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Analysis of trophoblastic cell lineages and mechanism for multinucleation in bovine trophoblastic cell lines

Research Project

Project/Area Number 23380162
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied animal science
Research InstitutionIwate University

Principal Investigator

HASHIZUME Kazuyoshi  岩手大学, 農学部, 教授 (10355737)

Co-Investigator(Kenkyū-buntansha) KIZAKI Keiichiro  岩手大学, 農学部, 准教授 (40337994)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Keywords細胞・組織 / 遺伝子 / ゲノム / マイクロアレイ / 発生・分化
Research Abstract

Trophoblastic cells, derived from the outer layer of morula, are key cell for implantation and placentation. Bovine trophoblastic cells contain two specific cells; mononucleate and binucleate, and they express and produce various specific molecules, individually. In this study, we examined the mechanism of trophoblastic cell lineage, namely morphological and functional differentiation, using previously established cell lines. Matrigel, which derived from extra-cellular matrix, effectively induced trophoblastic cell differentiation. The bi-nucleation associated with increasing expression of retro-element. The differentiated cells produced retro-element molecule, fematrin-1, which was named by fetomaternal trinucleate cell inducer 1, and it, has a fusion activity between trophoblastic cells and endometrial cells in bovine. These results showed a direct evidence for cell-to-cell fusion in bovine placenta and open a new sight for bovine reproduction, especially early gestation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (79 results)

All 2014 2013 2012 2011 Other

All Journal Article (17 results) (of which Peer Reviewed: 17 results) Presentation (61 results) (of which Invited: 9 results) Book (1 results)

  • [Journal Article] Expression profiles of perforin, granzyme B, and granulysin genes during the estrous cycle and gestation in the bovine endometrium2014

    • Author(s)
      Ohta T, Koshi K, Ushizawa K, Hosoe M, Takahashi T, Yamaguchi T, Kizaki K, Hashizume K
    • Journal Title

      Animal Sci. J

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiles of perforin, granzyme B, and granulysin genes during the estrous cycle and gestation in the bovine endometrium2014

    • Author(s)
      Ohta T, Koshi K, Ushizawa K, Hosoe M, Takahashi T, Yamaguchi T, Kizaki K, Hashizume K.
    • Journal Title

      Animal Sci. J.

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microarray-based gene expression profiling of peripheral blood mononuclear cells in dairy cows with experimental hypocalcemia and milk fever.2014

    • Author(s)
      Sasaki K, Yamagishi N, Kizaki K, Sasaki K, Devkota B, Hashizume K.
    • Journal Title

      J Dairy Sci.

      Volume: 97 Issue: 1 Pages: 247-258

    • DOI

      10.3168/jds.2013-7049

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamics of CD3+ T- cell Distribution throughout the Estrous Cycle and Gestation in the Bovine Endometrium2013

    • Author(s)
      Ohta T, Koshi K, Ushizawa K, Hosoe M, Takahashi T, Yamaguchi T, Kizaki K, Hashizume K
    • Journal Title

      J Reprod Dev

      Volume: 59 Pages: 507-511

    • NAID

      130003361054

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fematrin-1 is involved in fetomaternal cell-to-cell fusion in Bovinae placenta and has contributed to diversity of ruminant placentation.2013

    • Author(s)
      Nakaya Yuki, Koshi Katsuo, Nakagawa So, Hashizume Kazuyoshi, Miyazawa Takayuki.
    • Journal Title

      Journal of Virology

      Volume: 87 Issue: 19 Pages: 10563-10572

    • DOI

      10.1128/jvi.01398-13

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic expression of SOLD1 in bovine uteroplacental tissues during gestation2013

    • Author(s)
      Awad M, Kizaki K, Takahashi T, Hashizume K
    • Journal Title

      Placenta

      Volume: 34 Issue: 8 Pages: 635-641

    • DOI

      10.1016/j.placenta.2013.05.004

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of ADAMTS1 mRNA in bovine endometriumand placenta during gestation2013

    • Author(s)
      Mishra B, Koshi K, Kizaki K, Ushizawa K, Takahashi T, Hosoe M, Sato T, Ito A, Hashizume K
    • Journal Title

      Domestic Animal End

      Volume: 45 Issue: 1 Pages: 43-48

    • DOI

      10.1016/j.domaniend.2013.04.002

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamics of CD3+ T-cell Distribution throughout the Estrous Cycle and Gestation in the Bovine Endometrium.2013

