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Studies on comprehensive physiological functions of novel exogenous neuromodulating peptides

Research Project

Project/Area Number 23380076
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Food science
Research InstitutionKyoto University

Principal Investigator

OHINATA Kousaku  京都大学, (連合)農学研究科(研究院), 准教授 (00361147)

Co-Investigator(Renkei-kenkyūsha) URADE Yoshihiro  大阪バイオサイエンス研究所, 研究部長 (10201360)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywordsペプチド / 情動調節 / 睡眠 / 食欲 / エネルギー代謝 / 摂食 / 脳・神経 / 抗不安作用 / 中枢神経系 / ジペプチド
Research Abstract

We investigated interaction between low-molecular weight peptides and the nervous system. We found novel anxiolytic-like peptides released from food proteins by gastrointestinal proteases, based on structure-activity relationship of potent anxiolytic peptides. The food-derived peptides may be one of exogenous neuromodulating factors. We also found that low-molecular peptides with neuromodulating activities sometimes exhibited sleep inducting activity, changed food intake, and modulated energy metabolism.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (37 results)

All 2014 2013 2012 2011 Other

All Journal Article (26 results) (of which Peer Reviewed: 26 results,  Open Access: 1 results) Presentation (11 results) (of which Invited: 3 results)

  • [Journal Article] δ-Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice2014

    • Author(s)
      Kaneko K, Mizushige T, Miyazaki Y, Lazarus M, Urade Y, Yoshikawa M, Kanamoto R, Ohinata K
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 306(4)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Ile-His-Arg-Phe, a novel rice-derived vasorelaxing peptide with hypotensive and anorexigenic activities2014

    • Author(s)
      Kontani N, Omae R, Kagebayashi T, Kaneko K, Yamada Y, Mizushige T, Kanamoto R, Ohinata K
    • Journal Title

      Mol Nutr Food Res

      Volume: 58(2) Pages: 359-64

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel β-lactoglobulinderived peptides, wheylin-1 and -2, having anxiolytic-like activity in mice2014

    • Author(s)
      Yamada A, Mizushige T, Kanamoto R, Ohinata K
    • Journal Title

      Mol Nutr Food Res

      Volume: 58(2) Pages: 353-8

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] δ-Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice.2014

    • Author(s)
      Kaneko K, Mizushige T, Miyazaki Y, Lazarus M, Urade Y, Yoshikawa M, Kanamoto R, Ohinata K.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: 306(4) Issue: 4 Pages: 265-272

    • DOI

      10.1152/ajpregu.00405.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characterization of Ile-His-Arg-Phe, a novel rice-derived vasorelaxing peptide with hypotensive and anorexigenic activities.2014

    • Author(s)
      Kontani N, Omae R, Kagebayashi T, Kaneko K, Yamada Y, Mizushige T, Kanamoto R, Ohinata K.
    • Journal Title

      Mol Nutr Food Res.

      Volume: 58(2) Issue: 2 Pages: 359-64

    • DOI

      10.1002/mnfr.201300334

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of novel β-lactoglobulin-derived peptides, wheylin-1 and -2, having anxiolytic-like activity in mice.2014

    • Author(s)
      Yamada A, Mizushige T, Kanamoto R, Ohinata K.
    • Journal Title

      Mol Nutr Food Res.

      Volume: 58(2) Issue: 2 Pages: 353-8

    • DOI

      10.1002/mnfr.201300237

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Tyr-Leu-Gly, a novel anxiolytic-like peptide released from bovine αS-casein2013

    • Author(s)
      Mizushige T, Sawashi Y, Yamada A, Kanamoto R, Ohinata K
    • Journal Title

      FASEB J

      Volume: 27(7) Pages: 2911-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aromatic amino acid-leucine dipeptides exhibit anxiolytic-like activity in young mice2013

    • Author(s)
      Mizushige T, Kanegawa N, Yamada A, Ota A, Kanamoto R, Ohinata K
    • Journal Title

      Neurosci Lett

      Volume: 543 Pages: 126-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Tyr-Leu-Gly, a novel anxiolytic-like peptide released from bovine αS-casein.2013

    • Author(s)
      Mizushige T, Sawashi Y, Yamada A, Kanamoto R, Ohinata K.
    • Journal Title

      FASEB J

      Volume: 27(7) Issue: 7 Pages: 2911-7

    • DOI

      10.1096/fj.12-225474

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aromatic amino acid-leucine dipeptides exhibit anxiolytic-like activity in young mice.2013

    • Author(s)
      Mizushige T, Kanegawa N, Yamada A, Ota A, Kanamoto R, Ohinata K.
    • Journal Title

      Neurosci Lett.

