Synthetic study on biological active natural products by means of Ugi reaction

• Project/Area Number: 23390007
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: University of Shizuoka
• Principal Investigator: KAN Toshiyuki 静岡県立大学, 薬学部, 教授 (10221904)
• Co-Investigator(Kenkyū-buntansha): HAMASHIMA Yoshitaka 静岡県立大学, 薬学部, 教授 (40333900) ; ASAKAWA Tomohiro 静岡県立大学, 薬学部, 助教 (80571257)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2011: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: Ugi反応 / FR901483 / TAN1251A / イソニトリル / SB-203207 / MFPA / C-H挿入反応 / 全合成 / レモノマイシン / アルカロイド / TAN1251 / 免疫抑制活性

Research Abstract

The Ugi four-component condensation (Ugi 4CC) has been widely employed since it provides various alfa-amino amide derivatives by a simple experimental procedure under mild conditions. Recently, we have been developed novel isonitrile, which possessed odorless nature as well as readily convertible C-terminal amide of Ugi adducts. In this research, total synthesis of potent immunosuppressant FR901483 and TAN1251A, which possessed the subtype selective affinity against the muscarinic receptors have been accomplished by means of Ugi reaction with utilizing our novel isonitrile.

Research Products

• [Journal Article] Neuroprotective effect of nobiletin on cerebral ischemia-reperfusion injury in transient middle cerebral artery-occluded rats (2014)
  • Author(s): N. Yasuda, T. Ishii, D. Oyama, T. Fukuta, Y. Agato, A. Sato, K. Shimizu, T. Asai, T. Asakawa, T. Kan, S. Yamada, Y. Ohizumi, N. Oku
  • Journal Title: Brain Res Volume: 1559 Pages: 46-54
• [Journal Article] 2-Azahypoxanthine and imidazole-4-carboxamide produced by the fairy-ring-forming fungus increases wheat yield (2014)
  • Author(s): H. Tobina, J. Choi, T. Asai, Y. Kiriiwa, T. Asakawa, T. Kan, A. Morita, H. Kawagish
  • Journal Title: Field Crops Res Volume: 162 Pages: 6-11
  • NAID: 120005435979
• [Journal Article] Practical Total Syntheses of Acromelic Acids A and B (2014)
  • Author(s): H. Ouchi, A. Asahina, T. Asakawa, M. Inai, Y. Hamashima, T. Kan
  • Journal Title: Org. Lett Volume: 16 Pages: 1980-1983
  • NAID: 130005160054
• [Journal Article] Stereocontrolled Total Synthesis of Hedyotol A (2014)
  • Author(s): Y. Kawabe, R. Ishikawa, Y. Akao, A. Yoshida, M. Inai, T. Asakawa, Y. Hamashima, T. Kan
  • Journal Title: Org. Lett Volume: 16 Pages: 1976-1979
• [Journal Article] Enantioselective Synthesis of SB-203207 (2014)
  • Author(s): Y. Hirooka, K. Ikeuchi, Y. Kawamoto, Y. Akao, T. Furuta, T. Asakawa, M. Inai, T. Wakimoto, T. Fukuyama, T. Kan
  • Journal Title: Org. Lett Volume: 16 Pages: 1646-1649
• [Journal Article] Practical Synthesis of Kainoids : A New Chemical Probe Precursor and a Fluorescent Probe (2014)
  • Author(s): S. Sasaki, H. Suzuki, H. Ouchi, T. Asakawa, M. Inai, R. Sakai, K. Shimamoto, Y. Hamashima, T. Kan
  • Journal Title: Org. Lett Volume: 16 Pages: 564-567
• [Journal Article] The "Fairy" of Fairy Rings and Its Metabolite Exist in a Novel Purine Metabolic Pathway in Plants (2014)
  • Author(s): J. Choi, T. Ohnishi, Y. Yamakawa, S. Takeda, S. Sekiguchi, W. Maruyama, K. Yamashita, T. Suzuki, A. Morita, T. Ikka, R. Motohashi, Y. Kiriiwa, H. Tobina, T. Asai, S. Tokuyama, H. Hirai, N. Yasuda, K. Noguchi, T. Asakawa, S. Sugiyama, T. Kan, H. Kawagishi
  • Journal Title: Angew. Chem. Int. Ed Volume: 53 Pages: 1552-1552
• [Journal Article] Use of positron emission tomography for real-time imaging of biodistribution of green tea catechin (2014)
  • Author(s): K. Shimizu, T. Asakawa, N. Harada, D. Fukumoto, H. Tsukada, T. Asai, S. Yamada, T. Kan, and N. Oku
  • Journal Title: PLOS ONE Volume: 9
• [Journal Article] Synthetic Studies of Fisetin, Myricetin and Nobiletin Analogs and Related Probe Molecules (2014)
  • Author(s): A. Hiza, Y. Tsukaguchi, T. Ogawa, M. Inai, T. Asakawa, Y. Hamashima, T. Kan
  • Journal Title: Heterocycles Volume: 88 Pages: 1371-1396
• [Journal Article] Synthetic Studies of Fisetin, Myricetin and Nobiletin Analogs and Related Probe Molecules (2014)
  • Author(s): Aiki Hiza, Yuta Tsukaguchi, Takahiro Ogawa, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, and Toshiyuki Kan
  • Journal Title: HETEROCYCLES Volume: 88 Issue: 2 Pages: 1371-1371
  • DOI: 10.3987/com-13-s(s)107
  • Peer Reviewed
• [Journal Article] Practical synthesis of kainoids : a new chemical probe precursor and a fluorescent probe (2014)
  • Author(s): Sasaki, S.; Suzuki, H.; Ouchi, H.; Asakawa, T.; Inai, M.; Sakai, R.; Shimamoto, K.; Hamashima, Y.; Kan, T.