    • Author(s)
      Ohta T, Koshi K, Ushizawa K, Hosoe M, Takahashi T, Yamaguchi T, Kizaki K, Hashizume K.
    • Journal Title

      J Reprod Dev

      Volume: 59 Pages: 507-511

    • NAID

      130003361054

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tenascin-C expression in equine tendon-derived cells during proliferation and migration.2013

    • Author(s)
      Nemoto M, Kizaki K, Yamamoto Y, Oonuma T, Hashizume K
    • Journal Title

      J. Equine Sci.

      Volume: 24 Pages: 17-24

    • NAID

      10031183044

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic diversity and distances of three Egyptian local sheep breeds using microsatellite markers.2013

    • Author(s)
      Ghazy A, Mokhtar S, Eid M, Amin A, Elzarei M, Kizaki K, Hashizume K.
    • Journal Title

      Research in Zoology

      Volume: 3 Pages: 1-9

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic differentiation of two native Egyptian goat breeds assessed by microsatellite DNA markers2013

    • Author(s)
      Ghazy, A., S. Mokhtar, Manal Eid, A. Amin, M. Elzarei, K. Kizaki and K. Hashizume
    • Journal Title

      Journal of Animal, Poultry & Fish Production Suez Canal University

      Volume: 1 Pages: 7-12

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hormonal Differences in Peripheral Blood and Gene Profiling in the Liver and Lymphocytes in Japanese Black Cattle with Growth Retardation2013

    • Author(s)
      Ishida, S., Yonezawa, T., Eirai, S., Kizaki, K., Hashizume, K., Tomioka, M., Kurose, Y., Hirano, T. and Watanabe, D.
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 75 Issue: 1 Pages: 17-25

    • DOI

      10.1292/jvms.12-0141

    • NAID

      130001879681

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Role of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) in the Regulation of Bovine Endometrial Cell Functions2012

    • Author(s)
      Mishra B, Kizaki K, Sato T, Ito A, Hashizume K
    • Journal Title

      Biol Reprod

      Volume: 87 Issue: 6 Pages: 1-8

    • DOI

      10.1095/biolreprod.112.102152

    • NAID

      130007024941

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bovine trophoblastic cell differentiation and binucleation involves enhanced endogenous retrovirus element expression2012

    • Author(s)
      Koshi K, Suzuki Y, Nakaya Y, Imai K, Hosoe M, Takahashi T, Kizaki K, Miyazawa T, Hashizume K
    • Journal Title

      Reprod Biol Endocrinol

      Volume: 10 Issue: 1 Pages: 10-41

    • DOI

      10.1186/1477-7827-10-41

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of extracellular matrix metalloproteinase inducer (EMMPRIN) and its expected roles in the bovine endometrium during gestation2012

    • Author(s)
      Mishra B, Kizaki K, Koshi K, Ushizawa K, Takahashi T, Hosoe M, Sato T, Ito A, Hashizume K
    • Journal Title

      Domest Anim Endocrinol

      Volume: 42 Issue: 2 Pages: 63-73

    • DOI

      10.1016/j.domaniend.2011.09.004

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential neutrophil gene expression in early bovine pregnancy.2012

    • Author(s)
      Kizaki K, Shichijo-Kizaki A, Furusawa T, Takahashi T, Hosoe M, Hashizume K.
    • Journal Title

      Reprod Biol Endocrinol.

      Volume: 11 Issue: 1 Pages: 6-6

    • DOI

      10.1186/1477-7827-11-6

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bovine trophoblastic cell differentiation and binucleation involves enhanced endogenous retro virus element expression2012

    • Author(s)
      Koshi K, Suzuki Y, Nakaya Y, Imai K, Hosoe M, Takahashi T, Kizaki K, Miyazawa T, Hashizume K.
    • Journal Title

      Reproductive Biology and Endocrinology

      Volume: (印刷中)(未定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 畜産学研究におけるトランスクリプトーム解析の意義2014

    • Author(s)
      橋爪一善
    • Organizer
      日本畜産学会第118回大会
    • Place of Presentation
      つくば, つくば国際会議場
    • Year and Date
      2014-03-27
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] ウシの受胎性改善への提言 ー着床制御機構に関わる分子の解明ー2014

