Genetic study of molecular characteristic of autophagy-related proteins LC3A and LC3B

• Project/Area Number: 23390041
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Juntendo University
• Principal Investigator: UCHIYAMA Yasuo 順天堂大学, 医学部, 特任教授 (10049091)
• Co-Investigator(Kenkyū-buntansha): KOIKE Masato 順天堂大学, 医学部, 先任准教授 (80347210) ; SASAKI Mitsuho 順天堂大学, 医学部, 助教 (20432536) ; SUNABORI Takehiko 順天堂大学, 医学部, 助教 (00407115) ; SUZUKI Chigure 順天堂大学, 医学部, 助教 (40536629) ; SHIBATA Masahiro 新潟大学, 医歯学総合研究科, 准教授 (10343253)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000); Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
• Keywords: LC3 / オートファジー / 脂肪滴形成 / 脂肪滴 / ノックアウトマウス / RNAi

Research Abstract

The roles of autophagy-related proteins LC3A and LC3B largely remains unknown, although LC3 are used as a marker protein for autophagosome formation. To further understand their roles, single and double knockout (KO) mice of LC3A and LC3B were produced. These KO mice were born normally and grown-up to be capable of reproduction. Protein expression of the GABARAP family of proteins did not change between wild-type and LC3A/B-deficient mouse body tissues such as brain, liver, kidney and heart, indicating they maintain basic autophagy. Hippocampal pyramidal neurons of neonatal brains deficient in LC3A/B were resistant to hypoxic-ischemic brain injury. The result strongly suggests the presence of autophagic neuron death in the hippocampal pyramidal layer of mouse brains.

Research Products

• [Journal Article] Inhibitory effect of the selective secretion 5-HT receptor antagonist ramosetron on duodenal acidification-induced gastric hypersensitivity in rats. (2014)
  • Author(s): Nakafuku-Fukuda, M., Hirata, T., Keto, Y., Yamano, M., Yokoyama, T., Uchiyama, Y.
  • Journal Title: Eur J Pharmacol Volume: -
  • Peer Reviewed
• [Journal Article] NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization. (2014)
  • Author(s): Yamanaka, T., Tosaki, A., Kurosawa, M., Matsumoto, G., Koike, M., Uchiyama, Y., Maity, S.N., Shimogori, T., Hattori, N., *Nukina, N.
  • Journal Title: Nat Commun Volume: -
  • Peer Reviewed
• [Journal Article] SGLT2 selective inhibitor ipragliflozin reduces body fat mass by increasing fatty acid oxidation in high-fat diet-induced obese rats. (2014)
  • Author(s): Yokono, M., Takasu, T., Hayashizaki, Y., Mitsuoka, K., Kihara, R., Muramatsu, Y., Miyoshi, S., Tahara, A., Kurosaka, E., Li, Q., Tomiyama, H., Sasamata, M., Shibasaki, M., Uchiyama, Y.
  • Journal Title: Eur J Pharmacol Volume: 727 Pages: 66-74
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• [Journal Article] Deregulation of Pancreas-Specific Oxidoreductin ERO1β in the Pathogenesis of Diabetes Mellitus. (2014)
  • Author(s): Awazawa, M., Futami, T., Sakada, M., Kaneko, K., Ohsugi, M., Nakaya, K., Terai, A., Suzuki, R., Koike, M., Uchiyama, Y., Kadowaki, T., Ueki, K.
  • Journal Title: Mol Cell Biol Volume: -
  • Peer Reviewed
• [Journal Article] Generation and analysis of serine protease inhibitor Kazal type 3-Cre driver mice. (2014)
  • Author(s): Sakata, K., Ohmuraya, M., Araki, K., Suzuki C, Ida S, Hashimoto D, Wang J, Uchiyama Y, Baba H, *Yamamura K
  • Journal Title: Exp Animals Volume: 63 Pages: 45-53
  • NAID: 130003391605
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• [Journal Article] Local apoptosis modulates early mammalian brain development through the elimination of morphogen-producing cells. (2013)
  • Author(s): Nonomura, K., Yamaguchi, Y., Hamachi, M., Koike, M., Uchiyama, Y., Nakazato, K., Mochizuki, A., Sakaue-Sawano, A., Miyawaki, A., Yoshida, H., Kuida, K., *Miura, M.
