Biological Localization and Functionality of Allenic Carotenoids

• Project/Area Number: 23380068
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Hokkaido University
• Principal Investigator: MIYASHITA Kazuo 北海道大学, 大学院水産科学研究院, 教授 (10182015)
• Co-Investigator(Renkei-kenkyūsha): HOSOKAWA Masashi 北海道大学, 大学院・水産科学研究院, 准教授 (10241374)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000); Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000); Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
• Keywords: アレンカロテノイド / 抗肥満 / 抗糖尿病 / フコキサンチン / エネルギー代謝 / 抗肥満作用 / 抗糖尿病作用 / 構造相関 / アセチレンカロテノイド / キサントフィル

Research Abstract

In the present study, molecular mechanisms were made clear for the anti-obesity effect of fucoxanthin by the induction of UCP1 in abdominal WAT. The anti-obesity effect of fucoxanthin was suggested to be due to its specific structure that contains two carotenoid end rings of the polyene chromophore containing allenic bond and OH and epoxy groups. Therefore, other allenic carotenoids or scission products from fucoxanthin could not show such activities as found in fucoxanthin. Fucoxanthin also improves insulin resistance and decreases blood glucose level through the regulation of adipocytokine secretions from the abdominal WAT. Another important molecular mechanism for the improvement of glucose utilization by fucoxanthin will be glucose transporter 4 (GLUT4) up-regulation and promotion of its translocation to cell membrane from cytosol.

Research Products

• [Journal Article] Regulation of polyunsaturated fatty acid biosynthesis by seaweed fucoxanthin and its metabolite in cultured hepatocytes. (2014)
  • Author(s): Aki, T., Yamamoto, M., Takahashi, T., Tomita, K., Toyoura, Ri., Iwashita, K., Kawamoto, S., Hosokawa, M., Miyashita, K., Ono, K.
  • Journal Title: Lipids Volume: 49 Issue: 2 Pages: 133-141
  • DOI: 10.1007/s11745-013-3856-5
  • Peer Reviewed
• [Journal Article] Down-regulation of hepatic stearoyl-CoA desaturase-1 expression by fucoxanthin via leptin signaling in diabetic/obese KK-Ay mice. (2013)
  • Author(s): Beppu F, Hosokawa M, Yim MJ, Shinoda T, Miyashita K.
  • Journal Title: Lipids Volume: 48 Issue: 5 Pages: 449-455
  • DOI: 10.1007/s11745-013-3784-4
  • Peer Reviewed
• [Journal Article] Nomura, M., Kamogawa, H., Susanto, E., Kawagoe, C., Yasui, H., Saga, N., Hosokawa, M., Miyashita, K. (2013)
  • Author(s): Nomura, M., Kamogawa, H., Susanto, E., Kawagoe, C., Yasui, H., Saga, N., Hosokawa, M., Miyashita, K.
  • Journal Title: J. Appl. Phycol. Volume: 25 Issue: 4 Pages: 1159-1169
  • DOI: 10.1007/s10811-012-9934-x
  • Peer Reviewed
• [Journal Article] Fucoxanthin : a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms. (2013)
  • Author(s): Kumar, S. R., Hosokawa, M., Miyashita K.
  • Journal Title: Mar. Drugs Volume: 11 Issue: 12 Pages: 5130-5147
  • DOI: 10.3390/md11125130
  • Peer Reviewed
• [Journal Article] Chemical and nutritional characteristics of brown seaweed lipids: A review. (2013)
  • Author(s): Miyashita, K., Mikamia, N., Hosokawa, M.
  • Journal Title: J. Functional Foods Volume: 5 Issue: 4 Pages: 1507-1517
  • DOI: 10.1016/j.jff.2013.09.019
  • Peer Reviewed
• [Journal Article] Fucoxanthin as potential nutraceutical for obesity therapy: A Review. (2013)
  • Author(s): Miyashita, K., Maeda, H., Nishikawa, S., Tsukui, T., Widjaja-Adhi, M.A.K., Hosokawa, M.
