| Project/Area Number |
23380073
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Jiro 九州大学, 農学研究院, 准教授 (40217930)
TAKAHASHI Yoshimasa 国立感染症研究所, 免疫部, 室長 (60311403)
HOSONO Akira 日本大学, 生物資源科学部, 准教授 (70328706)
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| Research Collaborator |
NAKAJIMA Haruyo (ADACHI Haruyo) 東京大学, 農学生命科学研究科, 特任研究員 (20595962)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 腸管免疫系 / 腸内共生菌 / 機能性食品 / IgA抗体 / TLR / 制御性T細胞 / 樹状細胞 / 経口免疫寛容 / 制御性Ｔ細胞 / 感染防御 |
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| Research Abstract |
In this study, we tried to elucidate the functions of intestinal immune cells, focusing on their responses to microbes and microbial components, in relation to development of novel immunomodulating functional foods. We examined the suppressive response of Peyer's patch dendritic cells to multiple TLR simulation. We analyzed CD3-IL-2R+ cells, and found that they were also present in the lungs, and that they responded to influenza virus infection. We also examined gene expression of regulatory T cells induced in oral tolerance. Furthermore, we examined the mechanism of IgA induction by Bacteroides.
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