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Research on the molecular mechanism of metabolic syndrome and cardiovascular diseases and novel therapeutic strategy for these diseases

Research Project

Project/Area Number 23390058
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General pharmacology
Research InstitutionKumamoto University

Principal Investigator

MITSUYAMA Shokei  熊本大学, 生命科学研究部, 教授 (10195414)

Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,240,000 (Direct Cost: ¥14,800,000、Indirect Cost: ¥4,440,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords酸化ストレス / ASK1 / 高血圧 / 動脈硬化 / 認知症 / 脳卒中 / 腎神経 / 高脂肪食 / 肥満 / 血液脳関門 / ASKファミリー / メタボリックシンドローム / 血管障害 / 交感神経 / サーカディアンリズム
Research Abstract

The role of ASK1 and renal nerve was investigated to examine the molecular mechanism of metabolic syndrome and cerebrovascular and cardiovascular diseases and to develop promising therapeutic strategies for these diseases. ASK1 was involved in cognitive impairment induced by chronic cerebral ischemia or high-fat diet. Renal denervation suppressed the abnormality of blood pressure circadian rhythm and cardiovascular diseases induced by metabolic syndrome and also prevented the onset of cerebrovascular disease, thereby suggesting renal nerve as a promising therapeutic target for cerebrovascular and cardiovascular diseases. Furthermore, ASK2, the ASK1-binding protein, was found to participate in salt-sensitive hypertension and cardiovascular diseases. Thus, ASK1 and renal nerve seem to be a promising therapeutic target for cerebrovascular and cardiovascular diseases.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (53 results)

All 2014 2013 2012 2011 Other

All Journal Article (28 results) (of which Peer Reviewed: 28 results) Presentation (15 results) (of which Invited: 7 results) Book (9 results) Remarks (1 results)

  • [Journal Article] Apoptosis signal-regulating kinase 1 is a novel target molecule for cognitive impairment induced by chronic cerebral hypoperfusion.2014

    • Author(s)
      Toyama K, Koibuchi N, Uekawa K, Hasegawa Y, Kataoka K, Katayama T, Sueta D, Ma MJ, Nakagawa T, Yasuda O, Tomimoto H, Ichijo H, Ogawa H, Kim-Mitsuyama S
    • Journal Title

      Arteriosclerosis, thrombosis, and vascular biology

      Volume: 34 Issue: 3 Pages: 616-625

    • DOI

      10.1161/atvbaha.113.302440

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rosuvastatin Ameliorates Early Brain Injury after Subarachnoid Hemorrhage via Suppression of Superoxide Formation and Nuclear Factor-Kappa B Activation in Rats.2014

    • Author(s)
      Uekawa K, Hasegawa Y, Ma M, Nakagawa T, Katayama T, Sueta D, Toyama K, Kataoka K, Koibuchi N, Kawano T, Kuratsu JI, Kim-Mitsuyama S.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: 印刷中 Issue: 6 Pages: 1429-1439

    • DOI

      10.1016/j.jstrokecerebrovasdis.2013.12.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sex differences in response to angiotensin II receptor blocker-based therapy in elderly, high-risk, hypertensive Japanese patients: a subanalysis of the OSCAR study.2014

    • Author(s)
      Matsui K, Kim-Mitsuyama S, Ogawa H, Jinnouchi T, Jinnouchi H, Arakawa K.
    • Journal Title

      Hypertens Res.

