Quantitative analysis of nociceptive and motor reflexes in genetically modified mice
| Project/Area Number |
23380170
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Basic veterinary science/Basic zootechnical science
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
ITO Shigeo 北海道大学, (連合)獣医学研究科, 特任教授 (40109509)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
OTSUGURO Ken-ichi 北海道大学, 大学院・獣医学研究科, 准教授 (40344494)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
|
|---|
| Keywords | 脊髄 / 新生仔マウス / 鎮痛薬 / 反射電位 / キシラジン / α２受容体 / デクスメデトミジン / 新生マウス / モルヒネ |
|---|
| Research Abstract |
alpha-Adrenoceptor agonists, dexmedetomidine and xylazine inhibited spinal motor and nociceptive reflex potentials. In the alpha2A receptor-functional deficient D79N mice, the inhibitory effect on nociceptive but not motor reflex potentials by these agonists was attenuated. alpha2A-Receptors are suggested to be involved in the alpha2-agonist-evoked analgesia but not the inhibition of motor reflex. Adenosine and hydrogen sulfide (H2S) influence spinal neuronal activity. In the spinal astrocytes, the adenosine metabolic inhibitors released adenosine, while Ca2+-removal released ATP, which was degraded to adenosine. In the neurons, H2S is produced by the synthase CST/MPST.
|
Report
(4 results)
Research Products
(31 results)