    • Author(s)
      橋爪一善
    • Organizer
      平成25年度日本獣医師会獣医学学術集会年次大会
    • Place of Presentation
      千葉, 幕張メッセ
    • Year and Date
      2014-02-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 牛の子宮と胎盤の機能2013

    • Author(s)
      橋爪一善
    • Organizer
      平成25年度獣医療体制整備推進総合対策事業(管理獣医師等育成支援事業)
    • Place of Presentation
      盛岡, ホテル東日本
    • Year and Date
      2013-11-27
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Bovine SOLD1 (a member of Ly- 6 superfamily) expression was regulated by scaffold condition2013

    • Author(s)
      Awad Mahmound, 越 勝男, 鈴木康規, 木崎景一郎, 橋爪一善
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜, 岐阜大学
    • Year and Date
      2013-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] リピートブリーダーおよび正常に受胎する牛における子宮内膜遺伝子発現の網羅的解析による比較2013

    • Author(s)
      林 憲悟, 作本亮介, 細江実佐, 木崎景一郎, 橋爪一善, 高橋 透
    • Organizer
      第106回日本繁殖生物学会
    • Place of Presentation
      府中, 東京農工大学
    • Year and Date
      2013-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 家畜繁殖研究の最前線ー研究と臨床の融合ー2013

    • Author(s)
      橋爪一善
    • Organizer
      第10回ゼノアックエクステンションセミナー
    • Place of Presentation
      盛岡, 岩手大学
    • Year and Date
      2013-09-10
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Effects of Matrigel culture on bovine trophoblast differentiation2013

    • Author(s)
      Hashizume K, Koshi K, Toji N, Kizaki K
    • Organizer
      46th Annual Meeting Society for the Study of Reproduction
    • Place of Presentation
      Palais des congr&egrave ; s de Montr&eacute ; al, Montr&eacute ; al, Canada
    • Year and Date
      2013-07-24
    • Related Report
      2013 Final Research Report
  • [Presentation] ウシ内在性レトロウイルスエンベロープ遺伝子の細胞融合活性の検証2012

    • Author(s)
      越 勝男, 仲屋友喜, 木崎景一郎, 宮沢孝幸, 橋爪一善
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡, 岩手大学
    • Year and Date
      2012-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] ウシ科動物の進化とウシ内在性レトロウイルスK1の関係性2012

    • Author(s)
      仲屋友喜, 越 勝男, 中川 草, 木崎景一郎, 小林 剛, 橋爪一善, 宮沢孝幸
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡, 岩手大学
    • Year and Date
      2012-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Expression of SOLD1 in bovine trophoblast cell lines2012

    • Author(s)
      Awad M, Kizaki K, Takahashi T, Hashizume K
    • Organizer
      第105回日本繁殖生物学会大会
    • Place of Presentation
      つくば, 筑波大学
    • Year and Date
      2012-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Analysis for the differentiation pathway in bovine trophoblastic cells lineages in vitro2012

    • Author(s)
      Hashizume K, Koshi K, Suzuki Y, Kizaki K
    • Organizer
      45th Annual Meeting Society for the Study of Reproduction
    • Place of Presentation
      The Pennsylvania State University, State College, Pennsylvania, USA
    • Year and Date
      2012-08-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Bovine trophoblastic cell differentiation and binucleation involved enhanced endogenous retrovirus element expression2012

    • Author(s)
      Koshi K, Suzuki Y, Nakaya Y, Imai K, Hosoe M, Takahashi T, Kizaki K, Miyazawa T, Hashizume K
    • Organizer
      45th Annual Meeting Society for the Study of Reproduction
    • Place of Presentation
      The Pennsylvania State University, State College, Pennsylvania, USA
    • Year and Date
      2012-08-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene expression profiles and differentiation in new developing bovine trophoblastic cell line2012

    • Author(s)
      Hashizume K, Koshi K, Suzuki Y, Kizaki K, Imai K, Ito A, Takahashi T, Hosoe M, Watanabe D
    • Organizer
      17th International Congress on Animal Reproduction (ICAR)
    • Place of Presentation
      Vancouver Convention Centre, Vancouver, Canada
    • Year and Date
      2012-07-29
    • Related Report
      2013 Final Research Report
  • [Presentation] Hashizume K, Koshi K, Ushizawa K, Nakaya Y, Takahashi T, Kizaki K, Hosoe M, Miyazawa T, Suzuki Y2011

