Molecular mechanism of sporadic Alzheimer's disease onset

• Project/Area Number: 23390017
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Hokkaido University
• Principal Investigator: SUZUKI Toshiharu 北海道大学, 薬学研究科(研究院), 教授 (80179233)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000); Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2011: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
• Keywords: アルツハイマー病 / APP / 老化 / 認知症 / 高齢化社会 / アミロイドβペプチド / 神経変性疾患 / βアミロイド

Research Abstract

Amyloid beta (Ab) oligomer is a major causative factor of Alzheimer's disease (AD). Compared to familialAD (FAD), it remains unclear how neurotoxic Ab species is generated and/or what mechanism can increase the generation of Ab in sporadic AD (SAD). To reveal this, first I focused on the axonal transport of APP, which is a precursor protein of Ab and functions as kinesin-1 cargo, because disturbed anterograde transport of APP alters Ab generation. We revealed how APP connect with kinesin-1 motor mediated by JIP1b. Sexond I analyzed gamma-secretase malfunction in SAD patient. In FAD who carry mutations of causative gene, gamma-cleavage are altered. We found altered gamma-cleaved peptide in SAD patients, in other words, alcadein fragment in CSF are altered in SAD. These analyses support an idea that SAD is generated by several causes to induce a quantitative and/or qualitative change of Ab production, and results are useful to develop the tailor-made therapies.

Research Products

• [Journal Article] Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as ajunct techniques for screening and predicting dementia due to Alzheimer's disease in clinical practice (2014)
  • Author(s): Waragai M., Hata S., Suzuki T., Ishi R., Fujii C., Tokuda T., Arai H., Ohrui T., Higuchi S., Yoshida M., Igarashi K., Moriya M., Iwai N. and Uemura K
  • Journal Title: J. Alzheimers Dis Volume: (in press)
  • Peer Reviewed
• [Journal Article] Methylglyoxal produced by amyloid β-peptide-induced nitrotyrosination of triosephoshate isomerase triggers neuronal death in Alzheimer disease (2014)
  • Author(s): Tajes, M., Eraso-Pichot, A., Rubio-Moscardo, F., Guivernau, B., Ramos-Fernandez, E., Bosch-Morato, M., Guix, F. X., Clarimon, J., Miscione, G. P., Boada, M., Gil-Gomez, G., Suzuki, T., Molina, H., Villa-Freixa, J., Vicente, R. and Munoz, F. J
  • Journal Title: J. Alzheimers Dis Volume: 41 Pages: 273-288
  • Peer Reviewed
• [Journal Article] Transcriptome analysis of distinct mouse strains reveals kinesin light chain-1 splicing as as amyloid beta accumulation modifier (2014)
  • Author(s): Morihara, T., Hayashi, N., Yokokoji, M., Akatsu, H., Silverman, MA., Kimura, N., Saito, Y., Suzuki, T., Yanagida, K., Tanaka, T., Kazui, H., Kudo, T., Kodama, TS., Sato, M., Hashimoto, R., Tagami, S., Okochi, M., Ytoh, N., Nishitomi, K., Takamura, H., Katayama, T., Hashizumi, Y., Kimura, R., Kamino, K., Takeda, M
  • Journal Title: Proc. Acad. Natl. Sci. USA Volume: 111 Issue: 7 Pages: 2638-2643
  • DOI: 10.1073/pnas.1307345111
  • Peer Reviewed / Open Access
• [Journal Article] Increased levels of plasma p3-Alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease (2014)
  • Author(s): Omori C, Kaneko M, Nakajima E, Akatsu H, Waragai M, Maeda M, Moroshima-Kawashima M, Saito Y, Nakaya T, Taru H, Yamamoto T, Asada T, Hata S, Suzuki T. for J-ADNI
  • Journal Title: J. Alzheimers Dis Volume: 39 Issue: 4 Pages: 861-870
  • DOI: 10.3233/jad-131610
  • Peer Reviewed
• [Journal Article] Simple and direct assembly of kymographs from movies with Kymomaker (2014)
  • Author(s): Chiba, K., Shimada, Y., Kinjo, M., Suzuki, T., Uchida, S
  • Journal Title: Traffic Volume: 15 Issue: 1 Pages: 1-11
  • DOI: 10.1111/tra.12127
  • Peer Reviewed
• [Journal Article] Methylglyoxal produced by amyloid β-peptide-induced nitrotyrosination of triosephoshate isomerase triggers neuronal death in Alzheimer disease. (2014)
  • Author(s): Tajes, M., Eraso-Pichot, A., Rubio-Moscardo, F., Guivernau, B., Ramos-Fernandez, E., Bosch-Morato, M., Guix, F. X., Clarimon, J., Miscione, G. P., Boada, M., Gil-Gomez, G., Suzuki, T., Molina, H., Villa-Freixa, J., Vicente, R. and Munoz, F. J.