  • Journal Title: Org Lett Volume: 16 Issue: 2 Pages: 564-7
  • DOI: 10.1021/ol403434e
  • Peer Reviewed
• [Journal Article] The Source of “Fairy Rings”: 2-Azahypoxanthine and its Metabolite Found in a Novel Purine Metabolic Pathway in Plants (2014)
  • Author(s): J. Choi, T. Ohnishi, Y. Yamakawa, S. Takeda, S. Sekiguchi, W. Maruyama, K. Yamashita, T. Suzuki, A. Morita, T. Ikka, R. Motohashi, Y. Kiriiwa, H. Tobina, T. Asai, S. Tokuyama, H. Hirai, N. Yasuda, K. Noguchi, T. Asakawa, S. Sugiyama, T. Kan, and H. Kawagishi
  • Journal Title: Angew. Chem. Int. Ed. Volume: 53 Issue: 7483 Pages: 1552-1552
  • DOI: 10.1038/505298a
  • NAID: 120006727084
  • Peer Reviewed
• [Journal Article] Use of positron emission tomography for real-time imaging of biodistribution of green tea catechin (2014)
  • Author(s): Kosuke Shimizu, Tomohiro Asakawa, Norihiro Harada, Dai Fukumoto, Hideo Tsukada, Tomohiro Asai, Shizuo Yamada, Toshiyuki Kan, and Naoto Oku
  • Journal Title: PLOS ONE Volume: 9 Issue: 2 Pages: e85520-e85520
  • DOI: 10.1371/journal.pone.0085520
  • Peer Reviewed / Open Access
• [Journal Article] Enantioselective Synthesis of SB-203207 (2014)
  • Author(s): Yasuo Hirooka, Kazutada Ikeuchi, Yuichiro Kawamoto, Yusuke Akao, Takumi Furuta, Tomohiro Asakawa, Makoto Inai, Toshiyuki Wakimoto, Tohru Fukuyama and Toshiyuki Kan
  • Journal Title: Org. Lett. Volume: 16 Issue: 6 Pages: 1646-1646
  • DOI: 10.1021/ol5002973
  • Peer Reviewed
• [Journal Article] Stereocontrolled Total Synthesis of Hedyotol A (2014)
  • Author(s): Yusuke Kawabe, Ryo Ishikawa, Yusuke Akao, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima and Toshiyuki Kan
  • Journal Title: Org. Lett. Volume: 16 Issue: 7 Pages: 1976-1976
  • DOI: 10.1021/ol500524y
  • Peer Reviewed
• [Journal Article] Practical Total Syntheses of Acromelic Acids A and B (2014)
  • Author(s): Hitoshi Ouchi, Aya Asahina, Tomohiro Asakawa, Makoto Inai, Yoshitaka Hamashima and Toshiyuki Kan
  • Journal Title: Org. Lett. Volume: 16 Issue: 7 Pages: 1980-1980
  • DOI: 10.1021/ol500529w
  • NAID: 130005160054
  • Peer Reviewed
• [Journal Article] Stereocontrolled total synthesis of sphingofungin E (2013)
  • Author(s): K. Ikeuchi, M. Hayashi, T. Yamamoto, M. Inai, T. Asakawa, Y. Hamashima, T. Kan
  • Journal Title: Eur. J. Org. Chem Pages: 6789-6792
• [Journal Article] Physicochemical and biopharmaceutical characterization of amorphous solid dispersion of nobiletin, a citrus polymethoxylated flavone, with improved hepatoprotective effects (2013)
  • Author(s): S. Onoue, T. Nakamura, A. Uchida, K. Ogawa, K. Yuminoki, N. Hashimoto, A. Hiza, Y. Tsukaguchi, T. Asakawa, T. Kan, S. Yamada
  • Journal Title: Euro. J. Pharm. Sci Volume: 49 Pages: 453-460
• [Journal Article] Chemoselective Hydrogenation Reaction of Unsaturated Bonds in the Presence of o-Nitrobenzenesulfonyl Group (2013)
  • Author(s): A. Kawanishi, C. Miyamoto, Y. Yabe, M. Inai, T. Asakawa, Y. Hamashima, H. Sajiki, T. Kan
  • Journal Title: Org. Lett Volume: 15 Pages: 1306-1309
• [Journal Article] Synthesis of Theaflavins via Biomimetic Oxidative Coupling Reaction (2013)
  • Author(s): Y. Kawabe, Y. Aihara, Y. Hirose, A. Sakurada, A. Yoshida, M. Inai, T. Asakawa, Y. Hamashima, T. Kan
  • Journal Title: Synlett Pages: 479-482
• [Journal Article] Synthesis of Theaflavins via Biomimetic Oxidative Coupling Reaction (2013)
  • Author(s): Yusuke Kawabe, Yoshiyuki Aihara, Yoshitsugu Hirose, Asuka Sakurada, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, and Toshiyuki Kan
