Elucidation of recognition and response of intestinal immune cells to microbes in relation to development of immunomodulating functional foods
| Project/Area Number |
23380073
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Jiro 九州大学, 農学研究院, 准教授 (40217930)
TAKAHASHI Yoshimasa 国立感染症研究所, 免疫部, 室長 (60311403)
HOSONO Akira 日本大学, 生物資源科学部, 准教授 (70328706)
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| Research Collaborator |
NAKAJIMA Haruyo (ADACHI Haruyo) 東京大学, 農学生命科学研究科, 特任研究員 (20595962)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Keywords | 腸管免疫系 / 腸内共生菌 / 機能性食品 / IgA抗体 / TLR / 制御性T細胞 / 樹状細胞 / 経口免疫寛容 / 制御性Ｔ細胞 / 感染防御 |
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| Research Abstract |
In this study, we tried to elucidate the functions of intestinal immune cells, focusing on their responses to microbes and microbial components, in relation to development of novel immunomodulating functional foods. We examined the suppressive response of Peyer's patch dendritic cells to multiple TLR simulation. We analyzed CD3-IL-2R+ cells, and found that they were also present in the lungs, and that they responded to influenza virus infection. We also examined gene expression of regulatory T cells induced in oral tolerance. Furthermore, we examined the mechanism of IgA induction by Bacteroides.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Attenuation of migration properties of CD4+ T cells from aged mice correlates with decrease in chemokine receptor expression, response to retinoic acid and RALDH expression compared to young mice2014
Author(s)
Park, J., Miyakawa, T., Shiokawa, A., Nakajima-Adachi, H., Tanokura, M., Hachimura, S
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Journal Title
Biosci. Biotechnol. Biochem.
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice2014
Author(s)
Kikuchi, Y., Kunitoh-Asari, A., Hayakawa, K., Imai, S., Kasuya, K., Abe, K., Adachi, Y., Fukudome, S., Takahashi, Y., Hachimura, S
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Journal Title
PLoS ONE
Volume: 9, e86416
Related Report
Peer Reviewed
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[Journal Article] Attenuation of migration properties of CD4+ T cells from aged mice correlates with decrease in chemokine receptor expression, response to retinoic acid and RALDH expression compared to young mice.2014
Author(s)
Park, J., Miyakawa, T., Shiokawa, A., Nakajima-Adachi, H., Tanokura, M., Hachimura, S.
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Journal Title
Biosci. Biotechnol. Biochem.
Volume: N/A
Related Report
Peer Reviewed
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[Journal Article] Oral Administration of Lactobacillus plantarum Strain AYA Enhances IgA Secretion and Provides Survival Protection against Influenza Virus Infection in Mice.2014
Author(s)
Kikuchi, Y., Kunitoh-Asari, A., Hayakawa, K., Imai, S., Kasuya, K., Abe, K., Adachi, Y., Fukudome, S., Takahashi, Y., Hachimura, S.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Both unmutated and mutated memory B cells accumulate mutations and renew antibody repertoire optimally adopted to antigen upon re-exposure2013
Author(s)
Kaji, T., Furukawa, K., Ishige, A., Toyokura, I., Takahashi, Y., Shimoda, M., Takemori, T
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Journal Title
Int. Immunol
Volume: 25
Issue: 12
Pages: 683-695
DOI
Related Report
Peer Reviewed
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[Journal Article] IgA production in the large intestine is modulated by a different mechanism than in the small intestine: Bacteroides acidifaciens promotes IgA production in the large intestine by inducing germinal center formation and increasing the number of IgA+ B cells.2013
Author(s)
Tsutomu Yanagibashia, Akira Hosono, Akihito Oyama, Masato Tsuda, Ami Suzuki, Satoshi Hachimura, Yoshimasa Takahashi, Yoshika Momose, Kikuji Itoh, Kazuhiro Hirayama, Kyoko Takahashi, Shuichi Kaminogawa
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Journal Title
Immunobiology
Volume: 218
Issue: 4
Pages: 645-651
DOI
Related Report
Peer Reviewed
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[Journal Article] Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection2012
Author(s)
Onodera, T., Takahashi, Y., Yokoi, Y., Ato, M., Kodama, Y., Hachimura, S., Kurosaki, T., and Kobayashi, K
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Journal Title
Proc. Natl. Acad. Sci. U. S. A.
Volume: 109
Issue: 7
Pages: 2485-90
DOI
Related Report
Peer Reviewed
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