    • Author(s)
      Hashizume K, Koshi K, Ushizawa K, Nakaya Y, Takahashi T, Kizaki K, Hosoe M, Miyazawa T, Suzuki Y
    • Organizer
      The 2nd World Congress on Reproductive Biology
    • Place of Presentation
      Cairns Convention Center Cairns, Australia
    • Year and Date
      2011-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Expressional characterization of bovine endogenous retrovirus K envelopes in bovine placenta2011

    • Author(s)
      Nakaya Y, Koshi K, Baba K, Nakagawa S, Kizaki K, Hashizume K, Miyazawa T
    • Organizer
      The 2nd World Congress on Reproductive Biology
    • Place of Presentation
      Cairns Convention Center Cairns, Australia
    • Year and Date
      2011-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Expressional characterization of bovine endogenous retrovirus K envelopes in bovine placenta2011

    • Author(s)
      Nakaya Y, Koshi K, Baba K, Nakagawa S, Kizaki K, Hashizume K, Miyazawa T.
    • Organizer
      The 2^<nd> World Congress on Reproductive Biology
    • Place of Presentation
      Cairns Convention Center Cairns, Australia
    • Year and Date
      2011-10-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel factors involved in the cross-talk between mother and fetus during pregnancy : multinucleation and functions of bovine trophoblastc cells for implantation. Symposium : New aspects of uterus and placental function2011

    • Author(s)
      Hashizume K, Koshi K, Ushizawa K, Nakaya Y, Takahashi T, Kizaki K, Hosoe M, Miyazawa T, Suzuki Y.
    • Organizer
      The 2nd World Congress on Reproductive Biology
    • Place of Presentation
      Cairns Convention Center Cairns, Australia(招待講演)
    • Year and Date
      2011-10-11
    • Related Report
      2011 Annual Research Report
  • [Presentation] ウシ栄養膜細胞の分化にPOU5F1 は必要か?2011

    • Author(s)
      渡部大地, 越 勝男, 鈴木康規, 木崎景一郎, 橋爪一善
    • Organizer
      第152回日本獣医学会学術集会
    • Place of Presentation
      大阪府立大学, 堺(大阪府)
    • Year and Date
      2011-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] ウシ栄養膜細胞の分化にPOU5F1は必要か?2011

    • Author(s)
      渡部大地, 越勝男, 鈴木康規, 木崎景一郎, 橋爪一善
    • Organizer
      第152回日本獣医学会学術集会
    • Place of Presentation
      大阪府立大学、堺(大阪府)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 分化誘導ウシ栄養膜細胞における内在性レトロウイルス関連遺伝子の発現2011

    • Author(s)
      越 勝男, 鈴木康規, 仲屋友喜, 木崎景一郎, 宮沢孝幸, 橋爪一善
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      アイーナホール, 盛岡(岩手県)
    • Year and Date
      2011-09-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 分化誘導ウシ栄養膜細胞における内在性レトロウイルス関連遺伝子の発現2011

    • Author(s)
      越勝男, 鈴木康規, 仲屋友喜, 木崎景一郎, 宮沢孝幸, 橋爪一善
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      アイーナホール、盛岡(岩手県)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of extracelluar matric metalloproteinase inducer (EMMPRIN) in the regulation of bovine endometrial cell functions2011

    • Author(s)
      Mishira B, Kizaki K, Sato T, Ito A, Hashizume K
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      アイーナホール、盛岡(岩手県)
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規ウシ内在性レトロウイルス由来エンベロープタンパク質の胎盤形成過程における役割2011

    • Author(s)
      仲屋友喜, 越 勝男, 馬場健司, 木崎景一郎, 小林 剛, 今川和彦, 橋爪一善, 宮沢孝幸
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      アイーナホール, 盛岡(岩手県)
    • Year and Date
      2011-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] in silico解析によるウシ栄養膜細胞系の特性評価2011

    • Author(s)
      渡部大地, 木崎景一郎, 橋爪一善
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      アイーナホール, 盛岡(岩手県)
    • Year and Date
      2011-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] 新規ウシ内在性レトロウイルス由来エンベロープタンパク質の胎盤形成過程における役割2011

