| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Research Abstract |
In the present study, molecular mechanisms were made clear for the anti-obesity effect of fucoxanthin by the induction of UCP1 in abdominal WAT. The anti-obesity effect of fucoxanthin was suggested to be due to its specific structure that contains two carotenoid end rings of the polyene chromophore containing allenic bond and OH and epoxy groups. Therefore, other allenic carotenoids or scission products from fucoxanthin could not show such activities as found in fucoxanthin. Fucoxanthin also improves insulin resistance and decreases blood glucose level through the regulation of adipocytokine secretions from the abdominal WAT. Another important molecular mechanism for the improvement of glucose utilization by fucoxanthin will be glucose transporter 4 (GLUT4) up-regulation and promotion of its translocation to cell membrane from cytosol.
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