A study on the molecular mechanisms of neurodegeneration induced by high-mass amyloid-beta assembly, amylospheroids (ASPD)

• Project/Area Number: 23390079
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: Foundation for Biomedical Research and Innovation
• Principal Investigator: HOSHI Minako 公益財団法人先端医療振興財団, その他部局等, 研究員 (30374010)
• Co-Investigator(Kenkyū-buntansha): OHNISHI Takayuki 公益財団法人先端医療振興財団, 研究員 (30418959) ; INOUE Masafumi 公益財団法人先端医療振興財団, 研究員 (10586655) ; KAKITA Akiyoshi 新潟大学, 脳研究所, 教授 (80281012)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000); Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000); Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 認知症 / 神経細胞死 / 構造異常 / カルシウム / ミトコンドリア / タウ / アミロイド / シナプス

Research Abstract

Amyloid beta protein (Abeta) plays a central role in Alzheimer's disease (AD). To elucidate the molecular identities of pathogenic Abeta oligomers and their neuronal targets responsible for neurodegeneration, we have previously isolated highly toxic Abeta assemblies termed amylospheroids (ASPD) from AD patient brains. Patient-derived ASPD were toxic to human mature neurons and their amount in AD susceptible regions well correlated with pathological severity of AD. In this study, we found that ASPD neurotoxicity requires Ca2+ influx. We also found that voltage gated calcium channels (VGCC) are involved in ASPD neurotoxicity. Interestingly, the abnormal Ca2+ overload induced by ASPD activated two tau protein kinases, and increased the phosphorylation of tau. Importantly, we found that ASPD-binding to the ASPD target protein on mature neuronal surface impairs its activity, responsible for the above abnormal Ca2+ homeostasis and to the severe neurodegeneration.

Research Products

• [Journal Article] The kick-in system: a novel rapid knock-in strategy (2014)
  • Author(s): Tomonoh Y, Deshimaru M, Araki K, Miyazaki Y, Arasaki T, Tanaka Y, Kitamura H, Mori F, Wakabayashi K, Yamashita S, Saito R, Ihoh M, Uchida T, Yamada J, Migita K,, Ueno S, Kitaura H, Kakita A, Lossin C, Takano Y, Hirose S
  • Journal Title: PLoS One Volume: 9
  • Peer Reviewed
• [Journal Article] Hypertrophic pachymeningitis: significance of myeloperoxidase anti-neutrophil cytoplasmic antibody (2014)
  • Author(s): Yokoseki A, Saji E, Arakawa M, Kosaka T, Hokari M, Toyoshima Y, Okamoto K, Takeda S, Sanpei K, Kikuchi H, Hirohata S, Akazawa K, Kakita A, Takahashi H, Nishizawa M, Kawachi I
  • Journal Title: Brain Volume: 137 Pages: 520-536
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• [Journal Article] Co-localization of Bunina bodies and TDP-43 inclusions in lower motor neurons in amyotrophic lateral sclerosis (2014)
  • Author(s): Mori F, Kakita A, Takahashi H, Wakabayashi K
  • Journal Title: Neuropathology Volume: 34 Pages: 71-76
  • Peer Reviewed
• [Journal Article] ALS-associated protein FIG4 is localized in Pick and Lewy bodies, and neuronal nuclear inclusions in polyglutamine and intranuclear inclusion body diseases (2014)
  • Author(s): Kon T, Mori F, Yanji F, Miki Y, Toyoshima Y, Yoshida M, Sasaki H, Kakita A, Takahashi H, Wakabayashi K
  • Journal Title: Neuropathology Volume: 34 Pages: 19-26
  • Peer Reviewed
• [Journal Article] Increased L1 retrotransposition in the neuronal genome in schizophrenia (2014)
  • Author(s): Bundo M, Toyoshima M, Ueda J, Nemoto-Miyauchi T, Sunaga F, Toritsuka M, Ikawa D, Kakita A, Okada Y, Akamatsu W, Kato M, Okano H, Kasai K, Kishimoto T, Nawa H, Yoshikawa T, Kato T, Iwamoto K