    • Author(s)
      仲屋友喜, 越勝男, 馬場健司, 木崎景一郎, 小林剛, 今川和彦, 橋爪一善, 宮沢孝幸
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      アイーナホール、盛岡(岩手県)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] in silico解析によるウシ栄養膜細胞系の特性評価2011

    • Author(s)
      渡部大地, 木崎景一郎, 橋爪一善
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      アイーナホール、盛岡(岩手県)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] ウシ栄養膜細胞系における細胞増殖因子の発現解析2011

    • Author(s)
      古川翔, 木崎景一郎, 細江実佐, 林憲悟, 高橋透, 牛澤浩一, 橋爪一善
    • Organizer
      第104回日本繁殖生物学会大会
    • Place of Presentation
      アイーナホール、盛岡(岩手県)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Novel proteins affecting cell proliferation and angiogenesis of bovine placenta2011

    • Author(s)
      Takahashi T, Ushizawa K, Sasaki S, Hosoe M, Kizaki K, Hashizume K
    • Organizer
      International Meeting for Evolution of reproductive Biology and Task of Frontiers : Trajectory and Prospects of IVF, Stem Cell and Epigenetic Studies
    • Place of Presentation
      アイーナホール, 盛岡(岩手県)
    • Year and Date
      2011-09-14
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Development of the endometrial spheroids as a model for implantation in vitro2011

    • Author(s)
      Yamauchi N, Hashizume K, Hattori M
    • Organizer
      International Meeting for Evolution of reproductive Biology and Task of Frontiers : Trajectory and Prospects of IVF, Stem Cell and Epigenetic Studies
    • Place of Presentation
      アイーナホール, 盛岡(岩手県)
    • Year and Date
      2011-09-14
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Novel proteins affecting cell proliferation and angiogenesis of bovine placenta2011

    • Author(s)
      Takahashi T, Ushizawa K, Sasaki S, Hosoe M, Kizaki K, Hashizume K
    • Organizer
      International Meeting for Evolution of reproductive Biology and Task of Frontiers : Trajectory and Prospects of IVF, Stem Cell and Epigenetic Studies
    • Place of Presentation
      アイーナホール、盛岡(岩手県)(招待講演)
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of the endometrial spheroids as a model for implantation in vitro2011

    • Author(s)
      Yamauchi N, Hashizume K, Hattori M
    • Organizer
      International Meeting for Evolution of reproductive Biology and Task of Frontiers : Trajectory and Prospects of IVF, Stem Cell and Epigenetic Studies
    • Place of Presentation
      アイーナホール、盛岡(岩手県)(招待講演)
    • Year and Date
      2011-09-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] Comprehensive genes expression analysis in bovine trophoblastic cell lines2011

    • Author(s)
      Hashizume K, Watanabe D, Kizaki K, Suzuki Y, Hosoe M, Takahashi T
    • Organizer
      44th Annual Meeting Society for the Study of Reproduction
    • Place of Presentation
      44th Annual Meeting Society for the Study of Reproduction
    • Year and Date
      2011-08-03
    • Related Report
      2013 Final Research Report
  • [Presentation] Comprehensive genes expression analysis in bovine trophoblastic cell lines2011

    • Author(s)
      Hashizume K, Watanabe D, Kizaki K, Suzuki Y, Hosoe M, Takahashi T.
    • Organizer
      Soc.for the Study of Reprod.44rd Ann.Meeting
    • Place of Presentation
      Oregon Convention Center Portland, USA
    • Year and Date
      2011-08-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Gene expression of endogenous retrovirus-like transcripts in bovine trophoblastic cell lines2011

    • Author(s)
      Koshi K, Suzuki Y, Nakaya Y, Imai K, Takahashi T, Kizaki K, Miyazawa T, Hashizume K
    • Organizer
      44th Annual Meeting Society for the Study of Reproduction
    • Place of Presentation
      Oregon Convention Center Portland, USA
    • Year and Date
      2011-08-01
    • Related Report
      2013 Final Research Report
  • [Presentation] Gene expression of endogenous retrovirus-like transcripts in bovine trophoblastic cell lines2011

    • Author(s)
      Koshi K, Suzuki Y, Nakaya Y, Imai K, Takahashi T, Kizaki K, Miyazawa T, Hashizume K
    • Organizer
      Soc.for the Study of Reprod.44rd Ann.Meeting
    • Place of Presentation
      Oregon Convention Center Portland, USA
    • Year and Date
      2011-08-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of Matrigel culture on bovine trophoblast differentiation.

