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Neural mechanisms of food intake and social behavior: roles of neuropeptides

Research Project

Project/Area Number 23390052
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionJichi Medical University

Principal Investigator

ONAKA Tatsushi  自治医科大学, 医学部, 教授 (90177254)

Co-Investigator(Kenkyū-buntansha) TAKAYANAGI Yuki  自治医科大学, 医学部, 講師 (10418890)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Keywordsオキシトシン / 摂食 / 社会行動 / PrRP
Research Abstract

Epidemiological studies have suggested interactions between food intake and social behaviors. This study show that food intake and social stimuli activated oxytocin-synthesizing neurons in the hypothalamus, that activation of oxytocin-synthesizing neurons following food intake was caused by activation of prolactin releasing peptide-synthesizing neurons in the medulla oblongata, and that oxytocin released following food intake played an important role in termination of food intake. Considering the data that oxytocin modulates both food intake and social behavior, it is possible to consider that oxytocin plays a role in interaction between food intake and social behavior.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (48 results)

All 2014 2013 2012 2011 Other

All Journal Article (17 results) (of which Peer Reviewed: 5 results) Presentation (30 results) (of which Invited: 3 results) Book (1 results)

  • [Journal Article] ストレス・摂食・社会行動の相互作用 : オキシトシンの働き2014

    • Author(s)
      尾仲達史
    • Journal Title

      心身医学

      Volume: (印刷中)

    • Related Report
      2013 Final Research Report
  • [Journal Article] オキシトシンの働きと老化2014

    • Author(s)
      尾仲達史
    • Journal Title

      最新医学

      Volume: 69巻, 5号 Pages: 1021-1031

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] ストレス・摂食・社会行動の相互作用:オキシトシンの働き2014

    • Author(s)
      尾仲達史
    • Journal Title

      心身医学

      Volume: in press

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Involvement of prolactin-releasing peptide in the activation of oxytocin neurones in response to food intake.2013

    • Author(s)
      Yamashita,M., Takayanagi,Y., Yoshida,M., Nishimori,K., Kusama, M. and Onaka,T.
    • Journal Title

      Journal of Neuroendocrinology

      Volume: 25 Issue: 5 Pages: 455-465

    • DOI

      10.1111/jne.12019

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ストレスと摂食2013

    • Author(s)
      尾仲達史
    • Journal Title

      ストレスアンドヘルスケア

      Volume: 210巻 Pages: 1-4

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] 母性行動と下垂体ホルモン2013

    • Author(s)
      尾仲達史, 高柳友紀
    • Journal Title

      精神科治療学

      Volume: 28巻, 6号 Pages: 777-784

    • Related Report
      2013 Final Research Report
  • [Journal Article] 母性行動と下垂体ホルモン2013

    • Author(s)
      尾仲達史、高柳友紀
    • Journal Title

      精神科治療学

      Volume: 28 Pages: 777-784

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Roles of oxytocin neurones in the control of stress, energy metabolism, and social behaviour2012

    • Author(s)
      Onaka T, Takayanagi Y, Yoshida M
    • Journal Title

      J Neuroendocrinol

      Volume: 24 Issue: 4 Pages: 587-598

    • DOI

      10.1111/j.1365-2826.2012.02300.x

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of exocytosis proteins in rat supraoptic nucleus neurones2012

    • Author(s)
      Tobin V, Schwab Y, Lelos N, Onaka T, Pittman QJ, Ludwig M
    • Journal Title

      J Neuroendocrinol

      Volume: 24 Issue: 4 Pages: 629-641

    • DOI

      10.1111/j.1365-2826.2011.02237.x

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] オキシトシン・バゾプレシンの働きについて2012

    • Author(s)
      尾仲達史
    • Journal Title

      ベビーサイエンス

      Volume: 12巻 Pages: 13-15

    • Related Report
      2013 Final Research Report
  • [Journal Article] オキシトシンとストレス緩和作用2012

    • Author(s)
      尾仲達史, 高柳友紀, 吉田匡秀
    • Journal Title

      Clinical Neuroscience

      Volume: 30巻, 2号 Pages: 212-215

    • Related Report
      2013 Final Research Report
  • [Journal Article] プロラクチン放出ペプチド(PrRP)2012

    • Author(s)
      高柳友紀, 尾仲達史
    • Journal Title

      Clinical Neuroscience

      Volume: 30巻, 2号 Pages: 176-177

    • Related Report
      2013 Final Research Report
  • [Journal Article] オキシトシンとストレス緩和作用2012

    • Author(s)
      尾仲達史、高柳友紀、吉田匡秀
    • Journal Title

      Clinical Neuroscience

      Volume: 30 Pages: 212-215

    • Related Report
      2011 Annual Research Report
  • [Journal Article] プロラクチン放出ペプチド(PrRP)2012