  • Journal Title: Neuron Volume: 81 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Argyrophilic grains are reliable disease-specific features of corticobasal degeneration (2014)
  • Author(s): Tatsumi S, Mimuro M, Iwasaki Y, Takahashi R, Kakita A, Takahashi H, Yoshida M
  • Journal Title: J Neuropathol Exp Neurol Volume: 73 Pages: 30-38
  • Peer Reviewed
• [Journal Article] MRI で髄膜造影を呈し脳生検で診断した脳アミロイド β 関連血管炎の1例 (2013)
  • Author(s): 小池佑佳, 大内東香, 佐藤朋江, 新保淳輔, 佐藤晶, 佐々木修, 渋谷宏行, 岡本浩一郎, 柿田明美, 五十嵐修一
  • Journal Title: Brain and Nerve Volume: 65 (6) Pages: 693-697
• [Journal Article] Valosin-containing protein immunoreactivity in tauopathies, synucleinopathies, polyglutamine diseases and intranuclear inclusion body diseas (2013)
  • Author(s): Mori F, Tanji K, Toyoshima Y, Sasaki H, Yoshida M, Kakita A, Takahashi H, Wakabayashi K
  • Journal Title: Neuropathology Volume: 33 (6) Pages: 637-644
• [Journal Article] Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases (2013)
  • Author(s): Tanji K, Maruyama A, Odagiri S, Mori F, Itoh K, Kakita A, Takahashi H, Wakabayashi K
  • Journal Title: J Neuropathol Exp Neurol Volume: 72 (1) Pages: 18-28
• [Journal Article] Brain expression level and activity of HDAC6 protein in neurodegenerative dementia (2013)
  • Author(s): Odagiri S, Tanji K, Mori F, Miki Y, Kakita A, Takahashi H, Wakabayashi K
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 430 (1) Pages: 394-399
• [Journal Article] SORL1 is genetically associated with neuropathologically characterized late-onset Alzheimer's disease (2013)
  • Author(s): Wen Y, Miyashita A, Kitamura N, Tsukie T, Saito Y, Hatsuta H, Murayama S, Kakita A, Takahashi H, Akatsu H, Yamamoto T, Kosaka K, Yamaguchi H, Akazawa K, Ihara Y, Kuwano R
  • Journal Title: Journal of Alzheimer's Disease Volume: 35 (2) Pages: 387-394
• [Journal Article] Valosin-containing protein immunoreactivity in tauopathies, synucleinopathies, polyglutamine diseases and intranuclear inclusion body disease. (2013)
  • Author(s): Mori F, Tanji K, Toyoshima Y, Sasaki H, Yoshida M, Kakita A, Takahashi H, Wakabayashi K
  • Journal Title: Neuropathology Volume: 33 Pages: 633-644
  • Peer Reviewed
• [Journal Article] Decreased number of Gemini of coiled bodies and U12 snRNA level in amyotrophic lateral sclerosis (2013)
  • Author(s): Ishihara T, Ariizumi Y, Shiga A, Tan C-F, Sato T, Miki Y, Yokoo M, Fujino T, Koyama A, Yokoseki A, Nishizawa M, Kakita A, Takahashi H, Onodera O
  • Journal Title: Hum Mol Genet Volume: 22 Pages: 4136-4147
  • Peer Reviewed
• [Journal Article] Sporadic ALS with compound heterozygous mutations in the SQSTM1 gene. (2013)
  • Author(s): Shimizu H, Yokoseki A, Shiga A, Toyoshima Y, Arakawa K, Sekine Y, Shimohata T, Ikeuchi T, Nishizawa M, Kakita A, Onodera O, Takahashi H
  • Journal Title: Acta Neuropathol Volume: 126 Pages: 453-459
  • Peer Reviewed
• [Journal Article] Surgical pathologic features of cerebral cortical lesions taken from 600 patients with intractable epilepsy (2013)
  • Author(s): Kakita A
  • Journal Title: Brain Dev Volume: 35 Pages: 793-801
  • Peer Reviewed
• [Journal Article] MRIで髄膜造影を呈し脳生検で診断した脳アミロイドβ関連血管炎の１例 (2013)
  • Author(s): 小池佑佳、大内東香、佐藤朋江、新保淳輔、佐藤晶、佐々木修、渋谷宏行、岡本浩一郎、柿田明美、五十嵐修一
  • Journal Title: Brain and Nerve Volume: 65 Pages: 693-697
• [Journal Article] Asn 27 is Essential for the Neurotoxicity of Amyloid β(1-42) Peptide (2012)
  • Author(s): Sato, K., Maeda, T., and Hoshi, M.
