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Molecular mechanism for roles of chondroitin sulfate in tumor metastasis

Research Project

Project/Area Number 23390016
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionHokkaido University

Principal Investigator

SUGAHARA Kazuyuki  北海道大学, 先端生命科学研究科(研究院), 学術研究員 (60154449)

Co-Investigator(Kenkyū-buntansha) YAMADA Shuhei  北海道大学, 大学院・先端生命科学研究院, 准教授 (70240017)
Co-Investigator(Renkei-kenkyūsha) MIZUMOTO Shuji  名城大学, 薬学部, 助教 (40443973)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords癌 / 転移 / コンドロイチン硫酸 / ヘパラン硫酸 / RAGE / ルイス肺癌細胞 / グリコサミノグリカン / プロテオミクス / プロテオグリカン / オリゴ糖 / デルマタン硫酸
Research Abstract

Previously, we have demonstrated that Lewis lung carcinoma (LLC)-derived tumor cell line with high metastatic potential shows a higher proportion of E-disaccharide units, GlcUA-GalNAc(4, 6-O-disulfate), in CS chains, which are recognized by phage display antibody. Interestingly, the antibody strongly inhibited the pulmonary metastasis. In this research, to elucidate the molecular mechanism for tumor metastasis involved in the CS chains. The receptor molecule for CS chains containing E-disaccharides, Receptor for Advanced Glycation End-products (RAGE), was identified by proteomics approach. Furthermore, the colonization of the lungs by LLC cells was effectively inhibited by an anti-RAGE antibody. These results provide the clear evidence that RAGE is at least one of the critical receptors for CS chains expressed at the tumor cell surface and involved in experimental lung metastasis, and that CS/HS and RAGE are potential molecular targets in the treatment of pulmonary metastasis.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (82 results)

All 2014 2013 2012 2011 Other

All Journal Article (25 results) (of which Peer Reviewed: 25 results) Presentation (53 results) (of which Invited: 11 results) Book (2 results) Remarks (2 results)

  • [Journal Article] Glycosaminoglycans are functional ligands for Receptor for Advanced Glycation End-products (RAGE) in tumors2013

    • Author(s)
      Shuji Mizumoto, Kazuyuki Sugahara
    • Journal Title

      FEBS Journal

      Volume: 280(10) Pages: 2462-2470

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase involved in chondroitin sulfate synthesis is responsible for pulmonary metastasis2013

    • Author(s)
      Shuji Mizumoto, Moto Watanabe, Shuhei Yamada, Kazuyuki Sugahara
    • Journal Title

      BioMed Research International

      Volume: 2013 Pages: 656319-656319

    • NAID

      120005906914

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glycosaminoglycans are functional ligands for Receptor for Advanced Glycation End-products (RAGE) in tumors2013

    • Author(s)
      Mizumoto, S., and Sugahara, K.
    • Journal Title

      FEBS Journal

      Volume: 280 Issue: 10 Pages: 2462-2470

    • DOI

      10.1111/febs.12156

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase involved in chondroitin sulfate synthesis is responsible for pulmonary metastasis2013

    • Author(s)
      Mizumoto, S., Watanabe, M., Yamada, S., and Sugahara, K.
    • Journal Title

      BioMed Research International

      Volume: 2013 Pages: 656319-656319

    • DOI

      10.1155/2013/656319

    • NAID

      120005906914

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific interaction of the envelope glycoproteins E1 and E2 with liver heparan sulfate involved in the tissue tropismatic infection by hepatitis C virus2012

    • Author(s)
      Fumi Kobayashi, Shuhei Yamada, Shuhei Taguwa, Chikako Kataoka, Satomi Naito, Yoshiki Hama, Hideki Tani, Yoshiharu Matsuura, Kazuyuki Sugahara
    • Journal Title

      Glycoconjugate Journal

      Volume: 29(4) Pages: 211-220

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Receptor for Advanced Glycation End Products (RAGE) Functions as a Receptor for Specific Sulfated Glycosaminoglycans, and Anti-RAGE Antibody or The Sulfated Glycosaminoglycans Delivered in vivo Inhibit Pulmonary Metastasis of Tumor Cells2012

    • Author(s)
      Shuji Mizumoto, Jun Takahashi, Kazuyuki Sugahara
    • Journal Title

      Journal of Biological Chemistry

      Volume: 287(23) Pages: 18985-18994

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Receptor for Advanced Glycation End Products (RAGE) Functions as a Receptor for Specific Sulfated Glycosaminoglycans, and Anti-RAGE Antibody or The Sulfated Glycosaminoglycans Delivered in vivo Inhibit Pulmonary Metastasis of Tumor Cells2012