      Volume: 印刷中 Issue: 6 Pages: 526-532

    • DOI

      10.1038/hr.2014.23

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel mechanism for disrupted circadian blood pressure rhythm in a rat model of metabolic syndrome - the critical role of angiotensin II2013

    • Author(s)
      Sueta D, Kataoka K, Koibuchi N, Toyama K, Uekawa K, Katayama Ma MingJie, Nakagawa T, Waki H, Maeda M, Yasuda O, Matsui K, Ogawa H, Kim-Mitsuyama S
    • Journal Title

      J Am Heart Assoc

      Volume: 2 Issue: 3

    • DOI

      10.1161/jaha.113.000035

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Long-term renal denervation normalizes disrupted blood pressure circadian rhythm and ameliorates cardiovascular injury in a rat model of metabolic syndrome2013

    • Author(s)
      Katayama T, Sueta D, Kataoka K, Hasegawa Y, Koibuchi N, Toyama K, Uekawa K, Mingjie M, Nakagawa T, Maeda M, Ogawa H, Kim-Mitsuyama S
    • Journal Title

      J Am Heart Assoc

      Volume: 2(4) Issue: 4

    • DOI

      10.1161/jaha.113.000197

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Renal denervation prevents stroke and brain injury via attenuation of oxidative stress in hypertensive rats2013

    • Author(s)
      Nakagawa T, Hasegawa Y, Uekawa K, Ma M, Katayama T, Sueta D, Toyama K, Kataoka K, Koibuchi N, Maeda M, Kuratsu J, Kim-Mitsuyama S
    • Journal Title

      J Am Heart Assoc

      Volume: 2(5) Issue: 5

    • DOI

      10.1161/jaha.113.000375

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice.2013

    • Author(s)
      Nishida M, Ishikawa T, Saiki S, Sunggip C, Aritomi S, Harada E, Kuwahara K, Hirano K, Mori Y, Kim-Mitsuyama S
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 434 Issue: 2 Pages: 210-216

    • DOI

      10.1016/j.bbrc.2013.03.040

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pretreatment with rosuvastatin protects against focal cerebral ischemia/reperfusion injury in rats through attenuation of oxidative stress and inflammation.2013

    • Author(s)
      Ma M, Uekawa K, Hasegawa Y, Nakagawa T, Katayama T, Sueta D, Toyama K, Kataoka K, Koibuchi N, Kuratsu J, Kim-Mitsuyama S.
    • Journal Title

      Brain Res.

      Volume: 1519 Pages: 87-94

    • DOI

      10.1016/j.brainres.2013.04.040

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An angiotensin II receptor blocker - calcium channel blocker combination prevents cardiovascular events in elderly high-risk hypertensive patients with chronic kidney disease better than high-dose angiotensin II receptor blockade alone.2013

    • Author(s)
      im-Mitsuyama S, Ogawa H, Matsui K, Jinnouchi T, Jinnouchi H, Arakawa K.
    • Journal Title

      Kidney Int.

      Volume: 83 Issue: 1 Pages: 167-176

    • DOI

      10.1038/ki.2012.326

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] p-Cresyl sulfate causes renal tubular cell damage by inducing oxidative stress byactivation of NADPH oxidase.2013

    • Author(s)
      Hiroshi Watanabe^*, Yohei Miyamoto^*,Daisuke Honda, Hisae Tariaka, Qiong Wu,Masayuki Endo, Tsuyoshi Noguchi, DaisukeKadowaki, Yu Ishima, Shunsuke Kotani,Makoto Nakajima, Keiichiro Kataoka,Shokei Kim-Mitsuyama, Motoko Tanaka,Masafumi Fukagawa, Masaki Otagiri, ToruMaruyama. (^*:Hiroshi Watanabe and YoheiMiyamoto contributed equally to this work.)
    • Journal Title

      Kidney International

      Volume: (印刷中) Issue: 4 Pages: 582-592

    • DOI

      10.1038/ki.2012.448

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A dipeptidylpeptidase-4 inhibitor,des-fluoro-sitagliptin, improvesendothelial function and reducesatherosclerotic lesion formation inapolipoprotein E-deficient mice2012

    • Author(s)
      Matsubara J, Sugiyama S, Sugamura K,Nakamura T, Fujiwara Y, Akiyama E,Kurokawa H, Nozaki T, Ohba K, Konishi M,Maeda H, Izumiya Y, Kaikita K, Sumida H,Jinnouchi H, Matsui K, Kim-Mitsuyama S,Takeya M, Ogawa H
    • Journal Title

