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Food entrainable circadian rhythm in humans

Research Project

Project/Area Number 23390047
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionHokkaido University

Principal Investigator

HONMA Ken-ichi  北海道大学, ―, 名誉教授 (40113625)

Co-Investigator(Renkei-kenkyūsha) NISHIDE Shin-ya  北海道大学, 大学院・医学研究科, 助教 (40451398)
YAMANAKA Yujiro  北海道大学, 大学院・医学研究科, 助教 (20528343)
HASHIMOTO Satoko  北海道大学, 大学院・医学研究科, 学術研究員 (80374247)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords生物時計 / 食事 / 生体リズム / コルチゾール / 睡眠 / メラトニン / レプチン / グレリン / フリーランリズム / 食事回数 / リズム同調 / 睡眠覚醒リズム / メラトニンリズム / 血糖値 / インスリン
Research Abstract

Appearance of premeal anticipatory hormone peak and entrainability of restricted meal schedule were examined in humans who stayed in a temporal isolation facility without knowing the time of day. Meal was supplied once a day for 10 days. As a result, the premeal peak was not detected in plasma melatonin, cortisol, insulin, ghrelin, and leptin. On the other hand, the sleep-wake cycle was entrained by the meal schedule, whereas the circadian melatonin rhythm was not entrained showing phase-delay shifts. These findings indicated that the so-called food entrainable circadian rhythm failed to appear in humans under the present conditions, and that the meal schedule was the time cue for the sleep-wake cycle but not for the circadian pacemaker.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (56 results)

All 2014 2013 2012 2011 Other

All Journal Article (38 results) (of which Peer Reviewed: 24 results) Presentation (18 results) (of which Invited: 4 results)

  • [Journal Article] Dual regulation of clock gene Per2 expression in discrete brain areas by the circadian pacemaker and methamphetamine-induced oscillator in rats2014

    • Author(s)
      Natsubori A, Honma K and Honma S
    • Journal Title

      Eur J Neurosci

      Volume: 39(2) Pages: 229-240

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sleep-wake cycles in humans2013

    • Author(s)
      Honma, K., Hashimoto, S., Natsubori A., Masubuchi, S. and Honma S
    • Journal Title

      India J Sleep Med

      Volume: 8(2) Pages: 51-57

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Daily exposure to a running wheel entrains circadian rhythms in mice in parallel with development of an increase in spontaneous movement prior to running-wheel access2013

    • Author(s)
      Yamanaka Y, Honma S and Honma K
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 305(11)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Organ specific development characterizes circadian clock gene Per2 expression in rats2013

    • Author(s)
      Nishide SY, Hashimoto K, Nishio T, Honma K and Honma S
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 306(1)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Postnatal Constant Light Compensates Cryptochrome1 and 2 Double Deficiency for Disruption of Circadian Behavioral Rhythms in Mice under Constant Dark2013

    • Author(s)
      Ono D, Honma S and Honma K
    • Journal Title

      PLoS One

      Volume: 8(11) Issue: 11 Pages: 380615-380615

    • DOI

      10.1371/journal.pone.0080615

    • NAID

      120005348969

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential responses of circadian Per2 rhythms in cultured slices of discrete brain areas from rats showing internal desynchronisation by methamphetamine2013

    • Author(s)
      Natsubori A, Honma K and Honma S
    • Journal Title

      Eur J Neurosci

      Volume: 38(4) Pages: 2566-2571

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Monitoring circadian time in rat plasma using a secreted Cypridina luciferase reporter2013

    • Author(s)
      Yamada Y, Nishide S, Nakajima Y, Watanabe T, Ohmiya Y, Honma K and Honma S
    • Journal Title

      Anal Biochem

      Volume: 439(2) Pages: 80-87

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cryptochromes are critical for the development of coherent circadian rhythms in the mouse suprachiasmatic nucleus2013

    • Author(s)
      Ono D, Honma S and Honma K
    • Journal Title

      Nat Commun

      Volume: 4 Pages: 1666-1666

    • NAID

      120005343762

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Daily exposure to cold phase-shifts circadian clock of neonatal rat in vivo2013

    • Author(s)
      Yoshikawa T, Matsuno A, Yamanaka Y, Nishide S, Honma S and Honma K
    • Journal Title

