Brain mechanism mediating estrogen feedback controlling follicular development and ovulation
Project/Area Number |
23380163
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied animal science
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Research Institution | Nagoya University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
ISHII Hirotaka 日本医科大学, 医学部, 助手 (20445810)
HIRABAYASHI Masumi 生理学研究所, 行動・代謝分子解析センター, 准教授 (20353435)
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Project Period (FY) |
2011-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
|
Keywords | キスペプチン / Kiss1 / メタスチン / GPR54 / エストロジェン / ヒストン / エピジェネティック / 性腺刺激ホルモン / GnRH / エストロゲン / フィードバック / 卵胞発育 / 排卵 / 遺伝子改変動物 / LH / 視床下部 |
Research Abstract |
The present study aimed to investigate the brain mechanism mediating estrogen feedback to regulate two modes (pulse and surge) of gonadotropin-releasing hormone (GnRH)/gonadotropin release. Kisspeptin neurons located in the anteroventral periventricular nucleus (AVPV) and hypothalamic arcuate nucleus (ARC) are considered to control follicular development and ovulation via GnRH pulse and surge, respectively. In vivo and in vitro study using rats and mice revealed that epigenetic mechanism is involved in the both negative and positive feedback effects of estrogen to control expression of kisspeptin located in the AVPV and ARC. Since kisspeptin neurons are considered to govern reproductive function in mammals, the present results are expected to be applied to increase animal production efficiency in the future.
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Report
(4 results)
Research Products
(162 results)
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[Journal Article] KISS1 Gene Expression in the Developing Brain of Female Pigs at Preand PostPeri-pubertal Periods2014
Author(s)
Ieda, N., Uenoyama, Y., Tajima, Y., Nakata, T., Kano, M., Naniwa, Y., Watanabe, Y., Minabe, S., Tomikawa, J., Inoue, N., Matsuda, F., Ohkura, S., Maeda, K.-I. and Tsukamura, H
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Journal Title
J Reprod Dev
Volume: (In press)
Related Report
Peer Reviewed
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[Journal Article] Effects of full-length kisspeptin administration on follicular development in Japanese Black beef cows2013
Author(s)
Naniwa, Y., Nakatsukasa, K., Setsuda, S., Oishi, S., Fujii, N., Matsuda, F., Uenoyama, Y., Tsukamura, H., Maeda, K.-I. and Ohkura, S
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Journal Title
J Reprod Dev
Volume: 59(6)
Pages: 588-94
NAID
Related Report
Peer Reviewed
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[Journal Article] Molecular cloning and identification of transcriptional regulatory domain of the goat neurokinin B gene TAC32013
Author(s)
Suetomi, Y., Matsuda, F., Uenoyama, Y., Maeda, K.-I., Tsukamura, H. and Ohkura, S
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Journal Title
J Reprod Dev
Volume: 59(5)
Pages: 463-469
NAID
Related Report
Peer Reviewed
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[Journal Article] Kisspeptin and GnRH pulse generation2013
Author(s)
Okamura, H., Tsukamura, H., Ohkura, S., Uenoyama, Y., Wakabayashi, Y. and Maeda, K.-I
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Journal Title
Adv Exp Med Biol
Volume: 784
Pages: 297-323
DOI
ISBN
9781461461982, 9781461461999
Related Report
Peer Reviewed
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[Journal Article] Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats2013
Author(s)
Nakahara T, Uenoyama Y, Iwase A, Oishi S, Nakamura S, Minabe S, Watanabe Y, Deura C, Noguchi T, Fujii N, Kikkawa F, Maeda K, Tsukamura H
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Journal Title
J. Reprod. Dev
Volume: 59
Pages: 479-84
NAID
Related Report
Peer Reviewed
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[Journal Article] Dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats2013
Author(s)
Mostari, M.P., Ieda, N., Deura, C., Minabe, S., Yamada, S., Uenoyama, Y., Maeda, K.-I. and Tsukamura, H
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Journal Title
J Reprod Dev
Volume: 59(3)
Pages: 266-72
NAID
Related Report
Peer Reviewed
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[Journal Article] Dynorphin-kappa opioid receptor signaling partly mediates estrogen negative feedback effect on LH pulses in female rats.2013
Author(s)
Mostari, M.P., Ieda, N., Deura, C., Minabe, S., Yamada, S., Uenoyama, Y., Maeda, K.-I. and Tsukamura, H.
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Journal Title
J Reprod Dev.
