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Physiological and biochemical analysis of the autonomic nerve-like action by ghrelin and neuromedin U/S

Research Project

Project/Area Number 23380173
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology / General neuroscience
Research InstitutionUniversity of Miyazaki

Principal Investigator

NAKAHARA KEIKO  宮崎大学, 農学部, 准教授 (90315359)

Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Keywordsトランスレーショナルリサーチ / グレリン / ニューロメジンS / 体温上昇 / 自律神経 / デスアシルグレリン / 熱中症 / 体温 / 血圧 / ニューロメジン
Outline of Final Research Achievements

The intraperitoneal administration of the ghrelin raised respiratory quotient and decreased the body temperature. Peripheral administration of des acyl ghrelin increased a survival rate of rats maintained under the high temperature. The interventricular administration of neuromedin S (NMS) increased the body surface temperature. This rise was prevented by the pre- administration of SR59230A which was selective blocker for noradrenaline β3 receptors. In addition, it was also completely prevented by the pre-administration of indomethacin which inhibited cyclooxygenase for the synthesis of PGE2. NMS knockout mouse exhibited significant decrease of body surface temperature under cold exposure (4C x 90 min), in comparison with wild mouse.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (28 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Acknowledgement Compliant: 3 results) Presentation (18 results) (of which Invited: 1 results)

  • [Journal Article] Comparison of amino acid profiles between forced running exercise and voluntary running exercise in rats2015

    • Author(s)
      R.Okame, K.Nakahara, Y.Kato, M.Bannai, N.Murakami
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 77(6) Pages: 661-668

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Plasma amino acid profiles at various reproductive stages in female rats2015

    • Author(s)
      R.Okame, K.Nakahara*, N.Murakami
    • Journal Title

      J. Vet. Med. Sci.

      Volume: 77(7) Pages: 815-821

    • NAID

      130005089944

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Changes in mRNA expression of hypothalamic appetite-regulating peptides during different phases of lactation in rats2014

    • Author(s)
      Y Suzuki, K Nakahara, K Maruyama, R Okame, Y Inoue, N Murakami
    • Journal Title

      J Mol Endocrinol.

      Volume: 52(2) Issue: 2 Pages: 97-109

    • DOI

      10.1530/jme-13-0015

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Characterization of a novel genetically obese mouse model demonstrating early-onset hyperphagia and hyperleptinemia2013

    • Author(s)
      Nakahara K, Bannai M, Maruyama K, Suzuki Y, Okame R,Murakami N.
    • Journal Title

      Am. J. Physiology, Endocrinol. Metab

      Volume: 305 Issue: 3 Pages: 451-463

    • DOI

      10.1152/ajpendo.00540.2012

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes in mRNA expression of hypothalamic appetite-regulating peptides during different phases of lactation in rats2013

    • Author(s)
      Suzuki Y,Nakahara K, Maruyama K, Okame R, Ensho T, Inoue Y,Murakami N.
    • Journal Title

      J Mol Endocrinol

      Volume: 52 Issue: 1 Pages: 97-109

    • DOI

      10.1016/j.bbrc.2013.10.040

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Central and peripheral des-acyl ghrelin regulates body temperature in rats.2013

    • Author(s)
      Yoshiyuki INOUE
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 430 Issue: 1 Pages: 278-283

    • DOI

      10.1016/j.bbrc.2012.10.137

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothalamic gene expression involved in anorexia in rodents fedvaline-deficient diet2012

    • Author(s)
      K Nakahara, S Takata, M Ishii, K Nagao, M Bannai, M Takahashi, N Murakami
    • Journal Title

      Amino Acid

      Volume: 42 Issue: 4 Pages: 1397-1404

    • DOI

      10.1007/s00726-011-0836-z

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of glycine on subjective daytime performance in partially sleep-restricted healthy volunteers2012

    • Author(s)
      M Bannai
    • Journal Title

      Front Neurol

      Volume: 3 Pages: 1-8

    • DOI

      10.3389/fneur.2012.00061

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuromedin S regulates cardiovascular function through the sympathetic nervous system in mice2011

    • Author(s)
      T Sakamoto, K Nakahara, K Maruyama, T Katayama, K Mori, M Miyazato, K Kangawa, N Murakami
    • Journal Title

      Peptides

      Volume: 32 Pages: 1020-1026

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of the endogenous cysteine-rich peptide trissin, a ligand for an orphan Gprotein-coupled receptor in Drosophila2011

    • Author(s)
      T.Ida, M.Miyazato, X.Zi.Lin, H.Kaiya, T.Sato, K.Nakahara, N.Murakami, K.Kangawa, M.Kojim
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 414 Pages: 44-48

