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Generation of Monkey/Mouse Chimera with Monkey Liver by Interspecific Blastocyst Injection of Monkey induced Pluripotent Stem Cells

Research Project

Project/Area Number 23390036
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionNagoya City University

Principal Investigator

MATSUNAGA Tamihide  名古屋市立大学, 薬学研究科(研究院), 教授 (40209581)

Co-Investigator(Kenkyū-buntansha) OHMORI Shigeru  信州大学, 医学部附属病院, 教授 (70169069)
NARIMATSU Shizuo  岡山大学, 医歯薬学総合研究科, 教授 (20113037)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,980,000 (Direct Cost: ¥14,600,000、Indirect Cost: ¥4,380,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Keywords胚盤胞補完法 / サルiPS細胞 / 異種動物間キメラ / ラットiPS細胞 / カニクイザル / マーモセット / ラット / tk-NOGマウス / TK-NOGマウス / ES細胞 / 薬物動態 / FAH
Research Abstract

Monkey iPS cell lines were established from dermal fibroblasts by transforming of reprogramming factors. The differentiation ability into triploblastic cells of the iPS cells in vitro was determined by floating cultivation of embryoid bodies. To examine the potential for xenogenic approaches in blastocyst complementation, we injected rat iPS/ES cells into mouse blastocysts generating interspecific chimeras. The interspecific chimeras between mouse and rat using a blastocyst injection technique with rat iPS/ES cells were generated. These data provide basic knowledge of principle for interspecific blastocyst complementation and for generation in vivo of organs derived from monkey iPS/ES cells using a xenogenic environment.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (89 results)

All 2014 2013 2012 2011 Other

All Journal Article (23 results) (of which Peer Reviewed: 11 results) Presentation (63 results) (of which Invited: 5 results) Book (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Differentiation into pharmacokinetically functional enterocyte-like cells from human induced pluripotent stem cells using a simple method2014

    • Author(s)
      Iwao T, Toyota M, Miyagawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A, Nagata K, Matsunaga T
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 29 Pages: 44-51

    • Related Report
      2013 Final Research Report
  • [Journal Article] An Efficient Method for Differentiation of Human Induced Pluripotent Stem Cells into Hepatocyte-like Cells Retaining Drug Metabolizing Activity2014

    • Author(s)
      Kondo Y, Iwao T, Nakamura K, Sasaki T, Takahashi S, Kamada N, Matsubara T, Gonzalez FJ, Akutsu H, Miyagawa Y, Okita H, Kiyokawa N, Toyoda M, Umezawa A, Nagata K, Matsunaga T, Ohmori S
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 29 Issue: 3 Pages: 237-243

    • DOI

      10.2133/dmpk.DMPK-13-RG-104

    • NAID

      130004463382

    • ISSN
      1347-4367, 1880-0920
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Selective Culture Method for Hepatocyte-like Cells Differentiated from Human Induced Pluripotent Stem Cells2014

    • Author(s)
      Kondo Y, Yoshihashi S, Mimori K, Ogihara R, Kanehama Y, Maki Y, Enosawa S, Kurose K, Iwao T, Nakamura K, Matsunaga T
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 29 Issue: 5 Pages: 407-413

    • DOI

      10.2133/dmpk.DMPK-14-RG-022

    • NAID

      130004463403

    • ISSN
      1347-4367, 1880-0920
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of Human Induced Pluripotent Stem Cells into Functional Enterocyte-like Cells Using a Simple Method2014

    • Author(s)
      Iwao T et al.
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 29 Issue: 1 Pages: 44-51

    • DOI

      10.2133/dmpk.DMPK-13-RG-005

    • NAID

      130004463343

    • ISSN
      1347-4367, 1880-0920
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] G6PT Inhibition Model Using HL-60 Cells and Induction of ROS Production through PKC/NOX2 Activation: Clinical Condition for Elucidation of Glycogen Storage Disease Type Ib2014

    • Author(s)
      Satoh D et al.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 37 Issue: 4 Pages: 534-540

    • DOI

      10.1248/bpb.b13-00708

    • NAID

      130003382133

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of monkey embryonic stem cells to hepatocytes by feeder-free dispersion culture and expression analyses of cytochrome P450 enzymes responsible for drug metabolism2013

    • Author(s)
      Maruyama J, Matsunaga T, Yamaori S, Sakamoto S, Kamada N, Nakamura K, Kikuchi S, Ohmori S
    • Journal Title

