| Budget Amount *help |
¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2011: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Research Abstract |
The TOR (target of rapamycin) signaling pathway is evolutionally conserved in eukaryotes, and responds to the changes in environmental conditions. TOR is a protein kinase, and constitutes two distinct complexes, TORC1 and TORC2. TORC1 signaling is enhanced by amino acids. Meanwhile, it is obscure whether there is a common initiator for TORC2 signaling among eukaryotes. In this study, I found that methylglyoxal, a metabolite derived from energy producing process, functioned as a signal initiator of TORC2 in both yeast and mammalian cells.
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