  • Journal Title: Synlett Volume: 24 Issue: 04 Pages: 479-479
  • DOI: 10.1055/s-0032-1318131
  • Peer Reviewed
• [Journal Article] Chemoselective Hydrogenation Reaction of Unsaturated Bonds in the Presence of o-Nitrobenzenesulfonyl Group (2013)
  • Author(s): Akinori Kawanishi, Chiyako Miyamoto, Yuki Yabe, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Hironao Sajiki, Toshiyuki Kan
  • Journal Title: Org. Lett. Volume: 15 Issue: 6 Pages: 1306-1306
  • DOI: 10.1021/ol4002448
  • Peer Reviewed
• [Journal Article] Physicochemical and biopharmaceutical characterization of amorphous solid dispersion of nobiletin, a citrus polymethoxylated flavone, with improved hepatoprotective effects (2013)
  • Author(s): Satomi Onoue, Tatsuya Nakamura, Atsushi Uchida, Kazunori Ogawa, Kayo Yuminoki, Naofumi Hashimoto, Aiki Hiza, Yuta Tsukaguchi, Tomohiro Asakawa, Toshiyuki Kan, Shizuo Yamada
  • Journal Title: Euro. J. Pharm. Sci. Volume: 49 Issue: 4 Pages: 453-453
  • DOI: 10.1016/j.ejps.2013.05.014
  • Peer Reviewed
• [Journal Article] Stereocontrolled total synthesis of sphingofungin E (2013)
  • Author(s): Kazutada Ikeuchi, Moemi Hayashi, Tomohiro Yamamoto, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
  • Journal Title: Eur. J. Org. Chem., Volume: 2013 Issue: 30 Pages: 6789-6789
  • DOI: 10.1002/ejoc.201301065
  • Peer Reviewed
• [Journal Article] Effects of Green Tea Catechins on Cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A Activities in Human Liver and Intestinal Microsomes (2013)
  • Author(s): Misaka, Shingen; Kawabe, Keisuke; Onoue, Satomi; Werba, Jose Pablo; Giroli, Monica; Tamaki, Sekihiro; Kan, Toshiyuki; Kimura, Junko; Watanabe, Hiroshi; Yamada, Shizuo
  • Journal Title: Drug Metabolism and Pharmacokinetics Volume: 28 Issue: 3 Pages: 244-249
  • DOI: 10.2133/dmpk.DMPK-12-RG-101
  • NAID: 130004463306
  • ISSN: 1347-4367, 1880-0920
  • Peer Reviewed
• [Journal Article] Chemical synthesis of tea polyphenols and related compounds (2013)
  • Author(s): Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
  • Journal Title: Curr. Pharm. Des. Volume: 19 Pages: 6207-6207
  • Peer Reviewed
• [Journal Article] Stereocontrolled Total Synthesis of (-)-FR-901483 (2012)
  • Author(s): S. Ieda, A. Masuda, M. Kariyama, T. Wakimoto, T. Asakawa, T. Fukuyama, T. Kan
  • Journal Title: Heterocycles Volume: 86 Pages: 1071-1092
• [Journal Article] Catalytic Desymmetrization of Cyclohexadienes by Asymmetric Bromolactonization (2012)
  • Author(s): K. Ikeuchi, S. Ido, S. Yoshimura, T. Asakawa, M. Inai, Y. Hamashima, T. Kan
  • Journal Title: Org. Lett Volume: 14 Pages: 6016-6019
• [Journal Article] Stereocontrolled Total Synthesis of (+)- UCS1025A (2012)
  • Author(s): K. Uchida, T. Ogawa, Y. Yasuda, H. Mimura, T. Fujimoto, T. Fukuyama, T. Wakimoto, T. Asakawa, Y. Hamashima, T. Kan
  • Journal Title: Angew. Chem., Int. Ed Volume: 51 Pages: 12850-12853
• [Journal Article] Total Synthesis of (-)-Lemonomycin (2012)
  • Author(s): A. Yoshida, M. Akaiwa, T. Asakawa, Y. Hamashima, S. Yokoshima, T. Fukuyama, T. Kan
  • Journal Title: Chem. Eur. J Volume: 18 Pages: 11192-11195
• [Journal Article] 3, 3', 4', 5, 5'-Pentahydroxyflavone is a potent inhibitor of amyloid fibril formation (2012)
  • Author(s): H. Ushikubo, S. Watanabe, Y. Tanimoto, K. Abe, A. Hiza, T. Ogawa, T. Asakawa, T. Kan, T. Akaishi
