Analysis of signaling pathways involved in liver development, regeneration and disease using mice and medaka
| Project/Area Number |
23390018
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NISHINA Hiroshi 東京医科歯科大学, 難治疾患研究所, 教授 (60212122)
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| Co-Investigator(Kenkyū-buntansha) |
ASAOKA Yoichi 東京医科歯科大学, 難治疾患研究所, 助教 (10436644)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 肝臓 / シグナル伝達 / モデル生物 / JNK / Hippo / 肝細胞がん / 細胞競合 / 再生 / 再生医学 / 発生・分化 / Hippo系 / 質量顕微鏡 |
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| Research Abstract |
JNK singaling pawatyway is essential for liver development and Hippo signaling pathway regulates liver size. Interestingly, we fond that there is a cross talk between JNK and Hippo signaling pathways. Furthermore, we found that active YAP downstream Hippo signal could form hepatocellular carcinoma and induce cell competition. These results indicate that the Hippo-YAP pathway acts as a stress sensor to eliminate unfit cells in order to safeguard organ size and protect against tumourigenesis.
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Control of the Hippo pathway by Set7-dependent methylation of Yap2013
Author(s)
Menno J. Oudhoff, Spencer A. Freeman, Amber L. Couzens, Frann Antignano, Ekaterina Kuznetsova, Paul H. Min, Jeffrey P. Northrop, Bernhard Lehnertz, Dalia Barsyte-Lovejoy, Masoud Vedadi, Cheryl H. Arrowsmith, Hiroshi Nishina, Michael R. Gold, Fabio M.V. Rossi, Anne-Claude Gingras, and Colby Zaph
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Journal Title
Dev. Cell
Volume: 26
Pages: 188-194
Related Report
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[Journal Article] Control of the Hippo pathway by Set7-dependent methylation of Yap.2013
Author(s)
Oudhoff MJ. Freeman SA, Couzens AL, Antignano F, Kuznetsova E, Min PH, Northrop JP, Lehnertz B, Barsyte-Lovejoy D, Vedadi M, Arrowsmith CH, Nishinaet H et al.
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Journal Title
Dev. Cell
Volume: 26
Issue: 2
Pages: 188-194
DOI
Related Report
Peer Reviewed
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[Journal Article] RASSF7 negatively regulates pro-apoptotic JNK signaling by inhibiting the activity of phosphorylated-MKK72011
Author(s)
Takahashi, S., Ebihara, A., Kajiho, H., Kontani, K., Nishina, H., and Katada, T.
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Journal Title
Cell Death Differ
Volume: 18
Issue: 4
Pages: 645-655
DOI
Related Report
Peer Reviewed
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[Journal Article] RhoA activation participates in rearrangement of processing bodies and release of nucleated AU-rich mRNAs2011
Author(s)
Takahashi, S., Sakurai, K., Ebihara, A., Kajiho, H., Saito, K., Kontani, K., Nishina, H., and Katada, T.
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Journal Title
Nucleic Acids Res
Volume: 39
Issue: 8
Pages: 3446-3457
DOI
Related Report
Peer Reviewed
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[Journal Article] Autotaxin regulates vascular development via multiple lysophosphatidic acid(LPA)receptors in zebrafish2011
Author(s)
Yukiura H, Hama K, Nakanaga K, Tanaka M, Asaoka Y, Okudaira S, Arima N, Inoue A, Hashimoto T, Arai H, Kawahara A, Nishina H, Aoki J
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Journal Title
J Biol Chem
Volume: 286
Issue: 51
Pages: 43972-43983
DOI
Related Report
Peer Reviewed
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