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 肥満マウスの血液アミノ酸プロファイルと末梢アミノ酸センシングの中枢への神経伝達の可能性2014

    • Author(s)
      大亀 吏江子、鈴木 喜博、丸田めぐみ、中原 桂子、 村上 昇
    • Organizer
      第157回日本獣医学会
    • Place of Presentation
      北海道
    • Year and Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] ニューロメジンUとSの生理作用の比較とそれらKOマウスの表現系2014

    • Author(s)
      清水誠也、中原 桂子、村上 昇
    • Organizer
      第157回日本獣医学会
    • Place of Presentation
      北海道
    • Year and Date
      2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 内臓脂肪蓄積型肥満マウス"C57BL/6J-Daruma"の表現系とインスリン抵抗性の雌雄差について2014

    • Author(s)
      鈴木 喜博、中原 桂子、村上 昇
    • Organizer
      第157回日本獣医学会
    • Place of Presentation
      北海道
    • Year and Date
      2014-09-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] エネルギー代謝・バランス制御2011

    • Author(s)
      村上昇、中原桂子
    • Organizer
      第82回日本動物学会
    • Place of Presentation
      旭川(招待講演)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] デスアシルグレリンの副交感神経系を介した体温低下作用について2011

    • Author(s)
      井上貴之、中原桂子、中村潤子、村上昇
    • Organizer
      第152回日本獣医学会秋季大会
    • Place of Presentation
      大坂
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] ラットの脳の電気破壊による走行運動中枢と摂食中枢領域の探索2011

    • Author(s)
      東村勇介、中原桂子、村上昇
    • Organizer
      第152回日本獣医学会秋季大会
    • Place of Presentation
      大坂
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高脂肪食給餌および自由走行運動がマウスの摂食と体重におよぼす影響2011

    • Author(s)
      静谷成晃、中原桂子、村上昇
    • Organizer
      第152回日本獣医学会秋季大会
    • Place of Presentation
      大坂
    • Year and Date
      2011-09-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Des-acyl ghrelin protects against body damage by heat stroke in rats

    • Author(s)
      Y. Hayashi, Y. Inoue, K. Nakahara, K. Maruyama, Y. Suzuki, K. Kangawa, N. Murakami
    • Organizer
      2013 Society for Endocrinology Annual Meeting
    • Place of Presentation
      San Francisco,USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] ニューロメジンSとその関連ペプチドの生理作用について

    • Author(s)
      村上 昇、中原桂子、寒川賢治
    • Organizer
      第40回日本神経内分泌学会、第36回日本比較内分泌学会合同シンポジウム
    • Place of Presentation
      宮崎
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ラットの泌乳期間中の弓状核摂食関連ペプチド遺伝子発現による摂食亢進機序の解析

    • Author(s)
      鈴木 喜博、中原 桂子、延生 卓也、村上 昇
    • Organizer
      第156回日本獣医学会 秋季大会
    • Place of Presentation
      岐阜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ニューロペプチドSによる明期の交感神経を介した体温及び血圧への作用

    • Author(s)
      延生 卓也、中原 桂子、村上 昇
    • Organizer
      第156回日本獣医学会 秋季大会
    • Place of Presentation
      岐阜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 加齢・雌雄差による血液中アミノ酸濃度への影響と脳内アミノ酸トランスポーターの発現

    • Author(s)
      大亀 吏江子、中原 桂子、坂内 慎、村上 昇
    • Organizer
      第156回日本獣医学会 秋季大会
    • Place of Presentation
      岐阜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラットにおける様々な生理状態での血液 ・ 脳脊髄液中アミノ酸プロファイル作成の試み

    • Author(s)
      大亀 吏江子
    • Organizer
      第154回日本獣医学会 秋季大会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] ラットの泌乳期中の摂食亢進機序の解析、 特に視床下部摂食関連ペプチド遺伝子発現について

    • Author(s)
      鈴木 喜博
    • Organizer
      第154回日本獣医学会 秋季大会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] バリン欠乏食給餌が遺伝的肥満(ob/ob)マウスの脂質代謝に及ぼす影響

    • Author(s)
      高田 志織
    • Organizer
      第154回日本獣医学会 秋季大会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] ニューロペプチドSのラットの体温および血圧におよぼす効果

    • Author(s)
      延生 卓也
    • Organizer
      第154回日本獣医学会 秋季大会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] NMSの体温上昇作用の機序について

    • Author(s)
      赤木 愛
    • Organizer
      第154回日本獣医学会 秋季大会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] グレリン及びデスアシルグレリンによる体温低下作用の作用機序について

    • Author(s)
      井上 賀之
    • Organizer
      第154回日本獣医学会 秋季大会
    • Place of Presentation
      盛岡
    • Related Report
      2012 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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