  • Journal Title: Neurosci. Lett Volume: 513 Pages: 51-56
• [Journal Article] A Short-step Asymmetric Synthesis of Dehydrodiconiferyl Alcohol via C-H Insertion Reaction (2012)
  • Author(s): S. Matsumoto, T. Asakawa, Y. Hamashima, T. Kan
  • Journal Title: Synlett Pages: 1082-1084
• [Journal Article] Catalytic Desymmetrization of Cyclohexadienes by Asymmetric Bromolactonization (2012)
  • Author(s): Ikeuchi, Kazutada
  • Journal Title: Organic Letters Volume: 14 Issue: 23 Pages: 6016-6019
  • DOI: 10.1021/ol302908a
  • Peer Reviewed
• [Journal Article] Total Synthesis of (-)・Lemonomycin (2012)
  • Author(s): Atsushi Yoshida
  • Journal Title: Chemistry A European Journal Volume: 36 Issue: 36 Pages: 11192-11195
  • DOI: 10.1002/chem.201202073
  • Peer Reviewed
• [Journal Article] Furan Fatty Acid as an Anti-inflammatory Component from Green-Lipped Mussel, Perna canaliculus (2011)
  • Author(s): T. Wakimoto, H. Kondo, H. Nii, K. Kimura, Y. Egami, Y. Oka, M. Yoshida, E. Kida, Y. Ye, S. Akahoshi, T. Asakawa, K. Matsumura, H. Ishida, H. Nukaya, K. Tsuji, T. Kan, I. Abe
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108 Pages: 17533-17537
• [Journal Article] Enantioselective Total Synthesis of Aperidine (2011)
  • Author(s): T. Wakimoto, K. Miyata, H. Ouchi, T. Asakawa, H. Nukaya, Y. Suwa, T. Kan
  • Journal Title: Org. Lett Volume: 13 Pages: 2789-2791
• [Journal Article] Stereocntrolled Synthesis of (+)-Methoxyphenylkainic acid and (+)-Phenylkainic acid (2011)
  • Author(s): T. Higashi, Y. Isobe, H. Ouchi, H. Suzuki, Y. Okazaki, T. Asakawa T. Furuta, T. Wakimoto, T. Kan
  • Journal Title: Org. Lett Volume: 13 Pages: 1089-1091
• [Journal Article] PET Imaging Investigation of Nobiletin Based on a Practical Total Synthesis (2011)
  • Author(s): T. Asakawa, A. Hiza, M. Nakayama, M. Inai, D. Oyama, H. Koide, K. Shimizu, T. Wakimoto, N. Harada, H. Tsukada, N. Oku, T. Kan
  • Journal Title: Chem. Commun Volume: 47 Pages: 2868-2870
• [Journal Article] Anti-angiogenic activity and intracellular distribution of epigallalocatechin-3-gallate analogs (2011)
  • Author(s): S. PIYAVIRIYAKUL, K. Shimizu, T. Asakawa, T. Kan, P. SIRIPONG, N. Oku
  • Journal Title: Biol. Pharm. Bull Volume: 34 Pages: 396-400
• [Journal Article] Proof of the existence of an unstable amino acid, pleurocybellaziridine, in Pleurocybella porrigens (angel's wing mushroom) (2011)
  • Author(s): Toshiyuki Wakimoto, Tomohiro Asakawa, Saeko Akahoshi, Tomohiro Suzuki, Kaoru Nagai, Hirokazu Kawagishi, Toshiyuki Kan
  • Journal Title: Angew. Chem. Int. Ed Volume: 50 Pages: 1168-1170
• [Journal Article] Concise synthesis of catechin probes enabling analysis and imaging of EGCg (2011)
  • Author(s): A. Yoshida, Y. Hirooka, Y. Sugata, M. Nitta, T. Manabe, S. Ido, K. Murakami, R. K. Saha, T. Suzuki, M. Ohshima, A. Yoshida, K. Itoh, K. Shimizu, N. Oku, T. Furuta, T. Asakawa, T. Wakimoto, T. Kan
  • Journal Title: Chem. Commun Volume: 47 Pages: 1794-1796
• [Journal Article] Practical synthesis of natural plant-growth regulator 2-azahypoxanthine, its derivatives, and biotin-labeled probes
  • Author(s): K. Ikeuchi, R. Fujii, S. Sugiyama, T. Asakawa, M. Inai, Y. Hamashima, J. Choi, T. Suzuki, H. Kawagishi, T. Kan
  • Journal Title: Org. Biomol. Chem Volume: (in press)
  • NAID: 120005596545
• [Presentation] TAN1251C の全合成 (2014)
  • Author(s): 松村幸亮，長坂洋祐，升田明孝，浅川倫宏，稲井 誠，江木正浩，菅 敏幸
  • Organizer: 日本薬学会134年会
  • Place of Presentation: 熊本
• [Presentation] フロフランリグナン類の合成研究 (2014)