    • Author(s)
      高柳友紀、尾仲達史
    • Journal Title

      Clinical Neuroscience

      Volume: 30 Pages: 176-177

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Effects of RFamide-related peptide (RFRP)-1 and RFRP-3 on oxytocin release and anxiety-related behaviour in rats2011

    • Author(s)
      Kaewwongse M, Takayanagi Y, Onaka T
    • Journal Title

      J Neuroendocrinol

      Volume: Vol.23, No.1 Issue: 1 Pages: 20-27

    • DOI

      10.1111/j.1365-2826.2010.02077.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] オキシトシンに関する最近の話題2011

    • Author(s)
      尾仲達史
    • Journal Title

      ホルモンと臨床

      Volume: 59巻, 5号 Pages: 431-437

    • Related Report
      2013 Final Research Report
  • [Journal Article] The medial amygdala - medullary PrRP-synthesizing neuron pathway mediates neuroendocrine responses to contextual conditioned fear in male rodents

    • Author(s)
      Yoshida M, Takayanagi Y, Onaka T
    • Journal Title

      Endocrinology

      Volume: (In press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 社会的記憶の制御におけるセクレチンーオキシトシンシステムの役割2014

    • Author(s)
      高柳友紀, 尾仲達史
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Final Research Report
  • [Presentation] 社会的記憶の制御におけるセクレチンーオキシトシンシステムの役割2014

    • Author(s)
      高柳友紀、尾仲達史
    • Organizer
      第91回日本生理学会大会
    • Place of Presentation
      鹿児島大学郡元キャンパス(鹿児島市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 摂食によるオキシトシン産生ニューロンの活性化 : そのメカニズムと機能に関する研究2013

    • Author(s)
      山下雅子, 尾仲達史, 神部芳則, 草間幹夫
    • Organizer
      第58回日本口腔外科学会総会・学術大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 下垂体後葉ホルモンとストレス・摂食・社会行動2013

    • Author(s)
      尾仲達史, 高柳友紀, 吉田匡秀
    • Organizer
      創薬薬理フォーラム第21回シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
  • [Presentation] Stress and energy metabolisms : roles of PrRP and oxytocin2013

    • Author(s)
      Onaka T, Takayanagi Y, Yoshida M
    • Organizer
      The 36th Naito Conference on"Molecular Aspects of Energy Balance and Feeding Behavior"
    • Place of Presentation
      Sapporo
    • Related Report
      2013 Final Research Report
  • [Presentation] The medial amygdala-medullary prolactin-releasing peptide neuron pathway mediates neuroendocrine responses to conditioned fear stimuli2013

    • Author(s)
      Yoshida M, Takayanagi Y, Onaka T
    • Organizer
      10th World Congress on Neurohpophysial Hormones(WCNH2013)
    • Place of Presentation
      Bristol, England
    • Related Report
      2013 Final Research Report
  • [Presentation] ストレス, 摂食そして社会行動 : 最近注目されるオキシトシンの働き2013

    • Author(s)
      尾仲達史
    • Organizer
      第54回日本心身医学会総会ならびに学術講演会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 恐怖記憶の想起による神経内分泌反応には内側扁桃体-延髄PrRP 産生ニューロン経路が関与する2013

    • Author(s)
      吉田匡秀, 高柳友紀, 尾仲達史
    • Organizer
      第36回日本神経科学大会(Neuro2013)
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 摂食によるオキシトシン産生ニューロンの活性化:そのメカニズムと機能に関する研究2013

    • Author(s)
      山下雅子、尾仲達史、神部芳則、草間幹夫
    • Organizer
      第58回 日本口腔外科学会総会・学術大会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 下垂体後葉ホルモンとストレス・摂食・社会行動2013

    • Author(s)
      尾仲達史、高柳友紀、吉田匡秀
    • Organizer
      創薬薬理フォーラム第21回シンポジウム
    • Place of Presentation
      日本薬学会長井記念館(東京都渋谷区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ストレス,摂食そして社会行動:最近注目されるオキシトシンの働き2013

    • Author(s)
      尾仲達史
    • Organizer
      第54回日本心身医学会総会ならびに学術講演会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] The medial amygdala-medullary prolactin-releasing peptide neuron pathway mediates neuroendocrine responses to conditioned fear stimuli2013

    • Author(s)
      Yoshida M, Takayanagi Y, Onaka T
    • Organizer
      10th World Congress on Neurohpophysial Hormones(WCNH2013)
    • Place of Presentation
      St Georges, Bristol, England
    • Related Report
      2013 Annual Research Report
  • [Presentation] 恐怖記憶の想起による神経内分泌反応には内側扁桃体ー延髄PrRP産生ニューロン経路が関与する2013

    • Author(s)
      吉田匡秀、高柳友紀、尾仲達史
    • Organizer
      第36回日本神経科学大会(Neuro2013)
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Roles of PrRP-oxytocin system in the control of food intake2012