  • Journal Title: Carotenoid Sci. Volume: 17 Pages: 1-7
• [Journal Article] Combined antiproliferative effect of dietary PPARγ suppressing lipids fucoxanthinol and 1α,25-dihydroxyvitamin D3 in human colon cancer. (2013)
  • Author(s): Terasaki, M., Nagao, A., Maeda, H., Miyashita, K., Masuda, S.
  • Journal Title: Carotenoid Sci. Volume: 17 Pages: 40-43
• [Journal Article] Neoxanthin in Komatsuna improves lipid metabolism in adipocyte cells. (2013)
  • Author(s): Maeda, H., Abe, M., Hosokawa, M., Miyashita, K., Katagata, Y.
  • Journal Title: Carotenoid Sci. Volume: 17 Pages: 44-45
• [Journal Article] 褐藻カロテノイド, フコキサンチンのUCP1発現亢進作用 (2013)
  • Author(s): 宮下和夫・細川雅史
  • Journal Title: バイオインダストリー Volume: 30 Pages: 31-38
• [Journal Article] In vivo antioxidant activity of fucoxanthin on obese/diabetes KK-Ay mice. (2012)
  • Author(s): Iwasaki S, Widjaja-Adhi M. A. K., Koide A, Kaga T, Nakano S, Beppu F, Hosokawa M, Miyashita K.
  • Journal Title: Food and Nutrition Science Volume: 3 Issue: 11 Pages: 1491-1499
  • DOI: 10.4236/fns.2012.311194
  • Peer Reviewed
• [Journal Article] Effect of Caffeine and Capsaicin on the Blood Glucose Levels of Obese/Diabetic KK-<i>A^y</i> Mice (2012)
  • Author(s): Okumura T., Tsukui T., Hosokawa M., Miyashita K
  • Journal Title: Journal of Oleo Science Volume: 61 Issue: 9 Pages: 515-523
  • DOI: 10.5650/jos.61.515
  • NAID: 130004435983
  • ISSN: 1345-8957, 1347-3352
  • Peer Reviewed
• [Journal Article] Fucoxanthin Extractions of Brown Seaweeds and Analysis of Their Lipid Fraction in Methanol (2012)
  • Author(s): Jaswir I., Noviendri D., Salleh H.M., Miyashita K
  • Journal Title: Food Science and Technology Research Volume: 18 Issue: 2 Pages: 251-257
  • DOI: 10.3136/fstr.18.251
  • NAID: 10030918080
  • ISSN: 1344-6606, 1881-3984
  • Peer Reviewed
• [Journal Article] Effects of dietary fucoxanthin on cholesterol metabolism in diabetic/obese KK-Ay mice. (2012)
  • Author(s): Beppu F, Hosokawa M, Niwano Y, Miyashita K.
  • Journal Title: Lipids in Health and Disease Volume: 11 Issue: 1 Pages: 112-119
  • DOI: 10.1186/1476-511x-11-112
  • Peer Reviewed
• [Journal Article] Stability of Fucoxanthin in Dried <i>Undaria Pinnatifida</i> (Wakame) and Baked Products (Scones) Containing Wakame Powder (2012)
  • Author(s): Rumiko Sugimura, R., Suda, M., Sho, A., Takahashi, T., Sashima, T., Abe, M., Hosokawa, M., Miyashita, K.
  • Journal Title: Food Science and Technology Research Volume: 18 Issue: 5 Pages: 687-693
  • DOI: 10.3136/fstr.18.687
  • NAID: 130002538075
  • ISSN: 1344-6606, 1881-3984
  • Peer Reviewed
• [Journal Article] Carotenoid profile of edible Japanese seaweeds: an improved HPLC method for separation of major carotenoids (2012)
  • Author(s): Terasaki, M., Narayan, B., Kamogawa, H., Nomura, M., Nimish Mol Stephen, N.M., Kawagoe, C., Hosokawa, M., and Miyashita, K.
