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Carbohydrate recognition of B lymphocyte lectins and their function

Research Project

Project/Area Number 23390063
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field General medical chemistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TSUBATA Takeshi  東京医科歯科大学, 難治疾患研究所, 教授 (80197756)

Co-Investigator(Renkei-kenkyūsha) ITO Nobutoshi  東京医科歯科大学, 難治疾患研究所分子構造情報学分野, 教授
WATANABE Kozo  東京医科歯科大学, 難治疾患研究所免疫疾患分野, 助教 (20376718)
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
KeywordsBリンパ球、 / レクチン / 糖鎖 / 抑制性受容体 / Bリンパ球 / 硫酸化糖鎖 / Sm/RNP / CD72 / シグナル伝達 / 自己抗体 / Sm/RNP / ヘパリン / スルファチド
Outline of Final Research Achievements

CD72 is an inhibitory receptor expressed mostly in B lymphocytes, and contains a C-type lectin-like domain. We demonstrated that CD72 binds to various sulfated glycans and inhibits immune responses to sulfated glycans. Sulfated glycans are abundantly produced in vertebrates including human, but are not normally produced by microbes. These findings suggest that CD72 recognizes sulfated glycans as a self-associated molecular pattern, and is involved in distinction between self and microbes.

Report

(4 results)
  • 2014 Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (57 results)

All 2015 2014 2013 2012 2011

All Journal Article (16 results) (of which Peer Reviewed: 16 results,  Open Access: 6 results,  Acknowledgement Compliant: 4 results) Presentation (40 results) (of which Invited: 24 results) Book (1 results)

  • [Journal Article] Functional evaluation of activation-dependent alterations in the sialoglycan composition of T cells.2014

    • Author(s)
      Naito-Matsui Y, Takada S, Kano Y, Iyoda T, Sugai M, Shimizu A, Inaba K, Nitschke L, Tsubata T, Oka S, Kozutsumi Y, and Takematsu H.
    • Journal Title

      J. Biol. Chem.

      Volume: 289 Issue: 3 Pages: 1564-1579

    • DOI

      10.1074/jbc.m113.523753

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] LAPTM5 promotes lysosomal degradation of intracellular but not the cell surface CD3ζimmunol..2014

    • Author(s)
      Kawai, Y., Ouchida, R., Yamasaki, S., Dragone, L., Tsubata, T. and Wang, J.-Y.
    • Journal Title

      Cell Biol.

      Volume: 92 Issue: 6 Pages: 527-534

    • DOI

      10.1038/icb.2014.18

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] FcmR interacts and cooperates with the B cell receptor to promote B cell survival.2014

    • Author(s)
      Ouchida. R., Lu. Q., Liu. J., Li. Y., Chu. Y., Tsubata. T. and Wang, J.Y.
    • Journal Title

      J. Immunol.

      Volume: 194 Issue: 7 Pages: 3096-4101

    • DOI

      10.4049/jimmunol.1402352

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Constitutively CD40-activated B cells regulate CD8 T cell inflammatory response by IL-10 induction.2013

    • Author(s)
      Shimoda, M., Bolduc, A., Takezaki, M., Ametani, Y., Huang, L., Nutt S. L., Kamanaka, M., Flavell, R. A., Mellor A. L, Tsubata, T. andKoni, P.
    • Journal Title

      J. Immunol.

      Volume: 190 Issue: 7 Pages: 3189-3196

    • DOI

      10.4049/jimmunol.1203364

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] CD72c is a modifier gene that regulates Faslpr-induced autoimmune disease.2013

    • Author(s)
      Xu, M., Hou, R., Sato-Hayashizaki, A., Man, R., Zhu, C., Wakabayashi, C, Hirose, S., Adachi, T. and Tsubata, T.
    • Journal Title

      J. Immunol.

      Volume: 190 Issue: 11 Pages: 5436-5445

    • DOI

      10.4049/jimmunol.1203576

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Excess CD40L does not rescue anti-DNA B cells from clonal anergy.2013

    • Author(s)
      Aslam, M., Kishi, Y. and Tsubata, T.
    • Journal Title

      F1000 Research

      Volume: 2 Pages: 218-218

    • DOI

      10.12688/f1000research.2-218.v2

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells.2012

    • Author(s)
      Kishi, Y., Higuchi, T., Phoon, S., Kamiya, K., Riemekasten, G., Akiyoshi, K., Weigert, M. and Tsubata, T.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 109 Issue: 20 Pages: 7811-7816

    • DOI

      10.1073/pnas.1204509109

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy.2012

    • Author(s)
      Klionsky, D.J., Abdalla, F. C. Tsubata, T. et al.
    • Journal Title

