| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2011: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Research Abstract |
One of the biggest problems of cancer chemotherapy is the acquisition of drug resistance. Recent years, it has been considered that "cancer stem cell" plays a significant role in drug resistance. Most of tumor is originated from cancer stem cells, thus it is thought to be the severest malignant cells. Like this, cancer stem cells are promising targets for the development of antitumor drugs, however, cancer stem cells are difficult to be applied for drug screenings since it is unstable being to differentiate to various cell types. Glioblastoma multiforme (GBM) excised from cancer patients is stably shows the character of cancer stem cells when cultured in spheroid system. In this study, we performed the screening for substances which act on GBM cells using natural library.
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