| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
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| Research Abstract |
The aim of this study is to identify tumor-suppressive microRNAs (miRNAs) and their direct targets, which potentially contribute to the development of clinical application to miRNA-based therapy for cancers. Actually, in this study, three tumor-suppressive miRNAs, one EMT-suppressive miRNA, and their direct targets were identified through our integrated approach using function- and methylation-based screenings. Moreover, we demonstrated here the great potential of double-stranded RNAs (dsRNA) mimicking sequences of tumor-suppressive miRNAs to be applied to miRNA-based therapy for cancers.
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