| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
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| Research Abstract |
A new Alzheimer's disease (AD)-suppressive factor EH has been biologically examined. First, it was found that EH concentration in the cerebrospinal fluid is 1-5nM in humans. Second, intraperitoneal administration of EH ameliorates dementia of mice, caused by scopolamine, a muscarinic acetylcholine receptor blocker.. Combined with foregoing findings, these results suggest that EH, rather than Humanin, plays a central role in vivo as an AD-suppressive factor.. Furthermore, EH concentrations in the cerebrospinal fluids of AD patients appear to be lower than those of normal controls. Finally, it was found that EHIbeta inhibits secretion of into extracellular space and EHIsigma is secreted into the extracellular space and inhibits EH activity.
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