    • Author(s)
      Hashizume K, Koshi K, Toji N, Kizaki K.
    • Organizer
      46th Annual Meeting, Society for the Study of Reproduction
    • Place of Presentation
      Palais des congr&egrave;s de Montr&eacute;al, Montr&eacute;al, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] 家畜繁殖研究の最前線ー研究と臨床の融合ー

    • Author(s)
      橋爪一善
    • Organizer
      第10回 ゼノアックエクステンションセミナー
    • Place of Presentation
      盛岡,岩手大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ウシ末梢血に発現する妊娠成立関連遺伝子の探索

    • Author(s)
      菊地美緒, 松田秀雄, 茂野智子, 橋谷田豊, 今井敬, 平田統一, 木崎一郎, 橋爪一善
    • Organizer
      第106回日本繁殖生物学会
    • Place of Presentation
      府中, 東京農工大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Interferon-tau stimulated genes are potential indicators of establishment of bovine gestation.

    • Author(s)
      Hashizume K,Koshi K, Shigeno S, Kizaki K, Takahashi T.
    • Organizer
      17th Europian Society of Domestic Animal Reproduction Conference
    • Place of Presentation
      Bologna University, Bologna, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] リピートブリーダーおよび正常に受胎する牛における子宮内膜遺伝子発現の網羅的解析による比較

    • Author(s)
      林 憲悟,作本亮介,細江実佐,木崎景一郎,橋爪一善,高橋 透
    • Organizer
      第106回日本繁殖生物学会
    • Place of Presentation
      府中, 東京農工大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] ウシ子宮内膜間質細胞を用いたISG15およびID01遺伝子上流配列のインターフェロン応答性の解析

    • Author(s)
      越 勝男,古澤 軌,徳永智之,木崎景一郎,橋爪一善
    • Organizer
      第106回日本繁殖生物学会
    • Place of Presentation
      府中, 東京農工大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Bovine SOLD1 (a member of Ly-6 superfamily) expression was regulated by scaffold condition

    • Author(s)
      Awad Mahmound, 越 勝男、鈴木康規、木崎景一郎、橋爪一善
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜, 岐阜大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] バイオインフォマテイックスによるウシ肝臓機能を反映する末梢血球中遺伝子の推定

    • Author(s)
      影山朋美、木崎景一郎、高橋透、山岸則夫、吉田裕貴、佐藤繁、橋爪一善
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜, 岐阜大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 乳熱羅患牛の末梢血単核球における遺伝子発現解析

    • Author(s)
      佐々木恒弥、山岸則夫、木崎景一郎、佐々木一弥、Bhuminand Devkota、橋爪一善
    • Organizer
      第156回日本獣医学会学術集会
    • Place of Presentation
      岐阜, 岐阜大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] 牛の子宮と胎盤の機能

    • Author(s)
      橋爪一善
    • Organizer
      平成25年度獣医療体制整備推進総合対策事業(管理獣医師等育成支援事業)
    • Place of Presentation
      盛岡,ホテル東日本
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ウシの受胎性改善への提言 ー着床制御機構に関わる分子の解明ー

    • Author(s)
      橋爪一善
    • Organizer
      平成25年度日本獣医師会獣医学学術集会年次大会
    • Place of Presentation
      千葉,幕張メッセ
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 畜産学研究におけるトランスクリプトーム解析の意義

    • Author(s)
      橋爪一善
    • Organizer
      日本畜産学会第118回大会
    • Place of Presentation
      つくば,つくば国際会議場
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Gene expression profiles and differentiation in new developing bovine trophoblastic cell lines

    • Author(s)
      Hashizume, K., Koshi, K., Suzuki, Y., Kizaki, K., Imai, K., Ito, A., Takahashi, T. Hosoe, M. and Watanabe, D.
    • Organizer
      17th International Congress on Animal Reproduction (ICAR),
    • Place of Presentation
      Vancouver Convention Centre, Vancouver, Canada
    • Related Report
      2012 Annual Research Report
  • [Presentation] Bovine trophoblastic cell differentiation and binucleation involved enhanced endogenous retrovirus element expression.