      J AmColl Cardiol

      Volume: 59(3) Issue: 3 Pages: 265-76

    • DOI

      10.1016/j.jacc.2011.07.053

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amlodipine enhances amelioration of vascular insulin resistance, oxidative stress,and metabolic disorders by candesartan in metabolic syndrome rats2012

    • Author(s)
      Sueta, D., Nakamura, T., Dong, Y. F., Kataoka, K., Koibuchi, N., Yamamoto, E., Toyama, K., Yasuda, O.,Ogawa, H., Kim-Mitsuyama, S.
    • Journal Title

      Am J Hypertens

      Volume: 25 Issue: 6 Pages: 704-710

    • DOI

      10.1038/ajh.2012.26

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiotensin II receptor blocker-based therapy in Japanese elderly, high-risk, hypertensive patients.2012

    • Author(s)
      Ogawa H, Kim-Mitsuyama S, Matsui K, Jinnouchi T, Jinnouchi H, Arakawa K
    • Journal Title

      Am J Med.

      Volume: 125 Issue: 10 Pages: 981-990

    • DOI

      10.1016/j.amjmed.2011.12.010

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium channel blockers, more than diuretics, enhance vascular protective effectsof angiotensin receptor blockers in salt-loaded hypertensive rats2012

    • Author(s)
      Yamamoto, E., Kataoka, K., Dong, Y. F., Koibuchi, N., Toyama, K., Sueta, D., Katayama, T., Yasuda, O.,Ogawa, H., Kim-Mitsuyama, S.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 6 Pages: 39162-39162

    • DOI

      10.1371/journal.pone.0039162

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nanoparticle-Mediated Delivery of Pioglitazone Enhances Therapeutic Neovascularization in a Murine Model of Hindlimb Ischemia.2012

    • Author(s)
      Nagahama R, Egashira K ,他
    • Journal Title

      Arteri oscl er Thromb Vasc Biol.

      Volume: 32(10) Issue: 10 Pages: 2427-2434

    • DOI

      10.1161/atvbaha.112.253823

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ASK3 responds to osmotic stress and regulates blood pressure by suppressing WNK1-SPAK/OSR1 signaling in the kidney.2012

    • Author(s)
      Naguro I., et al.
    • Journal Title

      Nature Communications

      Volume: 3 Issue: 1 Pages: 1285-1285

    • DOI

      10.1038/ncomms2283

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel mechanism of angiotensin II-induced cardiacinjury in hypertensive rats : the critical role of ASK12012

    • Author(s)
      Nako, H., et al.
    • Journal Title

      Hypertens.Res.

      Volume: 35 Issue: 2 Pages: 194-200

    • DOI

      10.1038/hr.2011.175

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unique "delta lock" structure of telmisartan is involved in its strongest binding affinity to angiotensin II type 1 receptor2011

    • Author(s)
      Ohno K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 404 Issue: 1 Pages: 434-437

    • DOI

      10.1016/j.bbrc.2010.11.139

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptosis signal-regulating kinase 1 deficiency eliminates cardiovascular injuries induced by high-salt diet2011

    • Author(s)
      Kataoka K
    • Journal Title

      J Hypertens

      Volume: 29 Issue: 1 Pages: 76-84

    • DOI

      10.1097/hjh.0b013e32833fc8b0

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pentraxin 3 isa new inflammatory marker correlatedwith left ventricular diastolicdysfunction and heart failure withnormal ejection fraction2011

    • Author(s)
      Matsubara J, Sugiyama S, Nozaki T,Sugamura K, Konishi M, Ohba K, MatsuzawaY, Akiyama E, Yamamoto E, Sakamoto K,Nagayoshi Y, Kaikita K, Sumida H,Kim-Mitsuyama S, Ogawa H
    • Journal Title

      J Am CollCardiol

      Volume: 57(7) Issue: 7 Pages: 861-9

    • DOI

      10.1016/j.jacc.2010.10.018

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular responses to 8-nitro-cyclic GMP in non-diabetic and diabetic mice2011