  • Journal Title: J. Auat. Food Prod. Tech. Volume: 21 Issue: 5 Pages: 468-479
  • DOI: 10.1080/10498850.2011.610025
  • Peer Reviewed
• [Journal Article] Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscle of KK-Ay mice (2012)
  • Author(s): Sho Nishikawa
  • Journal Title: Phytomedicine Volume: 19 Issue: 5 Pages: 389-394
  • DOI: 10.1016/j.phymed.2011.11.001
  • Peer Reviewed
• [Journal Article] Nitrocapsanthin and nitrofucoxanthin, respective products of capsanthin and fucoxanthin reaction with peroxynitrite (2011)
  • Author(s): Tsuboi, M., Etoh, H.,Kato, K., Nakatugawa, H., Kato, H., Maejima, Y., Matsumoto, G., Mori, H., Hosokawa, M., Miyashita, K., Tokuda, H.
  • Journal Title: J.Agric.Food Chem. Volume: 59 Issue: 19 Pages: 10572-10578
  • DOI: 10.1021/jf203493k
  • Peer Reviewed
• [Journal Article] Effect of brown seaweed lipids on fatty acid composition and lipid hydroperoxide levels of mouse liver (2011)
  • Author(s): Airanthi, M.K.W.A., Sasaki, N., Iwasaki, S., Baba, N., Abe, M., Hosokawa,M.,Miyashita, K.
  • Journal Title: J.Agric.Food Chem. Volume: 59 Issue: 8 Pages: 4156-4163
  • DOI: 10.1021/jf104643b
  • Peer Reviewed
• [Journal Article] Suppressive effects of amarouciaxanthin A on 3T3-L1 adipocyte differentiation through down-regulation of PPARγ and C/EBPα mRNA expression (2011)
  • Author(s): Yim, M.-J., Hosokawa, M., Mizushina, Y., Yoshida, H., Saito, Y., Miyashita, K.
  • Journal Title: J.Agric.Food Chem. Volume: 59 Issue: 5 Pages: 1646-1652
  • DOI: 10.1021/jf103290f
  • Peer Reviewed
• [Journal Article] SAllenic carotenoid, fucoxanthin, as a novel marine nutraceutical from brown seaweed (2011)
  • Author(s): Miyashita, K., Nishikawa, S., Beppu, F., Tsukui, T.,Abe, M., Hosokawa, M.
  • Journal Title: J.Sci.Food Agric. Volume: 91 Issue: 7 Pages: 1166-1174
  • DOI: 10.1002/jsfa.4353
• [Presentation] Application of Brown Seaweed Lipids to Functional Foods (2014)
  • Author(s): Miyashita K
  • Organizer: 台湾保健食品学会2014年会員大会
  • Place of Presentation: 国立台湾海洋大学, 台湾
  • Year and Date: 2014-03-07
  • Invited
• [Presentation] "Fucoxanthin"- High Potential for the Prevention of Obesity and Type 2 Diabetes (2013)
  • Author(s): Hosokawa M., Miyashita K. Marine Chimeical
  • Organizer: 2013 The 80th Annual Meeting of KoSFoST
  • Place of Presentation: Cheonan Convention Center, Korea
  • Invited
• [Presentation] 褐藻脂質の機能性と有効活用 (2013)
  • Author(s): 宮下和夫
  • Organizer: 第67回日本栄養・食糧学会大会
  • Place of Presentation: 名古屋大学(名古屋市)
  • Invited
• [Presentation] 藻類脂質の機能性解析 (2013)
  • Author(s): 宮下和夫
  • Organizer: 第73回分析化学討論会
  • Place of Presentation: 北海道大学函館キャンパス（北海道函館市）
  • Invited
• [Presentation] 褐藻脂質の機能性と有効活用 (2013)
  • Author(s): 宮下和夫
  • Organizer: 第67回日本栄養・食糧学会大会
  • Place of Presentation: 名古屋大学東山キャンパス（愛知県名古屋市）
  • Invited
• [Presentation] Brown seaweed lipids: Potentially for novel nutraceuticals. (2013)
  • Author(s): Miyashita, K.
  • Organizer: 2013 International Symposium on Bioresource and Biotechnology
  • Place of Presentation: 国立中興大学（台湾台中市）
  • Invited
• [Presentation] Marine Chimeical “Fucoxanthin”- High Potential for the Prevention of Obesity and Type 2 Diabetes. (2013)
  • Author(s): Hosokawa, M., Miyashita, K.