  • Journal Title: J. Alzheim. Dis. Volume: in press
  • Peer Reviewed
• [Journal Article] Utility of SPM8 plus DARTEL (VSRAD) combined with magnetic resonance spectroscopy as ajunct techniques for screening and predicting dementia due to Alzheimer’s disease in clinical practice. (2014)
  • Author(s): Waragai M., Hata S., Suzuki T., Ishi R., Fujii C., Tokuda T., Arai H., Ohrui T., Higuchi S., Yoshida M., Igarashi K., Moriya M., Iwai N. and Uemura K.
  • Journal Title: J. Alzheimer Dis. Volume: in pree
  • Peer Reviewed
• [Journal Article] Suppression of Alzheimer's disease-related phenotypes by geranygeranylacetone in mice (2013)
  • Author(s): Hoshino, T., Suzuki, K., Matsushima, T., Yamakawa, N., Suzuki, T. and Mizushima, T
  • Journal Title: PLoS One Volume: 8 Issue: 10 Pages: e76306-e76306
  • DOI: 10.1371/journal.pone.0076306
  • Peer Reviewed
• [Journal Article] Mechanism of intramembrane cleavage of Alcadeins by γ-secretase (2013)
  • Author(s): Piao, Y., Kimura, A., Urano, S., Saito, Y., Taru, H., Yamamoto, T., Hata, S. and Suzuki, T
  • Journal Title: PLoS One Volume: 8 Issue: 4 Pages: e62431-e62431
  • DOI: 10.1371/journal.pone.0062431
  • Peer Reviewed
• [Journal Article] Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Abeta generation in Alzheimer's disease (2012)
  • Author(s): Saito Y
  • Journal Title: Mol Neurodegener Volume: 7 Issue: 1 Pages: 50-50
  • DOI: 10.1186/1750-1326-7-50
  • Peer Reviewed
• [Journal Article] Constitutive Cleavage of the Single-pass Transmembrane Protein Alcadeinα Prevents Aberrant Peripheral Retention of Kinesin-1. (2012)
  • Author(s): Chiaki Maruta
  • Journal Title: PLoS One Volume: 7 Issue: 8 Pages: e43058-e43058
  • DOI: 10.1371/journal.pone.0043058
  • Peer Reviewed
• [Journal Article] Age-related modulation of γ-secretase activity in non-human primate brains (2012)
  • Author(s): Nishimura M
  • Journal Title: J Neurochem Volume: 123 Issue: 1 Pages: 21-28
  • DOI: 10.1111/j.1471-4159.2012.07884.x
  • Peer Reviewed
• [Journal Article] Membrane-microdomain localization of amyloid β-precursor protein (APP) C-terminal fragments is regulated by phosphorylation of the cytoplasmic Thr668 residue (2012)
  • Author(s): Matsushima T
  • Journal Title: J Biol Chem Volume: 287 Issue: 23 Pages: 19715-19724
  • DOI: 10.1074/jbc.m111.334847
  • Peer Reviewed
• [Journal Article] Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer's disease subjects. (2012)
  • Author(s): Hata S
  • Journal Title: Mol Neurodegener. Volume: 16 Issue: 1 Pages: 16-16
  • DOI: 10.1186/1750-1326-7-16
  • Peer Reviewed
• [Journal Article] Potential utility of soluble p3-alcadeinα plasma levels as a biomarker for sporadic Alzheimer's disease (2012)
  • Author(s): Kamogawa K, Kohara K, Tabara Y, Takita R, Miki T, Konno T, Hata S, Suzuki T
  • Journal Title: J Alzheimers Dis Volume: 31 Issue: 2 Pages: 421-8
  • DOI: 10.3233/jad-2012-120601
  • Peer Reviewed
• [Journal Article] A small peptide sequence is sufficient for initiating Kinesin-1 activation through part of TPR region of KLC1 (2012)
  • Author(s): Kawano T, Araseki M, Araki Y, Kinjo M, Yamamoto T, Suzuki T
  • Journal Title: Traffic Volume: (掲載確定) Issue: 6 Pages: 834-848
  • DOI: 10.1111/j.1600-0854.2012.01350.x
  • Peer Reviewed
• [Journal Article] FE65 as a link between VLDLR and APP to regulate their trafficking and processing. (2012)
  • Author(s): Dumanis, S., Chamberlain, K. A., Sohn, Y. J., Lee, Y. J., Guenette, S. Y., Suzuki, T., Mathews, P. W., Pak, D. T. S., Rebexk, G. W., Suh, Y-h., Park, H-S., Hoe, H-S.