    • Author(s)
      Tokutomi Y., et al
    • Journal Title

      Br J Pharmabol

      Volume: 162 Issue: 8 Pages: 1884-1893

    • DOI

      10.1111/j.1476-5381.2011.01201.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eplerenone potentiates protective effects of amlodipine against cardiovascular injury in salt-sensitive hypertensive rats2011

    • Author(s)
      Nakamura T., Yamamoto E., et al
    • Journal Title

      Hypertens Res

      Volume: 34(7) Issue: 7 Pages: 817-824

    • DOI

      10.1038/hr.2011.35

    • NAID

      10031163263

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perindopril, a centrally-active ACE inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease2011

    • Author(s)
      Dong YF., Yamamoto E., et al
    • Journal Title

      FASEB J

      Volume: 25(9) Issue: 9 Pages: 2911-2920

    • DOI

      10.1096/fj.11-182873

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel mechanism of salt-induced glomerular injury : critical role of eNOS and angiotensin II2011

    • Author(s)
      Nakamura T., Yamamoto E., et al
    • Journal Title

      J Hypertens

      Volume: 29(8) Issue: 8 Pages: 1528-1535

    • DOI

      10.1097/hjh.0b013e328348ca95

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation of brain damage and cognitive impairment by direct renin inhibition in mice with chronic cerebral hypoperfusion2011

    • Author(s)
      Dong YF., Yamamoto E., et al
    • Journal Title

      Hypertension

      Volume: 58(4) Issue: 4 Pages: 194-200

    • DOI

      10.1161/hypertensionaha.111.173534

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Beneficial effects of combination of valsartan and amlodipine on salt-induced brain injury in hypertensive rats2011

    • Author(s)
      Dong YF., Yamamoto E., et al
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 339(2) Issue: 2 Pages: 358-366

    • DOI

      10.1124/jpet.111.182576

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Telmisartan protects against diabetic vascular complications in a mouse model of obesity and type 2 diabetes, partially through peroxisome proliferator activated receptor-γ-dependent activity2011

    • Author(s)
      Toyama K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 410 Issue: 3 Pages: 508-513

    • DOI

      10.1016/j.bbrc.2011.06.012

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Passive Exercise Using Whole-Body Periodic Acceleration Enhances Blood Supply to Ischemic Hindlimb2011

    • Author(s)
      Rokutanda T
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 31 Issue: 12 Pages: 2872-2880

    • DOI

      10.1161/atvbaha.111.229773

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] RA 系阻害による心血管保護のパラダイムシフト2013

    • Author(s)
      光山勝慶
    • Organizer
      第61回日本心臓病学会学術集会
    • Place of Presentation
      くまもと県民交流館パレア(熊本)
    • Year and Date
      2013-09-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 降圧薬開発の現状と近未来2012

    • Author(s)
      光山勝慶
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      ウエスティンナゴヤキャッスル(名古屋)
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 高齢化社会を踏まえた高血圧治療戦略-脳卒中, 認知症の治療戦略-2012

    • Author(s)
      光山勝慶
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      ウエスティンナゴヤキャッスル(名古屋)
    • Year and Date
      2012-09-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 生活習慣病とRAA 系2012

    • Author(s)
      光山勝慶
    • Organizer
      第16回日本適応医学会学術集会
    • Place of Presentation
      ホテルサンルート有明(東京)
    • Year and Date
      2012-06-09
    • Related Report
      2013 Final Research Report
  • [Presentation] ARBの12年を総括する:降圧を超えた心保護作用はあったのか?Significance of Pleiotropic effects of ARBs in Cardiovascular Protection2012

    • Author(s)
      光山勝慶
    • Organizer
      第76回日本循環器学会総会・学術集会
    • Place of Presentation
      福岡国際会議場(福岡)(招待講演)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] ARBをベースとした動脈硬化治療戦略-OSCAR studyからの考察-2012