  • Organizer: 2013 The 80th Annual Meeting of KoSFoST
  • Place of Presentation: Cheonan Art Center（韓国天安市）
  • Invited
• [Presentation] 褐藻中の機能性脂質成分の解析 (2013)
  • Author(s): 宮下和夫・細川雅史
  • Organizer: 日本植物学会第77回大会
  • Place of Presentation: 北海道大学札幌キャンパス（北海道札幌市）
  • Invited
• [Presentation] New perspective in fisheries product development: Importance of seaweeds as biomass resources. (2013)
  • Author(s): Miyashita, K.
  • Organizer: National Seminar of Indonesian Society of Fisheries Product Processing
  • Place of Presentation: Diponegoro University（Indonesia）
  • Invited
• [Presentation] Monocyclic carotenoid produced by marine bacteria. (2013)
  • Author(s): Hosokawa, M., Takatani, N., Nishida, K., Suzuki, R., Sawabe, T., Miyashita, K.
  • Organizer: 104th AOCS Annual Meeting & Expo
  • Place of Presentation: モントリオールコンベンションセンター（モントリオール、カナダ）
• [Presentation] Fucoxanthin suppresses macrophage infiltration into white adipose tissue through regulation of chemokine production in obese/diabetic mice. (2013)
  • Author(s): Hosokawa, M., Koide, A., Yim, M.-J., Oyama, M., Miyashita, K.
  • Organizer: 104th AOCS Annual Meeting & Expo
  • Place of Presentation: モントリオールコンベンションセンター（モントリオール、カナダ）
• [Presentation] ICRマウスにおけるフコキサンチンの吸収性 (2013)
  • Author(s): 高橋智也・須田正剛・阿部真幸・細川雅史・宮下和夫
  • Organizer: 第67回日本栄養・食糧学会大会
  • Place of Presentation: 名古屋大学東山キャンパス（愛知県名古屋市）
• [Presentation] 褐藻由来フコキサンチンの白色脂肪細胞におけるPGC-1発現誘導作用 (2013)
  • Author(s): 小出愛・西川翔・細川雅史・宮下和夫
  • Organizer: 第67回日本栄養・食糧学会大会
  • Place of Presentation: 名古屋大学東山キャンパス（愛知県名古屋市）
• [Presentation] Marine carotenoids as functional food components and nutraceuticalas. (2013)
  • Author(s): Miyashita, K., Hosokawa, M.
  • Organizer: 13th Asean Food conference 2013
  • Place of Presentation: Max Atria（Singapore）
• [Presentation] アスタキサンチンの炎症性サイトカイン発現制御機構 (2013)
  • Author(s): 木澤有希・山下栄次・宮下和夫・細川雅史
  • Organizer: 平成25年度日本水産学会秋季大会
  • Place of Presentation: 三重大学（三重県津市）
• [Presentation] ICRマウスにおけるフコキサンチンの吸収性 (2013)
  • Author(s): 高橋智也・須田正剛・阿部真幸・細川雅史・宮下和夫
  • Organizer: 平成25年度日本水産学会秋季大会
  • Place of Presentation: 三重大学（三重県津市）
• [Presentation] Fucoxanthin imporoves hyperglycemia through activating GLUT4 in sleletal muscle. (2013)
  • Author(s): Hosokawa, M., Nishikawa, S., Miyashita, K.
  • Organizer: 2013 International Conference on Nutraceuticalas and Functional Foods
  • Place of Presentation: Haward Civil Service International（台湾台北市）
• [Presentation] Brown seaweed lipids: Potentially for novel halal nutraceuticals. (2013)
  • Author(s): Miyashita, K.