  • Journal Title: Mol. Neurodegen Volume: 7 Issue: 1 Pages: 9-9
  • DOI: 10.1186/1750-1326-7-9
  • Peer Reviewed
• [Journal Article] Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor (2012)
  • Author(s): Hoshino T, Namba T, Takehara M, Murao N, Matsushima T, Sugimoto Y, Narumiya S, Suzuki T, Mizushima T
  • Journal Title: J.Neurochem. Volume: 120 Issue: 5 Pages: 795-805
  • DOI: 10.1111/j.1471-4159.2011.07567.x
  • Peer Reviewed
• [Journal Article] Costitutive cleavage of the single-pass transmembrane protein Alcadeinα prevents aberrant peripheral retention of kinesin-1. (2012)
  • Author(s): Maruta C.
  • Journal Title: Public Library of Science One Volume: 7
  • Peer Reviewed
• [Journal Article] Coordinated increase of y-secretase products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alca with a new ELISA system (2011)
  • Author(s): Konno, et al.
  • Journal Title: Molecular Neurodegeneration Volume: 6 Issue: 1 Pages: 76-76
  • DOI: 10.1186/1750-1326-6-76
  • Peer Reviewed
• [Journal Article] Effects of heparin and enoxaparin on APP processing and Ab production in primary cortical neurons from Tg2576 mouse (2011)
  • Author(s): Cui, H., Hung, A. C., Klaver, D. W., Suzuki, T., Freeman, C., Narkowicz, C., Jacobson, G. and Small, D. H.
  • Journal Title: PLoS One Volume: 6 Issue: 7 Pages: e23007-e23007
  • DOI: 10.1371/journal.pone.0023007
  • Peer Reviewed
• [Journal Article] Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like (2011)
  • Author(s): Saito Y
  • Journal Title: PLoS One Volume: 6 Issue: 7 Pages: e22108-e22108
  • DOI: 10.1371/journal.pone.0022108
  • Peer Reviewed
• [Journal Article] Cystein-rich intestinal protein 2 (CRIP2) acts as a repressor of NFkB-mediated pro-angiogenic cytokins transcription to suppress tumorigenesis and angiogenesis (2011)
  • Author(s): Cheung, K.L., 7名略, Suzuki, T., 4名略
  • Journal Title: Proceeding of National Academy of Science USA Volume: 108 Issue: 20 Pages: 8390-8395
  • DOI: 10.1073/pnas.1101747108
  • Peer Reviewed
• [Journal Article] Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease : evidence for γ-secretase dysfunction (2011)
  • Author(s): Hata S
  • Journal Title: Ann.Neurol. Volume: 69 Issue: 6 Pages: 1026-1031
  • DOI: 10.1002/ana.22343
  • Peer Reviewed
• [Journal Article] Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice. (2011)
  • Author(s): Hoshino T, Murao N, Namba T, Takehara M, Adachi H, Katsuno M, Sobue G, Matsushima T, Suzuki T, Mizushima T.
  • Journal Title: J Neurosci. Volume: 31 Issue: 14 Pages: 5225-5234
  • DOI: 10.1523/jneurosci.5478-10.2011
  • Peer Reviewed
• [Presentation] Phosphorylation of APP is not involved in the regulation of APP anterograde transport by kinesin-1 (2013)
  • Author(s): Shiraki, Y., Chiba, K., Hata, S., Suzuki, T
  • Organizer: Society for Neuroscience annual meeting, Neuroscience
  • Place of Presentation: San Diego Convention Center, San Diego, USA
• [Presentation] Predominance of neural X11L/Mint2 in the regulation of APP traffi cking and metabolism among X11/Mint family proteins (2013)
  • Author(s): Motodate, R., Saito, Y., Suzuki, T
  • Organizer: Society for Neuroscience annual meeting, Neuroscience
  • Place of Presentation: San Diego Convention Center, San Diego, USA
• [Presentation] p3-Alc peptide in the CSF and plasma of sporadic Alzheimer's disease patients (2013)
  • Author(s): Hata, S., Konno, T., Urakami, K., Ikeuchi, T., Akatsu, H., Suzuki, T
  • Organizer: Society for Neuroscience annual meeting, Neuroscience
  • Place of Presentation: San Diego Convention Center, San Diego, USA
• [Presentation] Expression of novel function of Alcadein intracellular domain (2013)
  • Author(s): Sobu, U., Takei, N., Hata, S., Suzuki, T
  • Organizer: Society for Neuroscience annual meeting, Neuroscience
  • Place of Presentation: San Diego Convention Center, San Diego, USA
• [Presentation] Neuron-specific phosphorylation of APP : The roles in APP metabolism and function. In the session of Basic Science : Cell Biology (2013)
  • Author(s): Suzuki, T., Matsushima, T., Chiba, K., Saito, Y., Taru, H., Hata, S
  • Organizer: Alzheimer's Association International Conference 2013 (AAIC2013)
  • Place of Presentation: Boston Convention and Exhibition Center, Boston MA, USA
• [Presentation] Quantitative alteration of p3-Alc peptides in CSF of people with Alzheimer's disease (2013)
  • Author(s): Hata, S., Omori, C., Kaneko, M., Waragai, M., Urakami, K., Taniguchi, M., Ikeuchi, T., Akatsu H., Suzuki, T
  • Organizer: Alzheimer's Association International Conference 2013 (AAIC2013)
  • Place of Presentation: Boston Convention and Exhibition Center, Boston MA, USA
• [Presentation] Quantification of plasma p3-Alc[alpha]35 with C-terminal end-specific sELISA system (2013)
  • Author(s): Kaneko, M., Omori, C., Maeda, M., Akatsu H., Waragai, M., Nakajima, E., Asada, T., Hata, S., Suzuki, T
  • Organizer: Alzheimer's Association International Conference 2013 (AAIC2013)
  • Place of Presentation: Boston Convention and Exhibition Center, Boston MA, USA
• [Presentation] Quantification of plasma p3-Alc[alpha]35 with C-terminal end-specific sELISA system. (2013)
  • Author(s): Kaneko, M., Omori, C., Maeda, M., Akatsu H., Waragai, M., Nakajima, E., Asada, T., Hata, S., Suzuki, T.
