Effects of insulin resistance-related factors on the stem cell functions in vivo.
| Project/Area Number |
23390056
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TORII Ryuzou 滋賀医科大学, 動物生命科学研究センター, 教授 (50106647)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Yoshinori 京都大学, iPS 細胞研究所, 講師 (20447965)
OKAMURA Tomio 滋賀医科大学, 医学部, 教授 (70152337)
TAWA Masashi 滋賀医科大学, 医学部, 助教 (10510274)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2011: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
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| Keywords | 幹細胞 / インスリン抵抗性因子 / 糖尿病 / 幹細胞機能 / iPS細胞 / 再生医療 / 幹細胞移植 / カニクイザル |
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| Research Abstract |
In this study, we planned to investigate whether the stem cell functions are damaged under the diabetic and/or insulin resistant conditions. Using the iPS cells established with the skin fibroblast of cynomolgus monkey, we identified the inhibitory effects of insulin resistant factor, IL-1beta on the ability of differentiation from iPS cells in vitro and in vivo. Thus, it is suggested that the stem cell functions are modified by the insulin resistant factors.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats2014
Author(s)
Okamura T, Tawa M, Geddawy A, Shimosato T, Iwasaki H, Shintaku H, Yoshida Y, Masada M, Shinozaki K, Imamura T
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Journal Title
J Pharmacol Sci
Volume: 124
Pages: 76-85
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] Effects of atorvastatin, amlodipine, and their combination on vascular dysfunction in insulin-resistant rats.2014
Author(s)
Okamura T, Tawa M, Geddawy A, Shimosato T, Iwasaki H, Shintaku H, Yoshida Y, Masada M, Shinozaki K, Imamura T.
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Journal Title
J Pharmacol Sci.
Volume: 124
Pages: 76-85
NAID
Related Report
Peer Reviewed
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[Journal Article] The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43.2013
Author(s)
Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi S, Shioi G, Inoue H, Tsujimoto G.
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Journal Title
Nat Commun.
Volume: 4
Issue: 1
Pages: 1829-1829
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43.2013
Author(s)
Kimura I, Ozawa K, Inoue D, Imamura T, Kimura K, Maeda T, Terasawa K, Kashihara D, Hirano K, Tani T, Takahashi T, Miyauchi S, Shioi G, Inoue H, Tsujimoto G
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Journal Title
Nat Commun.
Volume: in press
NAID
Related Report
Peer Reviewed
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