  • Organizer: International Seminar on Halal Science and Innovative Product Development
  • Place of Presentation: The Empire Hotel and Country Club (Burunei)
  • Invited
• [Presentation] 糖尿病/肥満モデルKK-Ayマウスの血糖値に対するアレンカロテノイドの影響. (2013)
  • Author(s): 加茂川寛之・細川雅史・宮下和夫
  • Organizer: 平成25度日本水産学会春季大会
  • Place of Presentation: 東京海洋大学 （東京都）
• [Presentation] フコキサンチノール誘導体による脂肪細胞の分化抑制と抗炎症作用に関する研究. (2013)
  • Author(s): 加賀岳朗・細川雅史・宮下和夫・山野由美子・和田昭盛
  • Organizer: 平成25度日本水産学会春季大会
  • Place of Presentation: 東京海洋大学 （東京都）
• [Presentation] Novel functionality and molecular mechanism of brown seaweed carotenoid, fucoxanthin (2012)
  • Author(s): Miyashita K
  • Organizer: The 9th Asia-Pacific Marine Biotechnology Conference
  • Place of Presentation: 高知文化プラザかるぽーと(高知市)
  • Invited
• [Presentation] Research and development in the area of functional food originating from marine products (2012)
  • Author(s): Miyashita K
  • Organizer: Indonesian Aquaculture 2012 (Indoaqua-FITA 2012)
  • Place of Presentation: Hotel Imperial Arya, Indonesia
  • Invited
• [Presentation] Production and conversion of functional carotenoids by bacteria. (2012)
  • Author(s): Hosokawa, M., Nishida, K., Sawabe, T., Miyashita, K., Hou, C.T.
  • Organizer: 103th AOCS Annual Meeting & Expo
  • Place of Presentation: Long Beach Convention Center (USA)
• [Presentation] Fucoxanthin extraction and fatty acid profiles of Malaysian brown seaweeds and cytotoxicity effect of fucoxanthin on human lung cancer (H1299) cell lines. (2012)
  • Author(s): Jaswir, I., Noviendri, D., Salleh, H.M., Taher, M., Miyashita, K.
  • Organizer: 103th AOCS Annual Meeting & Expo
  • Place of Presentation: Long Beach Convention Center (USA)
• [Presentation] Preventive effect of astaxanthin from Haematococcus pluvialis on inflammatory bowel disease. (2012)
  • Author(s): Hosokawa, M., Kizawa, Y., Yasui, Y., Tanaka, T., Miyashita, K., Yamashita, E.
  • Organizer: 103th AOCS Annual Meeting & Expo
  • Place of Presentation: Long Beach Convention Center (USA)
• [Presentation] Anti-obesity effect of vegetable allenic-carotenoid, neoxanthin. (2012)
  • Author(s): Kamogawa, H., Hosokawa, M., Abe, M., Miyashita, K.
  • Organizer: 103th AOCS Annual Meeting & Expo
  • Place of Presentation: Long Beach Convention Center (USA)
• [Presentation] フコキサンチンのKK-Ayマウス骨格筋におけるGLUT4発現及び細胞膜移行の促進. (2012)
  • Author(s): 西川翔・細川雅史・宮下和夫
  • Organizer: 第66回日本栄養・食糧学会大会
  • Place of Presentation: 東北大学 （仙台市）
• [Presentation] Carotenoids and xanthophylls as functional food components and nutraceuticals. (2012)
  • Author(s): Miyashita, K.
  • Organizer: 6th International Practical Short Course on Functional Foods, Nutraceuticals and Bioactives
  • Place of Presentation: AKS Hinista Bay Hotel (Greece)
  • Invited
• [Presentation] Research and development in the area of functional food originating from marine products. (2012)
  • Author(s): Miyashita, K.
  • Organizer: Indonesian Aquaculture 2012 (Indoaqua-FITA 2012)
  • Place of Presentation: Hotel Imperial Arya (Indonesia)
  • Invited
• [Presentation] Novel functionality and molecular mechanism of brown seaweed carotenoid, fucoxanthin. (2012)
  • Author(s): Miyashita, K.