  • Author(s): 5. 石川 諒，河辺佑介，吉田直人，赤尾祐介，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 日本薬学会134年会
  • Place of Presentation: 熊本
• [Presentation] アクロメリン酸A, B の合成研究 (2013)
  • Author(s): 大内仁志, 朝比奈彩, 浅川倫宏, 稲井誠, 濱島義隆, 菅敏幸
  • Organizer: 第39回反応と合成の進歩シンポジウム
  • Place of Presentation: 福岡
  • Year and Date: 2013-11-05
• [Presentation] (-)-Sphingofungin E の全合成 (2013)
  • Author(s): 池内和忠, 林萌未, 山本倫広, 稲井誠, 浅川倫宏, 濱島義隆, 菅敏幸
  • Organizer: 第55回天然有機化合物討論会
  • Place of Presentation: 京都
  • Year and Date: 2013-09-20
• [Presentation] アクロメリン酸B の全合成 (2013)
  • Author(s): 朝比奈彩, 大内仁志, 浅川倫宏, 稲井誠, 濱島義隆, 菅敏幸
  • Organizer: 第30回有機合成化学セミナー
  • Place of Presentation: 岡山
  • Year and Date: 2013-09-18
• [Presentation] アクロメリン酸A の全合成 (2013)
  • Author(s): 大内仁志, 浅川倫宏, 稲井誠, 濱島義隆, 菅敏幸
  • Organizer: 第103回有機合成シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2013-06-05
• [Presentation] アクロメリン酸類の合成研究 (2013)
  • Author(s): 朝比奈彩, 大内仁志, 浅川倫宏, 稲井誠, 濱島義隆, 菅敏幸
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-30
• [Presentation] TAN1251C の合成研究 (2013)
  • Author(s): 長坂洋祐, 升田明孝, 苅山真美, 稲井誠, 浅川倫宏, 濱島義隆, 菅敏幸
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-30
• [Presentation] アクロメリン酸A の実用的合成法の開発 (2013)
  • Author(s): 大内仁志, 浅川倫宏, 稲井誠, 濱島義隆, 菅敏幸
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-30
• [Presentation] (-)-Sphingofungin E の全合成 (2013)
  • Author(s): 池内和忠, 林萌未, 山本倫広, 稲井誠, 浅川倫宏, 濱島義隆, 菅敏幸
  • Organizer: 日本薬学会第133年会
  • Place of Presentation: 横浜
  • Year and Date: 2013-03-30
• [Presentation] パルメロライドAの合成研究 (2013)
  • Author(s): 河西昭典，相原義之，佐々木羽玲，朝比奈彩，村田武士，岩田 想，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 第11回次世代を担う有機化学シンポジウム
  • Place of Presentation: 東京
• [Presentation] ノビレチン類の合成とプローブ分子化 (2013)
  • Author(s): 浅川倫宏，塚口雄太，飛坐愛輝，砂川陽一，刀坂泰史，稲井 誠，濱島義隆，森本達也，菅 敏幸
  • Organizer: 学術領域研究「天然物ケミカルバイオロジー：分子標的と活性制御」第三回若手研究者ワークショップ
  • Place of Presentation: 東京
• [Presentation] アクロメリン酸Aの全合成 (2013)
  • Author(s): 大内仁志，浅川倫宏，稲井 誠，濱島義隆，菅 敏幸
  • Organizer: 第103回有機合成シンポジウム
  • Place of Presentation: 東京
• [Presentation] アクロメリン酸Aの全合成 (2013)
  • Author(s): 大内仁志，浅川倫宏，稲井 誠，濱島義隆，菅 敏幸
  • Organizer: 第12回新規素材探索研究会
  • Place of Presentation: 横浜
• [Presentation] 蛍光プローブ化を指向したカイノイドの合成研究 (2013)
  • Author(s): 佐々木真吾，鈴木寛人，大内仁志，浅川倫宏，稲井 誠，濱島義隆，菅 敏幸
  • Organizer: 第12回新規素材探索研究会
  • Place of Presentation: 横浜
• [Presentation] フロフランリグナン類の合成研究 (2013)
  • Author(s): 石川 諒，赤尾祐介，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 第12回新規素材探索研究会
  • Place of Presentation: 横浜
• [Presentation] パルメロライドAの合成研究 (2013)
  • Author(s): 森兼悠太，河西昭典，相原義之，佐々木羽玲，朝比奈彩，村田武士，岩田 想，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 第12回新規素材探索研究会
  • Place of Presentation: 横浜
• [Presentation] 天然フラボノイドの合成研究 (2013)
  • Author(s): 飛坐愛輝，塚口雄太，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 第48回天然物化学談話会
  • Place of Presentation: 滋賀
• [Presentation] パルメロライドAの合成研究 (2013)
  • Author(s): 河西昭典，相原義之，佐々木羽玲，朝比奈彩，村田武士， 岩田 想，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 第48回天然物化学談話会
  • Place of Presentation: 滋賀
• [Presentation] 蛍光プローブ化を指向したカイノイドの合成研究 (2013)
  • Author(s): 佐々木真吾，鈴木寛人，大内仁志，浅川倫宏，稲井 誠，濱島義隆，菅 敏幸
  • Organizer: 第48回天然物化学談話会
  • Place of Presentation: 滋賀
• [Presentation] フロフランリグナン類の合成研究 (2013)
  • Author(s): 石川 諒，赤尾祐介，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 第59回日本薬学会東海支部総会・大会
  • Place of Presentation: 名古屋
• [Presentation] パルメロライドA 誘導体の合成研究 (2013)
  • Author(s): 森兼悠太，朝比奈彩，河西昭典，相原義之，佐々木羽玲，村田武士，岩田 想，稲井 誠，浅川 倫宏，濱島義隆，菅 敏幸
  • Organizer: 第59回日本薬学会東海支部総会・大会