    • Author(s)
      Mizumoto, S., Takahashi, J., and Sugahara, K.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 287 Issue: 23 Pages: 18985-18994

    • DOI

      10.1074/jbc.m111.313437

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific interaction of the envelope glycoproteins E1 and E2 with liver heparan sulfate involved in the tissue tropismatic infection by hepatitis C virus2012

    • Author(s)
      Kobayashi, F., Yamada, S., Taguwa, S., Naito, S., Tani, H., Matsuura, Y., and Sugahara, K.
    • Journal Title

      Glycoconjugate Journal

      Volume: 29 Issue: 4 Pages: 211-220

    • DOI

      10.1007/s10719-012-9388-z

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ISCSM2011 Chondroitin sulfate E-type structure at tumor cell surface is involved in experimental metastasis2012

    • Author(s)
      Sugahara, K., and Mizumoto, S.
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: 749 Pages: 33-45

    • DOI

      10.1007/978-1-4614-3381-1_3

    • ISBN
      9781461433804, 9781461433811
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chondroitin sulfate E-type structure at tumor cell surface is involved in experimental metastasis2012

    • Author(s)
      Kazuyuki SUGAHRA, Shuji MIZUMOTO
    • Journal Title

      Advances in Experimental Medicine and Biology

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bone ana skin disorders caused by a disturbance in the bioynthesis of chondroitin sulfate and dermatan sulfate2012

    • Author(s)
      Mizumoto, S., Sugahara, K.
    • Journal Title

      Extracellular matrix : Pathobiology and signaling

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Receptor for Advanced Glycation End Products (RAGE) Functions as a Receptor for Specific Sulfated Glycosaminoglycans, and Anti-RAGE Antibody or The Sulfated Glycosaminoglycans Delivered in vivo Inhibit Pulmonary Metastasis of Tumor Cells2012

    • Author(s)
      Shuji MIZUMOTO, Jun TAKAHASHI, Kazuyuki SUGAHARA
    • Journal Title

      Journal of Biological Chemistry

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of HNK-1 Sulfotransferase in the Biosynthesis of Chondroitin Sulfate and the GlcUA(3-O-sulfate)-Gal-Gal-Xyl Tetrasaccharide Found in α-Thrombomodulin from Human Urine2011

    • Author(s)
      Taishi Hashiguchi, Shuji Mizumoto, Yuko Nishimura, Jun-ichi Tamura, Shuhei Yamada, Kazuyuki Sugahara
    • Journal Title

      Journal of Biological Chemistry

      Volume: 286(38) Pages: 33003-33011

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus2011

    • Author(s)
      Jiancheng Chen, Shuhei Yamada, Yoshiki Hama, Ajaya Kumar Shetty, Takanari Kobayashi, Hiroshi Oda, Kosuke Seiki, Eunmi Kim, Takashi Kimura, Naonori Takahashid, Kazuya Hidari, Takashi Suzuki, Yasuo Suzuki, Kazuyuki Sugahara
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 412(1) Pages: 136-142

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Faulty initiation of proteoglycan synthesis causes cardiac and joint defects2011

    • Author(s)
      Sevjidmaa Baasanjav, Lihadh Al-Gazali, Taishi Hashiguchi, Shuji Mizumoto, Bjoern Fischer, Denise Horn, Dominik Seelow, Bassam R. Ali, Samir A.A. Aziz, Ruth Langer, Ahmed A.H. Saleh, Christian Becker, Gudrun Nürnberg, Vincent Cantagrel, Joseph G. Gleeson, Delphine Gomez, Jean-Baptiste Michel, Sigmar Stricker, Tom H. Lindner, Peter Nürnberg, Kazuyuki Sugahara, Stefan Mundlos, Katrin Hoffmann
    • Journal Title

      American Journal of Human Genetics

      Volume: 89(1) Pages: 15-27

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Paradoxical effects of chondroitin sulfate-E on Japanese encephalitis viral infection2011

    • Author(s)
      Eunmi Kim, Megumi Okumura, Hirofumi Sawa, Tadaaki Miyazaki, Daisuke Fujikura, Shuhei Yamada, Kazuyuki Sugahara, Michihito Sasaki, Takashi Kimura
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 409(4) Pages: 717-722

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dermatan sulfate epimerase 2 is the predominant isozyme in the formation of the chondroitin sulfate/dermatan sulfate hybrid structure in postnatal developing mouse brain2011

