A novel physiological function of mast cells on tissue remodeling
Project/Area Number |
23380175
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Basic veterinary science/Basic zootechnical science
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Research Institution | Kitasato University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
YONEZAWA Tomohiro 東京大学, 大学院・農学生命科学研究科, 准教授 (10433715)
HASHIMOTO Osamu 北里大学, 獣医学部, 講師 (90317058)
吉川 泰永 北里大学, 獣医学部, 講師 (00552043)
|
Co-Investigator(Renkei-kenkyūsha) |
HASEGAWA Yoshihisa 北里大学, 客員教授 (40092001)
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Project Period (FY) |
2011-04-01 – 2014-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
|
Keywords | マスト細胞 / 組織リモデリング / 卵巣 / 前立腺 / 乳腺 / アネキシンA5 / GnRH / 下垂体 / アネキシンA5 |
Research Abstract |
Remarkable results are summarized as following. 1) The expressionof GnRH receptor in the mammary gland is augmented after weaning. 2) The number of ovarian mast cells varies during an estrous cycle with two peaks. Those peaks matched with the variation of ovarian expression of GnRH mRNA. 3) As a tissue remodeling model, the changes in histology and mast cell number of prostate were examined after orchidectomy. Mast cell, GnRH and annexin A5 all were increased in the prostate gland after orchidectomy. 4) We found two new signaling agents in the gonadotropes those expression was increased by GnRH. By this research the existence of a novel physiological function at tissue remodeling of mast cell was demonstrated.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Loss of maternal annexin A5 increases the likelihood of Placental platelet thrombosis and foetal loss2012
Author(s)
Ueki H, Mizushina T, Laharatchatathanin T, Terashima R, Nishimura Y, Rieanrakwong D, Yonezawa T, Kurusu S, Hasegawa Y, Brachyogel B, Poschl E, Kawaminami M
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Journal Title
Scientific reports
Volume: 2
Issue: 1
Pages: 827-827
DOI
Related Report
Peer Reviewed
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