Neurobiological mechanisms underlying olfactory bonds
| Project/Area Number |
23390050
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Kochi University |
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Principal Investigator |
KABA Hideto 高知大学, 教育研究部医療学系, 教授 (50136371)
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| Co-Investigator(Kenkyū-buntansha) |
OKUTANI Fumino 高知大学, 教育研究部医療学系, 准教授 (10194490)
TANIGUCHI Mutsuo 高知大学, 教育研究部医療学系, 助教 (10304677)
MURATA Yoshihiro 高知大学, 教育研究部医療学系, 助教 (40377031)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Keywords | 匂い / 記憶 / 学習 / 嗅球 / グルタミン酸受容体 / プロテインキナーゼ / タンパク質合成 / ヒストンアセチル化 / 副嗅球 / 主嗅球 / 僧帽細胞 / 顆粒細胞 / アセチル化ヒストン / 代謝型グルタミン酸受容体 |
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| Research Abstract |
In this study we demonstrate that (1) glutamate endogenously released from mitral cells in the accessory olfactory bulb suppresses synaptic transmission from mitral to granule cells by activating mGluR2, a metabotropic glutamate receptor on the pre- and postsynaptic sites, (2) the activation of the protein kinase PKM zeta and new protein synthesis are required for the late phase of long-term potentiation (L-LTP) at the mitral-to-granule cell synapse and (3) epigenetic mechanisms including histone acetylation are critical for aversive olfactory learning and synaptic plasticity at the mitral-to-granule cell synapse of the olfactory bulb in neonatal rats.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Neurobiology of secure infant attachm ent and attachment despite adversit y : a mouse model2013
Author(s)
Roth TL, Raineki C, Salstein L, Perr y R, Sullivan-Wilson TA, Sloan A, La lji B, Hammock E, Wilson DA, Levitt P, Okutani F, Kaba H, Sullivan RM
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Journal Title
Genes Brain and Behavior
Volume: 12
Issue: 7
Pages: 673-680
DOI
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Peer Reviewed
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[Presentation] フェロモン記憶と個体認知2013
Author(s)
椛秀人, 藤田博子, 吾妻 健, 奥谷文乃, 松波宏明
Organizer
日本味と匂学会第47回大会嗅覚シンポジウム「化学シグナルと嗅覚行動および脳機能」
Place of Presentation
仙台市民会館, 仙台
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