Volume: 59(3)
Pages: 266-272
NAID
Related Report
Peer Reviewed
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[Journal Article] Chronic peripheral administration of kappa-opioid receptor antagonist advances puberty onset associated with acceleration of pulsatile luteinizing hormone secretion in female rats.2013
Author(s)
Nakahara T, Uenoyama Y, Iwase A, Oishi S, Nakamura S, Minabe S, Watanabe Y, Deura C, Noguchi T, Fujii N, Kikkawa F, Maeda K, Tsukamura H.(
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Journal Title
J. Reprod. Dev.
Volume: 59
Pages: 479-484
NAID
Related Report
Peer Reviewed
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[Journal Article] Molecular cloning and identification of transcriptional regulatory domain of the goat neurokinin B gene TAC3.2013
Author(s)
Suetomi, Y., Matsuda, F., Uenoyama, Y., Maeda, K.-I., Tsukamura, H. and Ohkura, S.
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Journal Title
J Reprod Dev.
Volume: 59(5)
Pages: 463-469
NAID
Related Report
Peer Reviewed
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[Journal Article] Effects of full-length kisspeptin administration on follicular development in Japanese Black beef cows.2013
Author(s)
Naniwa, Y., Nakatsukasa, K., Setsuda, S., Oishi, S., Fujii, N., Matsuda, F., Uenoyama, Y., Tsukamura, H., Maeda, K.-I. and Ohkura, S.
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Journal Title
J Reprod Dev.
Volume: 59(6)
Pages: 588-594
NAID
Related Report
Peer Reviewed
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[Journal Article] Kisspeptin neurons mediate reflex ovulation in the musk shrew (Suncus murinus)2011
Author(s)
Inoue, N., Sasagawa, K., Ikai, K., Sasaki, Y., Tomikawa, J., Oishi, S., Fujii, N., Uenoyama, Y., Ohmori, Y., Yamamoto, N., Hondo, E., Maeda, K.-I. and Tsukamura, H
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Journal Title
Proc Natl Acad Sci USA
Volume: 108
Pages: 17527-17532
Related Report
Peer Reviewed
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[Journal Article] Morphological evidence for direct interaction between kisspeptin and GnRH neurones at the median eminence of the male goat : an immunoelectron microscopic study2011
Author(s)
Matsuyama, S., Ohkura, S., Mogi, K., Wakabayashi, Y., Mori, Y., Tsukamura, H., Maeda, K.-I., Ichikawa, M. and Okamura, H
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Journal Title
Neuroendocrinology
Volume: 94
Pages: 323-332
Related Report
Peer Reviewed
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[Journal Article] Single-stranded noncoding RNAs mediate local epigenetic alterations at gene promoters in rat cell lines2011
Author(s)
Tomikawa, J., Shimokawa, H., Uesaka, M., Yamamoto, N., Mori, Y., Tsukamura, H., Maeda, K.-I., and Imamura, T
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Journal Title
The Journal of Biological Chemistry
Volume: 286
Pages: 34788-34788
Related Report
Peer Reviewed
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[Journal Article] Ultrastructural evidence of kisspeptin-gonadotrophin-releasing hormone interaction in the median eminence of female rats : implication of axo-axonal regulation of GnRH release2011
Author(s)
Uenoyama, Y., Inoue, N., Pheng, V., Homma, T., Takase, K., Yamada, S., Ajiki, K., Ichikawa, M., Okamura, H., Maeda, K.-I., and Tsukamura, H
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Journal Title
Journal of Neuroendocrinology
Volume: 23
Pages: 863-870
Related Report
Peer Reviewed
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[Journal Article] Involvement of neurokinin receptors in the control of pulsatile luteinizing hormone secretion in rats2011
Author(s)
Noritake, K., Matsuoka, T., Ohsawa, T., Shimomura, K., Sanbuissho, A., Uenoyama, Y., Maeda, K.-I., and Tsukamura, H
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Journal Title
Journal of Reproduction and Development
Volume: 57
Pages: 409-415
NAID
Related Report
Peer Reviewed
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[Journal Article] Testicular toxicity induced by a triple neurokinin receptor antagonist in male dogs2011
Author(s)
Noritake, K.-I., Suzuki, J., Matsuoka, T., Makino, T., Ohnishi, H., Shimomura, K., Uenoyama, Y., Tsukamura, H., Maeda, K.-I. and Sanbuissho, A
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Journal Title
Reproductive Toxicology
Volume: 31
Pages: 440-446
Related Report
Peer Reviewed
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[Journal Article] Activation of Neuropeptide FF Receptors by Kisspeptin Receptor Ligands2011
Author(s)
Oishi, S., Misu, R., Tomita, K., Setsuda, S., Masuda, R., Ohno, H., Naniwa, Y., Ieda, N., Inoue, N., Ohkura, S., Uenoyama, Y., Tsukamura, H., Maeda, K.-I., Hirasawa, A., Tsujimoto, G. and Fujii N
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Journal Title
ACS Medicinal Chemistry Letters
Volume: 2
Pages: 53-57
Related Report
Peer Reviewed
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[Presentation] Kiss1 gene is required for abolishment of lordosis behavior and establishment of male sexual behaviors in rats.2013
Author(s)
Nakamura, S., Uenoyama, Y., Ikegami,K., Tomikawa, J., Goto, T., Tamura, C., Sanbo, M., Hirabayashi, M., Maeda, K.-I., and Tsukamura, H.