      Autophagy

      Volume: 8 Pages: 1-100

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of inhibitory BCR co-receptors in immunity.2012

    • Author(s)
      Tsubata, T.
    • Journal Title

      Infect Disord Drug Targets

      Volume: 12 Pages: 181-190

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Apoptotic volume decrease (AVD) is independent of mitochondrial dysfunction and initiator caspase activation.2012

    • Author(s)
      前野恵美、鍔田武志、岡田泰伸
    • Journal Title

      Cells

      Volume: 1 Issue: 4 Pages: 1156-1167

    • DOI

      10.3390/cells1041156

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum.2012

    • Author(s)
      Hitomi Y, et al.
    • Journal Title

      BMC Immunol

      Volume: 13 Issue: 1 Pages: 72-72

    • DOI

      10.1186/1471-2172-13-72

    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD22-antagonists with nanomolar potency: The synergistic effect of hydrophobic groups at C-2 and C-9 of sialic acid scaffold.2011

    • Author(s)
      Abdu-Allah,H.H.M.,Takematsu,H., Kozutsumi, Y.,Tsubata, H., Ishida, H. and Kiso,M. et al.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 19 Pages: 1966-1971

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cationic nanogels efficiently deliver proteins to myeloma cells and primary T lymphocytes poorly expressing heparan sulfate2011

    • Author(s)
      K.Watanabe, et al
    • Journal Title

      Biomaterials

      Volume: 32 Issue: 25 Pages: 5900-5905

    • DOI

      10.1016/j.biomaterials.2011.04.058

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of multivalent heterobifunctional CD22-ligand as a potential immunomodulator.2011

    • Author(s)
      Abdu-Allah, H. H. M, Watanabe, K., Kanie, O., Tsubata, T. Ishida, H. and Kiso, M.
    • Journal Title

      Synthesis

      Volume: 18 Pages: 2968-2974

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice.2011

    • Author(s)
      Poe, J. C., Smith , S. H., Haas, K. M., Yanabe, K., Tsubata, T., Matsushita, T. and Tedder, T. F.
    • Journal Title

      PLoS ONE

      Volume: 6 Issue: 7 Pages: 22464-22464

    • DOI

      10.1371/journal.pone.0022464

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-affinity ligands of Siglec receptors and their therapeutic potentials.2011

    • Author(s)
      Magesh, S., Ando, H., Tsubata, T., Ishida, H. and Kiso, M.
    • Journal Title

      Current Medicinal Chemistry

      Volume: 18 Pages: 3537-3550

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 糖鎖抗原への免疫応答・不応答のメカニズム2015

    • Author(s)
      鍔田武志
    • Organizer
      共同研究拠点研究集会 Glyco Immunology 2014.
    • Place of Presentation
      東京医科歯科大学、東京
    • Year and Date
      2015-02-17 – 2015-02-18
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A mouse model for chronic inflammatory diseases spontaneously develops CD4/CD8 double-positive T cell leukemia/lymphoma.2015

    • Author(s)
      P. A. Koni., Ren, M., Tsubata, T., Khleif, S., Maverakis, E. and Shimoda, M.
    • Organizer
      The 54th Midwinter Conference of Immunologists at Asilomar.
    • Place of Presentation
      Big Bear Lake, California (USA)
    • Year and Date
      2015-01-24 – 2015-01-25
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Bリンパ球に発現するCD22/Siglec-2を標的とした免疫増強化合物の開発2015

    • Author(s)
      鍔田武志
    • Organizer
      第8回次世代アジュバント研究会
    • Place of Presentation
      千里ライフサイエンスセンター、大阪
    • Year and Date
      2015-01-20
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] CD22-binding synthetic sialosides as a tool to elucidate the role of CD22 cis-ligand and as a novel immunostimulan.2014

    • Author(s)
      Tsubata, T.
    • Organizer
      Medical Research Institute 40th Anniversary, 13th Surugadai International Symposium & Joint Usage/Research Program of Medical Research Institute International Symposium.
    • Place of Presentation
      Tokyou Medical and Dental Univ. Tokyo, Japan
    • Year and Date
      2014-11-28
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Role of CD22/Siglec2 and its ligand in B lymphocyte activation.2014

    • Author(s)
      Tsubata, T.
    • Organizer
      Joint annual meeting of SFG &JSCR, Integrating Glycoscience from Biology and Chemistry to Medicine.
    • Place of Presentation
      Hilton Hawaiian Village, Honolulu, Hawaii (USA)
    • Year and Date
      2014-11-16 – 2014-11-19
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Synthetic sialosides that regulate CD22/Siglec-2, a B lymphocyte membrane molecule activating SH2-containing phosphatases.2014

