| Budget Amount *help |
¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
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| Research Abstract |
Gene expression changes induced in damaged mice skin by Mg-deficient diet or UV irradiation were elucidated by DNA microarray and PCR analyses. Oral administration of ECM components, such as ceramide and collagen, was found to attenuate the gene expression changes. In vitro experiments using a fibroblast-keratinocyte co-culture system constructed with mouse primary skin cells or human skin cell lines showed that metabolites of ceramide as well as collagen peptides induced similar effects on gene expression of skin cells. These results suggest that ECM components are digested and/or metabolized after oral administration, reach the skin tissue, and then affect keratinocyte functions via modulating fibroblast-keratinocyte interactions.
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