      Volume: 543 Pages: 126-9

    • DOI

      10.1016/j.neulet.2013.03.043

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel orexigenic pathway prostaglandin D2-NPY system--involvement in orally active orexigenic δ opioid peptide2012

    • Author(s)
      Kaneko K, Yoshikawa M, Ohinata K
    • Journal Title

      Neuropeptides

      Volume: 46(6) Pages: 353-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel CCK-dependent vasorelaxing dipeptide, Arg-Phe, decreases blood pressure and food intake in rodents2012

    • Author(s)
      Kagebayashi T, Kontani N, Yamada Y, Mizushige T, Arai T, Kino K, Ohinata K.
    • Journal Title

      Mol Nutr Food Res

      Volume: 56(9) Pages: 1456-63

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Orally administered rubiscolin-6, a δ opioid peptide derived from Rubisco, stimulates food intake via leptomeningeal lipocallin-type prostaglandin D synthase in mice2012

    • Author(s)
      Kaneko K, Lazarus M, Miyamoto C, Oishi Y, Nagata N, Yang S, Yoshikawa M, Aritake K, Furuyashiki T, Narumiya S, Urade Y, Ohinata K
    • Journal Title

      Mol Nutr Food Res

      Volume: 56(8) Pages: 1315-23

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of ovolin, an orally active tryptic peptide released from ovalbumin with anxiolytic-like activity2012

    • Author(s)
      Oda A, Kaneko K, Mizushige T, Lazarus M, Urade Y, Ohinata K
    • Journal Title

      J Neurochem

      Volume: 122(2) Pages: 356-62

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complement C5a exhibits anxiolytic-like activity via the prostaglandin D_2-DP_1 receptor system coupled to adenosine A_<2A> and GABA_<A> receptors2012

    • Author(s)
      Miyamoto C, Yoshida M, Yoshikawa M, Mizushige T, Ohinata K
    • Journal Title

      Prostaglandins Other Lipid Mediat

      Volume: 98(1-2) Pages: 17-22

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPARα systems in diabetic KKAy mice2012

    • Author(s)
      Yamada Y, Muraki A, Oie M, Kanegawa N, Oda A, Sawashi Y, Kaneko K, Yoshikawa M, Goto T, Takahashi N, Kawada T, Ohinata K
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 302(4)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of ovolin, an orally active tryptic peptide released from ovalbumin with anxiolytic-like activity.2012

    • Author(s)
      Oda A, Kaneko K, Mizushige T, Lazarus M, Urade Y, Ohinata K.
    • Journal Title

      J Neurochem.

      Volume: 122 Issue: 2 Pages: 356-362

    • DOI

      10.1111/j.1471-4159.2012.07777.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Orally administered rubiscolin-6, a δ opioid peptide derived from Rubisco, stimulates food intake vialeptomeningeal lipocallin-type prostaglandin D synthase in mice.2012

    • Author(s)
      Kaneko K, Lazarus M, Miyamoto C, Dishi Y, Nagata N, Yang S. Yoshikawa M. Aritake K, Furuyashiki T, Narumiya S, Urade Y, Chinata K.
    • Journal Title

      Mol Nutr Food Res.

      Volume: 56(8) Issue: 8 Pages: 1315-1323

    • DOI

      10.1002/mnfr.201200155

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel CCK-dependent vasorelaxing dipeptide, Arg-Phe, decreases blood pressure and food intake in rodents.2012

    • Author(s)
      Kagebayashi T, Kontani N, Yamada Y, Mizushige T, Arai T, Kino K, Ohinata K.
    • Journal Title

      Mol Nutr Food Res.

      Volume: 56(9): Issue: 9 Pages: 1456-63

    • DOI

      10.1002/mnfr.201200168

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complement C5a exhibits anxiolytic-like activity via the prostaglandin D2-DP1 receptor system coupled to adenosine A2A and GABAA receptors.2012

    • Author(s)
      Miyamoto C, Yoshida M, Yoshikawa M, Mizushige T, Ohinata K.
    • Journal Title

      Prostaglandins Other Lipid Mediat.

