Investigation for effects of blood coagulation factor XI deficiency on productivity to the genetic improvement of Japanese beef cattle

• Project/Area Number: 23380166
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied animal science
• Research Institution: Okayama University
• Principal Investigator: KUNIEDA Tetsuo 岡山大学, その他の研究科, 教授 (80178011)
• Co-Investigator(Kenkyū-buntansha): TSUJI Takehito 岡山大学, 大学院・環境生命科学研究科, 准教授 (90314682) ; IBI Takayuki 岡山大学, 大学院・環境生命科学研究科, 准教授 (70335305)
• Co-Investigator(Renkei-kenkyūsha): FUNAHASHI Hiroaki 岡山大学, 大学院・環境生命科学研究科, 教授 (50284089) ; ACOSTA Tomas 岡山大学, 大学院・環境生命科学研究科, 准教授 (80379718)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000); Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
• Keywords: 育種 / 遺伝性疾患 / 和牛 / 血液凝固異常症 / ゲノム / 異常産 / 新生仔死 / 遺伝 / 血液凝固 / 黒毛和種 / 繁殖性 / 遺伝子診断 / 血液凝固異常 / 流死産

Research Abstract

Blood coagulation factor XI deficiency is a hereditary disorder observed in Japanese Black cattle. While the clinical condition of this disorder is mild, the economical impact of this disorder is apprehended to be serious because of the remarkably high allelic frequency of the mutant allele in the population of Japanese Black cattle. We, therefore, investigated the effect of the factor XI deficiency on defects in pregnancy and delivery and carcass traits using large samples of Japanese Black cattle. As a result, we found that affected animals of factor XI deficiency have a tendencies for increased frequencies of abortion and stillborn, but no effect on the condition of calf and carcass traits. These findings will be useful to future breeding of Japanese Black cattle.

