| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2014: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
Reprogramming generates conversion of somatic cell into pluripotent stem cell. Molecular mechanisms of somatic reprogramming is explored by iPS cell induction and cell fusion between somatic and ES cells. Here, we demonstrated function of the Sox2, Nanog, Tet1, and Tet2 genes in reprogramming mechanisms, molecular events in X-chromosome reactivation in reprogramming of female somatic cells, applications of the technique of genome editing in iPS cells, differential response between human and mouse iPS cells to culture under the ground state.
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