Regulation by nesfatin and oxytocin of feeding, metabolism and circadian rhythm, as a basis for treating life style-related diseases
| Project/Area Number |
23390044
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKATA Masanori 自治医科大学, 医学部, 准教授 (10305120)
MAEJIMA Yuko 自治医科大学, 医学部, 助教 (40438669)
IWASAKI Yusaku 自治医科大学, 医学部, 助教 (60528420)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Keywords | Nesfatin-1 / オキシトシン / 視床下部室傍核 / 摂食 / 概日リズム / 抗肥満 / 求心性迷走神経 / 肥満症 / POMC / メタボリックシンドローム / 迷走神経 |
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| Research Abstract |
Nesfatin-1 mRNA expression in the paraventricular nucleus (PVN) of hypothalamus exhibits circadian rhythm with light phase rise, which drives circadian feeding rhythm in rats,. Impairment of the nesfatin-1 rhythm causes impairment of feeding rhythm, hyperphagia and obesity. Supplementation of nesfatin-1 in light phase ameliorates these metabolic disorders.The PNV nesfatin-1 neuron is directly activated by meal-evoked factors, glucose and insulin, and by light-induced neuropeptide PACAP, while it signals to the PVN oxytocin neuron as the downstream effector.
Peripheral administration of oxytocin corrects hyperphagia, obesity, hyperglycemia and fatty liver in high fat diet-fed mice with obesity syndrome. These effects are partly mediated by the signal transfer to the brain via vagal afferent nerves. These results provide a basis for the treatment of human obesity.
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Report
(4 results)
Research Products
(60 results)
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[Presentation] 膵臓を支配する求心性迷走神経は膵臓から分泌されるインスリンを効率良く受容する2013
Author(s)
岩崎有作, 下村健寿, 河野大輔, 出崎克也, Enkh-Amar Ayush, 中林肇, 窪田直人, 門脇孝, 加計正文, 中田正範, 矢田俊彦
Organizer
第34回日本肥満学会
Place of Presentation
東京
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