    • Author(s)
      Chizuru Akatsu, Shuji Mizumoto, Tomoyuki Kaneiwa, Marco Maccarana, Anders Malmström, Shuhei Yamada, Kazuyuki Sugahara
    • Journal Title

      Glycobiology

      Volume: 21(5) Pages: 565-574

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evolution of Glycosaminoglycans : Comparative Biochemical Study2011

    • Author(s)
      Shuhei Yamada, Kazuyuki Sugahara, Suat Özbek
    • Journal Title

      Communicative & Integrative Biology

      Volume: 4 Pages: 150-158

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Demonstration of the hepatocyte growth factor signaling pathway in the in vitro neuritogenic activity of chondroitin sulfate from ray fish cartilage2011

    • Author(s)
      Taishi Hashiguchi, Takanari Kobayashi, Duriya Fongmoon, Ajaya Kumar Shetty, Shuji Mizumoto, Nobuyuki Miyamoto, Toshikazu Nakamura, Shuhei Yamada, Kazuyuki Sugahara
    • Journal Title

      Biochimica et Biophysica Acta (General Subjects)

      Volume: 1810(4) Pages: 406-413

    • NAID

      120002934270

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Demonstration of the hepatocyte growth factor signaling pathway in the in vitro neuritogenic activity of chondroitin sulfate from ray fish cartilage2011

    • Author(s)
      Taishi Hashiguchi
    • Journal Title

      Bionchim.Biophys.Acta

      Volume: 1810 Issue: 4 Pages: 406-413

    • DOI

      10.1016/j.bbagen.2011.01.001

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dermatan sulfate epimerase 2 is the predominant isozyme in the formation of the chondroitin sulfate/dermatan sulfate hybrid structure in postnatal developing mouse brain2011

    • Author(s)
      Akatsu, C., Mizumoto, S., Kaneiwa, T., Maccarana, M., Malmstrom,. A., Yamada, S., Sugahara, K.
    • Journal Title

      Glycobiology

      Volume: 21 Issue: 5 Pages: 565-574

    • DOI

      10.1093/glycob/cwq208

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paradoxical effects of chondroitin sulfate-E on Japanese encephalitis viral infection2011

    • Author(s)
      Kim, E., Okumura, M., Sawa, H., Miyazaki, T., Fujikura, D., Yamada, S., Sugahara, K., Sasaki, M., Kimura, T.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 409 Issue: 4 Pages: 717-722

    • DOI

      10.1016/j.bbrc.2011.05.072

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Faulty initiation of proteoglycan synthesis causes cardiac and joint defects2011

    • Author(s)
      Baasanjav, S., Al-Gazali, L., Hashiguchi, T., Mizumoto, S., Fischer, B., Horn, D., Seelow, D., Ali, B.R., Aziz, S.A.A., Langer, R., Saleh,A.A.H., Becker, C., Nunberg,G., Cantagrel, V., Gleeson, J.G., Gomez, D., Michel, J-.B., Stricker, S., Lindner, T.H., Nunberg, P., Sugahara, K., Mundlos, S., Hoffmann, K.
    • Journal Title

      American Journal of Human Genetics

      Volume: 89 Issue: 1 Pages: 15-27

    • DOI

      10.1016/j.ajhg.2011.05.021

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unique heparan sulfate from shrimp heads exhibits a strong inhibitory effect on infections by dengue virus and Japanese encephalitis virus2011

    • Author(s)
      Jiancheng Chen
    • Journal Title

      Biochem.Biophys.Res.Commun

      Volume: 412 Issue: 1 Pages: 136-142

    • DOI

      10.1016/j.bbrc.2011.07.059

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of HNK-1 sulfotransferase in the biosynthesis of chondro itin sulfate and the GlcA(3-O-sulfate)-Gal-Gal-Xyl tetrasaccharide found in α-thrombomodulin from human urine2011

    • Author(s)
      Taishi Hashiguchi
    • Journal Title

      J.Biol.Chem

      Volume: 286 Issue: 38 Pages: 33003-33011

    • DOI

      10.1074/jbc.m111.279174

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Mechanism of glycosaminoglycan -mediated tumor metastasis2014

    • Author(s)
      Kazuyuki Sugahara, Shuji Mizumoto
    • Organizer
      The 27th International Carbohydrate Symposium
    • Place of Presentation
      Indian Institute of Science (India)
    • Year and Date
      2014-01-15
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Wobble chondroitin sulfate oligosaccharide motifs and mass production of oligosaccharides2013