      Eur J Neurosci

      Volume: 37(3) Pages: 491-497

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential responses of circadian Per2 expression rhythms in discrete brain areas to daily injection of methamphetamine and restricted feeding in rats2013

    • Author(s)
      Natsubori A, Honma K and Honma S
    • Journal Title

      Eur J Neurosci

      Volume: 37(2) Pages: 251-258

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 体温と睡眠の概日リズム2013

    • Author(s)
      本間研一
    • Journal Title

      概日リズムと疾患, 日本臨床

      Volume: 71(12) Pages: 2076-2081

    • Related Report
      2013 Final Research Report
  • [Journal Article] サマータイムと睡眠. 最新臨床睡眠学-睡眠障害の基礎と臨床-2013

    • Author(s)
      本間研一
    • Journal Title

      日本臨床

      Volume: 71(5) Pages: 736-741

    • Related Report
      2013 Final Research Report
  • [Journal Article] 生体リズムの基礎. 最新臨床睡眠学-睡眠障害の基礎と臨床-2013

    • Author(s)
      本間研一
    • Journal Title

      日本臨床

      Volume: 71(5) Pages: 40-45

    • Related Report
      2013 Final Research Report
  • [Journal Article] 睡眠リズムの分子生物学2013

    • Author(s)
      本間研一, 橋本聡子, 夏堀晃世
    • Journal Title

      Clinical Neuroscience

      Volume: 31(2) Pages: 152-156

    • Related Report
      2013 Final Research Report
  • [Journal Article] 睡眠リズムの分子生物学2013

    • Author(s)
      本間研一、橋本聡子、夏堀晃世
    • Journal Title

      Clinical Neuroscience

      Volume: 31 Pages: 152-156

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 生体リズムの基礎2013

    • Author(s)
      本間研一
    • Journal Title

      日本臨床

      Volume: 71 Pages: 736-741

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Skeep-wake cycles in humans2013

    • Author(s)
      Honma K, Hashimoto S, Matsubori A, Masubuchi S, Honma S.
    • Journal Title

      India J Sleep Med

      Volume: 8 Pages: 51-57

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Differential responses of circadian Per2 expression rhythms in discrete brain areas to daily injection of methamphetamine and restricted feeding in rats.2013

    • Author(s)
      Natsubori A. et al.
    • Journal Title

      Eur.J.Neurosci.

      Volume: 37 Issue: 2 Pages: 251-258

    • DOI

      10.1111/ejn.12034

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Daily exposure to cold phase-shifts circadian clock of neonatal rat in vivo2013

    • Author(s)
      Yoshikawa T, Matsuno A, Yamanaka Y, Nishide S, Honma S and Honma K
    • Journal Title

      Eur.J.Neurosci

      Volume: 37 Issue: 3 Pages: 491-497

    • DOI

      10.1111/ejn.12052

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fast synchronous oscillations of firing rate in cultured rat suprachiasmatic nucleus neurons: possible role in circadian synchronization in the intact nucleus.2013

    • Author(s)
      Kononenko KI, et al.
    • Journal Title

      Neurosci. Res.

      Volume: 75 Pages: 218-227

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-cell resolution fluorescence imaging of circadian rhythms detected with a Nipkow spinning disk confocal system2012

    • Author(s)
      Enoki R, Ono D, Hasan MT, Honma S, Honma K
    • Journal Title

      J Neurosci Methods

      Volume: 207(1) Pages: 72-79

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] De novo synthesis of PERIOD initiates circadian oscillation in cultured mouse suprachiasmatic nucleus after prolonged inhibition of protein synthesis by cycloheximide2012

    • Author(s)
      Nishide, S., D. Ono, Y. Yamada, S. Honma and K. Honma
    • Journal Title

      Eur J Neurosci

      Volume: 35(2) Pages: 291-299

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Topological specificity and hierarchical network of the circadian calcium rhythm in the suprachiasmatic nucleus2012

    • Author(s)
      Enoki R, Kuroda S, Ono D, Hasan MT, Ueda T, Honma S and Honma K
    • Journal Title

      Proc Natl Acad Sci USA

    • NAID

      120005295647

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 現代型不眠~日本人の体内時計の乱れを考える~2012

    • Author(s)
      本間研一
    • Journal Title

      実験治療

      Volume: 707 Pages: 113-113

    • Related Report
      2013 Final Research Report
  • [Journal Article] 体温・睡眠リズム2012

