| Project/Area Number |
23390056
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TORII Ryuzou 滋賀医科大学, 動物生命科学研究センター, 教授 (50106647)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Yoshinori 京都大学, iPS 細胞研究所, 講師 (20447965)
OKAMURA Tomio 滋賀医科大学, 医学部, 教授 (70152337)
TAWA Masashi 滋賀医科大学, 医学部, 助教 (10510274)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2011: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 幹細胞 / インスリン抵抗性因子 / 糖尿病 / 幹細胞機能 / iPS細胞 / 再生医療 / 幹細胞移植 / カニクイザル |
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| Research Abstract |
In this study, we planned to investigate whether the stem cell functions are damaged under the diabetic and/or insulin resistant conditions. Using the iPS cells established with the skin fibroblast of cynomolgus monkey, we identified the inhibitory effects of insulin resistant factor, IL-1beta on the ability of differentiation from iPS cells in vitro and in vivo. Thus, it is suggested that the stem cell functions are modified by the insulin resistant factors.
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