| Budget Amount *help |
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
|
|---|
| Research Abstract |
alpha-Adrenoceptor agonists, dexmedetomidine and xylazine inhibited spinal motor and nociceptive reflex potentials. In the alpha2A receptor-functional deficient D79N mice, the inhibitory effect on nociceptive but not motor reflex potentials by these agonists was attenuated. alpha2A-Receptors are suggested to be involved in the alpha2-agonist-evoked analgesia but not the inhibition of motor reflex. Adenosine and hydrogen sulfide (H2S) influence spinal neuronal activity. In the spinal astrocytes, the adenosine metabolic inhibitors released adenosine, while Ca2+-removal released ATP, which was degraded to adenosine. In the neurons, H2S is produced by the synthase CST/MPST.
|