Research Products

• [Journal Article] 黒毛和種牛における内因系凝固異常と胎子死の関連性 (2014)
  • Author(s): 緒方良彦, 斯琴図雅, 森友靖生, 大場恵典, 国枝哲夫, 北川均
  • Journal Title: 日本獣医師会雑誌 Volume: 67(1) Pages: 54-58
• [Journal Article] 黒毛和種牛における内因系凝固異常と胎子死の関連性 (2014)
  • Author(s): 斯琴図雅,森友靖生，大場恵典，国枝哲夫，北川均
  • Journal Title: 日本獣医師会雑誌 Volume: 67 Pages: 54-58
  • Peer Reviewed
• [Journal Article] The assessment of genetic diversity within and among the eight subpopulations of Japanese Black cattle using 52 microsatellite markers (2013)
  • Author(s): Nishimaki, T., Ibi, T., Kunieda, T.
  • Journal Title: Anim. Sci. J Volume: 84(8) Pages: 585-591
• [Journal Article] Genetic Relationship of Body Measurement Traits at Early Age with Carcass Traits in Japanese Black Cattle (2013)
  • Author(s): Munim, T., Oikawa, T., Ibi, T., Kunieda, T
  • Journal Title: Anim. Sci. J Volume: 84 Pages: 206-212
• [Journal Article] The assessment of genetic diversity within and among the eight subpopulations of Japanese Black cattle using 52 microsatellite markers. (2013)
  • Author(s): Nishimaki, T., Ibi, T., Tanabe, Y., Miyazaki, Y., Kobayashi, N., Matsuhashi, T., Akiyama, T., Yoshida, E., Imai, K., Matsui, M., Uemura, K., Watanabe, N., Fujita, T., Saito, Y., Komatsu, T., Yamada, T., Mannen, H., Sasazaki, S., Kunieda, T.
  • Journal Title: Anim. Sci. J. Volume: 62 Issue: 8 Pages: 585-591
  • DOI: 10.1111/asj.12045
  • Peer Reviewed
• [Journal Article] C-Type Natriuretic Peptide Specifically Acts on the Pylorus and Large Intestine in Mouse Gastrointestinal Tract (2013)
  • Author(s): Sogawa C, Wakizaka H, Aung W, Jin ZH, Tsuji AB, Furukawa T, Kunieda T, Saga T.
  • Journal Title: Am J Pathol. Volume: 182 Issue: 1 Pages: 172-179
  • DOI: 10.1016/j.ajpath.2012.09.015
  • Peer Reviewed
• [Journal Article] Genetic Variability of Maternal Effect on Body Measurements and its Intraand Inter- Genetic Relationship with Direct Effect in Japanese Black Calves (2012)
  • Author(s): Munim, T., Oikawa, T., Ibi, T., Kunieda, T., Hoque, MA
  • Journal Title: Anim. Sci. J Volume: 83 Pages: 199-206
• [Journal Article] Genetic Variability of Maternal Effect on Body Measurements and its Intra- and Inter-Genetic Relationship with Direct Effect in Japanese Black Calves (2012)
  • Author(s): Munim, T., Oikawa, T., Ibi, T., Kunieda, T., 他
  • Journal Title: Anim.Sci.J. Volume: 83 Issue: 3 Pages: 199-206
  • DOI: 10.1111/j.1740-0929.2011.00936.x
  • Peer Reviewed
• [Journal Article] Skeletal analysis of the long bone abnormality (lbab/lbab) mouse, a novel chondrodysplastic C-type natriuretic peptide mutant (2012)
  • Author(s): Kondo E, Nakao K, et al
  • Journal Title: Calcif Tissue Int. Volume: 90 Issue: 4 Pages: 307-318
  • DOI: 10.1007/s00223-011-9567-0
  • NAID: 120004057182
  • Peer Reviewed
• [Journal Article] NPPC/NPR2 signaling is essential for oocyte meiotic arrest and cumulus oophorus formation during follicular development in the mouse ovary (2012)
  • Author(s): Kiyosu C, Tsuji T, Yamada K, Kajita S, Kunieda T
  • Journal Title: Reproduction Volume: 144巻 Issue: 2 Pages: 187-193
  • DOI: 10.1530/rep-12-0050
  • Peer Reviewed
• [Journal Article] Genetic Relationship of Body Measurement Traits at Early Age with Carcass Traits in Japanese Black Cattle. (2012)
  • Author(s): Munim, T., Oikawa, T., Ibi, T., Kunieda, T.
  • Journal Title: Anim. Sci. J. Volume: 84 Issue: 3 Pages: 206-212
  • DOI: 10.1111/asj.12005
  • Peer Reviewed
• [Journal Article] CNP/NPR2 signaling maintains oocyte meiotic arrest in early antral follicles and is suppressed by EGFR-mediated signaling in preovulatory follicles (2012)
  • Author(s): Tsuji T, Kiyosu C, Akiyama K,KuniedaT