    • Author(s)
      本間研一. 橋本聡子
    • Journal Title

      医学のあゆみ

      Volume: 242(11) Pages: 845-850

    • Related Report
      2013 Final Research Report
  • [Journal Article] 図説 : 生体リズムと睡眠2012

    • Author(s)
      本間研一
    • Journal Title

      日本臨床

      Volume: 70(7) Pages: 1090-1093

    • Related Report
      2013 Final Research Report
  • [Journal Article] 体内時計と睡眠2012

    • Author(s)
      本間研一
    • Journal Title

      BRAIN and NERVE

      Volume: 64(6) Pages: 639-646

    • Related Report
      2013 Final Research Report
  • [Journal Article] De novo synthesis of PERIOD initiates circadian oscillation in cultured mouse suprachiasmatic nucleus after prolonged inhibition of protein synthesis by cycloheximide.2012

    • Author(s)
      Nishide S, et al.
    • Journal Title

      Eur J Neurosci

      Volume: 35 Pages: 291-299

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-cell resolution fluorescence imaging of circadian rhythms detected with a Nipkow spinning disk confocal system.2012

    • Author(s)
      Enoki R, et al.
    • Journal Title

      J Neurosci Methods

      Volume: 202 Pages: 72-29

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Topological specificity and hierarchical network of the circadian calcium rhythm in the suprachiasmatic nucleus2012

    • Author(s)
      Enoki R, Kuroda S, Ono C, Hasan MT, Honma S, Ueda T and Honma K
    • Journal Title

      Proc.Natl. Acad.Sci USA

      Volume: 109 Issue: 52 Pages: 21498-21503

    • DOI

      10.1073/pnas.1214415110

    • NAID

      120005295647

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 体内時計と睡眠2012

    • Author(s)
      本間 研一
    • Journal Title

      BRAIN and NERVE

      Volume: 64 Pages: 639-646

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 図説:生体リズムと睡眠2012

    • Author(s)
      本間 研一
    • Journal Title

      日本臨床

      Volume: 70 Pages: 1090-1093

    • Related Report
      2012 Annual Research Report
  • [Journal Article] 体温・睡眠のリズム2012

    • Author(s)
      本間 研一
    • Journal Title

      医学のあゆみ

      Volume: 242 Pages: 845-850

    • Related Report
      2012 Annual Research Report
  • [Journal Article] De novo synthesis of PERIOD initiates circadian oscillation in cultured mouse suprachiasmatic nucleus after prolonged inhibition of protein synthesis by cycloheximide2012

    • Author(s)
      Nishide, S.Y., Ono, D., Yamada, Y., Honma, S., Honma, K.
    • Journal Title

      Eur.J.Neurosci.

      Volume: 35 Issue: 2 Pages: 291-299

    • DOI

      10.1111/j.1460-9568.2011.07952.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] JNK regulates the photic response of the mammalian circadian clock2012

    • Author(s)
      Yoshitane H., et al.
    • Journal Title

      EMBO J

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-cell resolution fluorescence imaging of circadian rhythms detected with a Nipkow spinning disk confocal system2012

    • Author(s)
      Enoki R., et al.
    • Journal Title

      J Neruophysiol Method

      Volume: 207 Pages: 72-79

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Light responsiveness of clock genes, Per1 and Per2, in the olfactory bulb of mice2011

    • Author(s)
      Hamada T, Honma S and Honma K
    • Journal Title

      Biochem Biophys Re Comm

      Volume: 409 Pages: 727-731

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Light responsiveness of clock genes, Per1 and Per2 in the olfactory bulb of mice2011

    • Author(s)
      Hamada T., at al.
    • Journal Title

      Biochemi Biophys Res Comm

      Volume: 409 Pages: 727-731

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 衣食住の時間生物学-ある研究者の挑戦2013

    • Author(s)
      本間研一
    • Organizer
      第20回日本時間生物学会
    • Place of Presentation
      大坂
    • Year and Date
      2013-11-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Non-photic entrainment of human circadian rhythms : a possible mechanism2013