  • Place of Presentation: 名古屋
• [Presentation] Practical Synthesis of Nobiletin and its PET Imaging Study (2013)
  • Author(s): Aiki Hiza, Yuta Tsukaguchi, Inai makoto, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
  • Organizer: The First Asian Conference for "MONODUKURI" Strategy by Synthetic Organic Chemistry
  • Place of Presentation: Okinawa
• [Presentation] アクロメリン酸Bの全合成 (2013)
  • Author(s): 朝比奈彩，大内仁志，浅川倫宏，稲井 誠，濱島義隆，菅 敏幸
  • Organizer: 第30回有機合成化学セミナー
  • Place of Presentation: 岡山
• [Presentation] Hedyotol A の全合成 (2013)
  • Author(s): 河辺佑介，石川 諒，吉田直人，赤尾祐介，吉田篤史，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 第30回有機合成化学セミナー
  • Place of Presentation: 岡山
• [Presentation] フラボンおよびフラバノンの合成研究 (2013)
  • Author(s): 塚口雄太，飛坐愛輝，小川貴大，赤石樹泰，阿部和穂，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 第30回有機合成化学セミナー
  • Place of Presentation: 岡山
• [Presentation] (–)-Sphingofungin E の全合成 (2013)
  • Author(s): 池内和忠，林 萌未，山本倫広，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 第55回天然有機化合物討論会
  • Place of Presentation: 京都
• [Presentation] Practical Synthesis of Nobiletin and its PET Imaging Study (2013)
  • Author(s): Aiki Hiza, Yuta Tsukaguchi, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
  • Organizer: 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds
  • Place of Presentation: Yamanashi
• [Presentation] Total Synthesis of Acromelic Acid A and B (2013)
  • Author(s): Hitoshi Ohuchi, Aya Asahina, Tomohiro Asakawa, Makoto Inai, Yoshitaka Hamashima, Toshiyuki Kan
  • Organizer: 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds
  • Place of Presentation: Yamanashi
• [Presentation] Total synthesis of (–)-sphingofungin E (2013)
  • Author(s): Kazutada Ikeuchi, Moemi Hayashi, Tomohiro Yamamoto, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
  • Organizer: 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds
  • Place of Presentation: Yamanashi
• [Presentation] Total synthesis of Palmerolide A (2013)
  • Author(s): Akinori Kawanishi, Yoshiyuki Aihara, Harei Sasaki, Aya Asahina, Takeshi Murata, So Iwata, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
  • Organizer: 13th International Conference on the Chemistry of Antibiotics and other bioactive compounds
  • Place of Presentation: Yamanashi
• [Presentation] 天然フラボノイドの合成研究 (2013)
  • Author(s): 飛坐愛輝，塚口雄太，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 第43回複素環化学討論会
  • Place of Presentation: 岐阜
• [Presentation] Stereocontrolled total synthesis of teadenol A and B (2013)
  • Author(s): Ryunosuke Yoshida, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
  • Organizer: 第18回静岡健康・長寿学術フォーラム
  • Place of Presentation: 静岡
• [Presentation] Practical Synthesis of Nobiletin and its PET Imaging Study (2013)
  • Author(s): Aiki Hiza, Yuta Tsukaguchi, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
  • Organizer: 第18回静岡健康・長寿学術フォーラム
  • Place of Presentation: 静岡
• [Presentation] Synthetic studies of tea polyphenols and its probes (2013)
  • Author(s): Yusuke Kawabe, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
  • Organizer: 第18回静岡健康・長寿学術フォーラム
  • Place of Presentation: 静岡
• [Presentation] パルメロライドAの合成研究 (2013)
  • Author(s): 河西昭典，相原義之，佐々木羽玲，朝比奈彩，村田武士，岩田 想，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 第44回中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 静岡
• [Presentation] アクロメリン酸A, Bの合成研究 (2013)
  • Author(s): 大内仁志，朝比奈彩，浅川倫宏，稲井 誠，濱島義隆，菅 敏幸
  • Organizer: 第39回反応と合成の進歩シンポジウム
