| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2011: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
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| Research Abstract |
This study elucidated that MATEs which act as H+/organic cation exchanges mediate the urinary excretion of various drugs, endogenous metabolite (N-methylnicotinamide) and fluorescents in mouse, and that inhibition of MATEs is part of the mechanism underlying the drug-drug interactions in the urinary excretion with cimetidine and trimethoprim. NPT4 mediates facilitated diffusion of various anionic drugs such as diuretics in HEK293 cells. MCT9 is found to be expressed on the basolateral membrane of the proximal tubules. Among the drugs which undergo urinary excretion, OCT2 can recognize only hydrophilic compounds as substrate. MCT9 also acts as organic cation transporter showing substrate specificity distinct from OCT2. Since MCT9 is also expressed in the blood-brain barrier, it is speculated that MCT9 is involved in the disposition of drugs in the central nervous system in addition to the kidney.
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