|Budget Amount *help
¥18,460,000 (Direct Cost : ¥14,200,000、Indirect Cost : ¥4,260,000)
Fiscal Year 2014 : ¥4,420,000 (Direct Cost : ¥3,400,000、Indirect Cost : ¥1,020,000)
Fiscal Year 2013 : ¥4,550,000 (Direct Cost : ¥3,500,000、Indirect Cost : ¥1,050,000)
Fiscal Year 2012 : ¥4,550,000 (Direct Cost : ¥3,500,000、Indirect Cost : ¥1,050,000)
Fiscal Year 2011 : ¥4,940,000 (Direct Cost : ¥3,800,000、Indirect Cost : ¥1,140,000)
|Outline of Final Research Achievements
siRNA is expected to be used for the treatment of various diseases due to its capability to efficiently knockdown the target mRNA in a sequence-specific manner. However, the development of useful vehicles for siRNA is a critical issue. We have recently found that poly(ethylene glycol)-polycations block copolymers can form small-sized polyion complexes with single molecule siRNA, and in this study, we have studied the utility of small-sized polyion complexes named “PIC nanocarriers” as siRNA delivery systems. The optimized PIC nanocarriers exhibited prolonged circulation and enhanced tumor accumulation after the systemic administration. We have demonstrated the usefulness of PIC nanocarriers for the treatment of solid tumors and kidney diseases.