Chemical Biology on the hybrid peptide-induce non-apoptotic cell death
Project/Area Number |
23390027
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Drug development chemistry
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Research Institution | Sojo University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MURATA Kazuyoshi 生理学研究所, 脳機能計測支援センター, 准教授 (20311201)
|
Project Period (FY) |
2011-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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Keywords | ペプチドミメティックス / 細胞死 / 白血病 / ペプチド / ペプチド創薬 / ペプチドミメティック / ケミカルバイオロジー |
Research Abstract |
We developed a hybrid peptide, which induces non-apoptotic cell death against leukemia cells. We determined that the mode of the peptide induced cell death is similar to necrosis. In addition, we newly synthesized a series of the D-amino acid containing-peptide mimetic analogues of the hybrid peptide and evaluated the killing effect on the human leukemic cell lines. These peptides will be a useful tool for development of novel concept-based anti-leukemia agents.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus2013
Author(s)
Koga Y., Inazato M., Nakamura T., Hashikawa, C., Chirifu M., Michi A., Yamashita T., Toma S., Kuniyasu A., Ikemizu S., Nakabeppu Y., Yamagata Y
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Journal Title
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun
Volume: 69
Pages: 45-48
Related Report
Peer Reviewed
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[Journal Article] Crystallization and preliminary X-ray analysis of human MTH1 with a homogeneous N-terminus.2013
Author(s)
Koga Y, Inazato M, Nakamura T, Hashikawa C, Chirifu M, Michi A, Yamashita T, Toma S, Kuniyasu A, Ikemizu S, Nakabeppu Y, Yamagata Y.
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Journal Title
Acta Crystallogr Sect F Struct Biol Cryst Commun
Volume: 69(Pt 1)
Issue: 1
Pages: 45-48
DOI
Related Report
Peer Reviewed
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[Journal Article] Targeting neuropilin-1 in human leukemia and lymphoma2011
Author(s)
Karjalainen K., Jaalouk D.E., Bueso- Ramos C.E., Zurita A.J., Kuniyasu A., Lichtiger B., O'Brien S., Kantarjian H.M., Cortes J.E., Koivunen E., Arap W., Pasqualini R
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Journal Title
Blood
Volume: 117
Pages: 920-927
Related Report
Peer Reviewed
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