      Biol Pharm Bull

      Volume: 36 Pages: 292-298

    • NAID

      130002480763

    • Related Report
      2013 Final Research Report
  • [Journal Article] Hepatocyte nuclear factor 6 activates the transcription of CYP3A4 in hepatocyte-like cells differentiated from human induced pluripotent stem cells2013

    • Author(s)
      Sasaki T, Takahashi S, Numata Y, Narita M, Tanaka Y, Kondo Y, Matsunaga T, Ohmori S, Nagata K
    • Journal Title

      Drug Metabol Pharmacokinet

      Volume: 28 Pages: 250-259

    • NAID

      130004463310

    • Related Report
      2013 Final Research Report
  • [Journal Article] Clinical evidence of the pharmacokinetics change in thalidomide therapy2013

    • Author(s)
      Nakamura K, Matsuzawa N, Ohmori S, Ando Y, Yamazaki H, Matsunaga T
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 28 Pages: 38-43

    • NAID

      130004463295

    • Related Report
      2013 Final Research Report
  • [Journal Article] Establishment and directed differentiation of induced pluripotent stem cells from glycogen storage disease type Ib patient2013

    • Author(s)
      Satoh D, Maeda T, Ito T, Nakajima Y, Ohte M, Ukai A, Nakamura K, Enosawa S, Toyota M, Miyagawa Y, Okita H, Kiyokawa N, Akutsu H, Umezawa A, Matsunaga T
    • Journal Title

      Genes Cells

      Volume: 18 Pages: 1053-1069

    • Related Report
      2013 Final Research Report
  • [Journal Article] Establishment and directed differentiation of induced pluripotent stem cells from glycogen storage disease type Ib patient.2013

    • Author(s)
      Satoh D et al.
    • Journal Title

      Genes Cells

      Volume: 18 Issue: 12 Pages: 1053-1069

    • DOI

      10.1111/gtc.12101

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of monkey embryonic stem cells to hepatocytes by feeder-free dispersion culture and expression analyses of cytochrome P450 enzymes responsible for drug metabolism.2013

    • Author(s)
      Maruyama J
    • Journal Title

      Biol Pharm Bull

      Volume: 36 Pages: 292-298

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical evidence of the pharmacokinetics change in thalidomide therapy.2013

    • Author(s)
      Nakamura K
    • Journal Title

      Drug Metabol Pharmacokinet

      Volume: 28 Pages: 38-43

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatocyte nuclear factor 6 activates the transcription of CYP3A4 in hepatocyte-like cells differentiated from human induced pluripotent stem cells.2013

    • Author(s)
      Sasaki T
    • Journal Title

      Drug Metabol Pharmacokinet

      Volume: 28

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of Cytochrome P450 2C19 Gene Variations on Pharmacokinetic Parameters of Thalidomide in Japanese Patients2012

    • Author(s)
      Matsuzawa N, Nakamura K, Matsuda M, Ishida F, Ohmori S
    • Journal Title

      Biol Pharm Bull

      Volume: 35 Pages: 317-320

    • NAID

      130001872311

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Journal Article] 薬物動態研究におけるヒト多能性幹細胞の活用2012

    • Author(s)
      岩尾岳洋, 松永民秀
    • Journal Title

      薬剤学

      Volume: 72 Pages: 88-94

    • NAID

      10030452608

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Journal Article] Evaluation of human embryonic stem cell-derived hepatocyte-like cells for detection of CYP1A inducers2012

    • Author(s)
      Tsuchiya H, Matsunaga T, Aikawa K, Kamada N, Nakamura K, Ichikawa H, Sasaki K, Ohmori S
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 27 Pages: 598-604

    • NAID

      130004933512

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Journal Article] Mechanisms of CYP3A induction by glucocorticoids in human fetal liver cells2012

    • Author(s)
      Matsunaga T, Maruyama M, Matsubara T, Nagata K, Yamazoe Y, Ohmori S
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 27 Pages: 653-657

    • NAID

      130004933510

    • Related Report
      2013 Final Research Report
  • [Journal Article] Mechanisms of CYP3A induction by glucocorticoids in human fetal liver cells.2012

    • Author(s)
      Matsunaga T
    • Journal Title

      Drug Metabol Pharmacokinet

      Volume: 27 Pages: 653-657

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of hypoxia-inducible factor-1α chemical stablizer, CoCl_2 and hypoxia on gene expression of CYP3As in human fetal liver cells2012