    • Author(s)
      Tsubata, T.
    • Organizer
      11th International Conference on Protein Phosphatase
    • Place of Presentation
      Tohoku Univ. Sendai, Japan
    • Year and Date
      2014-11-12 – 2014-11-14
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 免疫グロブリンの機能多様性と疾患2014

    • Author(s)
      鍔田武志
    • Organizer
      第三回高齢者ネフローゼ症候群治療研究会・講演会
    • Place of Presentation
      KPP八重洲ビル、東京
    • Year and Date
      2014-10-18
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 近畿圏を中心としたリウマチ膠原病専門医2014

    • Author(s)
      鍔田武志
    • Organizer
      臨床免疫セミナー
    • Place of Presentation
      ウエスティン都ホテル、京都
    • Year and Date
      2014-10-04
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Bリンパ球の活性化制御と自己免疫2014

    • Author(s)
      鍔田武志
    • Organizer
      第23回日本シェーグレン症候群学会学術集会
    • Place of Presentation
      ホテルニュー長崎、長崎
    • Year and Date
      2014-09-12 – 2014-09-13
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 自己反応性Bリンパ球の制御と細胞死2014

    • Author(s)
      鍔田武志
    • Organizer
      第23回日本Cell Deth学会学術集会
    • Place of Presentation
      東京医科歯科大学、東京
    • Year and Date
      2014-07-18 – 2014-07-19
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] SHP-1-activating Receptors in B lymphocytes.2013

    • Author(s)
      Tsubata, T.
    • Organizer
      The 2nd Taiwan-Japan Bilateral Conference on Protein Phosphatase
    • Place of Presentation
      NHRI, Hsinchu, Taiwan.
    • Year and Date
      2013-11-27 – 2013-11-29
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Sialic acids and immune responses.2013

    • Author(s)
      Tsubata, T.
    • Organizer
      Molecular Frontier Science Conference for Humboltians and DAAD Alumni
    • Place of Presentation
      East China Univ., Shanghai, China
    • Year and Date
      2013-09-20 – 2013-09-22
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] CD72cはFas欠損マウスでの自己免疫疾患発症を制御する修飾遺伝子である2013

    • Author(s)
      鍔田武志
    • Organizer
      第22回日本cell deth 学会学術集会
    • Place of Presentation
      Kyoto Univ., Kyoto
    • Year and Date
      2013-07-19
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] CD72C , a hapolotype encoding the SHP-1-binding B lymphocyte molecule, is a modifier gene for murine lupus2013

    • Author(s)
      Tsubata, T.
    • Organizer
      the 10th International Conference on Protein Phosphatase
    • Place of Presentation
      Tokyo
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Invited
  • [Presentation] 自己抗体産生とアイソタイプ2013

    • Author(s)
      鍔田武志
    • Organizer
      第20回自己抗体と自己免疫シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Invited
  • [Presentation] Sialic acids and immune responses.2013

    • Author(s)
      Tsubata, T.
    • Organizer
      Molecular Frontier Science Conference for Humboltians and DAAD Alumni
    • Place of Presentation
      Shanghai, China
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] SHP-1-activating Receptors in B lymphocytes.2013

    • Author(s)
      Tsubata, T.
    • Organizer
      The 2nd Taiwan-Japan Bilateral Conference on Protein Phosphatase
    • Place of Presentation
      Hsinchu, Taiwan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Excess B cell CD40/CD40L signaling promotes CD4 T cell-mediated encephalomyelitis in mice.2013

    • Author(s)
      himoda. M., Bolduc. A., Takezaki. M., Tsubata. T. and Koni. P-A.
    • Organizer
      Immunology 2013 AAI Annual meeting.
    • Place of Presentation
      Honolulu, U.S.A.
    • Related Report
      2012 Annual Research Report
  • [Presentation] CD72cはFas欠損マウスでの自己免疫疾患発症を制御する修飾遺伝子である2013

    • Author(s)
      鍔田武志
    • Organizer
      第22回日本cell deth 学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Unconventional B cell antigen receptor endocytosis pathway.2013

    • Author(s)
      Takata. T., Tang. M. and Tsubata. T.
    • Organizer
      Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Chiba
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cd72c is a modifier gene that regulates Faslpr-induced autoimmune disease.2013

    • Author(s)
      Xu. M., Hou. R., Sato-Hayashizaki. A., Man. R-Y., Zhu. C., Wakabayashi. C., Hirose. S., Adachi. T. and Tsubata. T.
    • Organizer
      Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Chiba
    • Related Report
      2012 Annual Research Report
  • [Presentation] Distinct tolerance mechanisms for anti-DNA and anti-Sm B cells.2013

    • Author(s)
      Mohammad. A. and Tsubata T.
    • Organizer
      Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Chiba
    • Related Report
      2012 Annual Research Report
  • [Presentation] Glia maturation factor-γ regulates marginal zone B cell migration and humoral immune responses.2013

