Characterization of Muse cells, non-tumorigenic intrinsic pluripotent stem cells, and their application to regenerative medicine.
| Project/Area Number |
23390060
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
DEZAWA Mari 東北大学, 医学(系)研究科(研究院), 教授 (50272323)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2011: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 多能性幹細胞 / 体性幹細胞 / 間葉系幹細胞 / 皮膚 / 骨髄 / 脊髄 |
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| Research Abstract |
The unique property of Muse cells, novel type of non-tumorigenic pluripotent stem cells that normally reside in human mesenchymal tissues, was investigated in this project. Muse cells positively migrated and integrated into the damaged tissue when they were infused into the blood stream of animal models with liver or kidney damages, whereas such phenomenon was not observed in non-Muse cells. Non-Muse cells did not migrate or integrate into damaged liver and kidney nor did they remained in normal intact tissues. Muse cells were further observed to be spontaneously differentiated into hepatocytes, bile ducts and other liver component cells in the liver damage model, and into neural cells in the stroke model, and contributed into tissue regeneration and functional recovery. Such unique property of migration and integration abilities of Muse cells are found to be tightly related to specific expression of G-protein coupled receptor expression on their cell surface.
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Report
(4 results)
Research Products
(176 results)
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[Journal Article] Autologous mesenchymal stem cell-derived dopaminergic neurons function in parkinsonian macaques2013
Author(s)
Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M
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Journal Title
J Clin Invest
Volume: 123(1)
Issue: 1
Pages: 272-284
DOI
Related Report
Peer Reviewed
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[Journal Article] Transplantation of bone marrow stromal cell-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transection2013
Author(s)
Aizawa-Kohama M, Endo T, Kitada M, Wakao S, Sumiyoshi A, Matsuse D, Kuroda Y, Morita T, Riera JJ, Kawashima R, Tominaga T, Dezawa M
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Journal Title
Cell Transplant
Volume: 22(9)
Issue: 9
Pages: 1613-25
DOI
Related Report
Peer Reviewed
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[Journal Article] Autologous engraftment of A9 dopaminergic neurons induced from mesenchymal stem cells in parkinsonian rhesus macaques.2013
Author(s)
Hayashi T, Wakao S, Kitada M, Ose T, Watabe H, Kuroda Y, Mitsunaga K, Matsuse D, Shigemoto T, Ito A, Ikeda H, Fukuyama H, Onoe H, Tabata Y, Dezawa M.
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Journal Title
J. Clin. Invest.
Volume: 123(1)
Pages: 272-284
Related Report
Peer Reviewed
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[Journal Article] Transplantation of bone marrow stromal cells-derived neural precursor cells ameliorates deficits in a rat model of complete spinal cord transaction.2012
Author(s)
Aizawa-Kohama M, Endo T, Kitada M, Wakao S, Sumiyoshi A, Matsuse D, Kuroda Y, Morita T, Riera J.J, Kawashima R, Tominaga T, Dezawa M.
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Journal Title
Cell Transplantation
Volume: 掲載確定
Related Report
Peer Reviewed
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[Journal Article] Multiliineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts2011
Author(s)
Wakao S, Kitada M, Kuroda Y, Shigemoto T, Matsuse D, Akashi H, Tanimura Y, Tsuchiyama K, Kikuchi T, Goda M, Nakahata T, Fijiyoshi Y, Dezawa M
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Journal Title
Proc.Natl.Acad.Sci.U.S.A.
Volume: 108(24)
Issue: 24
Pages: 9875-9880
DOI
Related Report
Peer Reviewed
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[Journal Article] Transplantation of human bone marrow stromal cell-derived Schwann cells reduces cystic cavity and promotes functional recovery after contusion injury of adult rat spinal cord2011
Author(s)
Kamada T, Koda M, Dezawa M, ara R, Toyama Y, Yoshinaga K, Hashimoto M, Koshizuka S, Nishio Y, Mannoji C, Okawa A, Yamazaki M
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Journal Title
Neuropathology
Volume: 31(1)
Issue: 1
Pages: 48-58
DOI
Related Report
Peer Reviewed
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[Journal Article] Multilineage-differentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts2011
Author(s)
Wakao S, Kitada M, Kuroda Y, Shigemoto T, Matsuse D, Akashi H, Tanimura Y, Tsuchiyama K, Kikuchi T, Goda M, Nakahata T, Fujiyoshi Y, Dezawa M
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Journal Title
Proc.Natl.Acad.Sci.U.S.A.
Volume: 108(24)
Pages: 9875-9880
Related Report
Peer Reviewed
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