    • Author(s)
      Suzuki E, Matsunaga T, Aonuma A, Sasaki T, Nagata K, Ohmori S
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR overexpressed in human fetal liver cells2012

    • Author(s)
      Takezawa T, Matsunaga T, Aikawa K, Nakamura K, Ohmori S
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 薬物動態研究における実験材料及び評価系開発の最近の動向2011

    • Author(s)
      松永民秀
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 26 Pages: 5-6

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Journal Article] 実験材料及び評価系開発の最近の動向(第1回) 幹細胞の分化と薬物動態研究への応用 ヒトESおよびiPS 細胞から肝細胞様細胞および腸管組織への分化誘導2011

    • Author(s)
      岩尾岳洋, 松永民秀
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 26 Pages: 7-14

    • Related Report
      2013 Final Research Report
  • [Journal Article] 実験材料及び評価系開発の最近の動向(第1回)幹細胞の分化と薬物動態研究への応用ヒトESおよびiPS細胞から肝細胞様細胞および腸管組織への分化誘導2011

    • Author(s)
      岩尾岳洋、松永民秀
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 26 Pages: 7-14

    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒトiPS 細胞由来肝細胞及び腸管上皮細胞の作成と応用2014

    • Author(s)
      松永民秀
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Final Research Report
  • [Presentation] 糖原病Ib 型患者由来iPS細胞を用いた好中球モデルにおけるPKCを介したNOX2 活性化機序の解明2014

    • Author(s)
      大手万理子, 佐藤大介, 前田 徹, 中村克徳, 松永民秀
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] カニクイザル皮膚繊維芽細胞からのiPS 細胞の樹立2014

    • Author(s)
      小野里太智, 佐藤大介, 小枝暁子, 中村克徳, 松永民秀
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] 胚盤胞注入によるラットiPS 細胞由来細胞をもつキメラマウスの作出2014

    • Author(s)
      奥村啓樹, 鵜飼 茜, 佐藤大介, 宮本智美, 三好一郎, 平林真澄, 中村克徳, 松永民秀
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトiPS 細胞由来腸管上皮細胞様細胞におけるUDP-グルクロン酸転移酵素の発現解析2013

    • Author(s)
      畠山和久, 埴岡伸光, 黒瀬光一, 松永民秀, 成松鎭雄
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 再生医療・創薬研究の新規材料として期待されるiPS 細胞2013

    • Author(s)
      松永民秀
    • Organizer
      平成25年度製剤機械技術学会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト人工多能性幹細胞の肝細胞への分化における変法L-15 培地及び血清の効果2013

    • Author(s)
      松永民秀, 近藤祐樹, 荻原留理, 岩尾岳洋, 永田 清, 黒瀬光一, 堀川隆司, 丹羽卓朗, 山折 大, 大森 栄, 中村克徳
    • Organizer
      フォーラム2013 : 衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] Human small intestinal epithelial cells differentiated from adult intestinal stem cells - A novel system for the evaluation of oral drug absorption2013

    • Author(s)
      Takenaka T, Harada N, Kuze J, Chiba M, Matsunaga T
    • Organizer
      日本薬物動態学会第28回年会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Pharmacokinetic function of hepatocyte-like cells differentiated from human iPS cells2013

    • Author(s)
      Kondo Y, Iwao T, Ogihara R, Sasaki T, Nagata K, Kurose K, Horikawa T, Niwa T, Yamaori S, Ohmori S, Nakamura K Matsunaga T
    • Organizer
      日本薬物動態学会第28回年会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Small-molecule compounds enhance the differentiation of human induced pluripotent stem cells into enterocytes2013

    • Author(s)
      Iwao T, Kondo Y, Kodama N, Nakamura K, Horikawa T, Niwa T, Kurose K, Matsunaga T
    • Organizer
      日本薬物動態学会第28回年会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Guiding the differentiation of human induced pluripotent stem cells into definitive endoderm using a combination of small-molecule compounds2013

    • Author(s)
      Ogihara R, Kondo Y, Iwao T, Yamaori S, Ohmori S, Nakamura K, Matsunaga T
    • Organizer
      日本薬物動態学会第28回年会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Expectation toward human iPS cells as a good tool to use for examination of pharmacokinetics2013

    • Author(s)
      松永民秀
    • Organizer
      日本薬物動態学会第28回年会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 複数の低分子化合物はヒトiPS 細胞から機能性を持った小腸上皮細胞様細胞への分化効率を改善する2013