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      The 21st Symposium on Glycosaminoglycans
    • Place of Presentation
      Villa Vigoni (Italy)
    • Year and Date
      2013-09-19
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Receptor for Advanced Glycation End-products (RAGE) Functions as Receptor for Sulfated Glycosaminoglycans (GAGs) : Anti-RAGE Antibody or Sulfated GAGs Inhibit Lung Metastasis of Tumor Cells2013

    • Author(s)
      Kazuyuki Sugahara, Jun Takahashi, Shuji Mizumoto
    • Organizer
      22nd International Symposium on Glycoconjugates
    • Place of Presentation
      Dalian Institute of Chemical Phisics, Chinese Academy of Sciences (China)
    • Year and Date
      2013-06-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Development of novel monoclonal antibodies against chondroitin sulfate, and their application to glycobiology and glycopathology2013

    • Author(s)
      Peraphan Pothacharoen, Duriya Fongmoon, Shuji Mizumoto, Kazuyuki Sugahara, Prachya Kongtawlert
    • Organizer
      The 5th annual conference for Asian Communications of Glycobiology and Glycotechnology
    • Place of Presentation
      Khon Kaen University (Thailand.)
    • Related Report
      2013 Final Research Report
  • [Presentation] Novel Class of Tetrahydropyridine-fused Pyrazoles, Isoxazolines, and HS-Mimetic Small Molecules as Anti-cancer Agents2013

    • Author(s)
      Rangappa KS, Basappa, Mantelingu K, Sadashiva MP, Feng Li, Gautam Sethi, Kazuyuki Sugahara
    • Organizer
      The 14th tetrahedron symposium
    • Place of Presentation
      Hilton Vienna (Austria)
    • Related Report
      2013 Final Research Report
  • [Presentation] Mass preparation of oligosaccharides with intestinal absorption capacity by hydrolysis of chondroitin sulfate polysaccharides with subcritical water microreaction system2013

    • Author(s)
      Kazuyuki Sugahara, Shuhei Yamada, Shuji Mizumoto, Keiichiro Matsushima, Haruo Ura, and Nobuyuki Miyamoto
    • Organizer
      The 13th International Conference on Functional and Medical Foods with Bioactive Compounds : Science and Practical Applications/The First International Symposium of Academic Society for Functional Foods and Bioactive Compounds
    • Place of Presentation
      The Kyoto Prefectural University (Kyoto)
    • Related Report
      2013 Final Research Report
  • [Presentation] Novel Class of Tetrahydropyridine-fused Pyrazoles, Isoxazolines, and HS-Mimetic Small Molecules as Anti-cancer Agents2013

    • Author(s)
      Rangappa KS, Basappa, Mantelingu K, Sadashiva MP, Feng Li, Gautam Sethi, Kazuyuki Sugahara
    • Organizer
      The 14th tetrahedron symposium
    • Place of Presentation
      Hilton Vienna(オーストリア)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Development of novel monoclonal antibodies against chondroitin sulfate, and their application to glycobiology and glycopathology2013

    • Author(s)
      Peraphan Pothacharoen, Duriya Fongmoon, Shuji Mizumoto, Kazuyuki Sugahara,Prachya Kongtawlert
    • Organizer
      The 5th annual conference for Asian Communications of Glycobiology and Glycotechnology
    • Place of Presentation
      Khon Kaen University (タイ国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Receptor for Advanced Glycation End-products (RAGE) functions as a receptor for glycosaminoglycans involved in pulmonary metastasis2012

    • Author(s)
      Shuji Mizumoto, Jun Takahashi, Kazuyuki Sugahara
    • Organizer
      The 10th International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      Hokkaido Univ. (Sapporo)
    • Year and Date
      2012-10-03
    • Related Report
      2013 Final Research Report
  • [Presentation] GAG signals involved in pulmonary metastasis of tumor cells2012

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      The 20th Symposium on glycosaminoglycans
    • Place of Presentation
      Villa Vigoni (Italy)
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] RAGEは癌細胞の肺転移に関わるコンドロイチン硫酸の受容体として機能する2012

    • Author(s)
      水本秀二, 高橋潤, 菅原一幸
    • Organizer
      第31回日本糖質学会年会
    • Place of Presentation
      鹿児島市民ホール(鹿児島市)
    • Year and Date
      2012-09-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖鎖生物学による癌の肺転移の分子メカニズムの解明 抗癌剤開発に向けての洞察2012

    • Author(s)
      菅原一幸
    • Organizer
      第16回未来創薬・医療イノベーションセミナー(国際会議)
    • Place of Presentation
      北海道大学 (札幌市)
    • Year and Date
      2012-07-31
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] がんの肺転移に関わるグリコサミノグリカン受容体(RAGE)の同定2012

