| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
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| Outline of Final Research Achievements |
The intraperitoneal administration of the ghrelin raised respiratory quotient and decreased the body temperature. Peripheral administration of des acyl ghrelin increased a survival rate of rats maintained under the high temperature. The interventricular administration of neuromedin S (NMS) increased the body surface temperature. This rise was prevented by the pre- administration of SR59230A which was selective blocker for noradrenaline β3 receptors. In addition, it was also completely prevented by the pre-administration of indomethacin which inhibited cyclooxygenase for the synthesis of PGE2. NMS knockout mouse exhibited significant decrease of body surface temperature under cold exposure (4C x 90 min), in comparison with wild mouse.
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