Nutrient sensing and signaling mechanisms of hepatic and intestinal autophagy
| Project/Area Number |
23380074
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUJIMURA Shinobu 新潟大学, 自然科学系, 准教授 (20282999)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Hisanori 東京大学, 総括プロジェクト機構, 特任教授 (40211164)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | オートファジー / アミノ酸 / 肝細胞 / LC3 / アルギニン / 活性酸素種 / サーチュイン / 消化管 / エイジング / マイクロアレイ / 栄養学 / 細胞・組織 |
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| Research Abstract |
Autophagy is a ubiquitous, intracellular system to degrade and recycle cellular components. The nutritional regulation of autophagy was investigated in rat hepatoma H4-II-E cells and gastrointestinal tracts. Especially, the mechanism of regulation, various signaling mechanisms of each amino acid was proved to be ROS-dependent and -independent. Arginine uses NO pathway and mTOR-independent. The level of mRNA of LC3 molecule, an autophagy marker, and related Atg genes regulated by amino acids was discovered. Anti-oxidative food components, epigallocathecin gallate and resveratrol, stimulated autophagy. Finally, the relationship of amino acid regulation of autophagy with sirtuins, an anti-aging gene, were investigated.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Effect of dietary vitamin E on broiler meat qualities, color, water-holding capacity and shear force value, under heat stress conditions.2013
Author(s)
Hashizawa, Y., Kubota,M., Kadowaki, M., Fujimura, S
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Journal Title
Animal Science Journal
Volume: 84
Pages: 732-736
Related Report
Peer Reviewed
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[Presentation] Protective effects of alkali-extracted rice protein on diabetic nephropathy in obese type 2 diabetic rats.2013
Author(s)
Kubota, M., Watanabe, R., Yamaguchi, M., Hosojima, M., Saito, A., Fujii, M., Fujimura, S., Kadowaki, M.
Organizer
Experimental biology 2013
Place of Presentation
Boston, USA ボストンコンベンション＆エキシビションセンター
Related Report
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[Presentation] Dietary alkali-extracted rice pDietary alkali-extracted rice protein improves some diabetes-related markaerss in obese type 2 diabetic rats.2013
Author(s)
Watanabe, R., Kubota, M., Yamaguchi,M., Saito, A., Fujii, M., Fujimura, S., Kadowaki, M.
Organizer
Experimental biology 2013
Place of Presentation
Boston, USA ボストンコンベンション＆エキシビションセンター
Related Report
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[Presentation] Diverse signaling pathways of amino acids for autophagy control2013
Author(s)
Angcajas, A., Kaneshiro, K., Hirai, N., Fujimura, S., Kadowaki, M.
Organizer
20th International Congress of Nutrition
Place of Presentation
Granada, Spain グラナダカンファレンス＆エキシビションセンター
Related Report
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[Presentation] Regulation of autophagy by antioxidants in rat isolated hepatocytes.2013
Author(s)
Horii, Y., Karim, R., Rokeya, H., Kubota, M., Fujimura, S., Kadowaki, M.
Organizer
20th International Congress of Nutrition
Place of Presentation
Granada, Spain グラナダカンファレンス＆エキシビションセンター
Related Report
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[Presentation] Effect of rice protein on glucose homeostasis and diabetic nephropathy in diabetic ZDF rats.2013
Author(s)
Kubota, M., Yamaguchi, M., Watanabe, R., Saito, A., Fujii, M., Fujimura, S., Kadowaki, M.
Organizer
20th International Congress of Nutrition
Place of Presentation
Granada, Spain グラナダカンファレンス＆エキシビションセンター
Related Report
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[Presentation] Rice protein ameliorates progression of diabetic nephropathy in non-obese diabetic GK rats.2013
Author(s)
Watanabe, R., Kubota, M.,Saito, A., Kumagai, T., Fujii, M., Fujimura, S., Kadowaki, M.
Organizer
20th International Congress of Nutrition
Place of Presentation
Granada, Spain グラナダカンファレンス＆エキシビションセンター
Related Report
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