    • Author(s)
      高橋潤, 水本秀二, 菅原一幸
    • Organizer
      第49回日本生化学会北海道支部例会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-07-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Characterization of a receptor for glycosaminoglycans that mediate experimental lung metastasis2012

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      The 15th Gordon Research Conference on Proteoglycans
    • Place of Presentation
      Proctor Academy (USA)
    • Year and Date
      2012-07-10
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Receptor for Advanced Glycation End Products (RAGE)は癌細胞の肺転移に関わるコンドロイチン硫酸の受容体として機能する2012

    • Author(s)
      水本秀二, 高橋潤, 菅原一幸
    • Organizer
      日本薬学会北海道支部第138回例会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2012-06-16
    • Related Report
      2013 Final Research Report
  • [Presentation] ユニークな構造と機能をもつエビ頭部に由来するヘパラン硫酸2012

    • Author(s)
      羽磨紀城, 陳建成, Ajaya Kumar Shetty, 小林孝成, 織田浩司, 清木興介, Eunmi Kim, 木村享史, 菅原一幸, 山田修平
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-03-29
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] がん細胞の肺転移に関わる硫酸化グリコサミノグリカンの受容体の同定2012

    • Author(s)
      高橋潤, 水本秀二, 菅原一幸
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-03-29
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] グルクロン酸転移酵素-I の変異によって引き起こされる新規ラーセン様症候群2012

    • Author(s)
      水本秀二, Sevjidmaa Baasanjav, Lihadh Al-Gazali, 橋口太志, Bjoern Fischer, Denise Horn, Dominik Seelow, Bassam R. Ali, Samir A.A. Aziz, Ruth Langer, Ahmed A.H. Saleh, Christian Becker, Gudrun Nürnberg, Vincent Cantagrel, Joseph G. Gleeson, Delphine Gomez, Jean-Baptiste Michel, Sigmar Stricker, Tom H. Lindner, Peter Nürnberg, Stefan Mundlos, Katrin Hoffmann, 菅原一幸
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-03-29
    • Related Report
      2013 Final Research Report
  • [Presentation] グルクロン酸転移酵素-Iの変異によって引き起こされる新規ラーセン様症候群2012

    • Author(s)
      水本秀二, Sevjidmaa Baasanjav, Lihadh Al-Gazali, 橋口太志, Bjoern Fischer, Denise Horn, Dominik Seelow, Bassam R.Ali, Samir A.A.Aziz, Ruth Langer, Ahmed A.H.Saleh, Christian Becker, Gudrun Nurnberg, Vincent Cantagrel, Joseph G.Gleeson, Delphine Gomez, Jean-Baptiste Michel, Sigmar Stricker, Tom H.Lindner, Peter Nurnberg, Stefan Mundlos, Katrin Hoffmann, 菅原一幸
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Shrimp head heparan sulfate with unique structure and function2012

    • Author(s)
      Yoshiki Hama, Chen Jiancheng, Ajaya Kumar Shetty, Takanari Kobayashi, Hiroshi Oda, Kosuke Seiki, Eunmi Kim, Takashi Kimura, Kazuyuki Sugahara, Shuhei Yamada
    • Organizer
      The IGP International Symposium 2012
    • Place of Presentation
      Hokkaido Univ. (Sapporo)
    • Year and Date
      2012-03-02
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Receptor for Advanced Glycation End products (RAGE)は肺転移に関わるがん細胞表面のグリコサミノグリカン受容体として機能する2012

    • Author(s)
      高橋潤, 水本秀二, 菅原一幸
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2013 Final Research Report
  • [Presentation] Receptor for Advanced Glycation End-products (RAGE) Functions as a Receptor for Pulmonary Metastasis Mediated by Sulfated Glycosaminoglycans2012

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      2nd International Anatomical Sciences and Cell Biology Conference/36th Annual Conference of the Anatomy Association of Thailand
    • Place of Presentation
      Chiang Mai Univ. (Thailand)
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Receptor for Advanced Glycation End products (RAGE)は肺転移に関わるがん細胞表面のグリコサミノグリカン受容体として機能する2012

    • Author(s)
      ○高橋潤, 水本秀二 , 菅原一幸
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Involvement of HNK-1 Sulfotransferase in the Biosynthesis of Chondroitin Sulfate and the GlcUA(3-O-sulfate)-Gal-Gal-Xyl Tetrasaccharide Found in a-Thrombomodulin from Human Urine2011

