, an access to GdA having homogeneous glycan is required. In this research, the efficient synthetic route of GdA having homogeneous glycan was examined. The synthesis of LacdiNAc-containing carbohydrate was realized by our benzyl-protection strategy. The polypeptide composed of the entire GdA sequence carrying GlcNAcs was then assembled by the native chemical ligation method combined with our N-alklycysteine-assisted thioesterification method. After folding, GdA having GlcNAcs was reacted with LacdiNAc sugar by glycosynthase to derivatize into GdA having LacdiNAc sugar.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (73 results)

All 2014 2013 2012 2011 Other

All Journal Article (26 results) (of which Peer Reviewed: 25 results) Presentation (42 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Model Study Using Designed Selenopeptides on the Importance of the Catalytic Triad for the Antioxidative Functions of Glutathione Peroxidase2014

    • Author(s)
      T. Takei, Y. Urabe, Y. Asahina, H. Hojo, T. Nomura, K. Dedachi, K. Arai, M. Iwaoka
    • Journal Title

      J. Phys. Chem. B

      Volume: 118 Pages: 492-500

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Model Study Using Designed Selenopeptides on the Importance of the Catalytic Triad for the Antioxidative Functions of Glutathione Peroxidase2014

    • Author(s)
      Toshiki Takei, Yoshiko Urabe, Yuya Asahina, Hironobu Hojo, Takeshi Nomura, Kenichi Dedachi, Kenta Arai, and Michio Iwaoka
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 118 Issue: 2 Pages: 492-500

    • DOI

      10.1021/jp4113975

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2013

    • Author(s)
      Y Asahina, S. Kamitori, T. Takao, N. Nishi, H. Hojo
    • Journal Title

      Angew. Chem. Int. Ed

      Volume: 52 Pages: 9733-9737

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article]2013

    • Author(s)
      A. Wada, P.-F. Wong, H. Hojo, 他6 名
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 434 Pages: 223-227

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article]2013

    • Author(s)
      H. Katayama and H. Hojo
    • Journal Title

      Org. Biomol. Chem

      Volume: 11 Pages: 4405-4413

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article]2013

    • Author(s)
      Y. Asahina, M. Kanda, A. Suzuki, 他3名
    • Journal Title

      Org. Biomol. Chem

      Volume: 11 Pages: 7199-7207

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel post-ligation thioesterification device enables peptide ligation in the N to C direction : synthetic study of human glycodelin2013

    • Author(s)
      T. Takenouchi, H. Katayama, Y. Nakahara, Y. Nakahara, H. Hojo
    • Journal Title

      J. Pept. Sci

      Volume: 20 Pages: 55-61

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemoenzymatic synthesis of the immunoglobulin domain of Tim-3 carrying a complex-type N-glycan by using a one-pot ligation. Angew2013

    • Author(s)
      Asahina, Y., Kamitori, S., Takao, T., Nishi, N. & Hojo, H.
    • Journal Title

      Chem. Int

      Volume: 52 Issue: 37 Pages: 9733-9737

    • DOI

      10.1002/anie.201303073

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fast preparation of an N-acetylglucosaminylated peptide segment for the chemoenzymatic synthesis of a glycoprotein2013

    • Author(s)
      Y. Asahina, M. Kanda, A. Suzuki, H. Katayama, Y. Nakahara and H. Hojo
    • Journal Title

      Org. Biomol. Chem.

      Volume: 11 Issue: 41 Pages: 7199

    • DOI

      10.1039/c3ob41565a

    • URL

      https://pure.teikyo.jp/en/publications/80d0ada0-4df7-4bd1-88c3-5834ff1e6ca0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel post-ligation thioesterification device enables peptide ligation in the N to C direction: synthetic study of human glycodelin2013

    • Author(s)
      T. Takenouchi, H. Katayama, Y. Nakahara, Y. Nakahara and H. Hojo
    • Journal Title

      J. Pept. Sci.

      Volume: 20 Pages: 55-61

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2012

    • Author(s)
      H. Katayama, K. Nozawa, O. Nureki, Y. Nakahara, H. Hojo
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: 76 Pages: 205-208

