| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Research Abstract |
We developed a hybrid peptide, which induces non-apoptotic cell death against leukemia cells. We determined that the mode of the peptide induced cell death is similar to necrosis.
In addition, we newly synthesized a series of the D-amino acid containing-peptide mimetic analogues of the hybrid peptide and evaluated the killing effect on the human leukemic cell lines. These peptides will be a useful tool for development of novel concept-based anti-leukemia agents.
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