    • Author(s)
      Koshi, K., Suzuki, Y., Nakaya, Y., Imai, K., Hosoe, M., Takahashi, T., Kizaki, K., Miyazawa, T. and Hashizume, K.
    • Organizer
      45th Annual Meeting Society for the Study of Reproduction
    • Place of Presentation
      The Pennsylvania State Univeristy, State College, Pennsylvania, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Analysis for the differentiation pathway in bovine trophoblastic cells lineages in vitro.

    • Author(s)
      Hashizume, K., Koshi, K., Suzuki, Y. and Kizaki, K.
    • Organizer
      45th Annual Meeting Society for the Study of Reproduction
    • Place of Presentation
      The Pennsylvania State University, State College, Pennsylvania, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] ウシ着床期におけるヘパリン結合性上皮増殖因子(HBEGF)の機能解析

    • Author(s)
      古川 翔,木崎景一郎,橋爪一善
    • Organizer
      第105回日本繁殖生物学会大会
    • Place of Presentation
      つくば, 筑波大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] ウシ子宮内膜線維芽細胞および栄養膜細胞の遺伝子発現に及ぼすIFNTの影響

    • Author(s)
      茂野智子,高橋 透,木崎景一郎,橋爪一善
    • Organizer
      第105回日本繁殖生物学会大会
    • Place of Presentation
      つくば, 筑波大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Expression of SOLD1 in bovine trophoblast cell lines.

    • Author(s)
      Awad, M., Kizaki, K., Takahashi, T. and Hashizume, K
    • Organizer
      第105回日本繁殖生物学会大会
    • Place of Presentation
      つくば, 筑波大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] AIあるいはET後の妊娠ウシ末梢血白血球における遺伝子発現の比較

    • Author(s)
      伊藤悠紀,平田統一,赤坂 茂,千田広幸,佐々木修一,佐々木修,桃田優子,南雲鮎美,木崎景一郎,橋爪一善
    • Organizer
      第105回日本繁殖生物学会大会
    • Place of Presentation
      つくば, 筑波大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] ウシ科動物の進化とウシ内在性レトロウイルスK1の関係性

    • Author(s)
      仲屋友喜,越 勝男,中川 草,木崎景一郎,小林 剛,橋爪一善,宮沢孝幸
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡, 岩手大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] ウシ内在性レトロウイルスエンベロープ遺伝子の細胞融合活性の検証

    • Author(s)
      越 勝男,仲屋友喜,木崎景一郎,宮沢孝幸,橋爪一善
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡, 岩手大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 実験的低カルシウム血症牛を用いた末梢血単核球中遺伝子発現変化の網羅的解析

    • Author(s)
      佐々木恒弥,木崎景一郎,Devkota Bhuminand, 橋爪一善,山岸則夫
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡, 岩手大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] βクリプトキサンチン投与後における牛の血清濃度および末梢血好中球化学発光能の変化

    • Author(s)
      木村 淳,橋爪一善,伊東 晃,向井克之,岡田啓司,佐藤 繁
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡, 岩手大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヘパリン結合性EGF様増殖因子の着床界面における役割

    • Author(s)
      古川 翔,木崎景一郎,細江実佐,林 憲悟,高橋 透,橋爪一善
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      盛岡, 岩手大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] AIあるいはET後の牛末梢血顆粒球における妊娠関連遺伝子発現の比較

    • Author(s)
      伊藤悠紀, 平田統一, 赤坂 茂, 千田広幸, 佐々木修一, 佐々木 修, 桃田優子, 木崎景一郞, 橋爪一善
    • Organizer
      第28回東日本家畜受精卵移植技術研究会
    • Place of Presentation
      宇都宮, ホテル東日本宇都宮
    • Related Report
      2012 Annual Research Report
  • [Presentation] 妊娠牛肝臓における網羅的遺伝子発現プロファイル

    • Author(s)
      影山朋美,木崎景一郎,高橋 透,山岸則夫,橋爪一善
    • Organizer
      平成24年度日本獣医師会獣医学術学会年次大会
    • Place of Presentation
      大阪, 大阪国際交流センター
    • Related Report
      2012 Annual Research Report
  • [Book] Hormone Frontier in Gynecology2011

    • Author(s)
      橋爪一善, 高橋透, 木崎景一郎
    • Total Pages
      8
    • Publisher
      着床とプロラクチン-ウシPRL/GHファミリーは着床誘導物質か?-
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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