  • Organizer: The 9th Asia-Pacific Marine Biotechnology Conference
  • Place of Presentation: 高知文化プラザかるぽーと （高知市）
  • Invited
• [Presentation] フコキサンチンの糖尿病/肥満KK-Ay マウスにおける糖代謝改善機構. (2012)
  • Author(s): 西川 翔・細川 雅史・宮下 和夫
  • Organizer: 第26回カロテノイド研究談話会
  • Place of Presentation: 函館国際ホテル （函館市）
• [Presentation] ヘマトコッカス藻由来アスタキサンチンの潰瘍性大腸炎予防効果. (2012)
  • Author(s): 木澤有希・山下栄次・宮下和夫・細川雅史
  • Organizer: 平成24年度日本水産学会秋季大会
  • Place of Presentation: 水産大学校 （下関市）
• [Presentation] Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetes/obese KK-Ay mice. (2012)
  • Author(s): Nishikawa, S., Hosokawa, M., Miyashita, K.
  • Organizer: 10th Euro Fed Lipid Congress
  • Place of Presentation: Auditorium Maximum (Poland)
• [Presentation] Preventive effects of marine carotenoids on inflammatory bowl disease and colon carcinogenesis. (2012)
  • Author(s): Hosokawa, M., Yasui, Y., Mikami, N., Miyashita, K.,Tanaka, T.
  • Organizer: World Congress on Oleo Science & 29th ISF Congress
  • Place of Presentation: アルカス佐世保 (佐世保市)
• [Presentation] Dietary fucoxanthin, a marine carotenoids, suppresses hepatic stearoyl-CoA desaturase in mice. (2012)
  • Author(s): Beppu, F., Shinoda, M., Hosokawa, M., Miyashita K.
  • Organizer: World Congress on Oleo Science & 29th ISF Congress
  • Place of Presentation: アルカス佐世保 (佐世保市)
• [Presentation] Fatty acid and fucoxanthin contents of Malaysian brown seaweeds and inhibitory effect of fucoxanthin on human lung cancer (H1299) cell line. (2012)
  • Author(s): Jaswir, I., Noviendri, D., Saleh, M., Taher, M., Miyashita, K.
  • Organizer: World Congress on Oleo Science & 29th ISF Congress
  • Place of Presentation: アルカス佐世保 (佐世保市)
• [Presentation] Anti-obesity effects of fish oil and fucoxanthin on diet-induced obesity model mice. (2012)
  • Author(s): Maeda, H., Honma, K., Hosokawa, M., Miyashita K.
  • Organizer: World Congress on Oleo Science & 29th ISF Congress
  • Place of Presentation: アルカス佐世保 (佐世保市)
• [Presentation] Role of marine carotenoids in human health (2012)
  • Author(s): Hosokawa, M., Miyashita, K.
  • Organizer: 2012 International Conference on Nutraceuticalas and Functional Foods
  • Place of Presentation: Kona Beach Hotel (USA)
• [Presentation] Anti-obesity effects of fucoxanthin in diet-induced obese mice. (2012)
  • Author(s): Maeda, H., Hosokawa, M., Miyashita, K.
  • Organizer: 2012 International Conference on Nutraceuticalas and Functional Foods
  • Place of Presentation: Kona Beach Hotel (USA)
• [Presentation] 褐藻由来フコキサンチンの白色脂肪組織におけるUCP1発現誘導機構 (2012)
  • Author(s): 小出愛・松本伊代・別府史章・前多隼人・細川雅史・宮下和夫
  • Organizer: 日本農芸化学会2012年度大会
  • Place of Presentation: 京都女子大学(京都)
• [Presentation] Jejuia pallidilutea (11ShimoA1株)合成カロテノイドの同定と培養条件の検討 (2012)
  • Author(s): 細川雅史・西田健太郎・澤辺智雄・宮下和夫
  • Organizer: 日本農芸化学会2012年度大会
  • Place of Presentation: 京都女子大学(京都)
• [Presentation] 褐藻カロテノイド,フコキサンチンの生体内抗酸化活性 (2011)
  • Author(s): Widjaja-Adhi, A.・岩崎さやか・山口智代・阿部真幸・細川雅史・宮下和夫
  • Organizer: 日本食品科学工学会第58回大会
  • Place of Presentation: 東北大学(仙台)
  • Year and Date: 2011-09-11
• [Presentation] Novel functionality of allenic carotenoids (2011)
  • Author(s): Miyashita, K.
