| Project/Area Number |
23390044
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKATA Masanori 自治医科大学, 医学部, 准教授 (10305120)
MAEJIMA Yuko 自治医科大学, 医学部, 助教 (40438669)
IWASAKI Yusaku 自治医科大学, 医学部, 助教 (60528420)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | Nesfatin-1 / オキシトシン / 視床下部室傍核 / 摂食 / 概日リズム / 抗肥満 / 求心性迷走神経 / 肥満症 / POMC / メタボリックシンドローム / 迷走神経 |
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| Research Abstract |
Nesfatin-1 mRNA expression in the paraventricular nucleus (PVN) of hypothalamus exhibits circadian rhythm with light phase rise, which drives circadian feeding rhythm in rats,. Impairment of the nesfatin-1 rhythm causes impairment of feeding rhythm, hyperphagia and obesity. Supplementation of nesfatin-1 in light phase ameliorates these metabolic disorders.The PNV nesfatin-1 neuron is directly activated by meal-evoked factors, glucose and insulin, and by light-induced neuropeptide PACAP, while it signals to the PVN oxytocin neuron as the downstream effector.
Peripheral administration of oxytocin corrects hyperphagia, obesity, hyperglycemia and fatty liver in high fat diet-fed mice with obesity syndrome. These effects are partly mediated by the signal transfer to the brain via vagal afferent nerves. These results provide a basis for the treatment of human obesity.
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