  • Organizer: Alzheimer’s Association International Conference 2013
  • Place of Presentation: Boston Convention and Exhibition Center, Boston MA, USA
• [Presentation] Quantitative alteration of p3-Alc peptides in CSF of people with Alzheimer’s disease. (2013)
  • Author(s): Hata, S., Omori, C., Kaneko, M., Waragai, M., Urakami, K., Taniguchi, M., Ikeuchi, T., Akatsu H., Suzuki, T.
  • Organizer: Alzheimer’s Association International Conference 2013
  • Place of Presentation: Boston Convention and Exhibition Center, Boston MA, USA
• [Presentation] Neuron-specific phosphorylation of APP: The roles in APP metabolism and function. (2013)
  • Author(s): Suzuki, T., Matsushima, T., Chiba, K., Saito, Y., Taru, H., Hata, S.
  • Organizer: Alzheimer’s Association International Conference 2013
  • Place of Presentation: Boston Convention and Exhibition Center, Boston MA, USA
• [Presentation] Expression of novel function of Alcadein intracellular domain. (2013)
  • Author(s): Sobu, U., Takei, N., Hata, S., Suzuki, T.
  • Organizer: Society for Neuroscience annual meeting, Neuroscience 2013
  • Place of Presentation: San Diego Convention Center, San Diego, USA
• [Presentation] p3-Alc peptide in the CSF and plasma of sporadic Alzheimer’s disease patients. (2013)
  • Author(s): Hata, S., Konno, T., Urakami, K., Ikeuchi, T., Akatsu, H., Suzuki, T.
  • Organizer: Society for Neuroscience annual meeting, Neuroscience 2013
  • Place of Presentation: San Diego Convention Center, San Diego, USA
• [Presentation] Predominance of neural X11L/Mint2 in the regulation of APP traffi cking and metabolism among X11/Mint family proteins. (2013)
  • Author(s): Motodate, R., Saito, Y., Suzuki, T.
  • Organizer: Society for Neuroscience annual meeting, Neuroscience 2013
  • Place of Presentation: San Diego Convention Center, San Diego, USA
• [Presentation] Phosphorylation of APP is not involved in the regulation of APP anterograde transport by kinesin-1. (2013)
  • Author(s): Shiraki, Y., Chiba, K., Hata, S., Suzuki, T.