    • Author(s)
      T. Hashiguchi, S. Mizumoto, Y. Nishimura, J. Tamura, ○S. Yamada, K. Sugahara
    • Organizer
      7th International Conference on Proteoglycans
    • Place of Presentation
      Q STATION (Australia)
    • Year and Date
      2011-10-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Loss-of-function mutation of glucuronyltransferase-I causes Larsen-like syndrome2011

    • Author(s)
      S. Baasanjav, L. Al-Gazali, T. Hashiguchi, ○S. Mizumoto, B. Fischer, D. Horn, D. Seelow, B. R. Ali, S.A.A. Aziz, R. Langer, A. A.H. Saleh, C. Becker, G. Nürnberg, V. Cantagrel, J. G. Gleeson, D. Gomez, J.-B. Michel, S. Stricker, T. H. Lindner, P. Nürnberg, K. Sugahara, S. Mundlos, K. Hoffmann
    • Organizer
      7th International Conference on Proteoglycans
    • Place of Presentation
      Q STATION (Australia)
    • Year and Date
      2011-10-18
    • Related Report
      2013 Final Research Report
  • [Presentation] Characterization of a receptor for glycosaminoglycans that mediate experimental lung metastasis2011

    • Author(s)
      K.Sugahara, S.Mizumoto, J.Takahashi
    • Organizer
      7th International Conference on Proteoglycans
    • Place of Presentation
      QSTATION (Australia)(招待講演)
    • Year and Date
      2011-10-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Loss-of-function mutation of glucuronyltransferase-I causes Larsen-like syndrome2011

    • Author(s)
      S.Baasanjav, L.Al-Gazali, T.Hashiguchi, 〇S.Mizumoto, B.Fischer, D.Horn, D.Seelow, B.R.Ali, S.A.A.Aziz, R.Langer, A.A.H.Saleh, C.Becker, G.Nurnberg, V.Cantagrel, J.G.Gleeson, D.Gomez, J.-B.Michel, S.Stricker, T.H.Lindner, P.Nurnberg, K.Sugahara, S.Mundlos, K.Hoffmann
    • Organizer
      7th International Conference on Proteoglycans
    • Place of Presentation
      QSTATION (Australia)
    • Year and Date
      2011-10-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Involvement of HNK-1 Sulfotransferase in the Biosynthesis of Chondroitin Sulfate and the GlcUA(3-0-sulfate)-Gal-Gal-Xyl Tetrasaccharide Found in a-Thrombomodulin from Human Urine2011

    • Author(s)
      T.Hashiguchi, S.Mizumoto, Y.Nishimura, J.Tamura, 〇S.Yamada, K.Sugahara
    • Organizer
      7th International Conference on Proteoglycans
    • Place of Presentation
      QSTATION (Australia)
    • Year and Date
      2011-10-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] A deficiency of glycosaminoglycans causes cardiac and joint disorders2011

    • Author(s)
      Sevjidmaa Baasanjav, Lihadh Al-Gazali, Taishi Hashiguchi, ○ Shuji Mizumoto, Bjoern Fischer, Denise Horn, Dominik Seelow, Bassam R. Ali, Samir A.A. Aziz, Ruth Langer, Ahmed A.H. Saleh, Christian Becker, Gudrun Nürnberg, Vincent Cantagrel, Joseph G. Gleeson, Delphine Gomez, Jean-Baptiste Michel, Sigmar Stricker, Tom H. Lindner, Peter Nürnberg, Kazuyuki Sugahara, Stefan Mundlos, Katrin Hoffmann
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2011-09-24
    • Related Report
      2013 Final Research Report
  • [Presentation] A deficiency of glycosaminoglycans causes cardiac and joint disorders2011

    • Author(s)
      Sevjidmaa Baasanjav, Lihadh Al-Gazali, Taishi Hashiguchi, Shuji Mizumoto, Bjoern Fischer, Denise Horn, Dominik Seelow, Bassam R.Ali, Samir A.A.Aziz, Ruth Langer, Ahmed A.H.Saleh, Christian Becker, Gudrun Nurnberg, Vincent Cantagrel, Joseph G.Gleeson, Delphine Gomez, Jean-Baptiste Michel, Sigmar Stricker, Tom H.Lindner, Peter Nurnberg, Kazuyuki Sugahara, Stefan Mundlos, Katrin Hoffmann
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Involvement of chondroitin sulphate E-type structure in the experimental metastasis of the Lewis lung carcinoma cell line2011