  • Organizer: Workshop on Downstream Process Technology and Functional Properties of Seaweeds (Invited)
  • Place of Presentation: International Islamic University Malaysia (Kuala Lumpur, Malaysia)
  • Year and Date: 2011-05-16
• [Presentation] Beneficial health effects of seaweed bio-actives (2011)
  • Author(s): Miyashita, K.
  • Organizer: International Symposium on Seaweed Biomass Production & Bioenergy (Invited)
  • Place of Presentation: ChangPoGo Memorial Hall (Wando, Korea)
• [Presentation] Beneficial health effects of seaweed bio-actives (2011)
  • Author(s): Miyashita, K.
  • Organizer: XI Asian Congress of Nutrition 2011 (Invited)
  • Place of Presentation: Suntec Singapore International Convention & Exhibition Centre (Singapore)
• [Presentation] Novel functionality and molecular mechanism of fucoxantnin. (2011)
  • Author(s): Miyashita, K., Hosokawa, M.
  • Organizer: 16th International Symposium on Carotenoids (Invited)
  • Place of Presentation: Auditorium Maximum of the Jagiellonian University (Krakow, Poland)
• [Presentation] Allenic carotenoid, fucoxanthin, as a novel marine nutraceutical from brown seaweed (2011)
  • Author(s): Miyashita,K., Hosokawa, M.
  • Organizer: 2011 International Conference on Food Factors (Invited)
  • Place of Presentation: Taipei International Convention Center (Taipei, Taiwan)
• [Presentation] Bioconversion of marine carotenoids and their health function (2011)
  • Author(s): Hosokawa, M., Hou, C.T., Miyashita, K., Yim, M.-J.
  • Organizer: 102th AOCS Annual Meeting & Expo
  • Place of Presentation: Duke Energy Center (Cincinnati, USA)
• [Presentation] 褐藻由来フコキサンチンによるstearoyl-COA desaturase 1 (SCD1)発現抑制効果 (2011)
  • Author(s): 篠田太郎・別府史章・津久井隆行・細川雅史・宮下和夫
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: 御茶ノ水女子大学(東京)
• [Presentation] マボヤ由来カロテノイドのDSS誘発大腸炎に対する予防効果 (2011)
  • Author(s): 細川雅史・鈴木雄太・山本篤・安井由美子・宮下和夫・田中卓二
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: 御茶ノ水女子大学(東京)
• [Presentation] Preventive effects of marine carotenoids on inflammatory bowel disease (2011)
  • Author(s): Hosokawa, M., Yasui, Y.,Mikami, N., Miyashita, K., Tanaka T.
  • Organizer: 16th International Symposium on Carotenoids
  • Place of Presentation: Auditorium Maximum of the Jagiellonian University (Krakow, Poland)
• [Presentation] 褐藻由来フコキサンチンの糖尿病/肥満KK-Ayマウスに対する作用特性 (2011)
  • Author(s): 細川雅史・松本伊代・小出愛・別府史章・宮下和夫
  • Organizer: 第25回カロテノイド研究談話会
  • Place of Presentation: つくば国際会議場(つくば)
• [Presentation] 小松菜に含まれるネオキサンチンによる脂肪細胞での代謝調節作用 (2011)
  • Author(s): 前多隼人・阿部美菜子・細川雅史・宮下和夫・片方陽太郎
  • Organizer: 第25回カロテノイド研究談話会
  • Place of Presentation: つくば国際会議場(つくば)
• [Presentation] カロテノイドによるペルオキシナイトライトの消去と発がん予防効果 (2011)
  • Author(s): 坪井誠・衛藤英男・加藤久喜・細川雅史・宮下和夫・徳田春邦・鈴木信孝・松本岳・森啓信・眞岡孝至
  • Organizer: 第25回カロテノイド研究談話会
  • Place of Presentation: つくば国際会議場(つくば)
• [Presentation] 褐藻由来フコキサンチンによる肝臓でのSCD1発現抑制作用 (2011)