  • Organizer: Society for Neuroscience annual meeting, Neuroscience 2013
  • Place of Presentation: San Diego Convention Center, San Diego, USA
• [Presentation] APPとAlcadein代謝におけるApolipoproteinEの効果 (2013)
  • Author(s): 木村彩乃、羽田沙緒里、道川誠、鈴木利治
  • Organizer: 第18回 日本病態プロテアーゼ学会学術集会
  • Place of Presentation: 大阪市・千里ライフサイエンスセンター
• [Presentation] アルツハイマー病患者における血中ｐ３－Ａｌｃα解析 (2013)
  • Author(s): 金子窓香、大森智織、前田雅弘、赤津裕康、藁谷正明、中島悦子、朝田隆、 羽田沙緒里、鈴木利治
  • Organizer: 第3回 日本認知症予防学会学術集会
  • Place of Presentation: 新潟市・朱鷺メッセ新潟コンベンションセンター
• [Presentation] JIP1b-KLC1相互作用によるAPP軸索輸送制御 (2013)
  • Author(s): 千葉杏子、野澤啓輔、荒関雅彦、金城政孝、鈴木利治
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜市・パシフィコ横浜
• [Presentation] Function of Alcadein and its metabolite, p3-Alc (2013)
  • Author(s): 羽田沙緒里、鈴木利治
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: 横浜市・パシフィコ横浜
  • Invited
• [Presentation] Possible pathogenesis of sporadic Alzheimer's disease (2012)
  • Author(s): Suzuki, T
  • Organizer: The 15th MNRC International Symposium "New avenue for developing disease-modifying therapies of Alzheimer's disease : Reassessment of amyloid-β as the primary target"
  • Place of Presentation: Molecular Neuroscience Research Center, Shiga University of Medical Science, Kusatsu, Shiga Japan
  • Year and Date: 2012-11-10
• [Presentation] Molecular pathogenesis of sporadic Alzheimer's disease (2012)
  • Author(s): Suzuki, T
  • Organizer: Korea-Japan Joint Symposium for the 30th Anniversary of Hallym University : Aging and Neurodegenerative disease
  • Place of Presentation: Hallym University Sacred Heart Hospital, Anyang Korea
  • Year and Date: 2012-04-27
• [Presentation] Function and metabolism of Alcadein in the relation with Alzheimer's disease (2012)
  • Author(s): Suzuki, T
  • Organizer: Asian Aging Core for Longevity Research (AACL) 2012 Seoul Conference. "On Aging, Metabolism and Neurobiology"
  • Place of Presentation: University of Seoul, Seoul, Korea
• [Presentation] Role of Apolipoprotein E on Alcadeins metabolism (2012)
  • Author(s): Kimura, A., Hata, S., Suzuki, T
  • Organizer: Neuroscience 2012
  • Place of Presentation: Morial Convention Center New Orleans LA, New Orleans USA
• [Presentation] Mechanism of intramembrane cleavage of neural Alcadein proteins by γ-secretase (2012)
  • Author(s): Piao, Y., Hata, S., Suzuki, T
  • Organizer: Neuroscience 2012
  • Place of Presentation: Morial Convention Center New Orleans LA, New Orleans USA
• [Presentation] Transplocation of APP cytoplasmic fragment regulated by phosphorylation of Thr668 residue. NANOSYMPOSIUM "Alzheimer's disease and other dementia : Abeta Metabolism (Theme C : Disorder of the Nervous System)" (2012)
  • Author(s): Suzuki, T., Matsushima, T., Hata, S., Yamamoto, T., Saito, Y
  • Organizer: Neuroscience 2012
  • Place of Presentation: Morial Convention Center New Orleans LA, New Orleans USA
• [Presentation] Involvement of X11/X11L in Alzheimer's-related beta-amyloid generation and epileptogenesis (2012)
  • Author(s): Kanada, Y., Saito, Y., Nishimura, M., Kimura, N. and Suzuki, T
  • Organizer: Alzheimer's Association International Conference 2012
  • Place of Presentation: Vancourver Convention Center, Vancouver, British Columbia, Canada
• [Presentation] Membrane microdomain localization of APP C-terminal fragments regulated by the phosphorylation at cytoplasmic Thr668 residue (2012)
  • Author(s): Matsushima, T., Saito, Y., Nishimura, M., Kimura, N., Hata, S. and Suzuki, T
  • Organizer: Alzheimer's Association International Conference 2012
  • Place of Presentation: Vancourver Convention Center, Vancouver, British Columbia, Canada
• [Presentation] Increased p3-Alc peptides in the CSF and plasma of sporadic Alzheimer's disease patients (2012)
  • Author(s): Hata, S., Konno, T., Urakami, K., Ikeuchi, T., Akatsu, H. and Suzuki, T
  • Organizer: Alzheimer's Association International Conference 2012
  • Place of Presentation: Vancourver Convention Center, Vancouver, British Columbia, Canada
• [Presentation] Molecular pathogenesis of sporadic Alzheimer's disease. (2012)
  • Author(s): Suzuki T.
  • Organizer: Korea-Japan Joint Symposium for the 30th Anniversary of Hallym University: Aging and Neurodegenerative disease.
  • Place of Presentation: Hallym University Sacred Heart Hospital (Korea)
  • Invited
• [Presentation] Increased p3-Alc peptides in the CSF and plasma of sporadic Alzheimer's disease patients. (2012)
  • Author(s): Hata S.
  • Organizer: Alzheimer's Association International Conference 2012
  • Place of Presentation: Vancouver Convention Center (Canada)
• [Presentation] Membrane microdomain localization of APP C-terminal fragments regulated by the phosphorylation at cytoplasmic Thr668 residue. (2012)
  • Author(s): Matsushima T.
  • Organizer: Alzheimer's Association International Conference 2012
  • Place of Presentation: Convention Center (Canada)
• [Presentation] Involvement of X11/X11L in Alzheimer's-related beta-amyloid generation and epileptogenesis. (2012)
  • Author(s): Kanada Y.