    • Author(s)
      Honma, K
    • Organizer
      XIII Congress of European Biological Rhythm Society
    • Place of Presentation
      Munich (Germany)
    • Year and Date
      2013-08-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 睡眠・覚醒リズムの進化2013

    • Author(s)
      本間研一
    • Organizer
      日本睡眠学会第38回定期学術集会
    • Place of Presentation
      秋田
    • Year and Date
      2013-06-27
    • Related Report
      2013 Final Research Report
  • [Presentation] Interaction of Methamphetamine-induced Oscillation and the SCN Circadian Clock2013

    • Author(s)
      Honma, K
    • Organizer
      25th Annual Meeting of Society for Light Treatment and Biological Rhythms
    • Place of Presentation
      Geneva (Switzerland)
    • Year and Date
      2013-06-22
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト概日リズムの位相変化に対する高照度光下での身体運動の影響2013

    • Author(s)
      山仲勇二郎、他
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      タワーホール船堀(東京都)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Sleep in the Seasons2012

    • Author(s)
      Honma, K
    • Organizer
      13th Congress of Turkish Sleep Medicine
    • Place of Presentation
      Antalya (Turkey)
    • Year and Date
      2012-12-13
    • Related Report
      2013 Final Research Report
  • [Presentation] How to realize a causality of sequential events of bodily functions with sleep. Symposium : Active Brain in Sleep - New Approaches to the Brain Functions -2012

    • Author(s)
      Honma, K
    • Organizer
      The 7th ASRS Congress
    • Place of Presentation
      Taipei (Taiwan)
    • Year and Date
      2012-12-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Sleep-Wake Cycle in Humans : a classic but new approach2012

    • Author(s)
      Honma K
    • Organizer
      International Symposium on Frontiers in Sleep and Biological Rhythms' Research
    • Place of Presentation
      Izmir (Turkey)
    • Year and Date
      2012-04-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional Structure of Circadian Clock in the Suprachiasmatic Nucleus - a hierarchical multi-oscillator system2012

    • Author(s)
      本間研一
    • Organizer
      第89回日本生理学会
    • Place of Presentation
      松本
    • Year and Date
      2012-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional structure of circadian clock in the suprachiasmatic nulceus ; a hierarchical multi-oscillator system2012

    • Author(s)
      本間研一
    • Organizer
      第8回日本生理学会大会
    • Place of Presentation
      松本文化会館(長野)(招待講演)
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Circadian Clock and Slee-Wake Cycle2011

    • Author(s)
      Honma K.
    • Organizer
      Worldsleep2011
    • Place of Presentation
      Kyoto International Conference Centre (Kyoto)(招待講演)
    • Year and Date
      2011-10-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Circadian organization of brain functions in mammals-from molecular to behavior2011

    • Author(s)
      Honma K.
    • Organizer
      The7th Congress of the Federation of Asian and Oceanian Physiological Societies
    • Place of Presentation
      Conference Hall of Taipei University (Taiwan)(招待講演)
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Circadian regulation of behaviors in mammalian2011

    • Author(s)
      Honma K.
    • Organizer
      The 3rd World Congress of Chronobiology
    • Place of Presentation
      Cultural Complex of the Benemerita Universidad Auto noma de Puebla (Mexico)(招待講演)
    • Year and Date
      2011-05-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Non-photic entrainment of human circadian rhythms

    • Author(s)
      Honma K
    • Organizer
      XIII Congress of European Biological Rhythm Society
    • Place of Presentation
      Munich, Germany
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 睡眠・覚醒リズムの進化

    • Author(s)
      本間研一
    • Organizer
      日本睡眠学会第38回定期学術集会
    • Place of Presentation
      秋田市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 衣食住の時間生物学

    • Author(s)
      本間研一
    • Organizer
      第20回日本時間生物学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 一日一食の制限給餌がヒト給餌性リズムを発現させるか

    • Author(s)
      本間研一、他
    • Organizer
      第19回日本時間生物学会学術大会
    • Place of Presentation
      北海道大学学術交流会館(札幌市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Sleep in the Seasons

    • Author(s)
      Honma K.
    • Organizer
      13th Congress of Turkish Sleep Medicine
    • Place of Presentation
      Zeynep Golf Resort Hotel (Turkey)
    • Related Report
      2012 Annual Research Report
    • Invited

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Published: 2011-04-06   Modified: 2019-07-29  

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