  • Journal Title: Mol Reprod Dev. Volume: 79巻 Issue: 11 Pages: 795-802
  • DOI: 10.1002/mrd.22114
  • Peer Reviewed
• [Journal Article] A missense mutation of the Dhh gene is associated with male pseudohermaphrodite of rats showing impaired Leydig cell development (2011)
  • Author(s): Kawai, Y., Kunieda, T., 他
  • Journal Title: Reproduction Volume: 141 Pages: 1-9
  • Peer Reviewed
• [Journal Article] Expression analysis of MIF4GD in the rat testis (2011)
  • Author(s): Okada, K., Kunieda, T., Nakai, M., Noguchi, J., 他
  • Journal Title: J.Reprod.Dev. Volume: 57 Pages: 256-261
  • NAID: 10028275441
  • Peer Reviewed
• [Presentation] 口之島牛のおける各種遺伝子の対立遺伝子頻度の調査 (2013)
  • Author(s): 斯琴図雅, 下桐 猛, 印牧美佐生, 大島一郎, 片平清美, 万年英之, 国枝哲夫
  • Organizer: 日本動物遺伝育種学会第14回大会
  • Place of Presentation: 東京海洋大学
• [Presentation] A mutation of the GFRΑ1 gene is responsible for forelimb-girdle muscular anomaly (FMA) of Japanese Black cattle (2013)
  • Author(s): Akiyama, K., Takashi Hirano, Ali Akbar Masoudi, Kazuyuki Uchida, Takehito Tsuji , Tetsuo Kunieda 10名
  • Organizer: Plant and Animal genome conference XXI
  • Place of Presentation: San Diego, CA
• [Presentation] 岡山ジャージー種における乳脂肪の淡黄色に影響するBCO2遺伝子の多型解析 (2013)
  • Author(s): 清水佑起、石倉健一、国枝哲夫、辻岳人
  • Organizer: 日本動物遺伝育種学会第14回大会
  • Place of Presentation: 東京海洋大学
• [Presentation] mtDNA塩基配列を用いた口之島野生化牛、日本短角種、無角和種の遺伝的多様性解析 (2013)
  • Author(s): 稲吉洋裕、印牧美佐生、国枝哲夫、向井文雄、笹崎晋史、万年英之
  • Organizer: 日本動物遺伝育種学会第14回大会
  • Place of Presentation: 東京海洋大学
• [Presentation] A mutation of the GFRΑ1 gene is responsible for forelimb-girdle muscular anomaly (FMA) of Japanese Black cattle (2013)
  • Author(s): Kouyou Akiyama, Takashi Hirano, Ali Akbar Masoudi, Kazuyuki Uchida, Takehito Tsuji, Taeko Kumagai, Kouji Ohwada, Yoshikazu Sugimoto, and Tetsuo Kunieda.
  • Organizer: Plant and Animal genome conference XXI
  • Place of Presentation: San Diego USA
• [Presentation] 黒毛和種における第XI因子欠乏症と異常産, 新生仔死との関連 (2012)
  • Author(s): 斯琴図雅, 緒方良彦, 森友靖生, 三浦潔, 西牧孝洋, 揖斐隆之, 国枝哲夫
  • Organizer: 日本動物遺伝育種学会第13大会
  • Place of Presentation: 仙台
• [Presentation] 黒毛和種の枝肉形質に対するSCD、SREBP1、FASおよびNCAPG遺伝子多型の関連解析 (2012)
  • Author(s): 西牧孝洋、揖斐隆之、斯琴図雅、小林直彦、松橋珠子、今井佳積、松井茉由、上村圭一、衛藤央好、渡辺直人、藤田達男、齋藤陽介、小松智彦、万年英之、笹崎晋史、国枝哲夫
  • Organizer: 日本動物遺伝育種学会第１３大会
  • Place of Presentation: 仙台
• [Presentation] 160) 黒毛和種における第XI因子欠乏症と異常産、新生仔死との関連 (2012)
  • Author(s): 斯琴図雅、緒方良彦、森友靖生、三浦潔、西牧孝洋、揖斐隆之、国枝哲夫
  • Organizer: 日本動物遺伝育種学会第１３大会
  • Place of Presentation: 仙台
• [Presentation] 黒毛和種牛に発生する前肢帯筋異常症の原因遺伝子の同定と遺伝子診断法の確立秋山耕陽、平野貴、Ali Akbar Masoudi、内田和幸、辻岳人、熊谷多妙子、大和田孝二、杉本喜憲、国枝哲夫 (2011)
  • Author(s): 秋山耕陽、平野貴、Ali Akbar Masoudi、内田和幸、辻岳人、熊谷多妙子、大和田孝二、杉本喜憲、国枝哲夫
  • Organizer: 日本動物遺伝育種学会第12回大会
  • Place of Presentation: 東広島
  • Year and Date: 2011-11-19
• [Presentation] 黒毛和種における各地域集団の遺伝的多様性と類縁関係の解析 (2011)
  • Author(s): 西牧孝洋, 揖斐隆之, 国枝哲夫 19名
  • Organizer: 日本動物遺伝育種学会第12回大会
  • Place of Presentation: 東広島
• [Presentation] 黒毛和種牛に発生する前肢帯筋異常症の原因遺伝子の同定と遺伝子診断法の確立 (2011)
  • Author(s): 秋山耕陽, 辻岳人国枝哲夫 10名
  • Organizer: 日本動物遺伝育種学会第12回大会
  • Place of Presentation: 東広島
• [Book] 獣医遺伝育種学(国枝哲夫, 今川和彦, 鈴木勝士編) (2014)
  • Author(s): 国枝哲夫, 他
  • Publisher: 朝倉書店
• [Patent(Industrial Property Rights)] 哺乳動物個体における前肢帯筋異常症を診断するためのマーカーおよびそれを用いた検出方法 (2012)
  • Inventor(s): 国枝哲夫, 平野貴
  • Industrial Property Rights Holder: 国立大学法人岡山大学
  • Industrial Property Rights Type: 特許
  • Acquisition Date: 2012-11-09
• [Patent(Industrial Property Rights)] 哺乳動物個体における前肢帯筋異常症を診断するためのマーカーおよびそれを用いた検出方法 (2011)
  • Inventor(s): 国枝哲夫, 平野貴
  • Industrial Property Rights Holder: 国立大学法人岡山大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2011-253314
  • Filing Date: 2011-11-18