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Anti-obesity activity of siphonaxanthin, a unique carotenoid in green algae, and its mechanism.

Research Project

Project/Area Number 23380124
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Fisheries chemistry
Research InstitutionShijonawate Gakuen University (2013)
Kyoto University (2011-2012)

Principal Investigator

TAKASHI HIRATA  四條畷学園大学, リハビリテーション学部, 教授 (40273495)

Co-Investigator(Kenkyū-buntansha) SUGAWARA Tatsuya  京都大学, 大学院・農学研究科, 教授 (70378818)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Keywordsカロテノイド / 緑藻 / 肥満 / 脂肪細胞 / シフォナキサンチン / 食品機能性 / 抗肥満作用 / 血管新生
Research Abstract

Siphonaxanthin is a specific carotenoid found in siphonaceous green algae and its bio-functional properties are yet to be studied. In this regard, we focused on elucidating the anti-obesity effect of siphonaxanthin. Siphonaxanthin potently inhibited the differentiation of 3T3-L1 preadipocytes. In addition, mRNA expression of adipogenic genes was decreased by the treatment with siphonaxanthin. In the animal study using KK-Ay mice as obesity model, abdominal white adipose tissue was decreased by oral administration of siphonaxanthin. In this case, mRNA expression of lipogenic genes was suppressed and lipolytic genes were increased in siphonaxanthin-treated mice.
These findings suggest that siphonaxanthin could be potentially useful as a nutraceutical.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (21 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 1 results) Presentation (15 results) Remarks (1 results)

  • [Journal Article] Marine algal carotenoids inhibit angiogenesis by down-regulating FGF-2-mediated intracellular signals in vascular endothelial cells2013

    • Author(s)
      Ganesan, P., K. Matsubara, T. Sugawara T. Hirata
    • Journal Title

      Molecular and Cellular Biochemistry

      Volume: 380 Pages: 1-9

    • Related Report
      2013 Final Research Report
  • [Journal Article] 海洋性カロテノイドの機能性について ~アンチエイジングを中心に~2013

    • Author(s)
      菅原達也
    • Journal Title

      食品加工技術

      Volume: 33(4) Pages: 1-9

    • NAID

      40019930651

    • Related Report
      2013 Final Research Report
  • [Journal Article] Marine algal carotenoids inhibit angiogenesis by down-regulating FGF-2-mediated intracellular signals in vascular endothelial cells.2013

    • Author(s)
      Ganesan, P., K. Matsubara, T. Sugawara T. Hirata
    • Journal Title

      Molecular and Cellular Biochemistry

      Volume: 380 Issue: 1-2 Pages: 1-9

    • DOI

      10.1007/s11010-013-1651-5

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 海洋性カロテノイドの機能性について ~アンチエイジングを中心に~2013

    • Author(s)
      菅原達也
    • Journal Title

      食品加工技術

      Volume: 33 Pages: 1-9

    • NAID

      40019930651

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Siphonaxanthin, a green algal carotenoid, as a novel functional compound

    • Author(s)
      Sugawara, T., P. Ganesan, Z. Li, Y. Manabe, T. Hirata
    • Journal Title

      Marine Drugs

      Volume: (in press)

    • NAID

      120005458286

    • Related Report
      2013 Final Research Report
  • [Presentation] 海洋性カロテノイドの抗肥満効果などの機能性について2013

    • Author(s)
      菅原達也
    • Organizer
      第12回美容・アンチエイジング食品研究会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Year and Date
      2013-06-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 緑藻由来シフォナキサンチンの脂肪細胞分化抑制作用2013

    • Author(s)
      李 卓思, 藤田絵里子, 大久保剛, 橋爪 論, 菅原達也, 平田 孝
    • Organizer
      日本農芸化学会
    • Place of Presentation
      東北大学川内キャンパス(仙台)
    • Year and Date
      2013-03-25
    • Related Report
      2013 Final Research Report
  • [Presentation] Novel biological functions of siphonaxanthin from green algae2013

    • Author(s)
      Tatsuya Sugawara, Yuki Manabe
    • Organizer
      2013 The International Society for Nutraceuticals and Functional Foods (ISNFF) Conference and Exhibition
    • Place of Presentation
      Howard Civil Service International House, Taipei, Taiwan
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 海洋性カロテノイドの抗肥満効果などの機能性について2013

    • Author(s)
      菅原達也
    • Organizer
      第12回美容・アンチエイジング食品研究会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] 緑藻由来シフォナキサンチンの抗肥満作用の評価2012

    • Author(s)
      李卓思, 藤田絵里子, 菅原達也, 平田 孝
    • Organizer
      日本食品科学工学会
    • Place of Presentation
      藤女子大学北16条キャンパス(札幌)
    • Year and Date
      2012-08-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 海藻カロテノイドによる血管新生抑制作用の分子機構2012

    • Author(s)
      Ganesan Ponesakki、松原主典、菅原達也、平田孝
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学(京都)
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] シフォナキサンチン含有クビレヅタ抽出物の抗肥満作用の評価2011

    • Author(s)
      藤田絵里子、野田賢二、菅原達也、平田孝
    • Organizer
      平成23年度日本水産学会近畿支部後期例会
    • Place of Presentation
      大阪市立大学文化交流センター(大阪)
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 藻類カロテノイドの有効利用を目指した新規機能性の探索2011

    • Author(s)
      菅原達也
    • Organizer
      藻類談話会
    • Place of Presentation
      京都大学(京都)(招待講演)
    • Year and Date
      2011-11-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Antiangiogenic effects of marine algal carotenoids2011

    • Author(s)
      Tatsuya Sugawara
    • Organizer
      International Society for Nutraceuticals and Functional Foods 2011
    • Place of Presentation
      Royton Sapporo Hotel (Sapporo)
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 海藻カロテノイドによる血管新生抑制の作用機構2011

    • Author(s)
      Ponesakki Ganesan, 菅原達也, 松原主典, 平田孝
    • Organizer
      第25回カロチノイド研究談話会
    • Place of Presentation
      つくば国際会議場(つくば)
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 海藻カロテノイドの血管新生抑制作用2011

    • Author(s)
      Ponessakki Ganesan, 菅原達也, 松原主典, 平田孝
    • Organizer
      食品科学工学会第58回大会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 海藻由来カロテノイドの健康機能性2011

    • Author(s)
      平田孝
    • Organizer
      日本応用藻類学会第10回大会
    • Place of Presentation
      東京海洋大学(東京)(招待講演)
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation on the anti-angiogenic activity of marine algal carotenoids2011

    • Author(s)
      Ponasakki Ganasan, Kiminori Matsubara, Takeshi Okubo, Yukihisa Tanaka, Tatsuya Sugawara, Takashi Hirata
    • Organizer
      アメリカ食品科学工学会(ニューオリンズ)
    • Place of Presentation
      New Orleans Morial Convention
    • Year and Date
      2011-06-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 緑藻由来シフォナキサンチンの抗肥満作用の評価

    • Author(s)
      李卓思、藤田絵里子、菅原達也、(平田 孝)
    • Organizer
      日本食品科学工学会
    • Place of Presentation
      藤女子大学北16条キャンパス(札幌)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 緑藻由来シフォナキサンチンの脂肪細胞分化抑制作用

    • Author(s)
      李 卓思、藤田絵里子、大久保剛、橋爪 論、菅原達也、(平田 孝)
    • Organizer
      日本農芸化学会
    • Place of Presentation
      東北大学川内キャンパス(仙台)
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.bioproducts.marine.kais.kyoto-u.ac.jp/

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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