  • Author(s): 別府史章・篠田太郎・細川雅史・宮下和夫
  • Organizer: 平成23年度日本水産学会秋季大会
  • Place of Presentation: 長崎大学(長崎)
• [Presentation] ホタテガイ生殖巣由来ペクテノロンの炎症性サイトカイン発現制御 (2011)
  • Author(s): 山本篤・三瓶雄司・田中彰・宮下和夫・細川雅史
  • Organizer: 平成23年度日本水産学会秋季大会
  • Place of Presentation: 長崎大学(長崎)
• [Presentation] フコキサンチンのKK-Ayマウスに対する抗肥満作用特性 (2011)
  • Author(s): 細川雅史・松本伊代・西川翔・宮下和夫
  • Organizer: 平成23年度日本水産学会秋季大会
  • Place of Presentation: 長崎大学(長崎)
• [Presentation] フコキサンチンの肥満初期における抗炎症作用 (2011)
  • Author(s): 任美珍・小出愛・別府史章・宮下和夫・細川雅史
  • Organizer: 平成23年度日本水産学会秋季大会
  • Place of Presentation: 長崎大学(長崎)
• [Presentation] Bacillus megatherium ALA2によるFucoxanthinからFucoxanthinolへの変換反応 (2011)
  • Author(s): 西田健太郎・渾辺智雄・Hou, C.T.・宮下和夫・細川雅史
  • Organizer: 平成23年度日本水産学会秋季大会 20110928-20111002
  • Place of Presentation: 長崎大学(長崎)
• [Presentation] Apo-fucoxanthinalの調製と脂肪細胞に対する分化制御機能 (2011)
  • Author(s): 加賀岳朗・細川雅史・宮下和夫・眞岡孝至
  • Organizer: 平成23年度日本水産学会秋季大会
  • Place of Presentation: 長崎大学(長崎)
• [Presentation] Preventive effect of fucoxanthin on oxidative stress in obese-model mice (2011)
  • Author(s): Airanthi, W.-A.M.K., Hosokawa, M., Miyashita, K.
  • Organizer: International Conference and Exhibition on Nutraceuticalas and Functional Foods 2011
  • Place of Presentation: Royton Sapporo Hotel (Sapporo)
• [Presentation] Fucoxanthin improves blood glucose level and increases GLUT4 translocation of skeletal muscle in diabetic/obese KK-Ay mice. (2011)
  • Author(s): Nishikawa, S., Hosokawa, M., Miyashita, K.
  • Organizer: International Conference and Exhibition on Nutraceuticalas and Functional Foods 2011
  • Place of Presentation: Royton Sapporo Hotel (Sapporo)
• [Presentation] Application of Brown Seaweed Lipids to Functional Foods.
  • Author(s): Miyashita, K.
  • Organizer: 台灣保健食品學會2014年會員大會
  • Place of Presentation: 国立海洋大学（台湾基隆市）
  • Invited
• [Presentation] 褐藻素材の機能性と有効活用.
  • Author(s): 宮下和夫
  • Organizer: 新規素材探索研究会第11回セミナー
  • Place of Presentation: 新横浜フジビューホテル （横浜市）
  • Invited
• [Book] Carotenoids as nutraceutical therapy for visceral obesity (2014)
  • Author(s): Miyashita K, 他
  • Publisher: Elsevier
• [Book] Therapeutic effect of fucoxanthin on metabolic syndrome and type 2 diabetes (2012)
  • Author(s): Miyashita K, 他
  • Publisher: Academic
• [Book] Advances in Food Science and Technology (2012)
  • Author(s): Stephen, N.M., Bhaskar, N., Hosokawa, M., Miyashita, K.
  • Total Pages: 17
  • Publisher: Nova Science Publishers, Inc., New York
• [Book] Nutritional and Therapeutic Interventions for Diabetes and Metabolic Syndrome (2012)
  • Author(s): Miyashita, K., Nishikawa, S., Hosokawa, M.
  • Total Pages: 20
  • Publisher: Academic Press, Waltham, MA
• [Book] Marine Cosmeceuticals (2012)
  • Author(s): Miyashita, K., Mikami, N., Airanthi, M.K.W.A., Abe, M., Hosokawa, M.
  • Total Pages: 13
  • Publisher: CRC Press, Boca Raton FL