  • Journal Title: Dev Cell Volume: 27 Pages: 621-634
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• [Journal Article] Exendin-4 improves beta cell function in autophagy-deficient beta cells. (2013)
  • Author(s): Abe, H., Uchida, T., Hara, A., Mizukami, H., Komiya, K., Koike, M., Shigihara, N., Toyofuku, Y., Ogihara, T., Uchiyama, Y., Yagihashi, S., Fujitani, Y., Watada, H.
  • Journal Title: Endicrinology Volume: 154 Pages: 4512-4524
  • Peer Reviewed
• [Journal Article] Immunocytochemical study of the autophagy marker microtubule-associated protein 1 light chain 3 in normal and steatotic human livers. (2013)
  • Author(s): Kashima, J., Shintani-Ishida, K., Nakajima, M., Maeda, H., Unuma, K., Uchiyama, Y., *Yoshida, K.
  • Journal Title: Hepatology Research Volume: -
  • Peer Reviewed
• [Journal Article] Tuberin activates and controls the distribution of Rac1 via association with p62 and ubiquitin through the mTORC1 signaling pathway. (2013)
  • Author(s): Okura, H., Kobayashi, T., Koike, M., Ohsawa, M., Zhang, D., Arai, H., Uchiyama, Y., *Hino O
  • Journal Title: Int J Oncol Volume: 43 Issue: 2 Pages: 447-456
  • DOI: 10.3892/ijo.2013.1984
  • Peer Reviewed
• [Journal Article] Particle size of latex beads dictates IL-1 production mechanism. (2013)
  • Author(s): Adachi, T., Takahara, K., Taneo, J., Uchiyama, Y., *Inaba, K.
  • Journal Title: PLos One Volume: 8
  • Peer Reviewed
• [Journal Article] Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons. (2013)
  • Author(s): Koike, M., *Tanida, I., Nanao, N., Tada, N., Iwata, J., Ueno, T., Kominami, E., *Uchiyama, Y.
  • Journal Title: PLos One Volume: 8
  • Peer Reviewed
• [Journal Article] ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons. (2013)
  • Author(s): Matsui, H., Sato, F., Sato, S., Koike, M., Taruno, Y., Saiki, S., Funayama, M., Ito, H., Taniguchi, Y., Uemura, N., Toyoda, A., Sakaki, Y., Takeda, S., Uchiyama, Y., Hattori, N., *Takahashi, R.
  • Journal Title: FEBS letters Volume: 9 Pages: 1316-25
  • Peer Reviewed
• [Journal Article] Biogenesis and proteolytic processing of lysosomal DNase II. (2013)
  • Author(s): Ohkouchi S, Shibata M, Sasaki M, Koike M, Safig P, Peters C, Nagata S, *Uchiyama Y
  • Journal Title: PLos One Volume: 8
  • Peer Reviewed
• [Journal Article] Lysosomal storage and advanced senescence in the brain of LAMP-2-deficient Danon disease. (2013)
  • Author(s): Furuta, A., Wakabayashi, K., Haratake, J., Kikuchi, H., Kabuta, T., Mori, F., Tokonami, F., Katsumi, Y., Tanioka, F., Uchiyama, Y., Nishino, I., Wada, K.
  • Journal Title: Acta Neuropathol Volume: 125 Pages: 459-461
  • Peer Reviewed
• [Journal Article] Differences in expression patterns of cathepsin C/dipeptidyl peptidase I in normal, pathological and aged mouse central nervous systems. (2013)
  • Author(s): Koike, M., Shibata, M., Ezaki, J., Peters, C., Saftig, P., Kominami, E., Uchiyama, Y.
  • Journal Title: Eur J Neurosci Volume: 37 Pages: 816-830
  • Peer Reviewed
• [Journal Article] Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons. (2013)
  • Author(s): Koike M
  • Journal Title: ProsOne Volume: in press
  • Peer Reviewed
• [Journal Article] Biogenesis and Proteolytic Processing of Lysosomal DNase II. (2013)
  • Author(s): Ohkouchi, S., Shibata, M., Sasaki, M., Koike, M., Safig, P., Peters, C., Nagata, S., and Uchiyama, Y.