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article]2012

    • Author(s)
      H. Hojo, H. Tanaka, M. Hagiwara, 他8名
    • Journal Title

      J. Org. Chem

      Volume: 77 Pages: 9437-9446

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemoenzymatic synthesis of hydrophobic glycoprotein: Synthesis of saposin c carrying complex-type carbohydrate2012

    • Author(s)
      Hironobu Hojo
    • Journal Title

      J. Org. Chem.

      Volume: 77 Issue: 21 Pages: 9437

    • DOI

      10.1021/jo3010155

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pyrrolysine Analogs as Substrates for Bacterial Pyrrolysyl-tRNA Synthetase in Vitro and in Vivo2012

    • Author(s)
      Hidekazu Katayama, 他4名
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 76 Issue: 1 Pages: 205-208

    • DOI

      10.1271/bbb.110653

    • NAID

      10030399195

    • ISSN
      0916-8451, 1347-6947
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-Methyl-phenacyloxycarbamidomethyl (Pocam) group : a novel thiol protecting group for solid-phase peptide synthesis and peptide condensation reactions2011

    • Author(s)
      H. Katayama, Y. Nakahara, H. Hojo
    • Journal Title

      Org. Biomol. Chem

      Volume: 9 Pages: 4653-4661

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of biantennary complex-type nonasaccharyl Asn building blocks for solid-phase glycopeptide synthesis2011

    • Author(s)
      M. Hagiwara, M. Dohi, Y. Nakahara, 他6名
    • Journal Title

      J. Org. Chem

      Volume: 76 Pages: 5229-5239

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient preparation of Fmoc-aminoacyl-Nethylcysteine unit, a key device for the synthesis of peptide thioesters2011

    • Author(s)
      H. Hojo, H. Kobayashi, R. Ubagai, 他5名
    • Journal Title

      Org. Biomol. Chem

      Volume: 9 Pages: 6807-6813

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts2011

    • Author(s)
      T. Kawakami, T. Sameshima, H. Hojo, 他7名
    • Journal Title

      BMC Cancer

      Volume: 11 Pages: 300-300

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chemical synthesis of the S-linked glycopeptide, sublancin2011

    • Author(s)
      H. Katayama, Y. Asahina, H. Hojo
    • Journal Title

      J. Pept. Sci

      Volume: 17 Pages: 818-821

    • Related Report
      2013 Final Research Report
  • [Journal Article] Synthesis of an O-acyl isopeptide by using native chemical ligation to efficiently construct a hydrophobic polypeptide2011

    • Author(s)
      Y. Sohma, H. Kitamura, H. Kawashima, H. Hojo, M. Yamashita, K. Akaji, Y. Kiso
    • Journal Title

      Tetrahedron Lett

      Volume: 52 Pages: 7146-7148

    • NAID

      10030204148

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-Methyl-phenacyloxycarbamidomethyl (Pocam) group : a novel thiol protecting group for solid-phase peptide synthesis and peptide condensation reactions2011

    • Author(s)
      Katayama, H., Nakahara, Y., Hojo, H.
    • Journal Title

      Org.Biomol.Chem.

      Volume: 9 Pages: 4653-4661

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Biantennary Complex-Type Nonasaccharyl Asn Building Blocks for Solid-Phase Glycopeptide Synthesis2011

    • Author(s)
      Hagiwara, M., Dohi, M., Nakahara, Y., Komatsu, K., Asahina, Y., Ueki, A., Hojo, H., Nakahara, Y., Ito, Y.
    • Journal Title

      J.Org.Chem.

      Volume: 76 Issue: 13 Pages: 5229-5239

    • DOI

      10.1021/jo200149d

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient preparation of Fmoc-aminoacyl-N-ethylcysteine unit, a key device for the synthesis of peptide thioesters2011

    • Author(s)
      Hojo, H., Kobayashi, H., Ubagai, R., Asahina, Y., Nakahara, Y., Katayama, H., Ito, Y., Nakahara, Y.
    • Journal Title

      Org.Biomol.Chem.