    • Author(s)
      小玉菜央, 岩尾岳洋, 壁谷知樹, 堀川隆司, 丹羽卓朗, 黒瀬光一, 中村克徳, 松永民秀
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト人工多能性幹細胞から分化させた肝細胞様細胞による薬物代謝酵素の酵素誘導評価2012

    • Author(s)
      中村克徳, 近藤祐樹, 杉山留理, 相川香織, 松永民秀, 大森 栄
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] ペプチド輸送機能を有するヒトiPS 細胞由来腸管細胞の作製2012

    • Author(s)
      岩尾岳洋, 中村克徳, 永田 清, 松永民秀
    • Organizer
      日本薬物動態学会第27回年会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] 低分子化合物はヒト人工多能性幹細胞から肝細胞への分化を促進する2012

    • Author(s)
      近藤祐樹, 岩尾岳洋, 吉橋幸美, 三森佳代, 杉山留理, 佐々木崇光, 永田 清, 黒瀬光一, 丹羽卓朗, 山折 大, 大森 栄, 中村克徳, 松永民秀
    • Organizer
      日本薬物動態学会第27回年会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト人工多能性幹細胞の肝細胞への分化における変法L-15 培地及び血清の効果2012

    • Author(s)
      吉橋幸美, 近藤祐樹, 三森佳代, 荻原留理, 岩尾岳洋, 金濱吉範, 牧与志幸, 松永民秀
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトiPS 細胞由来肝細胞の剥離・凍結保存法の検討2012

    • Author(s)
      三森佳代, 近藤祐樹, 吉橋幸美, 荻原留理, 岩尾岳洋, 松永民秀
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Differentiation into functional enterocyte-like cells from human induced pluripotent stem cells2012

    • Author(s)
      Iwao T, Nagata K, Matsunaga T
    • Organizer
      19th Microsomes and Drug Oxidations (MDO) and 12th European Regional International Society for the Study of Xenobiotics (ISSX) Meeting
    • Place of Presentation
      Noordwijk aan Zee, The Netherlands
    • Related Report
      2013 Final Research Report
  • [Presentation] Examination of simple prediction system of the differentiation characteristics into hepatocyte between human induced pluripotent stem cell lines2011

    • Author(s)
      Daisuke Sato, Nobuhiko Harimoto, Chiho Matsumura, Tamihide Matsunaga
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-12-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内胚葉及び中胚葉を介したヒト人工多能性幹細胞から肝細胞への分化誘導2011

    • Author(s)
      張本伸彦、佐藤大介、松村治穂、松永民秀
    • Organizer
      日本薬学会東海支部合同学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-11-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Differentiation characteristics of human induced pluripotent stem cells are prescribed at early stage2011

    • Author(s)
      Daisuke Sato, Nobuhiko Harimoto, Chiho Matsumura, Tamihide Matsunaga
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト組織由来iPS細胞の樹立とその機能評価2011

    • Author(s)
      佐藤大介、張本伸彦、前田徹、松永民秀
    • Organizer
      日本薬学会東海支部合同学術大会2011
    • Place of Presentation
      名古屋
    • Year and Date
      2011-07-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト iPS 細胞由来分化肝細胞様細胞におけるCYP及びUGT mRNA発現解析2011

    • Author(s)
      花房弘之, 埴岡伸光, 松永民秀, 成松鎭雄
    • Organizer
      第52回日本生化学会中国・四国支部総会
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] マイクロ空間プレートを用いた 3次元培養 HepG2 細胞における UGT 発現解析2011

    • Author(s)
      伊豆野祥太郎, 埴岡伸光, 江尻洋子, 細田雅也, 内藤真策, 成松鎭雄
    • Organizer
      第52回日本生化学会中国・四国支部総会
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト iPS 細胞の肝細胞様細胞への分化と薬物代謝酵素の発現2011

    • Author(s)
      松永民秀, 近藤祐樹, 岩尾岳洋, 大森 栄
    • Organizer
      日本法中毒学会第30年会
    • Place of Presentation
      長崎
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト組織由来iPS 細胞の樹立とその機能評価2011

    • Author(s)
      佐藤大介, 張本伸彦, 前田 徹, 松永民秀
    • Organizer
      日本薬学会東海支部合同学術大会2011
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト人工多能性幹細胞からの肝細胞への効率的な分化方法の検討2011

