Targeting bioactive lipid receptors for drug development
| Project/Area Number |
23390061
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Akita University |
|---|
Principal Investigator |
ISHII Satoshi 秋田大学, 医学(系)研究科(研究院), 教授 (10300815)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OHTO Takayo 秋田大学, 大学院・医学系研究科, 助教 (80511378)
YASUDA Daisuke 秋田大学, 大学院・医学系研究科, 助教 (70594951)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
|
|---|
| Keywords | 脂質 / シグナル伝達 / LPA / リゾホスファチジン酸 / LPA4 / 化合物ライブラリー |
|---|
| Research Abstract |
Through the analysis of mice deficient in the fourth lysophosphatidic receptor (LPA4), we previously revealed that LPA4 is involved in development of type 2 diabetes. In this study, we found that LPA4 negatively regulates mitochondria biogenesis by activating the Rho/Rho kinase pathway and then suppresses adipogenesis. LPA4 antagonists are expected to promote adipogenesis and may be useful for the treatment of patients with type 2 diabetes. In this study, therefore, we screened LPA4 antagonists from a chemical library.
|
Report
(4 results)
Research Products
(21 results)
-
[Journal Article] TDAG8 activation inhibits osteoclastic bone resorption2014
Author(s)
Hikiji, H., Endo, D., Horie, K., Harayama, T., Akahoshi, N., Igarashi, H., Kihara, Y., Yanagida, K., Takeda, J., Koji, T., Shimizu, T., and Ishii, S
-
Journal Title
FASEB J
Volume: 28
Issue: 2
Pages: 871-879
DOI
Related Report
Peer Reviewed
-
[Journal Article] Antiobese function of platelet-activating factor : increased adiposity in platelet-activating factor receptor-deficient mice with age2014
Author(s)
Sugatani, J., Sadamitsu, S., Yamaguchi, M., Yamazaki, Y., Higa, R., Hattori, Y., Uchida, T., Ikari, A., Sugiyama, W., Watanabe, T., Ishii, S., Miwa, M., and Shimizu, T
-
Journal Title
FASEB J
Volume: 28
Issue: 1
Pages: 440-452
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Roles of lysophosphatidic acid receptor LPA4 in diet-induced obesity and insulin resistance
Author(s)
Yanagida, K., Kubota, N., Kadowaki, T., Shimizu, T., and Ishii, S.
Organizer
FASEB Summer Research Conference / Lysophospholipid and Other Related Mediators -From Bench to Clinic
Place of Presentation
Niseko, Japan
Related Report
-
-
-
-
-
-
