Research Project
Grant-in-Aid for Scientific Research (B)
In order to examine the molecular mechanisms how growth factor signaling play roles for maintenance of tissue specific stem cells and cancer stem cells, we made mutant mice of FRS2alpha or FRS2beta, mediators for intracellular signaling through FGF or EGF, respectively. We found that FRS2alpha plays important roles for axon path finding of optic nerves, development of inner ears and sensory neurons. On the other hand, FRS2beta plays important roles for maintenance of breast cancer stem cells.
All 2014 2013 2012 2011 Other
All Journal Article (25 results) (of which Peer Reviewed: 23 results) Presentation (16 results) (of which Invited: 11 results) Book (3 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)
PLOS Genetics
Volume: 10 Pages: e1004118
J. Cell Sci
Volume: 127 Pages: 571-582
Development
Volume: 140 Pages: 2711-2723
Cancer Sci
Volume: 104 Pages: 345-352
J. Cell Sci.
Oncol. Lett.
Volume: 6 Pages: 323-328
Oncogenesis
Volume: 2 Pages: 1-27
10.1038/oncsis.2013.30.
Biochem. Biophys. Res. Commun.
Volume: 432 Pages: 175-181
Biochem. Biophys. Res. Commun
10.1016/j.bbrc.2013.01.034.
PLoS ONE
Volume: 7 Pages: e43923
Proc. Natl. Acad. Sci., USA
Volume: 109 Pages: 6584-6589
Cancer Res
Volume: 72 Pages: 100-111
10.1158/0008-5472.CAN-11-1403. Epub 2011 Nov 11.
BMC Genomics
Volume: Suppl. 1, Pages: S6
10.1186/1471-2164-13-S1-S6. Epub 2012 Jan 17.
10.1073/pnas.1113271109. Epub 2012 Apr 5.
Expert Opin. Ther. Targets
Volume: 16 Pages: 771-781
10.1517/14728222.2012.697155. Epub 2012 Jul 5.
10.1371/journal.pone.0043923. Epub 2012 Sep 19.
Molecular Therapy
Volume: 21 Pages: 185-191
10.1038/mt.2012.180. Epub 2012 Oct 2.
Breast cancer, Bentham eBooks, Bentham Science
Volume: 巻なし Pages: in press
In : Cancer Stem Cells Theories and Practice , Chapter 13, Nikolic, A. (Ed.), INTECH, NY, USA
Journal of Clinical Bioinformatics
Volume: 1 Pages: -
10.1186/2043-9113-1-23.
Am. J. Cancer. Res
Volume: 1 Pages: 823-833
Int. J. Clin. Exp. Pathol
Volume: 4 Pages: 403-409
403-9. Epub 2011 Apr 26.
Journal of Osaka Medical Center & Research Institute for Maternal & Child Health
Volume: 26 Pages: 101-108
Encyclopedia of Signaling Molecules. Springer, Heidelberg, Germany
Volume: 巻なし Pages: -
http://www.ims.u-tokyo.ac.jp/system-seimei/index.htm