  • Journal Title: PloS One Volume: 8 Issue: 3 Pages: e59148-e59148
  • DOI: 10.1371/journal.pone.0059148
  • Peer Reviewed
• [Journal Article] c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis. (2013)
  • Author(s): Piao X
  • Journal Title: Sci Signal Volume: ra93 Issue: 255
  • DOI: 10.1126/scisignal.2003558
  • Peer Reviewed
• [Journal Article] Resveratrol affects undifferentiated and differentiated PC12 cells differently, particularly with respect to possible differences in mitochondrial and autophagic fuctions (2013)
  • Author(s): Hyakawa N., Shiozaki M., Shibata M., Koike M., Uchiyama Y., Matsuura N., Gotow T.
  • Journal Title: Eur. J. Cell Biol Volume: 92 Issue: 1 Pages: 30-43
  • DOI: 10.1016/j.ejcb.2012.10.002
  • Peer Reviewed
• [Journal Article] Motor neuron-specific disruption of proteasomes, but not autophagy, replicates amyotrophic lateral sclerosis (2012)
  • Author(s): Y. Tashiro
  • Journal Title: Journal of Biological Chemistry Volume: 287 Issue: 51 Pages: 42984-42994
  • DOI: 10.1074/jbc.m112.417600
  • Peer Reviewed
• [Journal Article] Development of Purkinje cell degeneration in a knockin mouse model reveals lysosomal involvement in the pathogenesis of SCA6. (2012)
  • Author(s): Unno T
  • Journal Title: Proc Natl Acad Sci USA Volume: 109 Pages: 17693-17698
  • Peer Reviewed
• [Journal Article] Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5. (2012)
  • Author(s): Sekine S
  • Journal Title: J Biol Chem Volume: 287 Pages: 34635-34645
  • Peer Reviewed
• [Journal Article] Mitochondrial dysfunction associated with increased oxidative stress and -synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue. (2012)
  • Author(s): Imaizumi Y
  • Journal Title: Mol Brain Volume: 5 Issue: 1 Pages: 35-35
  • DOI: 10.1186/1756-6606-5-35
  • Peer Reviewed
• [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy. (2012)
  • Author(s): Klionsky D
  • Journal Title: Atuophagy Volume: 8:4 Pages: 1-100
  • Peer Reviewed
• [Journal Article] 脂肪滴とオートファジー (2011)
  • Author(s): 内山安男
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 33(4) Pages: 338-343
• [Journal Article] Dissociation and dispersion of claudin-3 from the tight junction could be one of the most sensitive indicators of reflux esophagitis in a rat model of the disease (2011)
  • Author(s): Oguro M, ら
  • Journal Title: J Gastroenterol Volume: 46 Pages: 629-638
  • Peer Reviewed
• [Journal Article] Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1 (2011)
  • Author(s): Koyanagi M, ら
  • Journal Title: PLos One Volume: 6
  • Peer Reviewed
• [Journal Article] Closer association of mitochondria with lipid droplets in hepatocytes and activation of Kupffer cells in resveratrol-treated senescence-accelerated mice (2011)
  • Author(s): Shiozaki, M, ら
  • Journal Title: Histochem.Cell Biol. Volume: 136 Pages: 475-489
  • Peer Reviewed
• [Journal Article] Intracellular Phosphatidylserine Regulates Membrane Traffic Through Endosomes (2011)
  • Author(s): Uchida, Y, ら
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 108 Pages: 15846-15851
  • Peer Reviewed