Organizer
5th Parental Brain conference
Place of Presentation
Regensburg (Germany).
Related Report
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[Presentation] Determination of receptors expressed in gonadotropin-releasing hormone and kndy (Kisspeptin / Nerokinin B / Dynorphin) neurons in rat.2013
Author(s)
Ieda, N., Uenoyama, Y., Minabe, S., Ikegami, K., Ishii, H., Kato, M., Yin, C., Sakuma, Y., Maeda, K.-I., and Tsukamura, H.
Organizer
5th Parental Brain conference
Place of Presentation
Regensburg (Germany).
Related Report
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[Presentation] Synchronized intracellular Ca2+ oscillations in cultured kisspeptin/neurokinin B/dynorphin-GFP neurons obtained from the hypothalamic arcuate nucleus of transgenic mice.2013
Author(s)
Ikegami, K., Abe, H., Haruta, T., Minabe, S., Goto, T., Sanbo, M., Tamura, C., Hirabayashi, Uenoyama, Y., Maeda, K.-I., Tsukamura, H.
Organizer
Neuroscience 2013
Place of Presentation
San Diego, California
Related Report
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[Presentation] Estrogen positive feedback mechanism governing luteinizing hormone surge is conserved in the male primate brain.2013
Author(s)
Watanabe, Y., Uenoyama, Y., Suzuki, J., Takase, K., Suetomi, Y., Ohkura, S., Inoue, N., Maeda, K.-I., Tsukamura, H.
Organizer
Neuroscience 2013
Place of Presentation
San Diego, California
Related Report
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[Presentation] : Region-specific enhancer for Kiss1 expression in the Hypothalamic arcuate nucleus of female mice.2013
Author(s)
Goto, T., Tomikawa, J., Abe, H., Fukanuma, T., Imamura, T., Takase, K. , Sanbo, M., Tomita, K., Hirabayashi, M., Tsukamura, H., Maeda, K.-I., and Uenoyama, Y.
Organizer
Neuroscience 2013
Place of Presentation
San Diego, California
Related Report
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[Presentation] Suppression of hypothalamo-pitutary-gonadal axis in Kiss1 knockout rats.2012
Author(s)
Uenoyama, Y., Nakamura, S., Hayakawa, Y., MInabe, S., Tomikawa, J., Goto, T., Ieda, N., Sambo, M., Tamura, C., Hirabayashi, M., Maeda, K.-I., Tsukamura, H.
Organizer
Neuroscience 2012
Place of Presentation
New Orleans, USA.
Related Report
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[Presentation] Kiss1 gene is needed for defeminization of sexual behavior in rats.2012
Author(s)
Nakamura, S., Uenoyama, Y., Ikegami, K., Tomikawa, J., Goto, T., Tamura, C., Sambo, M., Hirabayashi, M., Maeda, K.-I., Tsukamura, H.
Organizer
Neuroscience 2012
Place of Presentation
New Orleans, USA.
Related Report
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[Presentation] Role of dynorphin in mediating estrogen negative feedback effect on pulsatile LH release in adult female rats.2012
Author(s)
Mostari, M., P., Ieda, N., Deura, C., Minabe, S., Uenoyama, Y., Maeda, K.-I. and Tsukamura.
Organizer
Neuroscience 2012
Place of Presentation
New Orleans, USA.
Related Report
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[Presentation] Generation of transgenic mice with vimentin-driven reporter fluorescence in the ependymocytes.2012
Author(s)
Minabe, S., Deura, C,, Goto, T. Sanbo, M., Tomita, K., Hirabayashi, M., Uenoyama, Y., Maeda, K., Tsukamura, H.
Organizer
Neuroscience 2012
Place of Presentation
New Orleans, USA.
Related Report
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[Presentation] Neuronal tract tracing of a pathway relaying energetic signals originating in ependymocytes of the lower brainstem.2012
Author(s)
Deura, C,. Minabe, S., Uenoyama, Y., Maeda, K., Tsukamura, H.
Organizer
Neuroscience 2012
Place of Presentation
New Orleans, USA.