      Volume: 9 Pages: 6807-6813

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic emmprin peptides with chitobiose substitution stimulate MMP-2 production by fibroblasts2011

    • Author(s)
      Kawakami T., Sameshima T., Hojo H., Koga K., Nakahara Y., Toole B.P., Okada Y., Iwasaki A., Nabeshima K.
    • Journal Title

      BMC Cancer

      Volume: 11 Issue: 1 Pages: 300-300

    • DOI

      10.1186/1471-2407-11-300

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chemical synthesis of the S-linked glycopeptide, sublancin2011

    • Author(s)
      Hidekazu Katayama, Yuya Asahina, Hironobu Hojo
    • Journal Title

      Journal of Peptide Science

      Volume: 17 Issue: 12 Pages: 818

    • DOI

      10.1002/psc.1406

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of an O-acyl isopeptide by using native chemical ligation to efficiently construct a hydrophobic polypeptide.2011

    • Author(s)
      Youhei Sohma, Hitomi Kitamura, Hiroyuki Kawashima, Hironobu Hojo, Masayuki Yamashita, Kenichi Akaji, Yoshiaki Kiso
    • Journal Title

      Tetrahedron Letters

      Volume: 52(52) Issue: 52 Pages: 7146-7148

    • DOI

      10.1016/j.tetlet.2011.10.116

    • NAID

      10030204148

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 4-メチルベンジル基を保護基とするO-結合型糖アミノ酸の合成と応用2014

    • Author(s)
      朝比奈雄也, 神田美華, 北條裕信
    • Organizer
      日本農芸化学会2014年度大会
    • Place of Presentation
      東京
    • Year and Date
      2014-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Chemoenzymatic synthesis of glycoprotein2013

    • Author(s)
      Asahina, Y., Kamitori, S., Takao, T., Nishi, N., Suzuki, A., Katayama, H., Nakahara, Y., Hojo, H
    • Organizer
      4th Asia-Pacific International Peptide Symposium
    • Place of Presentation
      Osaka
    • Year and Date
      2013-11-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Study of the Substituent effect on the N-alkylcysteine-assisted thioesterification2013

    • Author(s)
      Asahina, Y., Nabeshima, K., Hojo, H
    • Organizer
      4th Asia-Pacific International Peptide Symposium
    • Place of Presentation
      Osaka
    • Year and Date
      2013-11-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Facile synthesis of gelatinase biosynthesisactivating pheromone (GBAP), a bacterical peptide lactone2013

    • Author(s)
      Katayama, H., Nagata, K., Tanokura, M., Nakayama, J., Sonomoto, K., Hojo, H
    • Organizer
      4th Asia-Pacific International Peptide Symposium
    • Place of Presentation
      Osaka
    • Year and Date
      2013-11-06
    • Related Report
      2013 Final Research Report
  • [Presentation] The Effect of the Alkyl Substituent on the N-Alkylcysteine-Assisted Thioesterification2013

    • Author(s)
      Asahina, Y., Nabeshima, K., Hojo, H
    • Organizer
      4th Modern Solid Phase Peptide Symposium and Its Application Symposium
    • Place of Presentation
      Kobe
    • Year and Date
      2013-11-03
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Phenacyl group acts efficiently as a Cys protecting group on thioester condensation reaction2013

    • Author(s)
      Katayama, H., Kiga, T., Hojo, H
    • Organizer
      4th Modern Solid Phase Peptide Symposium and Its Application Symposium
    • Place of Presentation
      Kobe
    • Year and Date
      2013-11-03
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 酸感受性保護基を有するGlcNAc-Asn 誘導体の合成と糖タンパク質調製への応用2013

    • Author(s)
      朝比奈雄也, 神田美華, 北條裕信
    • Organizer
      第32回日本糖質学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2013-08-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Synthesis of TIM-3 Ig-like domain carrying a complex-type carbohydrate2013

    • Author(s)
      Asahina, Y., Kamitori, S., Hojo, H
    • Organizer
      23rd American Peptide Symposium
    • Place of Presentation
      Hawaii
    • Year and Date
      2013-06-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Prompt preparation of N-acetylglucosaminylated peptide for the chemoenzymatic synthesis of glycoprotein2013