      Volume: 98(1-2) Issue: 1-2 Pages: 17-22

    • DOI

      10.1016/j.prostaglandins.2012.03.004

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel orexigenic pathway prostaglandin D2-NPY system - involvement in orally active orexigenic δopioid peptide.2012

    • Author(s)
      Kaneko K, Yoshikawa M, Ohinata K.
    • Journal Title

      Neuropeptides

      Volume: 46(6) Issue: 6 Pages: 353-357

    • DOI

      10.1016/j.npep.2012.10.003

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soymorphin-5, a soy-derived μ-opioid peptide, decreases glucose and triglyceride levels through activating adiponectin and PPAR α systems in2012

    • Author(s)
      Yamada Y, Muraki A, Oie M, Kanegawa N, Oda A, Sawashi Y
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 302

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-Lactotensin derived from bovine β-lactoglobulin exhibits anxiolytic-like activity as an agonist for neurotensin NTS2 receptor via activation of dopamine D1 receptor in mice2011

    • Author(s)
      Hou IC, Suzuki C, Kanegawa N, Oda A, Yamada A, Yoshikawa M, Yamada D, Sekiguchi M, Wada E, Wada K, Ohinata K
    • Journal Title

      J Neurochem

      Volume: 119(4) Pages: 785-90

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Central PGE_2 exhibits anxiolytic-like activity via EP_1 and EP_4 receptors in a manner dependent on serotonin 5-HT_<1A>, dopamine D_1 and GABA_A receptors2011

    • Author(s)
      Suzuki C, Miyamoto C, Furuyashiki T, Narumiya S, Ohinata K
    • Journal Title

      FEBS Lett

      Volume: 585(14) Pages: 2357-62

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] β-lactotensin derived from bovine b-lactoglobulin exhibits a nxiolytic-kike activity as an agonist for neurotensin NTS2 receptor via activation of dopatnine D1 receptor in mice2011

    • Author(s)
      Hou, I.C., et al
    • Journal Title

      J Neurochem

      Volume: 119 Issue: 4 Pages: 785-790

    • DOI

      10.1111/j.1471-4159.2011.07472.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central PGE_2 exhibits anxiolytic-like activity via EP1 and EP4 receptors in a manner dependent on serotonin 5-HT1A, dopamine D1 and GABAA receptors2011

    • Author(s)
      Suzuki, C., Miyamoto, C., Furuyashiki, T., Narumiya, S., Ohinata, K.
    • Journal Title

      FEBS Lett.

      Volume: 585 Issue: 14 Pages: 2357-2362

    • DOI

      10.1016/j.febslet.2011.06.004

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Food-derived orexigenic peptide2013

    • Author(s)
      Kousaku Ohinata
    • Organizer
      第7回国際カヘキシアカンファランス種子島シンポジウム
    • Place of Presentation
      種子島
    • Year and Date
      2013-12-13
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 消化管ホルモンを介する外因性ペプチドの多様な生理作用2013

    • Author(s)
      大日向耕作
    • Organizer
      第5回アミノ酸学会夏のシンポジウム
    • Place of Presentation
      小樽
    • Year and Date
      2013-07-26
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 神経調節ペプチド2013

    • Author(s)
      大日向耕作, 水重貴文, 金本龍平
    • Organizer
      日本栄養・食糧学会シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2013-05-26
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Novel orally active peptides derived from food proteins2012

    • Author(s)
      Kousaku Ohinata
    • Organizer
      Cornell University-Kyoto University Joint Symposium on Bioactive Food Components
    • Place of Presentation
      Cornell Univ., Ithaka, NY, USA
    • Year and Date
      2012-03-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Orally Active Neuromodulatory Peptides2012

    • Author(s)
      Kousaku Ohinata
    • Organizer
      103th AOCS Annual Meeting & Expo
    • Place of Presentation
      Long Beach, CA, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] コメ由来ペプチドの多機能性と持続化作用2012

    • Author(s)
      大日向耕作
    • Organizer
      日本栄養・食糧学会シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] Orally Active Neuromodulatory Peptides2012

    • Author(s)
      Ohinata Kousaku
    • Organizer
      103th AOCS Annual Meeting & Expo
    • Place of Presentation
      Long Beach, CA,USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] コメ由来ペプチドの多機能性と持続化作用2012

    • Author(s)
      大日向耕作
    • Organizer
      第66回 日本栄養・食糧学会大会
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] PGE_2 はEP_4/EP_1 受容体を介して抗不安作用を示す2011

    • Author(s)
      大日向耕作
    • Organizer
      日本生化学会シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] FGE2はEP1/EF4受容体を介して抗不安作用を示す2011

    • Author(s)
      大日向耕作
    • Organizer
      日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel orally active peptides derived from food proteins

    • Author(s)
      Ohinata Kousaku
    • Organizer
      Cornell University-Kyoto University Joint Symposium on Bioactive Food Components
    • Place of Presentation
      Cornell University, Ithaka, NY, USA
    • Related Report
      2012 Annual Research Report
    • Invited

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Published: 2011-04-06   Modified: 2019-07-29  

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