    • Author(s)
      光山勝慶
    • Organizer
      第76回日本循環器学会総会・学術集会
    • Place of Presentation
      福岡国際会議場(福岡)(招待講演)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] OSCAR studyにみる糖尿病合併高血圧患者における降圧薬の選択:ARB増量かCCB併用か2011

    • Author(s)
      光山勝慶
    • Organizer
      第34回日本高血圧学会総会
    • Place of Presentation
      栃木県総合文化センター(宇都宮)(招待講演)
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] ARBをベースにした高血圧治療戦略-次の一手は?-2011

    • Author(s)
      光山勝慶
    • Organizer
      第34回日本高血圧学会総会
    • Place of Presentation
      宇都宮東武ホテルグランデ(宇都宮)(招待講演)
    • Year and Date
      2011-10-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] RA系阻害による心血管保護のパラダイムシフト

    • Author(s)
      光山勝慶
    • Organizer
      第61回日本心臓病学会学術集会
    • Place of Presentation
      くまもと県民交流館パレア
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] シンポジウム:生活習慣病とRAA系

    • Author(s)
      光山 勝慶
    • Organizer
      第16回日本適応医学会学術集会
    • Place of Presentation
      ホテルサンルート有明(東京)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ランチョンセミナー:Ca拮抗薬のクラスエフェクトとドラッグエフェクトーL型、T型、N型Caチャネルの意義ー

    • Author(s)
      光山 勝慶
    • Organizer
      第60回日本心臓病学会学術集会
    • Place of Presentation
      石川県立音楽堂他(金沢)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ランチョンセミナー:ARBと心血管保護戦略~メタボサルタンの可能性~

    • Author(s)
      光山 勝慶
    • Organizer
      第60回日本心臓病学会学術集会
    • Place of Presentation
      石川県立音楽堂他(金沢)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] フォーカスセッション:降圧薬開発の現状と近未来

    • Author(s)
      光山 勝慶
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      ウェスティンナゴヤキャッスル他(名古屋)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ランチョンセミナー:高齢化社会を踏まえた高血圧治療戦略ー脳卒中、認知症の治療戦略ー

    • Author(s)
      光山 勝慶
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      ウェスティンナゴヤキャッスル他(名古屋)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] シンポジウム:新しい高血圧治療ガイドライン JSH2014はいかに進化すべきか

    • Author(s)
      光山 勝慶
    • Organizer
      第77回日本循環器学会総会・学術集会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Modern Physician2013

    • Author(s)
      光山勝慶
    • Publisher
      新興医学出版社
    • Related Report
      2013 Annual Research Report
  • [Book] 日本医師会雑誌2013

    • Author(s)
      光山勝慶
    • Publisher
      日本医師会
    • Related Report
      2013 Annual Research Report
  • [Book] EBM循環器疾患の治療2012

    • Author(s)
      小室一成
    • Total Pages
      424
    • Publisher
      中外医学社
    • Related Report
      2012 Annual Research Report
  • [Book] あなたも名医! 高血圧、再整理2012

    • Author(s)
      浦 信行
    • Total Pages
      205
    • Publisher
      日本医事新報社
    • Related Report
      2012 Annual Research Report
  • [Book] Annual Review循環器20112011

    • Author(s)
      光山勝慶
    • Publisher
      中外医学社
    • Related Report
      2011 Annual Research Report
  • [Book] Annual Review腎臓20112011

    • Author(s)
      光山勝慶
    • Publisher
      中外医学社
    • Related Report
      2011 Annual Research Report
  • [Book] 成功に導くPCI治療戦略2011

    • Author(s)
      光山勝慶
    • Publisher
      南山堂
    • Related Report
      2011 Annual Research Report
  • [Book] 高血圧ナビゲーター2011

    • Author(s)
      光山勝慶
    • Publisher
      メディカルレビュー社
    • Related Report
      2011 Annual Research Report
  • [Book] 血管生物医学事典2011

    • Author(s)
      光山勝慶
    • Publisher
      朝倉書店
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.yggcsp.com/Pharmacology/

    • Related Report
      2013 Final Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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