• [Journal Article] Grafted human induced pluripotent stem cell-derived neurospheres promotes motor functional recovery after spinal cord injury in mice (2011)
  • Author(s): Nori, S, ら
  • Journal Title: Proc.Natl.Acad.Sci.USA Volume: 108 Pages: 16825-16830
  • Peer Reviewed
• [Journal Article] Enhancement of autophagy is a potential modality for tumors refractory to radiotherapy (2011)
  • Author(s): Kuwahara Y, Oikawa T, Ochiai Y, Roudkenar, M Fukumoto, T Shimura, Y Ohtake M H, Ohkubo Y, Mori S, Uchiyama Y, Fukumoto M
  • Journal Title: Cell Death Dis (2011) Volume: 2 Issue: 6 Pages: e177-e177
  • DOI: 10.1038/cddis.2011.56
  • Peer Reviewed
• [Journal Article] 虚血性細胞死とオートファジー (2011)
  • Author(s): 内山安男
  • Journal Title: 神経内科 Volume: 75 Pages: 169-175
• [Journal Article] リソソームプロテアーゼの多様性とその病態生理学的役割 (2011)
  • Author(s): 小池正人、内山安男
  • Journal Title: 実験医学増刊号 Volume: 29 Pages: 1903-1908
• [Presentation] 中枢神経系におけるLC3A/B の役割 (2014)
  • Author(s): 山口隼司, 砂堀毅彦, 七尾友久, 佐々木光穂, 小池正人, 内山安男
  • Organizer: 第119回日本解剖学会総会
  • Place of Presentation: 自治医科大学
  • Year and Date: 2014-03-29
• [Presentation] 低酸素脳虚血障害とLC3 欠損マウス (2014)
  • Author(s): 山口隼司, 砂堀毅彦, 七尾友久, 佐々木光穂, 小池正人, 内山安男
  • Organizer: 第19回グリアクラブ
  • Place of Presentation: 新潟県湯沢
  • Year and Date: 2014-03-02
• [Presentation] リソソーム蓄積症とオートファジー (学術教育講演) (2014)
  • Author(s): 内山 安男
  • Organizer: 第１１９回日本解剖学会総会•全国学術集会
  • Place of Presentation: 自治医科大学
  • Invited
• [Presentation] 神経細胞の極性とオートファジー (2014)
  • Author(s): 内山 安男
  • Organizer: 第１９回グリアクラブ特別講演
  • Place of Presentation: 新潟
  • Invited
• [Presentation] 神経系におけるオートファジー (2014)
  • Author(s): 内山 安男
  • Organizer: 大阪大学蛋白質研究所セミナー 「オートファジーと疾患」
  • Place of Presentation: 大阪大学蛋白質研究所
  • Invited
• [Presentation] Memorial lecture for the Late Prof. emer. Tsuneo Fujita – Lesson from “Science” of Prof. Fujita. (2013)
  • Author(s): Yasuo Uchiyama
  • Organizer: The 23rd International Symposium on Morphological Sciences
  • Place of Presentation: Niigata
  • Invited
• [Presentation] 極性のあるニューロンへのリソソームオートファゴソームの局在について (2013)
  • Author(s): 内山安男
  • Organizer: 日本薬学会１３３年会
  • Place of Presentation: パシフィコ横浜
  • Invited
• [Presentation] 軸索終末部におけるAtg9Aを含む小胞の膜成分の精製および解析 (2013)
  • Author(s): 山口隼司
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] 初代培養神経細胞の成熟過程におけるリソソームの局在動態について (2013)
  • Author(s): 七尾友久
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] オートファジーモニタリングトランスジェニックマウスを用いた軸索終末部におけるオートファジーの機能解析 (2013)
  • Author(s): 佐々木光穂
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] オートファジー／リソソームプロテアーゼの腎虚血再灌流尿細管傷害における役割について (2013)
  • Author(s): 鈴木ちぐれ
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] SCA1モデルマウスにおけるプルキンエ細胞の初期変化について (2013)
  • Author(s): 古田晶子
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] Characteristic differences between Purkinje cells specifically deficient in cathepsin D and Atg7 (2013)
  • Author(s): 小池正人
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] Toll様受容体を介したオートファジー誘導機構について (2013)
  • Author(s): 砂堀毅彦
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] スリット1,2ダブルノックアウトマウスにおけるGnRHニューロンの移動と軸索投射 (2013)
  • Author(s): 村上志津子
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] 発生に伴う脳の内外の周皮細胞の変化 (2013)
  • Author(s): 宮川桃子
