| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Research Abstract |
Remarkable results are summarized as following. 1) The expressionof GnRH receptor in the mammary gland is augmented after weaning. 2) The number of ovarian mast cells varies during an estrous cycle with two peaks. Those peaks matched with the variation of ovarian expression of GnRH mRNA. 3) As a tissue remodeling model, the changes in histology and mast cell number of prostate were examined after orchidectomy. Mast cell, GnRH and annexin A5 all were increased in the prostate gland after orchidectomy. 4) We found two new signaling agents in the gonadotropes those expression was increased by GnRH. By this research the existence of a novel physiological function at tissue remodeling of mast cell was demonstrated.
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