    • Author(s)
      Asahina, Y., Kanda, M., Hojo, H
    • Organizer
      23rd American Peptide Symposium
    • Place of Presentation
      Hawaii
    • Year and Date
      2013-06-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖鎖受容ペプチドの簡便な合成法の開発2013

    • Author(s)
      朝比奈雄也, 神田美華, 北條裕信
    • Organizer
      日本農芸化学会
    • Place of Presentation
      仙台
    • Year and Date
      2013-03-26
    • Related Report
      2013 Final Research Report
  • [Presentation] クルマエビのインスリン様造雄腺因子の化学合成研究2013

    • Author(s)
      片山秀和, 窪田のぞみ, 粂圭一郎, 大平剛, 北條裕信
    • Organizer
      日本農芸化学会
    • Place of Presentation
      仙台
    • Year and Date
      2013-03-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Synthesis of TIM-3 Ig-like domain carrying a complex-type carbohydrate2013

    • Author(s)
      Y. Asahina, S. Kamitori, H. Hojo
    • Organizer
      23rd American Peptide Symposium
    • Place of Presentation
      Hawaii, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Prompt preparation of N-acetylglucosaminylated peptide for the chemoenzymatic synthesis of glycoprotein2013

    • Author(s)
      Y. Asahina, M. Kanda, H. Hojo
    • Organizer
      23rd American Peptide Symposium
    • Place of Presentation
      Hawaii,USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Chemoenzymatic Synthesis of Glycoprotein2013

    • Author(s)
      Y Asahina, S. Kamitori, T. Takao, N. Nishi, A. Suzuki, H. Katayama, Y. Nakahara, H. Hojo
    • Organizer
      4th Asia-Pacific International Peptide Symposium
    • Place of Presentation
      Osaka
    • Related Report
      2013 Annual Research Report
  • [Presentation] Synthetic study of a membrane protein using the protected O-acyl isopeptide as a solubility enhancing element2012

    • Author(s)
      Hojo, H., Haris, P.I
    • Organizer
      49th Japanese Peptide Symposium
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-11-08
    • Related Report
      2013 Final Research Report
  • [Presentation] Synthesis of Tim-3 Ig domain carrying complex-type N-glycan using the sequential one-pot condensation by the thioester method2012

    • Author(s)
      Asahina, Y., Kamitori, S., Hojo, H
    • Organizer
      49th Japanese Peptide Symposium
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-11-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Phenacyl group is an efficient protecting group of Cys side chain on the peptide condensation reaction by the thioester method2012

    • Author(s)
      Katayama, H., Hojo, H
    • Organizer
      49th Japanese Peptide Symposium
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-11-07
    • Related Report
      2013 Final Research Report
  • [Presentation] N-結合型糖鎖を持つTIM-3 Immunoglobulin 様ドメインの酵素化学合成2012

    • Author(s)
      朝比奈雄也, 神鳥成弘, 北條裕信
    • Organizer
      第31回日本糖質学会年会
    • Place of Presentation
      鹿児島
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Chemoenzymatic synthesis of saposin C carrying complex-type carbohydrate2012

    • Author(s)
      Asahina, Y., Tanaka, H., Hagiwara, M., Ueki, A., Katayama, H., Nakahara, Y., Yoneshige, A., Matsuda, J., Nakahara, Y., Hojo, H
    • Organizer
      The 26th International Carbohydrate Symposium (ICS2012)
    • Place of Presentation
      Madrid
    • Year and Date
      2012-07-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Chemical synthesis of immunoglobulin domain of TIM-3 using the ligation method2012

    • Author(s)
      Hojo, H., Asahina, Y., Kamitori, S
    • Organizer
      The 26th International Carbohydrate Symposium (ICS2012)
    • Place of Presentation
      Madrid
    • Year and Date
      2012-07-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 疎水性ペプチドの化学合成研究2012

