Identification of food component which selectively inhibits abnormal vascular contraction
| Project/Area Number |
23380077
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
KOBAYASHI Sei 山口大学, 医学(系)研究科(研究院), 教授 (80225515)
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| Co-Investigator(Kenkyū-buntansha) |
KISHI Hiroko 山口大学, 大学院医学系研究科, 准教授 (40359899)
KAJIYA Katsuko 鹿児島大学, 農学部, 講師 (00379942)
ZHANG Ying 山口大学, 大学院医学系研究科, 助教 (10711260)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
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| Keywords | 病態生理 / 血管攣縮 / 血管異常収縮 / 血管病 / 機能性食品 / 膜ラフト / 食品機能 |
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| Outline of Final Research Achievements |
The purpose of this study is to clarify the molecular mechanism of abnormal vascular contraction and to identify the food component which selectively inhibit abnormal vascular contraction without affecting the normal contraction.
In this study, we identified the novel signal mediator mediating between Fyn tyrosine kinase and Rho-kinase in the regulation of abnormal vascular contractions.
We identified the food component which selectively inhibit abnormal vascular contraction without affecting the normal contraction. By these results we applied two patents.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-12015
Author(s)
Yoshiteru Kagawa, Yuki Yasumoto, Kazem Sharifi, Majid Ebrahimi, Ariful Islam, Hirofumi Miyazaki, Yui Yamamoto, Tomoo Sawada, Hiroko Kishi, Sei Kobayashi, Motoko Maekawa, Takeo Yoshikawa, Eiichi Takaki Akira Nakai, Hiroshi Kogo, Toyoshi Fujimoto, Yuji Owada
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Journal Title
Glia
Volume: 63
Pages: 780-794
Related Report
Peer Reviewed
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