  • Place of Presentation: 福岡
• [Presentation] Hedyotol A の全合成研究 (2013)
  • Author(s): 河辺佑介，石川 諒，吉田篤史，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 第104回有機合成シンポジウム
  • Place of Presentation: 東京
• [Presentation] Synthetic studies of tea polyphenols and its probes (2013)
  • Author(s): Yusuke Kawabe, Atsushi Yoshida, Makoto Inai, Tomohiro Asakawa, Yoshitaka Hamashima, Toshiyuki Kan
  • Organizer: The 5th International Conference on O-CHA (Tea) Culture and Science
  • Place of Presentation: Shizuoka
• [Presentation] ニトロベンゼンスルホニル基存在下での炭素‐炭素多重結合の選択的還元反応の開発 (2013)
  • Author(s): 河西昭典，宮本知矢子，矢部雄貴，稲井 誠，浅川倫宏，濱島義隆，佐治木弘尚，菅 敏幸
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会
  • Place of Presentation: 三重
• [Presentation] フラボンおよびフラバノンの合成研究 (2013)
  • Author(s): 塚口雄太，飛坐愛輝，小川貴大，赤石樹泰，阿部和穂，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会
  • Place of Presentation: 三重
• [Presentation] アクロメリン酸Bの全合成 (2013)
  • Author(s): 朝比奈彩，大内仁志，浅川倫宏，稲井 誠，濱島義隆，菅 敏幸
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会
  • Place of Presentation: 三重
• [Presentation] ヘジオトール A の全合成 (2013)
  • Author(s): 河辺佑介，石川 諒，赤尾祐介，吉田篤史，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会
  • Place of Presentation: 三重
• [Presentation] パクタマイシンの合成研究 (2013)
  • Author(s): 吉村 諭，後藤篤実，稲井 誠，浅川倫宏，濱島義隆，菅 敏幸
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会
  • Place of Presentation: 三重
• [Presentation] 固相合成を利用した長鎖ポリアミンの合成研究 (2013)
  • Author(s): 淺沼雄太，假屋唯香，稲井 誠，浅川倫宏，濱島義隆，福田裕穂，菅 敏幸
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会
  • Place of Presentation: 三重
• [Presentation] 蛍光プローブ化を指向したカイノイドの合成研究 (2013)
  • Author(s): 佐々木真吾，鈴木寛人，大内仁志，浅川倫宏，稲井 誠，濱島義隆，菅 敏幸
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会
  • Place of Presentation: 三重
• [Presentation] カテキンプローブの効率的合成と分子イメージングによる動態解析 (2013)
  • Author(s): 菅 敏幸，浅川倫宏，清水広介，奥 直人，原田典弘，塚田秀夫
  • Organizer: 第31回メディシナルケミストリーシンポジウム
  • Place of Presentation: 広島
• [Presentation] 効率的ヘテロ環構築を基盤とする生理活性天然物の合成 (2013)
  • Author(s): 菅 敏幸
  • Organizer: 千葉大学大学院薬学研究科講演会
  • Place of Presentation: 千葉
  • Invited
• [Presentation] 効率的ヘテロ環構築を基盤とする生理活性天然物の合成 (2013)
  • Author(s): 菅 敏幸
  • Organizer: 第103回有機合成シンポジウム
  • Place of Presentation: 東京
  • Invited
• [Presentation] 独自の合成方法論を基盤とするプローブ分子の創製 (2013)
  • Author(s): 菅 敏幸
  • Organizer: 天然物ケミカルバイオロジー第４回公開シンポジウム
  • Place of Presentation: 筑波
  • Invited
• [Presentation] 独自の合成方法論を基盤とするプローブ分子の創製 (2013)
  • Author(s): 菅 敏幸
  • Organizer: 第3回有機分子構築法夏の勉強会
  • Place of Presentation: 静岡
  • Invited
• [Presentation] TAN1251C の合成研究 (2012)
  • Author(s): 長坂洋祐, 升田明孝, 岩永耕治, 浅川倫宏, 濱島義隆, 横島 聡, 福山 透, 菅 敏幸
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会
  • Place of Presentation: 岐阜
  • Year and Date: 2012-11-18
• [Presentation] (-)-レモノマイシンの全合成 (2012)
  • Author(s): 吉田篤史, 赤岩路則, 濱島義隆, 横島 聡, 福山 透, 菅敏幸
  • Organizer: 第54回天然有機化合物討論会
  • Place of Presentation: 東京
  • Year and Date: 2012-09-20
• [Presentation] (-)-レモノマイシンの全合成 (2012)
  • Author(s): 吉田篤史, 赤岩路則, 濱島義隆, 横島 聡, 福山 透, 菅敏幸
  • Organizer: 第29回有機合成化学セミナー
  • Place of Presentation: 静岡
  • Year and Date: 2012-09-06
• [Presentation] Sphingofungin E の不斉合成研究 (2012)
  • Author(s): 池内和忠, 林 萌未, 井戸俊輔, 山本倫広, 稲井 誠, 浅川倫宏, 濱島義隆, 菅 敏幸
  • Organizer: 第29回有機合成化学セミナー
  • Place of Presentation: 静岡
  • Year and Date: 2012-09-06
• [Presentation] アクロメリン酸の触媒的不斉合成 (2012)
  • Author(s): 大内仁志, 濱島義隆, 袖岡幹子, 浅川倫宏, 稲井誠, 菅 敏幸
  • Organizer: 第29回有機合成化学セミナー
  • Place of Presentation: 静岡
  • Year and Date: 2012-09-06