  • Journal Title: International J. of Peptide Res. And Therapeutics Volume: 18 Pages: 341-345
• [Journal Article] Optineurin immunoreactivity in neuronal nuclear inclusions of polyglutamine diseases (Huntington's, DRPLA, SCA2, SCA3) and intranuclear inclusion body disease (2012)
  • Author(s): Mori F, Tanji K, Toyoshima Y, Yoshida M, Kakita A, Takahashi H, Wakabayashi K
  • Journal Title: Acta Neuropathologica Volume: 123 (5) Pages: 747-749
• [Journal Article] Dynein and dynactin components modulate neurodegeneration induced by excitotoxicity (2012)
  • Author(s): Fujiwara T, Morimoto K, Kakita A, Takahashi H
  • Journal Title: Journal of Neurochemistry Volume: 122 (1) Pages: 162-174
• [Journal Article] Characteristics of aquaporin expression surrounding senile plaques and cerebral amyloid angiopathy in Alzheimer disease (2012)
  • Author(s): Hoshi A, Yamamoto T, Shimizu K, Ugawa Y, Nishizawa M, Takahashi H, Kakita A
  • Journal Title: Journal of Neuropathology and Experimental Neurology Volume: 71 (8) Pages: 750-759
• [Journal Article] Involvement of the γ-secretase-mediated EphA4 signaling pathway in synaptic pathogenesis of Alzheimer's disease (2012)
  • Author(s): Matsui C, Inoue E, Kakita A, Arita K, Deguchi-Tawarada M, Togawa A, Yamada A, Takai Y, Takahashi H
  • Journal Title: Brain Pathology Volume: 22 (6) Pages: 776-787
• [Journal Article] Asn27 is Essential for the Neurotoxicity of Amyloid β(1-42) Peptide (2012)
  • Author(s): Sato, K., Maeda, T., and Hoshi, M.
  • Journal Title: International J. of Peptide Res. And Therapeutics Volume: 18 Pages: 341-345
  • Peer Reviewed
• [Journal Article] Two distinct amyloid β-protein (Aβ) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology and toxicity analyses (2011)
  • Author(s): Matsumura, S., Shinoda, K., Yamada, M., Yokojima, S., Inoue, M., Ohnishi, T., Shimada, T., Kikuchi, K., Masui, D., Hashimoto, S., Sato, M., Ito, A., Akioka, M., Takagi, S., Nakamura, Y., Nemoto, K., Hasegawa, Y., Takamoto, H., Inoue, H., Nakamura, S., Nabeshima, Y., Teplow, D.B., Kinjo, M., and Hoshi, M.
  • Journal Title: J. Biol. Chem Volume: 286 Pages: 11555-11562
• [Journal Article] A Simplified Recipe For Assigning Amide NMR Signals Using Combinatorial 14N Amino Acid Inverse-Labeling J. Struct (2011)
  • Author(s): Hiroaki, H., Umetsu, Y., Nabeshima, Y., Hoshi, M., Kohda, D
  • Journal Title: Functional Genomics Volume: 12 Pages: 167-174
• [Journal Article] Alteration of autophagosomal proteins (LC3, GABARAP and GATE-16) in Lewy body disease (2011)
  • Author(s): Tanji K, Mori F, Kakita A, Takahashi H, Wakabayashi K
  • Journal Title: Neurobiology of Disease Volume: 43 (3) Pages: 690-697
• [Journal Article] Unmyelinated axons are more vulnerable to degeneration than myelinated axons of the cardiac nerve in Parkinson's disease (2011)
  • Author(s): Orimo S, Uchihara T, Kanazawa T, Wakabayashi K, Kakita A, Takahashi H
  • Journal Title: Neuropathology and Applied Neurobiology Volume: 37 (7) Pages: 791-802
• [Journal Article] Two distinct amyloid β-PROTEIN (Aβ) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology and toxicity analyses (2011)
  • Author(s): Matsumura, S., et al
  • Journal Title: J.Biol.Chem. Volume: 286 Pages: 11555-11562
  • Peer Reviewed
• [Journal Article] A Simplified Recipe For Assigning Amide NMR Signals Using Combinatorial 14N Amino Acid Inverse-Labeling (2011)
  • Author(s): Hiroaki, H., et al
  • Journal Title: J.Struct.Functional Genomics Volume: 12 Pages: 167-174
  • Peer Reviewed
• [Presentation] How Does An Amyloid β-Protein Assembly Kill Mature Neurons In Alzheimer Disease Brain? (2013)
  • Author(s): Minako Hoshi
  • Organizer: 6 th Asian Aging Core for Longevity (AACL) conference in Kyoto Aging Research Forum between Japan and Korea, organized by Prof. Mori and Dr. Nabeshima
