Studies on comprehensive physiological functions of novel exogenous neuromodulating peptides
Project/Area Number |
23380076
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Food science
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Research Institution | Kyoto University |
Principal Investigator |
OHINATA Kousaku 京都大学, (連合)農学研究科(研究院), 准教授 (00361147)
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Co-Investigator(Renkei-kenkyūsha) |
URADE Yoshihiro 大阪バイオサイエンス研究所, 研究部長 (10201360)
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
|
Keywords | ペプチド / 情動調節 / 睡眠 / 食欲 / エネルギー代謝 / 摂食 / 脳・神経 / 抗不安作用 / 中枢神経系 / ジペプチド |
Research Abstract |
We investigated interaction between low-molecular weight peptides and the nervous system. We found novel anxiolytic-like peptides released from food proteins by gastrointestinal proteases, based on structure-activity relationship of potent anxiolytic peptides. The food-derived peptides may be one of exogenous neuromodulating factors. We also found that low-molecular peptides with neuromodulating activities sometimes exhibited sleep inducting activity, changed food intake, and modulated energy metabolism.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Orally administered rubiscolin-6, a δ opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin-type prostaglandin D synthase in mice2012
Author(s)
Kaneko K, Lazarus M, Miyamoto C, Oishi Y, Nagata N, Yang S, Yoshikawa M, Aritake K, Furuyashiki T, Narumiya S, Urade Y, Ohinata K
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Journal Title
Mol Nutr Food Res
Volume: 56(8)
Pages: 1315-23
Related Report
Peer Reviewed
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[Journal Article] Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice2012
Author(s)
Yamada Y, Muraki A, Oie M, Kanegawa N, Oda A, Sawashi Y, Kaneko K, Yoshikawa M, Goto T, Takahashi N, Kawada T, Ohinata K
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 302(4)
Related Report
Peer Reviewed
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[Journal Article] Orally administered rubiscolin-6, a δ opioid peptide derived from Rubisco, stimulates food intake vialeptomeningeal lipocallin-type prostaglandin D synthase in mice.2012
Author(s)
Kaneko K, Lazarus M, Miyamoto C, Dishi Y, Nagata N, Yang S. Yoshikawa M. Aritake K, Furuyashiki T, Narumiya S, Urade Y, Chinata K.
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Journal Title
Mol Nutr Food Res.
Volume: 56(8)
Issue: 8
Pages: 1315-1323
DOI
Related Report
Peer Reviewed
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[Journal Article] β-Lactotensin derived from bovine β-lactoglobulin exhibits anxiolytic-like activity as an agonist for neurotensin NTS2 receptor via activation of dopamine D1 receptor in mice2011
Author(s)
Hou IC, Suzuki C, Kanegawa N, Oda A, Yamada A, Yoshikawa M, Yamada D, Sekiguchi M, Wada E, Wada K, Ohinata K
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Journal Title
J Neurochem
Volume: 119(4)
Pages: 785-90
Related Report
Peer Reviewed
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[Journal Article] Central PGE_2 exhibits anxiolytic-like activity via EP1 and EP4 receptors in a manner dependent on serotonin 5-HT1A, dopamine D1 and GABAA receptors2011
Author(s)
Suzuki, C., Miyamoto, C., Furuyashiki, T., Narumiya, S., Ohinata, K.
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Journal Title
FEBS Lett.
Volume: 585
Issue: 14
Pages: 2357-2362
DOI
Related Report
Peer Reviewed
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[Presentation] 神経調節ペプチド2013
Author(s)
大日向耕作, 水重貴文, 金本龍平
Organizer
日本栄養・食糧学会シンポジウム
Place of Presentation
名古屋
Year and Date
2013-05-26
Related Report
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