• [Presentation] TAN1251C の全合成 (2012)
  • Author(s): 升田明孝, 苅山真美, 稲井 誠, 浅川倫宏, 濱島義隆, 菅 敏幸
  • Organizer: 日本薬学会132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-31
• [Presentation] レモノマイシンの合成におけるアミノ糖の合成及びその導入 (2012)
  • Author(s): 長坂洋祐, 吉田篤史, 赤岩路則, 浅川倫宏, 濱島義隆, 横島 聡, 福山 透, 菅 敏幸
  • Organizer: 日本薬学会132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-31
• [Presentation] (-)-レモノマイシンの合成研究 (2012)
  • Author(s): 吉田篤史, 赤岩路則, 横島 聡, 濱島義隆, 福山 透, 菅 敏幸
  • Organizer: 日本薬学会132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-31
• [Presentation] TAN1251Cの全合成 (2012)
  • Author(s): 升田明孝, 苅山真美、稲井誠、浅川倫宏、濱島義隆、菅敏幸
  • Organizer: 日本薬学会132年会
  • Place of Presentation: 北海道
  • Year and Date: 2012-03-31
• [Presentation] Sphingofungin E の全合成 (2012)
  • Author(s): 池内和忠, 林 萌未, 井戸俊輔, 山本倫広, 稲井 誠, 浅川倫宏, 濱島義隆, 菅 敏幸
  • Organizer: 第10回次世代を担う有機化学シンポジウム
  • Place of Presentation: 大阪
• [Presentation] 非対称化を伴う不斉ブロモラクトン化反応 (2012)
  • Author(s): 吉村 諭
  • Organizer: 第58回日本薬学会東海支部 総会・大会
  • Place of Presentation: 静岡
• [Presentation] (－)-レモノマイシンの全合成 (2012)
  • Author(s): 吉田篤史
  • Organizer: 第29回有機合成化学セミナー
  • Place of Presentation: 静岡
• [Presentation] (－)-レモノマイシンの全合成 (2012)
  • Author(s): 吉田篤史
  • Organizer: 第54回天然有機化合物討論会
  • Place of Presentation: 東京
• [Presentation] Synthetic Study on Heterocyclic Natural Products (2012)
  • Author(s): Toshiyuki Kan
  • Organizer: Japan-Singapore Bilateral Symposium on Synthetic Organic Chemistry
  • Place of Presentation: Nanyang
  • Invited
• [Presentation] 効率的ヘテロ環構築を基盤とする生理活性天然物の合成 (2012)
  • Author(s): 菅 敏幸
  • Organizer: 第2回大塚 有機合成シンポジウム
  • Place of Presentation: 徳島
  • Invited
• [Presentation] Synthetic Study on Heterocyclic Natural Products (2012)
  • Author(s): Toshiyuki Kan
  • Organizer: University of Pennsylvania
  • Place of Presentation: Pennsylvania
  • Invited
• [Presentation] Synthetic Study on Heterocyclic Natural Products (2012)
  • Author(s): Toshiyuki Kan
  • Organizer: Colorado State University
  • Place of Presentation: Colorado
  • Invited
• [Presentation] Synthetic Study on Heterocyclic Natural Products (2012)
  • Author(s): Toshiyuki Kan
  • Organizer: University of California Irvine
  • Place of Presentation: California
  • Invited
• [Presentation] Synthetic Study on Heterocyclic Natural Products (2012)
  • Author(s): Toshiyuki Kan
  • Organizer: Scripps Research Institute
  • Place of Presentation: California
  • Invited
• [Presentation] Synthetic Study on Heterocyclic Natural Products (2012)
  • Author(s): Toshiyuki Kan
  • Organizer: University of California San Diego
  • Place of Presentation: California
  • Invited
• [Presentation] 不斉ハロラクトン化と生理活性化合物の合成 (2012)
  • Author(s): 濱島義隆
  • Organizer: 有機分子触媒による未来型分子変換 第１回全体会議
  • Place of Presentation: 京都
  • Invited
• [Presentation] Asymmetric bromolactonization and its application to natural product synthesis (2012)
  • Author(s): Yoshitaka Hamashima
  • Organizer: Japan-USA Organo-Catalytic Symposium in Hawaii
  • Place of Presentation: Hawaii
  • Invited
• [Presentation] TAN1251 の合成研究 (2011)
  • Author(s): 升田明孝, 浅川倫宏, 濱島義隆, 菅 敏幸
  • Organizer: 日本薬学会東海支部合同学術2011
  • Place of Presentation: 愛知
  • Year and Date: 2011-11-23
• [Presentation] (-)-FR901483の全合成 (2011)
  • Author(s): 升田明孝, 家田成, 苅山真美, 脇本敏幸, 浅川倫宏, 福山透, 濱島義隆, 菅敏幸
  • Organizer: 第41回複素環化学討論会
  • Place of Presentation: 熊本
  • Year and Date: 2011-10-22
• [Book] 天然物合成で活躍した反応-実験のコツとポイント (2011)
  • Author(s): 菅敏幸(編集委員、執筆者)
  • Total Pages: 209
  • Publisher: 化学同人