    • Author(s)
      Li. Y., Hase. K., Tsubata. T. and Wang. J-Y.
    • Organizer
      Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Chiba
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of a putative form of AID that inhibits Ig gene hypermutation.2013

    • Author(s)
      Kano. C., Ohno. H., Tsubata. T. and Wang. J-Y.
    • Organizer
      Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Chiba
    • Related Report
      2012 Annual Research Report
  • [Presentation] Replenishment of long-live plasma cellsis constitutively restrictedby CD4+ T cells in the ir maintenance phase after influenza vaccination.2013

    • Author(s)
      Onodera. T., Takahashi. Y., Adachi. T., Tsubata. T., Kurosaki. T. and Ato. M.
    • Organizer
      Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Chiba
    • Related Report
      2012 Annual Research Report
  • [Presentation] CD72の構造解析に向けて2013

    • Author(s)
      品川健朗、沼本修孝、鍔田武志、伊藤暢聡
    • Organizer
      第51回日本生物物理学会年会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] Synthesis and biological evaluation of the mimics of cis ligand for CD222012

    • Author(s)
      Suganuma, Y., Matsubara, N., Iwayama, Y., Ueki, A., Imamura, A., Ando, H., Tsubata, T., Ishida, H. and Kiso, M.
    • Organizer
      The 4th Asian Communication for Glycobiology and Glycotechnology (ACGG)
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
  • [Presentation] シグレックと感染免疫2012

    • Author(s)
      鍔田武志
    • Organizer
      5回感染病態研究フロンティア
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 全身性自己免疫疾患と自己トレランス2012

    • Author(s)
      鍔田武志
    • Organizer
      第四回全国共同利用・共同研究「酵素学研究拠点」シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Invited
  • [Presentation] C型レクチン様分子CD72による硫酸糖鎖への免疫応答の制御2012

    • Author(s)
      鍔田武志
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report 2011 Annual Research Report
    • Invited
  • [Presentation] Time, place and pathway-specific involvement of reactive oxygen species in B cell antigen receptor signaling.2012

    • Author(s)
      Tang, M., Takata, T., Tsubata, T.
    • Organizer
      Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Kobe
    • Related Report
      2012 Annual Research Report
  • [Presentation] Excess CD40L specifically perturbs self-tolerance of anti-Sm antibody recognizing the same components as patient-derived antibodies.2012

    • Author(s)
      Kishi, Y., Phoon., S., Tsubata, T.
    • Organizer
      Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      Kobe
    • Related Report
      2012 Annual Research Report
  • [Presentation] シグレックと感染免疫2012

    • Author(s)
      鍔田武志
    • Organizer
      第5回感染病態研究フロンテ
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] Time, place and pathway-specific involvement of reactive oxygen species in B cell antigen receptor signaling.2012

    • Author(s)
      Tang, M., Takata, T., Tsubata, T.
    • Organizer
      .日本免疫学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] Excess CD40L specifically perturbs self-tolerance of anti-Sm antibody recognizing the same components as patient-derived antibodies.2012

    • Author(s)
      Kishi, Y., Phoon., S., Tsubata, T.
    • Organizer
      .日本免疫学会学術総会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] チロシンフォスファターゼSHP-1を活性化するBリンパ球膜分子CD72の多型と自己免疫2012

    • Author(s)
      鍔田武志
    • Organizer
      第5回日本プロティンホスファターゼ研究会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] 辺緑帯Bリンパ球のアポトーシスと自己免疫2011

    • Author(s)
      鍔田武志
    • Organizer
      第20回日本Cell Deth学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
    • Invited
  • [Presentation] The C-type lectin-like domain containing B lymphocyte membrane molecule CD72 shows Ca2 +-independent lectin activity to sulfated glycans2011

    • Author(s)
      渡辺幸造、安達貴弘、鍔田武志
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Related Report
      2011 Annual Research Report
  • [Presentation] Apoptotic marginal zone deletion of anti-Sm/RNP B cells is reversed by excess CD40L2011

    • Author(s)
      岸祐介、鍔田武志
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of Reactive Oxygen Species in B Cell Antigen Receptor Signaling2011

    • Author(s)
      Tang Miao、高田俊太朗、鍔田武志
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張
    • Related Report
      2011 Annual Research Report
  • [Book] Siglecs and B cell regulation.In: Taniguchi N., Endo T., Hart G., Seeberger P., Wong C. (Ed.) Glycoscience: Biology and Medicine: SpringerReference (www.springerreference.com)..2014

    • Author(s)
      Tsubata, T.
    • Total Pages
      400
    • Publisher
      Springer-Verlag Berlin Heidelberg
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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