  • Organizer: Alzheimer's Association International Conference 2012
  • Place of Presentation: Convention Center (Canada)
• [Presentation] Transplocation of APP cytoplasmic fragment regulated by phosphorylation of Thr668 residue. (2012)
  • Author(s): Suzuki, T.
  • Organizer: Neuroscience 2012
  • Place of Presentation: Morial Convention Center New Orleans (USA)
• [Presentation] Mechanism of intramembrane cleavage of neural Alcadein proteins by γ-secretase. (2012)
  • Author(s): Piao Y.
  • Organizer: Neuroscience 2012
  • Place of Presentation: Morial Convention Center New Orleans (USA)
• [Presentation] Role of Apolipoprotein E on Alcadeins metabolism. (2012)
  • Author(s): Kimura A.
  • Organizer: Neuroscience 2012
  • Place of Presentation: Morial Convention Center New Orleans (USA)
• [Presentation] Function and metabolism of Alcadein in the relation with Alzheimer's disease. (2012)
  • Author(s): Suzuki, T.
  • Organizer: The 15th MNRC International Symposium "New avenue for developing disease-modifying therapies of Alzheimer's disease
  • Place of Presentation: Shiga University of Medical Science (Shiga)
  • Invited
• [Presentation] Function and metabolism of Alcadein in the relation with Alzheimer's disease. (2012)
  • Author(s): Suzuki, T.
  • Organizer: Asian Aging Core for Longevity Research (AACL) 2012 Seoul Conference. "On Aging, Metabolism and Neurobiology"
  • Place of Presentation: University of Seoul (Korea)
  • Invited
• [Presentation] 血中p3-Alcαの定量によるアルツハイマー病のγセクレターゼ切断変化解析 (2012)
  • Author(s): 大森智織
  • Organizer: 第17回 日本病態プロテアーゼ学会学術集会
  • Place of Presentation: オークラアクトシティホテル浜松 （静岡）
• [Presentation] p3-Alcのアルツハイマー病早期診断マーカーとしての有用性の検証 (2012)
  • Author(s): 金子窓香
  • Organizer: 第17回 日本病態プロテアーゼ学会学術集会
  • Place of Presentation: オークラアクトシティホテル浜松 （静岡）
• [Presentation] γセクレターゼによるAlcadeinの膜内切断は、膜脂質組成によって変化する -孤発性アルツハイマー病の発症機構と予防への分子機構- (2012)
  • Author(s): 朴懿
  • Organizer: 第2回 日本認知症予防学会 学術集会
  • Place of Presentation: 北九州国際会議場（福岡）
• [Presentation] gamma-secretaseによるAlcadeinの膜内切断と孤発性アルツハイマー病ぼ発症機構の解明 (2012)
  • Author(s): Yi Piao
  • Organizer: 第85回 日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡 （福岡）
• [Presentation] ヒト型ApolipoproteinEノックインマウスにおけるAlcadein代謝の解析 (2012)
  • Author(s): 木村彩乃
  • Organizer: 第85回 日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡 （福岡）
• [Presentation] APP細胞質ドメインThr668のリン酸化によるAPP CTF の膜ラフト局在制御機構 (2012)
  • Author(s): 齋藤優実
  • Organizer: 第85回 日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡 （福岡）
• [Presentation] X11Lの構造変換によるAPPの輸送・代謝制御機構 (2012)
  • Author(s): 本館利佳
  • Organizer: 第85回 日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡 （福岡）
• [Presentation] Alcadein代謝産物による機能発現 (2012)
  • Author(s): 江波綾佳
  • Organizer: 第85回 日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡 （福岡）
• [Presentation] てんかん発作、アルツハイマー病発症におけるX11/X11Lの関与 (2012)
  • Author(s): 木村尚紀
  • Organizer: 第85回 日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡 （福岡）
• [Presentation] Alcadeinのリン酸化 (2012)
  • Author(s): 蘇武佑里子
  • Organizer: 第85回 日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡 （福岡）
• [Presentation] Alcadeinによるkinesin-1活性と膜小胞輸送制御機構 (2012)
  • Author(s): 白木柚葉
  • Organizer: 第85回 日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡 （福岡）
• [Presentation] Molecular mechanism of kinesin-1 activation by Alcadeinα (2011)
  • Author(s): Araseki, M., Kawano, T., Araki, Y., Kinjo, M., Yamamoto, T., Suzuki, T
  • Organizer: 51th The American Society for Cell Biology annual meeting
  • Place of Presentation: Denver (CO)
• [Presentation] Intracellular Trafficking of the Amyloid β-Protein Precursor Regulated by PDZ domains of X11-Like (2011)
  • Author(s): Saito, Y., Suzuki, T
  • Organizer: 51th The American society for cell biology annual meeting
  • Place of Presentation: Denver (CO)
• [Presentation] Altered processing of gamma-secretase substrates and clearance of peptide products (Abeta and p3-Alc) as a pathogenesis of sporadic Alzheimer's disease. in "Invited Symposium 2-The pathological mechanisms underlying Alzheimer's disease" (2011)
  • Author(s): Suzuki, T., Hata, S
  • Organizer: Gerontology & Geriatrics 2011
  • Place of Presentation: Melbourne Australia
