| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Research Abstract |
NF-kappaB signaling and interferon production pathway play a pivotal role on biological defense system in various spices. In this study, we identified that SHARPIN is an additional subunit of LUBAC, which produces a novel type of linear polyubiquitin chain and regulates NF-kappaB pathway. Genetic deficiency of SHARPIN causes severe inflammation such as dermatitis in mice. Furthermore, we showed that A20, a deubiquitinatinase, involves evolutionary conserved linear ubiquitin specific binding site at 7th ZF domain. Moreover, we analyzed structure-function study of virus DNA sensor protein, cyclic GMP-AMP synthease (cGAS).
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