    • Author(s)
      近藤祐樹, 岩尾岳洋, 三森佳代, 吉橋幸美, 大森 栄, 松永民秀
    • Organizer
      第57回日本薬学会東海支部総会・大会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Effect of quercetin on differentiation into hepatocyte-like cells from human induced pluripotent stem cells2011

    • Author(s)
      近藤祐樹, 岩尾岳洋, 斎藤昌良, 丹羽卓朗, 黒瀬光一, 永田 清, 松永民秀
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Differentiation into the enterocyte-like cells from human induced pluripotent stem cells2011

    • Author(s)
      岩尾岳洋, 永田 清, 松永民秀
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Enzymatic properties of cynomolgus monkey and marmoset CYP2B6s : Comparison with human CYP2B62011

    • Author(s)
      Mayumi K, Hanioka N, Masuda K, Koeda A, Naito S, Miyata A, Narimatsu S
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Expression of CYP and UGT mRNAs in human induced pluripotent stem cell-derived hepatocyte-like cells2011

    • Author(s)
      Hanafusa H, Matsunaga T, Kurose K, Saito Y, Hanioka N, Narimatsu S
    • Organizer
      日本薬物動態学会第26回年会
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] ヒト人工多能性幹細胞から肝細胞への分化に対する低分子化合物の効果2011

    • Author(s)
      近藤祐樹, 杉山留理, 三森佳代, 吉橋幸美, 岩尾岳洋, 黒瀬光一, 松永民秀
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] ヒトiPS細胞由来分化肝細胞様細胞におけるCYP及びUGT mRNA発現解析2011

    • Author(s)
      花房弘之、埴岡伸光、松永民秀、成松鎭雄
    • Organizer
      第52回日本生化学会中国・四国支部総会
    • Place of Presentation
      広島
    • Related Report
      2011 Annual Research Report
  • [Presentation] マイクロ空間プレートを用いた3次元培養HepG2細胞におけるUGT発現解析2011

    • Author(s)
      伊豆野祥太郎、埴岡伸光、江尻洋子、細田雅也、内藤真策、成松鎭雄
    • Organizer
      第52回日本生化学会中国・四国支部総会
    • Place of Presentation
      広島
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒトiPS細胞の肝細胞様細胞への分化と薬物代謝酵素の発現2011

    • Author(s)
      松永民秀, 近藤祐樹, 岩尾岳洋, 大森栄
    • Organizer
      日本法中毒学会第30年会
    • Place of Presentation
      長崎
    • Related Report
      2011 Annual Research Report
  • [Presentation] 再生医療・創薬研究の新規材料として期待されるiPS細胞

    • Author(s)
      松永 民秀 他
    • Organizer
      平成25年度 製剤機械技術学会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ヒト人工多能性幹細胞の肝細胞への分化における変法L-15培地及び血清の効果

    • Author(s)
      松永 民秀 他
    • Organizer
      フォーラム2013:衛生薬学・環境トキシコロジー
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] Human small intestinal epithelial cells differentiated from adult intestinal stem cells - A novel system for the evaluation of oral drug absorption

    • Author(s)
      武中 徹 他
    • Organizer
      日本薬物動態学会第28回年会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pharmacokinetic function of hepatocyte-like cells differentiated from human iPS cells

    • Author(s)
      近藤 祐樹 他
    • Organizer
      日本薬物動態学会第28回年会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Small-molecule compounds enhance the differentiation of human induced pluripotent stem cells into enterocytes

    • Author(s)
      岩尾 岳洋 他
    • Organizer
      日本薬物動態学会第28回年会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Guiding the differentiation of human induced pluripotent stem cells into definitive endoderm using a combination of small-molecule compounds

    • Author(s)
      荻原 留理 他
    • Organizer
      日本薬物動態学会第28回年会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Expectation toward human iPS cells as a good tool to use for examination of pharmacokinetics

    • Author(s)
      松永 民秀 他
    • Organizer
      日本薬物動態学会第28回年会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 複数の低分子化合物はヒトiPS細胞から機能性を持った小腸上皮細胞様細胞への分化効率を改善する

    • Author(s)
      小玉 菜央 他
    • Organizer
      第36回 日本分子生物学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒトiPS細胞由来肝細胞及び腸管上皮細胞の作成と応用

    • Author(s)
      松永 民秀 他
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 糖原病Ib型患者由来iPS細胞を用いた好中球モデルにおけるPKCを介したNOX2活性化機序の解明