  • Organizer: 第１１８回日本解剖学会総会ポスター発表
  • Place of Presentation: サンポートホール高松・かがわ国際会議場
• [Presentation] 腎虚血尿細管傷害におけるオートファジー・リソソーム系の関わりについて (2012)
  • Author(s): 鈴木ちぐれ, ら
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
  • Year and Date: 2012-03-28
• [Presentation] リソソーム膜タンパク質LAMP-2の中枢神経系における役割 (2012)
  • Author(s): 古田晶子、内山安男
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
  • Year and Date: 2012-03-28
• [Presentation] Protective effects of hyaluronan tetrasaccharide on hippocampal pyramidal neurons in neonatal mouse after hypoxic-ischemic injury (2012)
  • Author(s): Sunabori Takehiko, Masato Koike, Yasuo Uchiyama
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
  • Year and Date: 2012-03-28
• [Presentation] 正常および老齢マウス脳におけるリソゾームカテプシンCの分布 (2012)
  • Author(s): 小池正人、内山安男
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
  • Year and Date: 2012-03-27
• [Presentation] ほ乳類Atg9AmRNAノックダウンHeLa細胞について/A study on Atg9AmRNA-knockdown HeLa cells (2012)
  • Author(s): 多村博澄、佐々木光穂、小池正人、内山安男
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
  • Year and Date: 2012-03-27
• [Presentation] mAtg9A-AcGFPおよびmDFCP1-mCherryトランスジェェニックマウスの作製 (2012)
  • Author(s): 佐々木光穂、多村博澄、多田昇弘、内山安男
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
  • Year and Date: 2012-03-27
• [Presentation] Autophagy in the neural network and its impairment (2012)
  • Author(s): Yasuo Uchiyama
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
  • Year and Date: 2012-03-26
• [Presentation] 発生初期過程の脳におけるPSA-NCAM陽性周皮細胞の動態 (2012)
  • Author(s): 宮川桃子、石龍徳、内山安男
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
  • Year and Date: 2012-03-26
• [Presentation] 鼻プラコード由来ソマトスタチンmRNA陽性細胞の前脳進入と定着 (2012)
  • Author(s): 村上志津子、浜崎浩子、内山安男
  • Organizer: 第117回日本解剖学会総会・全国学術集会
  • Place of Presentation: 山梨大学甲府キャンパス
  • Year and Date: 2012-03-26
• [Presentation] リソソーム蓄積症とオートファジー (2012)
  • Author(s): 内山安男
  • Organizer: 平成23年度蛋白研セミナー神経疾患の克服に向けて
  • Place of Presentation: 大阪大学蛋白質研究所(招待講演)
  • Year and Date: 2012-03-02
• [Presentation] カテプシンBDダブルノックアウトマウスの中枢神経系の形態学的解析 (2012)
  • Author(s): 小池正人、山口隼司、内山安男
  • Organizer: 第17回グリアクラブ
  • Place of Presentation: ヒルトンニセコビリッジ
  • Year and Date: 2012-03-01
• [Presentation] 初代培養神経細胞の成熟過程に見られるリソソーム/オートファジー関連タンパク質の動態 (2012)
  • Author(s): 七尾友久、内山安男
  • Organizer: 第17回グリアクラブ
  • Place of Presentation: ヒルトンニセコビリッジ
  • Year and Date: 2012-03-01
• [Presentation] Hyaluronan tetrasaccharide rescues hippocampal pyramidal neuron death after hypoxic-ischemic injury. (2012)
  • Author(s): Yasuo Uchiyama
  • Organizer: 第１４回国際組織細胞化学会（ICHC２０１２）
  • Place of Presentation: 国立京都国際会館
  • Invited
• [Presentation] Characteristic differences between Purkinje cells specifically deficient in cathepsin D and Atg7 (2012)
  • Author(s): Yasuo Uchiyama
  • Organizer: 6th International Symposium on Autophagy
  • Place of Presentation: 沖縄 万国津梁館
  • Invited
• [Presentation] Cell death and autophagy (2012)
  • Author(s): Uchiyama, Y
  • Organizer: The XXII International Symposium on Morphological Sciences
  • Place of Presentation: Sao Paulo in Brazil(招待講演)
• [Presentation] New neurons use Slit 1 to maintain astrocytic tunnels for their rapidmigration in the adult brain (2011)