• [Presentation] Nitrotyrosination of triosephoshate isomerase by amyloid β-peptide induces neutronal death (2011)
  • Author(s): Guivernau, B., Tajes, M., Rubio-Moscardo, F., Ramos-Fernandez E., Bosch-Morato, M., Palomer, E., Suzuki, T., Molina, H., , Miscione, GP., Villa-Fereixa, J. and Munoz FJ
  • Organizer: Global Alzheimer's research Summit
  • Place of Presentation: Madrid, Spain
• [Presentation] Intracellular trafficking and metabolism of APP regulated by novel function of X11L (2011)
  • Author(s): Suzuki, T
  • Organizer: Alzheimer's Association International Conference 2011 "Developing Topics"
  • Place of Presentation: Paris, France
• [Presentation] Alcadeine epsilon-cleavage followed by gamma-cleavage (2011)
  • Author(s): Piao, Y., Hata, S., Suzuki, T
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Paris, France
• [Presentation] APP metabolism in brain of Alcadein alpha CTF transgenic mice (2011)
  • Author(s): Kimura, A., Takei, N., Hata, S., Saito, Y., Suzuki, T
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Paris, France
• [Presentation] Alternative gamma-secretase processing in sporadic Alzheimer's disease suggested by p3-Alc peptide, metabolic product of Alcadein (2011)
  • Author(s): Hata, S., Urakami, K., Taniguchi, M., Akatsu, H., Gandy, S., Suzuki, T
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Paris, France
• [Presentation] Quantification of plasma p3-Alcα level with sELISA systems (2011)
  • Author(s): Fang, J., Konno, T., Horikoshi-Sakuraba, Y., Hata, S., Saito, Y., Maeda, M., Akatsu, H., Suzuki, T
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Paris, France
• [Presentation] Enhanced amyloidogenic processing of APP in Alcadein-deficient mice (2011)
  • Author(s): Gotoh, N., Saito, Y., Hata, S., Yamamoto, T., Suzuki, T
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Paris, France
• [Presentation] Molecular mechanism of JIP1b-mediated APP association to kinesin-1 in APP transport and metabolic regulation (2011)
  • Author(s): Chiba, K., Nozawa, K., Araseki, M., Kinjo, M., Taru, H., Suzuki, T
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Paris, France
• [Presentation] Malfunction of HCN chanels in X11/X11L doubly deficient mice (2011)
  • Author(s): Saito, Y., Inoue, T., Suzuki, T
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Paris, France
• [Presentation] Increased levels of soluble p3-Alcadeinα in plasma of patients with Alzheimer's disease (2011)
  • Author(s): Kamogawa, K., Kohara, K., 10名略., Suzuki, T.
  • Organizer: American Academy of Neurology 63rd AAN Annual meeting
  • Place of Presentation: Hawai'I Convention Center (USA)
• [Presentation] Malfunction of HCN chanels in X11/X11L doubly deficient mice (2011)
  • Author(s): Saito, Y, Inoue, T., Suzuki, T.
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Porte de Versailles (France)
• [Presentation] Molecular mechanism of JIP1b-mediated APP association to kinesin-1 in APP transport and metabolic regulation (2011)
  • Author(s): Chiba, K., 4名略., Suzuki, T.
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Porte de Versailles (France)
• [Presentation] Enhanced amyloidogenic processing of APP in Alcadein-deficient mice (2011)
  • Author(s): Gotoh, N., 4名略., Suzuki, T.
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Porte de Versailles (France)
• [Presentation] Quantification of plasma p3-Alcα level with sELISA systems (2011)
  • Author(s): Fang, J., 6名略., Suzuki, T.
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Porte de Versailles (France)
• [Presentation] Alternative gamma-secretase processing in sporadic Alzheimer's disease suggested by p3-Alc peptide, metabolic product of Alcadein (2011)
  • Author(s): Hata, S., 4名略., Suzuki, T.
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Porte de Versailles (France)
• [Presentation] APP metabolism in brain of Alcadein alpha CTF transgenic mice (2011)
  • Author(s): Kimura, A., 3名略., Suzuki, T.
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Porte de Versailles (France)
• [Presentation] Alcadeine epsilon-cleavage followed by gamma-cleavage (2011)
  • Author(s): Piao, Y., Hata, S., Suzuki, T.