  • Place of Presentation: Kyoto
  • Year and Date: 2013-11-01
  • Invited
• [Presentation] アルツハイマー病の根本治療を目指した新規治療法の研究開発 (2013)
  • Author(s): 星 美奈子
  • Organizer: 第13回日本蛋白質科学会年会
  • Place of Presentation: 鳥取
  • Year and Date: 2013-06-14
  • Invited
• [Presentation] 病態解明に基づくアルツハイマー病新規治療法の研究開発;基礎研究から大学発ベンチャーでの創薬へ (2013)
  • Author(s): 星 美奈子
  • Organizer: 第28回老年精神医学会
  • Place of Presentation: 香川大医学部
  • Year and Date: 2013-06-05
  • Invited
• [Presentation] Solid-state NMR study of pathologically relevant amyloid intermediate of 42-residue Alzheimer’s beta (2013)
  • Author(s): S. Parthasarathy, M. Inoue, Y. Xiao, M. Hoshi, Y. Ishii
  • Organizer: 57th annual meeting for biophysical society
  • Place of Presentation: Philadelphia
• [Presentation] High-Mass Amyloid β-Protein Assembly With Unique Toxic Surfaces From Patient Brains Towards Rational Therapy For Alzheimer Disease (2012)
  • Author(s): Minako Hoshi
  • Organizer: Advances in Aging Research 2012
  • Place of Presentation: Osaka
  • Year and Date: 2012-04-05
  • Invited
• [Presentation] Molecular level structural studies of the Aβ(1-42) amylo-spheroids by solid-state NMR and resolution enhanced solid-state NMR by SAIL labeling and ultra fast MAS (2012)
  • Author(s): S. Parthasarathy, M. Inoue, Y. Nishiyama, Y. Endo, Y. Xiao, T. Nemoto, M. Hoshi, M. Kainosho, Y. Ishii
  • Organizer: The 55th Annual Rocky Mountain Conference on Magnetic Resonance
  • Place of Presentation: Denver
• [Presentation] 14. SSNMR studies of amyloid fibril and pathologically relevant spherical amyloid amylospheroid (ASPD) for Aβ(1-42) (2012)
  • Author(s): Y. Xiao, S. Parthasarathy, M. Inoue, M. Hoshi, Y. Ishii
  • Organizer: 54th Experimental Nuclear Magnetic Resonance Conference
  • Place of Presentation: Pacific Grove
• [Presentation] Enlightening Protein Assembly Pathways Leading to Alzheimer Disease" IBRI Mini-Workshop on amyloid-beta protein oligomer amyloid-beta protein assembly "Deciphering the mystery of amyloid-beta protein assembly.", organized by Professors Hiroaki and Hoshi Kobe (2011)
  • Author(s): Hoshi, M.
  • Organizer: Annual meeting for Japanese Biochemical Societies
  • Place of Presentation: Kobe(オーガナイザー)(招待講演)
  • Year and Date: 2011-09-22
• [Presentation] A new toxic target for a high-mass amyloid β-protein assembly with a unique toxic structure (2011)
  • Author(s): Hoshi, M., Ohnishi, T., Inoue, M., Hiroaki, H., Nabeshima, Y., Kakita, A
  • Organizer: "International conference on Alzheimer's disease : Return to the Basics" at Annual meeting for Japanese Biochemical Societies, organized by Professors Iwata and Hoshi
  • Place of Presentation: Kyoto
  • Year and Date: 2011-09-21
  • Invited
• [Presentation] A New Toxic Target For A High-Mass Amyloid β-Protein Assembly With A Unique Toxic Surface 'A Return to the Basics - Molecular Decoding of the Alzheimers Disease Pathogenesis' (2011)
  • Author(s): Minako Hoshi
  • Organizer: the 2011 annual meeting for the Japanese Biochemical Society
  • Place of Presentation: Kyoto
  • Year and Date: 2011-09-21
  • Invited
• [Presentation] A new toxic target for a high-mass amyloid ss-protein assembly with a unique toxic structure "International conference on Alzheimer's disease : Return to the Basics" at Annual meeting for Japanese Biochemical Societies, organized by Professors Iwata and Hoshi (2011)
  • Author(s): Hoshi, M., Ohnishi, T., Inoue, M., Hiroaki, H., Nabeshima, Y., Kakita, A.
  • Organizer: Annual meeting for Japanese Biochemical Societies
  • Place of Presentation: Kyoto(オーガナイザー)(招待講演)
  • Year and Date: 2011-09-21
• [Presentation] Mechanism of mature neuron-specific toxicity induced by high-mass a myloid β-protein assembly with a unique toxic structure (2011)
  • Author(s): Hoshi, M., Ohnishi, T., Inoue, M., Hiroaki, H., Nabeshima, Y., Kakita, A.