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      The 3rd FEBS-MPST Advanced Lecture Course on Matrix Pathobiology, Signaling and Molecular Targets
    • Place of Presentation
      Spetses Hotel and the Anargyrios College (Greece)
    • Year and Date
      2011-09-06
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Involvement of chondroitin sulphate E-type structure in the experimental metastasis of the Lewis lung carcinoma cell line2011

    • Author(s)
      K.Sugahara
    • Organizer
      The 3rd FEBS-MPST Advanced Lecture Course on Matrix Pathobiology, Signaling and Molecular Targets (FEBS-MPST2011)
    • Place of Presentation
      Spetses Hotel and Anargyrios College (Greece)(招待講演)
    • Year and Date
      2011-09-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] ルイス肺癌細胞表面上のコンドロイチン硫酸E 構造の発現低下による転移抑制2011

    • Author(s)
      水本秀二, 渡邊基夫, 山田修平, 菅原一幸
    • Organizer
      日本薬学会北海道支部第136回例会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2011-05-21
    • Related Report
      2013 Final Research Report
  • [Presentation] エビ頭部由来へパラン硫酸の構造と機能の研究2011

    • Author(s)
      陳建成, 羽磨紀城, Ajaya Kumar Shetty, 小林孝成, 織田浩司, 清木興介, 木村享史, 高橋尚徳, 左一八, 鈴木隆, 鈴木康夫, ○山田修平, 菅原一幸
    • Organizer
      日本薬学会北海道支部第136回例会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Year and Date
      2011-05-21
    • Related Report
      2013 Final Research Report
  • [Presentation] エビ頭部由来ヘパラン硫酸の構造と機能の研究2011

    • Author(s)
      陳建成、羽磨紀城、Ajaya Kumar Shetty、小林孝成、織田浩司、清木興介、木村享史、高橋尚徳、左一八、鈴木隆、鈴木康夫、〇山田修平、菅原一幸
    • Organizer
      日本薬学会北海道支部第136回例会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] ルイス肺癌細胞表面上のコンドロイチン硫酸E構造の発現低下による転移抑制2011

    • Author(s)
      水本秀二、渡邊基夫、山田修平、菅原一幸
    • Organizer
      日本薬学会北海道支部第136回例会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2011-05-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Analysis of the expression pattern of dermatan sulfate epimerase-2, which is involved in the bipolar disorder, in the mouse brain during postnatal development2011

    • Author(s)
      Chizuru Akatsu, Shuji Mizumoto, Tomoyuki Kaneiwa, Marco Maccarana, Anders Malmström, Shuhei Yamada, ○Kazuyuki Sugahara
    • Organizer
      The 9th International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      Hokkaido Univ. (Sapporo)
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] エビ頭部に由来するヘパラン硫酸の構造と生物活性2011

    • Author(s)
      羽磨紀城, 陳建成, Ajaya Kumar Shetty, 小林孝成, 織田浩司, 清木興介, Eunmi Kim, 木村享史, 菅原一幸, 山田修平
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      長岡リリックホール(長岡市)
    • Related Report
      2013 Final Research Report
  • [Presentation] ルイス肺癌細胞表面上のコンドロイチン硫酸E 構造の発現低下による転移抑制2011

    • Author(s)
      渡邊基夫, 水本秀二, 山田修平, ○菅原一幸
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      長岡リリックホール(長岡市)
    • Related Report
      2013 Final Research Report
  • [Presentation] ルイス肺癌細胞表面上のコンドロイチン硫酸E構造の発現低下による転移抑制2011

    • Author(s)
      渡邊基夫、水本秀二、山田修平、菅原一幸
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      長岡リリックホール(新潟県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] エビ頭部に由来するヘパラン硫酸の構造と生物活性2011

    • Author(s)
      羽磨紀城、陳建成、Ajaya Kumar Shetty、小林孝成、織田浩司、清木興介、Eunmi Kim、木村享史、菅原一幸、山田修平
    • Organizer
      第30回日本糖質学会年会
    • Place of Presentation
      長岡リリックホール(新潟県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mass preparation of oligosaccharides with intestinal absorption capacity by hydrolysis of chondroitin sulfate polysaccharides with subcritical water microreaction system

    • Author(s)
      Kazuyuki Sugahara, Shuhei Yamada, Shuji Mizumoto, Keiichiro Matsushima, Haruo Ura, and Nobuyuki Miyamoto
    • Organizer
      The 13th International Conference on Functional and Medical Foods with Bioactive Compounds: Science and Practical Applications”
    • Place of Presentation
      The Kyoto Prefectural University of Medicine (京都)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Receptor for Advanced Glycation End-products (RAGE) Functions as Receptor for Sulfated Glycosaminoglycans (GAGs): Anti-RAGE Antibody or Sulfated GAGs Inhibit Lung Metastasis of Tumor Cells

