Role of reactive oxygen species in the genesis of atrial fibrillation and novel therapeutic strategy
| Project/Area Number |
23390053
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Chiba University |
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Principal Investigator |
NAKAYA HARUAKI 千葉大学, 医学(系)研究科(研究院), 教授 (60113594)
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| Co-Investigator(Renkei-kenkyūsha) |
MATSUMOTO Akio 千葉大学, 大学院・医学研究院, 准教授 (60437308)
NISHIDA Hirohumi 千葉大学, 大学院・医学研究院, 助教 (80513043)
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| Research Collaborator |
REIEN Yoshie 千葉大学, 医学部, 技術職員
MARUYAMA Hiroo 千葉大学, 医学部, 技術職員
TATIDANA Tomoko 千葉大学, 大学院・医学研究院, 派遣技術職員
SUZUKI Kazumasa 千葉大学, 大学院生
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
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| Keywords | 活性酸素種 / 老化 / 心房細動 / アップストリームアプローチ / Mn-SOD欠損マウス / Mn-SODマウス |
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| Research Abstract |
Reactive oxygen species (ROS) are suggested to play an important role in the genesis of atrial fibrillation in elderly patients. However, a direct evidence of arrhythmogenic properties associated with chronic exposure to ROS is lacking. This study was undertaken to evaluate electrophysiological alterations induced by chronic exposure to ROS using heart/muscle-specific manganese-superoxide dismutase-deficient (H/M-SOD-/-) mice. Atrial action potential was prolonged with a decreased K+ current density and susceptibility to atrial fibrillation was increased. In atrial tissues of H/M-SOD-/- mice fibrotic changes and decreased expression of connexin 43 protein were observed. These electrophysiological and histological abnormalities were lessened by chronic intake of an antioxidant in H/M-SOD-/- mice. Thus, chronic exposure to ROS can increase susceptibility to atrial fibrillation and dietary intake of antioxidant nutrients may prevent oxidative stress-induced arrhythmias.
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Report
(4 results)
Research Products
(83 results)
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[Journal Article] 抗不整脈薬2014
Author(s)
中谷 晴昭
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Journal Title
医薬ジャーナルMedicine and Drug Journal 新薬展望2014 増刊号
Volume: 50(S-1)
Pages: 235-240
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[Journal Article] Apple polyphenols regulate mitochondrial superoxide generation and extend survival in a mouse model of dilated cardiomyopathy2012
Author(s)
Sunagawa T, Watanabe K, Ozawa Y, Nakashima S, Kanda T, Tagashira M, Sami M, Kaneko T, Tahara S, Nakaya H, Shirasawa T, Shimizu T
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Journal Title
Int J Life Sci Med Res
Volume: 2
Pages: 46-51
Related Report
Peer Reviewed
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[Journal Article] Randomized trial of angiotensin II-receptor blocker vs.dihydropiridine calcium channel blocker in the treatment of paroxysmal atrial fibrillation with hypertension (J-RHYTHM II study)2011
Author(s)
Takeshi Yamashita, Hiroshi Inoue, Ken Okumura, Itsuo Kodama, Yoshifusa Aizawa, Hirotsugu Atarashi, Tohru Ohe, Hiroshi Ohtsu, Takao Kato, Shiro Kamakura, Koichiro Kumagai, Yoshihisa Kurachi, Yukihiro Koretsune, Tetsunori Saikawa, Masayuki Sakurai, Toshiaki Sato, Kaoru Sugi, Haruaki Nakaya, Makoto Hirai, Atsushi Hirayama, Masahiko Fukatani, Hideo Mitamura, Tsutomu Yamazaki, Eiichi Watanabe, Satoshi Ogawa, on behalf of the J-RHYTHM II Investigators
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Journal Title
Europace
Volume: 13(4)
Issue: 4
Pages: 473-479
DOI
Related Report
Peer Reviewed
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[Presentation] イヌ心房ペーシングモデルにおける選択的K_<Ach> チャネル遮断薬NTC-801 の抗心房細動効果 : Ic およびIII群薬との比較2012
Author(s)
山本 渉, 橋本 哲郎, 松浦 潤治, 荻野恭浩, 町田 泰一, 小林 恒文, 山中 義弘, 石綿 紀久, 山下 徹, 谷本 耕司郎, 三好俊一郎, 中谷 晴昭, 小川 聡
Organizer
第29回日本心電学会学術集会
Place of Presentation
千葉
Year and Date
2012-10-12
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[Presentation] Electropharmacological profilies of NTC-801, a novel selective acetylcholine- activated K^+ channel blocker2011
Author(s)
Matsumoto R, Machida T, Hashimoto N, Kuwahara I, Ogino Y, Matsuura J, Yamamoto W, Itano Y, ZammmaA, Kamon J, Kobayashi T, Ishiwata N, Yamashita T, Ogura T, Nakaya H
Organizer
Heart Rhythm 2011
Place of Presentation
サンフランシスコ(アメリカ合衆国)
Year and Date
2011-05-04
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