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Porte de Versailles (France)
• [Presentation] Intracellular trafficking and metabolism of APP regulated by novel functi on of X11L (2011)
  • Author(s): Suzuki, T.
  • Organizer: Alzheimer's Association International Conference 2011
  • Place of Presentation: Porte de Versailles (France)
• [Presentation] Altered processing of gamma-secretase substrates and clearance of pep tide products (Abeta and p3-Alc)as a pathogenesis of sporadic Alzheimer's disease. in "Invited Symposium 2-The pathological mechanisms underlying Alzheimer's disease" (2011)
  • Author(s): Suzuki, T., Hata, S.
  • Organizer: Gerontology & Geriatrics 2011
  • Place of Presentation: Melbourne Convention and Exhibition Center (Australia)(招待講演)
• [Presentation] Intracellular Trafficking of the Amyloid β-Protein Precursor Regulated by PDZ domains of X11-Like (2011)
  • Author(s): Saito, Y., Suzuki, T.
  • Organizer: 51th The American society for cell biology annual meeting
  • Place of Presentation: Colorado Convention Center (USA)
• [Presentation] Molecular mechanism of kinesin-1 activation by Alcadeinα (2011)
  • Author(s): Araseki, M., 4名略., Suzuki, T.
  • Organizer: 51th The American society for cell biology annual meeting
  • Place of Presentation: Colorado Convention Center (USA)
• [Presentation] アルツハイマー病におけるγセクレターゼの機能変化を反映するAlcadein膜内の切断機構の解析 (2011)
  • Author(s): 朴懿、羽田沙緒里、鈴木利治
  • Organizer: 第16回日本病態プロテアーゼ学会学術集会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)
• [Presentation] アルツハイマー病の新たな生化学的マーカー、p3-Alcの早期診断マーカーとしての可能性の検証 (2011)
  • Author(s): 羽田沙緒里、浦上克哉、谷口美也子、池内健、鈴木利治
  • Organizer: 第1回日本認知症予防学会学術集会
  • Place of Presentation: 米子コンベンションセンター(鳥取)
• [Presentation] Alcadeinのγセクレターゼによる膜内切断機構の解明 (2011)
  • Author(s): Piao Yi(朴懿)、羽田沙緒里、鈴木利治
  • Organizer: 第84回 日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] リン酸化によるAPPの膜マイクロドメインへの移行制御機構の解析 (2011)
  • Author(s): 松島隆英、鈴木利治
  • Organizer: 第84回 日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] アポリポタンパク質EによるAlcadein代謝への影響 (2011)
  • Author(s): 木村彩乃、羽田沙緒里、鈴木利治
  • Organizer: 第84回 日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都)
• [Presentation] JIP-KLC1結合によるAPP輸送の効率化 (2011)
  • Author(s): 千葉杏子、野澤啓輔、荒関雅彦、齋藤有紀、金城政孝、鈴木利治
  • Organizer: 第84回 日本生化学会大会
  • Place of Presentation: 国立京都国際会館(京都)
• [Book] Mechanism of Alzheimer amyloid β-protein precursor localization to membrane lipid rafts in "Understanding Alzheimer's Disease" (Edits by Inga Zerr) Chapter 2 in e-book (2013)
  • Author(s): Saito Y., Matsushima T., Suzuki, T
• [Book] Mechanism of Alzheimer amyloid β-protein precursor localization to membrane lipid rafts in "Understanding Alzheimer's Disease" (Edits by Inga Zerr") (2013)
  • Author(s): Saito Y., Matsushima T., Suzuki, T.
  • Total Pages: 484
  • Publisher: INTECH
• [Book] Mechanism of Alzheimer amyloid β-protein precursor localization to membrane lipid rafts in "Understanding Alzheimer's Disease" (2013)
  • Author(s): Saito Y.
  • Total Pages: 15
  • Publisher: InTech(ISBN 978-953-51-1009-5)
• [Book] Alzheimer's disease as a membrane-associated enzymopathy of β-amyloid precursor protein (APP) secretases, in "Lipids and Cellular Membranes in Amyloid Disease" (Eds by Jelinek, R.) (2011)
  • Author(s): Hata, S., Saito, Y. and Suzuki, T
• [Book] Alzheimer's disease as a membrane-associated enzymopathy of β-amyloid precursor protein (APP) secretases, in "Lipids and Cellular Membranes in Amyloid Disease" (Eds by Jelinek, R.) (2011)
  • Author(s): Hata, S., Saito, Y., Suzuki, T.
  • Publisher: Wiley-VCH (ISBN : 978-3-527-32860-4)
• [Remarks] 研究室HP
  • URL: http://www.pharm.hokudai.ac.jp/org/shinkei01.html
• [Remarks]
  • URL: http://www.pharm.hokudai.ac.jp/shinkei/index.html