    • Author(s)
      Takayanagi Y, Yamashita M, Kusama M, Onaka T
    • Organizer
      89th Annual Meeting of Physiological society of Japan
    • Place of Presentation
      Matsumoto, Japan
    • Year and Date
      2012-03-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roles of oxytocin and vasopressin in the control of social behavior2012

    • Author(s)
      Onaka T
    • Organizer
      Satellite symposium of 7th Asia and Oceania Society for Comparative Endocrinology Congress
    • Place of Presentation
      Penang, Malaysia
    • Year and Date
      2012-03-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] エネルギー代謝とストレスにおけるPrRP-オキシトシン系の働き2012

    • Author(s)
      高柳友紀, 山下雅子, 草間幹夫, 尾仲達史
    • Organizer
      第39回日本神経内分泌学会学術集会
    • Place of Presentation
      北九州
    • Related Report
      2013 Final Research Report
  • [Presentation] PrRP-オキシトシン系による摂食調節2012

    • Author(s)
      高柳友紀, 山下雅子, 草間幹夫, 尾仲達史
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Related Report
      2013 Final Research Report
  • [Presentation] 摂食とストレスと社会記憶におけるオキシトシンの働き2012

    • Author(s)
      尾仲達史, 高柳友紀, 吉田匡秀
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] オキシトシンとストレス・摂食・社会行動2012

    • Author(s)
      尾仲達史
    • Organizer
      第2回金沢大学子どものこころサミット
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Roles of oxytocin and vasopressin in the control of social behavior2012

    • Author(s)
      Onaka T
    • Organizer
      Satellite symposium of the 7th Asia and Oceania Society for Comparative Endocrinology (AOSCE) Congress
    • Place of Presentation
      Penang, Malaysia
    • Related Report
      2013 Final Research Report
  • [Presentation] Roles of the medial amygdala in the control of social behaviour in mice2011

    • Author(s)
      Wang Y, Takayanagi Y, Onaka T
    • Organizer
      34th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Yokohama, Japan
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of posterior pituitary hormones in the control of social recognition2011

    • Author(s)
      Onaka T, Takayanagi Y
    • Organizer
      12th International Congress on Amino Acids, Peptides and Proteins
    • Place of Presentation
      Beijing, China
    • Year and Date
      2011-08-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Stress, energy metabolism and social behavior : roles of neurohypophysial hormones2011

    • Author(s)
      Onaka T, Takayanagi Y, Yoshida M
    • Organizer
      9th World Congress on Neurohypophysial Hormones
    • Place of Presentation
      Boston, USA
    • Year and Date
      2011-07-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] 社会行動における内側扁桃体破壊の効果2011

    • Author(s)
      王宇, 高柳友紀, 尾仲達史
    • Organizer
      第34回日本神経科学大会(Neuroscience 2011)
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Roles of oxytocin in the control of social recognition2011

    • Author(s)
      Onaka T, Takayanagi Y
    • Organizer
      The 12th International Congress on Amino Acids, Peptides and Proteins
    • Place of Presentation
      Beijing, China
    • Related Report
      2013 Final Research Report
  • [Presentation] Stress, energy metabolism and social behaviour : Roles of Neurohypophysial Hormones2011

    • Author(s)
      Onaka T, Takayanagi Y, Yoshida M
    • Organizer
      The 9th World Congress on Neurohypophysial Hormones (WCNH 2011)
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Recognising 'significant others' by smell ; the role of vasopressin in the olfactory system2011

    • Author(s)
      Ludwig M, Tobin VA, Hashimoto H, Wacker DW, Bishop VR, Duszkiewicz AJ, Takayanagi Y, Langnaese K, Caquineau C, Noack J, Landgraf R, Meddle SL, Leng G, Onaka T, Engelmann, M
    • Organizer
      The 9th World Congress on Neurohypophysial Hormones (WCNH 2011)
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Roles of oxytocin in the control of social recognition following secretin administration2011

    • Author(s)
      Takayanagi Y, Takashima A, Onaka T
    • Organizer
      The 9th World Congress on Neurohypophysial Hormones (WCNH 2011)
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Effects of medial amygdala lesions upon social behaviour in mice2011

    • Author(s)
      Wang Y, Takayanagi Y, Onaka T
    • Organizer
      The 3rd International Conference on Cognitive Neurodynamics (ICCN 2011)
    • Place of Presentation
      Niseko, Japan
    • Related Report
      2013 Final Research Report
  • [Presentation] 心身ストレスとその機序

    • Author(s)
      尾仲達史
    • Organizer
      生体機能の理解にもとづく災害ストレス支援の推進事業第1回シンポジウム
    • Place of Presentation
      野村総合研究所(東京都千代田区)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Advances in Congnitive Neurodynamics(III)2014

    • Author(s)
      Wang Y, Takayanagi Y, Onaka T
    • Total Pages
      846
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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