  • Author(s): Naoko Kaneko, ら
  • Organizer: 41st Annual Meeting Society for Neuroscience
  • Place of Presentation: ワシントン・コンベンション・センター
  • Year and Date: 2011-11-15
• [Presentation] Possible roles of LC3, ubiquitin, and P62 and/or Nbr1 in the accumulation of lysosomes in neurons deficient in Cathepsin D (2011)
  • Author(s): Masato Koike, Yasuo Uchiyama
  • Organizer: 41st Annual Meeting Society for Neuroscience
  • Place of Presentation: ワシントン・コンベンション・センター
  • Year and Date: 2011-11-13
• [Presentation] Protective effects of hyaluronan tetrasaccharide on hippocampal pyramidal neurons in neonatal mouse brains after hypoxic-ischemic injury (2011)
  • Author(s): Sunabori Takehiko, Masato Koike, Yasuo Uchiyama
  • Organizer: 41 st Annual Meeting Society for Neuroscience
  • Place of Presentation: ワシントン・コンベンション・センター
  • Year and Date: 2011-11-13
• [Presentation] 神経分化と造腫瘍性から迫るヒトiPS細胞の品質評価 (2011)
  • Author(s): 岡田洋平, ら
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-09-17
• [Presentation] 虚血生侵襲に対するヒアルロン酸4糖の神経細胞保護効果の検討 (2011)
  • Author(s): 砂堀毅彦、小池正人、内山安男
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-09-17
• [Presentation] カテプシンD欠損に伴う神経性ロイドリポフスチン蓄積症の病態形成にオートファジーが果たす役割について (2011)
  • Author(s): 小池正人、内山安男
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-09-15
• [Presentation] The autophagy/lysosomal system is essential for the maintenance of the axon and its terminal (2011)
  • Author(s): Uchiyama, Y
  • Organizer: The synapse from physiology to pathology
  • Place of Presentation: Stresa in Italy(招待講演)
• [Presentation] Acceleration of autophagy results in neurodegeneration (2011)
  • Author(s): Uchiyama, Y
  • Organizer: 第10回日中合同組織細胞化学セミナー
  • Place of Presentation: 中国北京市首都医科大学(招待講演)
• [Presentation] 電子顕微鏡方法論
  • Author(s): 内山 安男
  • Organizer: （独）医薬基盤研セミナー
  • Place of Presentation: （独）医薬基盤研究所
  • Invited
• [Book] Autophagy regulates lipid droplet formation and adipogenesis. In : Lipid metabolism. (Ed by Rodrigo Valenzuela Baez) (2013)
  • Author(s): Uchiyama Y, Kominami E
• [Book] Autophagy regulates lipid droplet formation and adipogenesis. In: Lipid metabolism. Ed by Rodrigo Valenzuela Baez. (2013)
  • Author(s): Uchiyama Y, Kominami E
  • Publisher: InTech
• [Book] Autophagy regulates lipid droplet formation and adipogenesis. In: Lipid metabolism. Ed by Rodrigo Valenzuela Baez. (2013)
  • Author(s): Uchiyama Y
  • Publisher: InTech
• [Book] Genetic mouse models for elucidation of autophagy-lysosomal systems in neurons under physiologic and pathologic conditions. In Ed. Zhenyu yue, Charleen T Chu: Autophagy of the nervous system – Cellular self-digestion in neurons and neurological diseases. (2012)
  • Author(s): Komatsu M
  • Publisher: World Scientific
• [Book] Autophagy of the nervous system World Scientifc(Ed by Zhenyu Yue and Charleen Chu) (2012)
  • Author(s): Komatsu M, Koike M, Ichimura Y, Uchiyama Y
  • Total Pages: 464
  • Publisher: Genetic Mouse Models for Elucidation of Autophagy-Lysosomal Systems in Neurons Under Physiologic and Pathologic Condition
• [Remarks]
  • URL: http://www.juntendo.ac.jp/graduate/laboratory/labo/shinkei_kozo/