    • Author(s)
      田野千春, 片山秀和, 北條裕信
    • Organizer
      日本化学会第92回春季年会
    • Place of Presentation
      神奈川
    • Year and Date
      2012-03-27
    • Related Report
      2013 Final Research Report
  • [Presentation] N-結合型糖鎖を有するSaposin C の合成2012

    • Author(s)
      小林 甫, 田中洋成, 朝比奈雄也, 田野千春, 片山秀和, 中原義昭, 中原悠子, 米重あずさ, 松田純子, 北條裕信
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Bacillus subtilis 由来S-結合型糖ペプチドsublancinの化学合成2012

    • Author(s)
      片山秀和, 朝比奈雄也, 北條裕信
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] セグメント縮合法を用いた糖タンパク質Tim-3 IgV ドメインの合成研究2012

    • Author(s)
      朝比奈雄也, 片山秀和, 神鳥成弘, 北條裕信
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都
    • Year and Date
      2012-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] ペプチド,蛋白質合成の未来像2012

    • Author(s)
      北條裕信
    • Organizer
      大阪大学蛋白質研究所セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2012-03-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Synthesis of Tim-3 Ig domain carrying complex-type N-glycan using the sequential one-pot condensation by the thioester method2012

    • Author(s)
      Yuya Asahina
    • Organizer
      49th Japanese Peptide Symposium
    • Place of Presentation
      鹿児島県民交流センター、鹿児島
    • Related Report
      2012 Annual Research Report
  • [Presentation] Phenacyl group is an efficient protecting group of Cys side chain on the peptide condensation reaction by the thioester method2012

    • Author(s)
      Hidekazu Katayama
    • Organizer
      49th Japanese Peptide Symposium
    • Place of Presentation
      鹿児島県民交流センター、鹿児島
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthetic study of a membrane protein using the protected O-acyl isopeptide as a solubility enhancing element2012

    • Author(s)
      Hironobu Hojo
    • Organizer
      49th Japanese Peptide Symposium
    • Place of Presentation
      鹿児島県民交流センター、鹿児島
    • Related Report
      2012 Annual Research Report
  • [Presentation] Chemoenzymatic synthesis of saposin C carrying complex-type carbohydrate2012

    • Author(s)
      Yuya Asahina
    • Organizer
      The 26th International Carbohydrate Symposium
    • Place of Presentation
      Hotel Melia Castilla, Spain
    • Related Report
      2012 Annual Research Report
  • [Presentation] Chemical synthesis of immunoglobulin domain of TIM-3 using the ligation method2012

    • Author(s)
      Hironobu Hojo
    • Organizer
      The 26th International Carbohydrate Symposium
    • Place of Presentation
      Hotel Melia Castilla, Spain
    • Related Report
      2012 Annual Research Report
  • [Presentation] The effects of chemically synthesized saposin C on glucosylceramide-β-glucosidase2012

    • Author(s)
      Azusa Yoneshige
    • Organizer
      The 26th International Carbohydrate Symposium
    • Place of Presentation
      Hotel Melia Castilla, Spain
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthesis of glycoportein by ligation methods2011

    • Author(s)
      Hojo, H
    • Organizer
      15th Korean Peptide-Protein Symposium
    • Place of Presentation
      Chung Ju
    • Year and Date
      2011-12-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Synthetic study of glycosylated IgV domain of Tim-3 using the thioester method2011

    • Author(s)
      Asahina, Y., Katayama, H., Kamitori, S., Hojo, H
    • Organizer
      15th Korean Peptide-Protein Symposium
    • Place of Presentation
      Chung Ju
    • Year and Date
      2011-12-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Synthesis of glycoportein by ligation methods2011

    • Author(s)
      Hojo, H
    • Organizer
      Korean Peptide-Protein Symposium
    • Place of Presentation
      Chung Ju, Korea
    • Year and Date
      2011-12-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Synthesis of hydrophobic glycoprotein by the thioester method2011

    • Author(s)
      Katayama, H., Nakahara, Y. Yoneshige, A., Matsuda, J., Hojo, H
    • Organizer
      3rd Modern Solid Phase Peptide Synthesis and its Applications Symposium
    • Place of Presentation
      Queensland
    • Year and Date
      2011-10-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Synthesis of Hydrophobic Glycoprotein by the Thioester Method2011

