Protectivity of extensive infections by a bacterial outer membrane protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH)
| Project/Area Number |
23380111
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General fisheries
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| Research Institution | Ehime University |
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Principal Investigator |
KAWAI Kenji 愛媛大学, (連合)農学研究科(研究院), 教授 (60127925)
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| Co-Investigator(Kenkyū-buntansha) |
OSHIMA Syun-ichirou 高知大学, 教育研究部総合科学系, 教授 (80325406)
IMAJOH Masayuki 高知大学, 教育研究部自然科学系, 講師 (20565741)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
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| Keywords | 魚病 / ワクチン / 外膜タンパク質 / GAPDH / Edwardsiella tarda / 免疫 / 抗原 / ヒト病原体 |
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| Research Abstract |
Protective effects of an outer membrane protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from a bacterium Edwardsiella tarada against other difficult fish diseases, pseudotuberculosis and nocardiosis, was investigated using yellowtail (Seriola quinqueradiata). The fish immunized with GAPDH did not show enough level of protection against both diseases. However, it showed the growth inhibition of infecting Nocardia inside fish body, increased the production of immunoglobulin, and stimulated some immuno-competent genes. Fish pathogenic Mycobacterium sp. was found to be a model bacterium that may show pathogenicity to humans.
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Report
(4 results)
Research Products
(5 results)
