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Targeting bioactive lipid receptors for drug development

Research Project

Project/Area Number 23390061
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionAkita University

Principal Investigator

ISHII Satoshi  秋田大学, 医学(系)研究科(研究院), 教授 (10300815)

Co-Investigator(Kenkyū-buntansha) OHTO Takayo  秋田大学, 大学院・医学系研究科, 助教 (80511378)
YASUDA Daisuke  秋田大学, 大学院・医学系研究科, 助教 (70594951)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords脂質 / シグナル伝達 / LPA / リゾホスファチジン酸 / LPA4 / 化合物ライブラリー
Research Abstract

Through the analysis of mice deficient in the fourth lysophosphatidic receptor (LPA4), we previously revealed that LPA4 is involved in development of type 2 diabetes. In this study, we found that LPA4 negatively regulates mitochondria biogenesis by activating the Rho/Rho kinase pathway and then suppresses adipogenesis. LPA4 antagonists are expected to promote adipogenesis and may be useful for the treatment of patients with type 2 diabetes. In this study, therefore, we screened LPA4 antagonists from a chemical library.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (21 results)

All 2014 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Open Access: 1 results) Presentation (10 results) (of which Invited: 1 results) Remarks (4 results)

  • [Journal Article] TDAG8 activation inhibits osteoclastic bone resorption2014

    • Author(s)
      Hikiji, H., Endo, D., Horie, K., Harayama, T., Akahoshi, N., Igarashi, H., Kihara, Y., Yanagida, K., Takeda, J., Koji, T., Shimizu, T., and Ishii, S
    • Journal Title

      FASEB J

      Volume: 28 Issue: 2 Pages: 871-879

    • DOI

      10.1096/fj.13-233106

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antiobese function of platelet-activating factor : increased adiposity in platelet-activating factor receptor-deficient mice with age2014

    • Author(s)
      Sugatani, J., Sadamitsu, S., Yamaguchi, M., Yamazaki, Y., Higa, R., Hattori, Y., Uchida, T., Ikari, A., Sugiyama, W., Watanabe, T., Ishii, S., Miwa, M., and Shimizu, T
    • Journal Title

      FASEB J

      Volume: 28 Issue: 1 Pages: 440-452

    • DOI

      10.1096/fj.13-233262

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decrease in circulating autotaxin by oral administration of prednisolone2013

    • Author(s)
      Sumida H
    • Journal Title

      Clin Chim Acta

      Volume: 415 Pages: 74-80

    • DOI

      10.1016/j.cca.2012.10.003

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current progress in non-Edg family LPA receptor research2013

    • Author(s)
      Yanagida, K., Kurikawa, Y., Shimizu, T., and Ishii, S
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1831 Issue: 1 Pages: 33-41

    • DOI

      10.1016/j.bbalip.2012.08.003

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An orally active lysophosphatidic acid receptor antagonist attenuates panereatic cancer invasion and metastasis in vivo2012

    • Author(s)
      Komachi M
    • Journal Title

      Cancer Science

      Volume: (印刷中) Issue: 6 Pages: 1099-1104

    • DOI

      10.1111/j.1349-7006.2012.02246.x

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Non-Edg family LPA receptors : the cutting edge of LPA research2011

    • Author(s)
      Yanagida, K., Ishii, S.
    • Journal Title

      J.Biochem.

      Volume: 150 Issue: 3 Pages: 223-232

    • DOI

      10.1093/jb/mvr087

    • NAID

      10030587104

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 脂肪酸摂取と呼吸器疾患2011

    • Author(s)
      石井聡
    • Journal Title

      呼吸と循環

      Volume: 59 Pages: 773-781

    • Related Report
      2011 Annual Research Report
  • [Presentation] 骨髄造血幹細胞の維持と分化におけるリゾホスファチジン酸受容体LPA4 の機能解析2013

    • Author(s)
      五十嵐秀光, 石井聡
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Year and Date
      2013-09-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Roles of lysophosphatidic acid receptor LPA4 in diet-induced obesity and insulin resistance2013

    • Author(s)
      Yanagida, K., Kubota, N., Kadowaki, T., Shimizu, T., and Ishii, S
    • Organizer
      FASEB Summer Research Conference/Lysophospholipid and Other Related Mediators -From Bench to Clinic
    • Place of Presentation
      Niseko (Japan)
    • Year and Date
      2013-08-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 内蔵脂肪型肥満/インスリン抵抗性の進行におけるリゾホスファチジン酸受容体LPA4 の関与2013

    • Author(s)
      柳田圭介, 窪田直人, 門脇孝, 清水孝雄, 石井聡
    • Organizer
      第55回脂質生化学会
    • Place of Presentation
      松島
    • Year and Date
      2013-06-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Involvement of lysophosphatidic acid receptor LPA4 in chronic inflammation in adipose tissue and insulin resistance caused by diet-induced obesity2012

    • Author(s)
      Yanagida, K., Kubota, N., Kadowaki, T., Shimizu, T., and Ishii, S
    • Organizer
      International Endotoxin and Innate Immunity Society Meeting 2012 (IEIIS2012)
    • Place of Presentation
      Tokyo (Japan)
    • Year and Date
      2012-10-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Involvement of lysophosphatidic acid receptor LPA4 in chronic inflammation in adipose tissue and insulin resistance caused by diet-induced obesity2012

    • Author(s)
      Yanagida, K., et al.
    • Organizer
      International Endotoxin and Innate Immunity Society Meeting 2012 (IEIIS2012)
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脂質メディエーターの多彩な機能2011

    • Author(s)
      石井聡, 清水孝雄
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 脂質メディエーターの多彩な機能2011

    • Author(s)
      石井聡、清水孝雄
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roles of lysophosphatidic acid receptor LPA4 in diet-induced obesity and insulin resistance

    • Author(s)
      Yanagida, K., Kubota, N., Kadowaki, T., Shimizu, T., and Ishii, S.
    • Organizer
      FASEB Summer Research Conference / Lysophospholipid and Other Related Mediators -From Bench to Clinic
    • Place of Presentation
      Niseko, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] 内蔵脂肪型肥満/インスリン抵抗性の進行におけるリゾホスファチジン酸受容体LPA4の関与

    • Author(s)
      柳田圭介、窪田直人、門脇孝、清水孝雄、石井聡
    • Organizer
      第55回脂質生化学会
    • Place of Presentation
      松島
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 骨髄造血幹細胞の維持と分化におけるリゾホスファチジン酸受容体LPA4の機能解析

    • Author(s)
      五十嵐秀光、石井聡
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.akita-u.ac.jp/~bougyo/Home.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 秋田大学大学院医学系研究科生体防御学講座ホームページ

    • URL

      http://www.med.akita-u.ac.jp/~bougyo/Home.html

    • Related Report
      2013 Annual Research Report
  • [Remarks] 秋田大学大学院医学系研究科生体防御学講座ホームページ

    • URL

      http://www.med.akita-u.ac.jp/~bougyo/Home.html

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.akita-u.ac.jp/~bougyo/Home.html

    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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