    • Author(s)
      Katayama, H., Nakahara, Y.Yoneshige, A., Matsuda, J., Hojo, H.
    • Organizer
      3^<rd> Modern Solid Phase Peptide Synthesis and its Applications Symposium
    • Place of Presentation
      Queensland, Australia
    • Year and Date
      2011-10-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Chemoenzymatic synthesis of lipid-binding protein, saposin C2011

    • Author(s)
      Hojo, H., Tanaka, H., Asahina, Y., Tano, C., Katayama, H., Nakahara, Y., Nakahara, Y., Yoneshige, A., Matsuda, J
    • Organizer
      48th Japanese Peptide Symposium
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Synthetic study of glycosylated IgV domain of Tim-3 using segment condensation method2011

    • Author(s)
      Asahina, Y., Katayama, H., Kamitori, S., Hojo, H
    • Organizer
      48th Japanese Peptide Symposium
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Chemoenzymatic synthesis of lipid-binding protein, saposin C2011

    • Author(s)
      Hojo, H., Tanaka, H., Asahina, Y., Tano, C, Katayama, H., Nakahara, Y., Nakahara, Y., Yoneshige, A., Matsuda J.
    • Organizer
      48^<th> Japanese Peptide Symposium
    • Place of Presentation
      札幌、札幌コンベンションセンター
    • Year and Date
      2011-09-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Chemical synthesis of sublancin, a bacterial S-linked glycopeptide2011

    • Author(s)
      Katayama, H., Asahina, Y., Hojo, H
    • Organizer
      48th Japanese Peptide Symposium
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Efficient synthesis of Fmoc-aminoacyl-N-ethylcysteine, a key device for peptide thioester preparation2011

    • Author(s)
      Asahina, Y., Kobayashi, H., Ubagai, R., Katayama, H., Nakahara, Y., Ito, Y., Nakahara, Y., Hojo, H
    • Organizer
      48th Japanese Peptide Symposium
    • Place of Presentation
      札幌
    • Year and Date
      2011-09-27
    • Related Report
      2013 Final Research Report
  • [Presentation] The effects of chemically synthesized saposin C on glucosylceramide-β-glucosidase

    • Author(s)
      Yoneshige, A., Mutou, M., Watanabe, T., Tano, C., Hojo, H., Matsuda, J
    • Organizer
      The 26th International Carbohydrate Symposium (ICS2012)
    • Place of Presentation
      Madrid
    • Related Report
      2013 Final Research Report
  • [Book] 最新ペプチド合成技術とその創薬研究への応用(木曽良明編集),第2 章ライゲーション法によるペプチド・糖タンパクの合成と創薬への応用 「疎水性糖タンパク質の化学-酵素合成」2012

    • Author(s)
      北條裕信
    • Publisher
      メディカルドゥ
    • Related Report
      2013 Final Research Report
  • [Book] ペプチド医薬の最前線(木曽良明,向井秀仁監修),第2 章ペプチド医薬の基礎 「糖タンパク質の合成とその糖鎖機能解明への応用」2012

    • Author(s)
      北條裕信, 松田純子
    • Publisher
      シーエムシー出版
    • Related Report
      2013 Final Research Report
  • [Book] 最新ペプチド合成技術とその創薬研究への応用(木曽良明編集)、第2章ライゲーション法によるペプチド・糖タンパクの合成と創薬への応用 「疎水性糖タンパク質の化学-酵素合成」2012

    • Author(s)
      北條裕信
    • Total Pages
      6
    • Publisher
      メディカルドゥ
    • Related Report
      2012 Annual Research Report
  • [Book] ペプチド医薬の最前線(木曽良明、向井秀仁監修)、第2章ペプチド医薬の基礎 「糖タンパク質の合成とその糖鎖機能解明への応用」2012

    • Author(s)
      北條裕信
    • Total Pages
      5
    • Publisher
      シーエムシー
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.protein.osaka-u.ac.jp/organic/index.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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