Related Report
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[Presentation] Cloning of goat TAC3 upstream region and evaluation of its promoter activity.2012
Author(s)
Suetomi, Y., Matsuda, F., Uenoyama, Y., Tsukamura, H., Maeda, K.-I., Ohkura, S.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Comparison of the efficacy of intravenous treatment of kisspeptin and GnRH on ovarian 1ctivity in Japanese black beef cows.2012
Author(s)
Naniwa, Y., Nakatsukasa, K., Setsuda, S. Oishi, S., Fujii, N., Wakabayashi, Y., Okamura, H., Uenoyama, Y., Tsukamura, H., Maeda, K.-I., Matsuda, F., Ohkura, S.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Kisspeptin neurons in the medial preoptic area of castrated male goats mediate the surge-like luteinizing hormone secretion induced by acute elevations in circulating estrogen.2012
Author(s)
Nakatsukasa, K., Suetomi, Y., Naniwa, Y., Ito, D., Inoue, N., Wakabayashi, Y ., Okamura, H., Maeda, K.-I., Uenoyama, Y., Tsukamura, H., Matsuda, F., Ohkura, S.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Generation of immortalized neuronal cell lines derived from goat hypothalamic arcuate nucleus and medial preoptic area.2012
Author(s)
Matsuda, F., Suetomi, Y., Uenoyama, Y., Maeda, K.-I., Tsukamura, H., Ohkura, S.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Involvement of kisspeptin neurons in the regulation of estrogen-induced luteinizing hormone surge in both sexes of the Japanese macaque (Macaca fuscata fuscate).2012
Author(s)
Watanabe, Y., Uenoyama, Y., Ieda, N., Kawahara, M., Takase, K., Suetomi, Y., Suzuki, J., Ohkura, S., Maeda, K.-I., Tsukamura, H.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Hypothalamic kiss1 expression is not associated with onset of puberty in pigs.2012
Author(s)
Ieda, N., Uenoyama, Y., Tomikawa, J., Inoue, N., Matsuda, F., Ohkura, S., Maeda, K.-I., Tsukamura, H.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Kappa-opioid receptor partially mediates estrogen-negative feedback effect on LH pulses.2012
Author(s)
Mostari, M. P., Ieda, N., Deura, C., Minabe, S., Uenoyama, Y., Maeda, K.-I., Tsukamura, H.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Analysis of luteinizing hormone pulse and surge in female mice.2012
Author(s)
Minabe, M., Deura, C., Uenoyama, Y., Maeda, K.-I., Tsukamura, H.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Kisspeptin neurons mediate excitatory amino acid-induced luteinizing horomone secretion in rats.2012
Author(s)
Ikegami, K., Uenoyama, Y., Nakamura, S., Tomikawa, J., Goto, T., Sambo, M., Tamura, C., Hirabayashi, M., Maeda, K.-I., Tsukamura, H.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Establishment of primary kiss1 neuron culture for the analysis of gonadotropin-releasing hormone pulse generating system using kiss1-GFP transgenic mouse.2012
Author(s)
Abe, H., Haruta, T., Goto, T., Fukanuma, T., Takase, K., Sambo, M., Tomita, K., Hirabayashi, M., Imamura, T., Tomikawa, J., Uenoyama, Y., Maeda, K.-I., Tsukamura, H.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Kiss1 knockout rats to define role of kisspeptin in regulating luteinizing hormone secretion.2012
Author(s)
Uenoyama, Y., Nakamura, S., Hayakawa, Y., Minabe, S., Tomikawa, J., Goto, T., Ieda, N., Sanbo, M., Tamura, C., Hirabayashi, M., Maeda, K.-I., Tsukamura, H.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Kiss1 gene is required for defeminization of the brain controlling sexual behaviors in rats.2012
Author(s)
Nakamura, S., Uenoyama, Y., Ikegami, K., Tomikawa, J., Goto, T., Sanbo, M., Tamura, C., Hirabayashi, M., Maeda, K.-I., Tsukamura, H.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Kiss1 upstream region regultes hypothalamic arcuate nucleus-specific kisspeptin expression.2012
Author(s)
Goto, T., Tomikawa, J., Abe, H., Fukanuma, T., Imamura, T., Takase, K., Sanbo, M., Tomita, K., Hirabayashi, M., Tsukamura, H., Maeda, K.-I., Uenoyama, Y.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Effects of kisspeptins on LH secretion and GnRH1 neuronal activities in goldfish and medaka.2012
Author(s)
Karigo, T., Uenoyama, Y., Oishi, S., Fujii, N., Mitani, Y., Kanda, S., Oka, Y.
Organizer
2nd World Conference on Kisspeptin Signaling in the Brain
Place of Presentation
Tokyo, Japan
Related Report
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[Presentation] Long-term neonatal estrogen exposure suppresses pulsatile LH release by an irreversible suppression of arcuate kiss1 gene expressions through ER alfa in rodents2011
Author(s)
Tsukamura H., Homma T., Ieda N., Minabe S., Inamoto Y., Yoshida K., Tomikawa J., Yamada S., Ohkura S., Inoue N., Uenoyama Y., Maeda K.-I
Organizer
The Second World Congress on Reproductive Biology
Place of Presentation
Cairns, Australia
Related Report
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