    • Author(s)
      大手 万理子 他
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] カニクイザル皮膚繊維芽細胞からのiPS細胞の樹立

    • Author(s)
      小野里 太智 他
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] 胚盤胞注入によるラットiPS細胞由来細胞をもつキメラマウスの作出

    • Author(s)
      奥村 啓樹 他
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒトiPS細胞由来肝細胞様細胞におけるUDP-グルクロン酸転移酵素の発現解析

    • Author(s)
      畠山 和久
    • Organizer
      第53回(平成24年度) 日本生化学会中国・四国支部例会
    • Place of Presentation
      岡山
    • Related Report
      2012 Annual Research Report
  • [Presentation] 肝特異的転写因子HNF-6による薬物代謝酵素発現誘導:新規薬物代謝研究ツールを志向した肝分化iPS 細胞樹立への応用

    • Author(s)
      佐々木 崇光
    • Organizer
      平成24 年度 東北薬科大学創薬研究センターシンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] Differentiation into functional enterocyte-like cells from human induced pluripotent stem cells.

    • Author(s)
      Iwao T
    • Organizer
      19th Microsomes and Drug Oxidations (MDO) and 12th European Regional International Society for the Study of Xenobiotics (ISSX) Meeting,
    • Place of Presentation
      Noordwijk aan Zee, The Netherlands
    • Related Report
      2012 Annual Research Report
  • [Presentation] microRNA 導入による肝薬物代謝酵素発現への影響

    • Author(s)
      菅野 高弘
    • Organizer
      第51 回日本薬学会東北支部大会
    • Place of Presentation
      青森
    • Related Report
      2012 Annual Research Report
  • [Presentation] HNF6 導入時期による肝分化iPS 細胞の薬物代謝酵素発現へ の影響

    • Author(s)
      佐々木 崇光
    • Organizer
      第51 回日本薬学会東北支部大会
    • Place of Presentation
      青森
    • Related Report
      2012 Annual Research Report
  • [Presentation] 糖原病Ib型患者肝非実質由来iPS細胞の樹立と肝臓、好中球への分化誘導及び機能評価

    • Author(s)
      佐藤 大介
    • Organizer
      日本人類遺伝学会 第57回大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] ペプチド輸送機能を有するヒトiPS細胞由来腸管細胞の作製

    • Author(s)
      岩尾 岳洋
    • Organizer
      日本薬物動態学会第27回年会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 低分子化合物はヒト人工多能性幹細胞から肝細胞への分化を促進する

    • Author(s)
      近藤祐樹
    • Organizer
      日本薬物動態学会第27回年会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 疾患及び創薬研究の新規材料として期待されるヒトiPS細胞

    • Author(s)
      松永 民秀
    • Organizer
      桜山ウイルス研究会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ヒト人工多能性幹細胞の肝細胞への分化における変法L-15培地及び血清の効果

    • Author(s)
      吉橋幸美
    • Organizer
      第35回 日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヒトiPS細胞由来肝細胞の剥離・凍結保存法の検討

    • Author(s)
      三森佳代
    • Organizer
      第35回 日本分子生物学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] VEGF添加時期が iPS-sac形成に与える影響の検討

    • Author(s)
      大手 万理子
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] iPS細胞由来肝細胞の三次元スフェロイド培養による糖原病Ib型長期遺伝子治療評価系の構築

    • Author(s)
      佐藤 大介
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 糖原病Ib型患者iPS細胞を用いた遺伝子導入評価系の構築

    • Author(s)
      鵜飼 茜
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ヒトiPS細胞由来腸管上皮細胞様細胞におけるUDP-グルクロン酸転移酵素の発現解析

    • Author(s)
      畠山和久
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Book] 薬剤学実験 必携マニュアル ―Pharmacist-Scientistのために―2014

    • Author(s)
      松永 民秀 他
    • Total Pages
      768
    • Publisher
      南江堂
    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 人工多能性幹細胞を肝細胞へ分化誘導する方法2012

    • Inventor(s)
      松永民秀, 岩尾岳洋, 近藤祐樹, 吉橋幸美
    • Industrial Property Rights Holder
      公立大学法人名古屋市立大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-11-09
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 人工多能性幹細胞を肝細胞へ分化誘導する方法2012

    • Inventor(s)
      松永民秀、岩尾岳洋、近藤祐樹、吉橋幸美
    • Industrial Property Rights Holder
      名古屋市立大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-247010
    • Filing Date
      2012-11-09
    • Related Report
      2012 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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