Physiological and biochemical analysis of the autonomic nerve-like action by ghrelin and neuromedin U/S
| Project/Area Number |
23380173
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Keywords | トランスレーショナルリサーチ / グレリン / ニューロメジンS / 体温上昇 / 自律神経 / デスアシルグレリン / 熱中症 / 体温 / 血圧 / ニューロメジン |
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| Outline of Final Research Achievements |
The intraperitoneal administration of the ghrelin raised respiratory quotient and decreased the body temperature. Peripheral administration of des acyl ghrelin increased a survival rate of rats maintained under the high temperature. The interventricular administration of neuromedin S (NMS) increased the body surface temperature. This rise was prevented by the pre- administration of SR59230A which was selective blocker for noradrenaline β3 receptors. In addition, it was also completely prevented by the pre-administration of indomethacin which inhibited cyclooxygenase for the synthesis of PGE2. NMS knockout mouse exhibited significant decrease of body surface temperature under cold exposure (4C x 90 min), in comparison with wild mouse.
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Report
(5 results)
Research Products
(28 results)