    • Author(s)
      Kazuyuki SUGAHARA, Jun TAKAHASHI, Shuji MIZUMOTO
    • Organizer
      22nd International Symposium on Glycoconjugates
    • Place of Presentation
      Dalian Institute of Chemical Phisics, Chinese Academy of Sciences(中国)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Wobble chondroitin sulfate oligosaccharide motifs and mass production of oligosaccharides

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      The 21st Symposium on Glycosaminoglycans
    • Place of Presentation
      Loveno, Lake Como(イタリア)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Mechanism of glycosaminoglycan-mediated tumor metastasis

    • Author(s)
      Kazuyuki Sugahara and Shuji Mizumoto
    • Organizer
      The 27th International Carbohydrate Symposium
    • Place of Presentation
      Indial Institute of Science (インド)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Receptor for Advanced Glycation End Products (RAGE)は癌細胞の肺転移に関わるコンドロイチン硫酸の受容体として機能する

    • Author(s)
      ○水本秀二、高橋潤、菅原一幸
    • Organizer
      日本薬学会北海道支部第138回例会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] がんの肺転移に関わるグリコサミノグリカン受容体(RAGE)の同定

    • Author(s)
      ○高橋潤、水本秀二、菅原一幸
    • Organizer
      第49 回日本生化学会北海道支部例会
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Characterization of a receptor for glycosaminoglycans that mediate experimental lung metastasis

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      The 15th Gordon Research Conference on Proteoglycans
    • Place of Presentation
      Proctor Academy(米国)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 糖鎖生物学による癌の肺転移の分子メカニズムの解明 -抗癌剤開発に向けての洞察-

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      第16回未来創薬・医療イノベーションセミナー
    • Place of Presentation
      北海道大学(札幌市)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] RAGEは癌細胞の肺転移に関わるコンドロイチン硫酸の受容体として機能する

    • Author(s)
      ○ 水本秀二, 高橋潤, 菅原一幸
    • Organizer
      第31回日本糖質学会年会
    • Place of Presentation
      鹿児島市民ホール(鹿児島市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Receptor for Advanced Glycation End-products (RAGE) functions as a receptor for glycosaminoglycans involved in pulmonary metastasis

    • Author(s)
      ◯Shuji MIZUMOTO, Jun TAKAHASHI, Kazuyuki SUGAHARA
    • Organizer
      The 10th International Symposium for Future Drug Discovery and Medical Care
    • Place of Presentation
      Hokaido Univ. (Sapporo)
    • Related Report
      2012 Annual Research Report
  • [Presentation] GAG signals involved in pulmonary metastasis of tumor cells

    • Author(s)
      Kazuyuki Sugahara
    • Organizer
      The 20th Symposium on glycosaminoglycans
    • Place of Presentation
      Villa VigoniVilla(イタリア)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Receptor for AdvancedGlycation End-products (RAGE) Functions as a Receptor for Pulmonary Metastasis Mediated by Sulfated Glycosaminoglycans

    • Author(s)
      Kazuyuki SUGAHARA
    • Organizer
      2nd International Anatomical Sciences and Cell Biology Conference & 36th Annual Conference of the Anatomy Association of Thailand
    • Place of Presentation
      Chiang Mai Grandview Hotel & Convention Center(タイ)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 「ISCSM2011 Chondroitin sulfate E-type structure at tumor cell surface is involved in experimental metastasis (Chapter 3)」, Advances in Experimental Medicine and Biology "Biochemical Roles of Eukaryotic Cell Surface Macromolecules", (P. R. Sudhakaran and A. Surolia, eds)2012

    • Author(s)
      Kazuyuki Sugahara, Shuji Mizumoto
    • Publisher
      Springer, New York
    • Related Report
      2013 Final Research Report
  • [Book] 「Bone and Skin Disorders Caused by a Disturbance in the Bioynthesis of Chondroitin Sulfate and Dermatan Sulfate 」, Extracellular matrix : Pathobiology and signaling , (N. Karamanos ed.)2012

    • Author(s)
      Shuji Mizumoto, Kazuyuki Sugahara
    • Publisher
      Walter De Gruyter, Berlin, Germany
    • Related Report
      2013 Final Research Report
  • [Remarks] 研究業績

    • URL

      http://www.lfsci.hokudai.ac.jp/labs/infmem/sugaken/lonbun.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.lfsci.hokudai.ac.jp/labs/infmem/index.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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