  • Organizer: The 10^<th> international conference on Alzheimer's diseases
  • Place of Presentation: Paris
• [Presentation] How Does An Amyloid β-Protein Assembly Kill Mature Neurons In Alzheimer Disease Brain?
  • Author(s): M. Hoshi
  • Organizer: 6th Asian Aging Core for Longevity (AACL) conference in Kyoto (Aging Research Forum between Japan and Korea)
  • Place of Presentation: Kyoto
  • Invited
• [Presentation] 病態解明に基づくアルツハイマー病新規治療法の研究開発；基礎研究から大学発ベンチャーでの創薬へ
  • Author(s): 星 美奈子
  • Organizer: 第２８回老年精神医学会（日本大阪）
  • Place of Presentation: 大阪
  • Invited
• [Presentation] アルツハイマー病の根本治療を目指した新規治療法の研究開発
  • Author(s): 星 美奈子
  • Organizer: 第１３回日本蛋白質科学会年会(鳥取) ワークショップ：アミロイド凝集の統一的理解を目指してー分子から細胞の視点までーオーガナイザー：八木寿梓、茶谷絵理
  • Place of Presentation: 鳥取
  • Invited
• [Presentation] ASPDは新薬の標的となるか：アルツハイマー病新規治療法の研究開発
  • Author(s): 星 美奈子
  • Organizer: 日経バイオテクノロジー バイオファイナンスギルド講演会 「アルツハイマー病創薬の突破口」
  • Place of Presentation: 東京
  • Invited
• [Presentation] アルツハイマー病の根本治療を目指した研究開発；基礎研究から大学発ベンチャーでの創薬へ
  • Author(s): 星 美奈子
  • Organizer: 第５９回MACメディカル交流会
  • Place of Presentation: 東京
  • Invited
• [Presentation] High-Mass Amyloid β-Protein Assembly With Unique Toxic Surfaces From Patient Brains Towards Rational Therapy For Alzheimer Disease
  • Author(s): Minako Hoshi
  • Organizer: ‘Advances in Aging Research 2012’ Oraganized by Professors Komuro and Nabeshima
  • Place of Presentation: Osaka
  • Invited
• [Presentation] アルツハイマー病の根本治療を目指した新規治療法の研究開発
  • Author(s): 星美奈子
  • Organizer: Bio Japan 2012 TR事業成果報告会（ＮＥＤＯ主催）
  • Place of Presentation: 横浜
  • Invited
• [Presentation] 神経細胞における球状アミロイドβ凝集体の細胞内形成機構
  • Author(s): H. Komura, N. Takino, S. Muramatus, M.Hoshi
  • Organizer: ワークショップ：神経・筋疾患に関する最近の研究; 発症メカニズムの解明・治療・細胞骨格 オーガナイザー: 石浦章一 (東大・院・総合文化・生命) 第35回日本分子生物学会年会
  • Place of Presentation: 博多
  • Invited
• [Presentation] Intraneuronal formation of high-mass spherical amyloid beta assemblies from amyloid precursor proteins in neurons with Alzheimer mutations
  • Author(s): H. Komura, N. Takino, S. Muramatsu, M. Hoshi
  • Organizer: Society for Neuroscience 2012
  • Place of Presentation: New Orleans
• [Presentation] Mechanism of mature neuron-specific toxicity induced by amylospheroids (ASPDs): analyses of the down-stream signal transduction pathways leading to the severe neurodegeneration.
  • Author(s): T. Ohnishi T, M. Inoue, H. Komura, M. Tada, Y. Nabeshima, M. Hagiwara, A. Kakita and M. Hoshi M.
  • Organizer: Society for Neuroscience 2012
  • Place of Presentation: New Orleans
• [Presentation] Chemically essential substructure and solution conditions activate the amyloid-β protein as soluble and toxic spherical assembly
  • Author(s): M. Inoue, T. Onishi, D. Masui, Y. Nabeshima, M. Hagiwara, H. Hiroaki, M. Hoshi
  • Organizer: Society for Neuroscience 2012
  • Place of Presentation: New Orleans
• [Presentation] アミロイドβペプチドの毒性会合体形成経路の解明
  • Author(s): 井上雅文、大西隆之、廣明秀一、菊地和也、鍋島陽一、萩原正敏、金城政孝、星美奈子
  • Organizer: 第7回日本ケミカルバイオロジー学会年会
  • Place of Presentation: 京都
  • Invited
• [Book] てんかん原性の病理．第2章 てんかんの病因・病態生理．(In) 日本てんかん学会（編集）てんかん専門医ガイドブック．―てんかんにかかわる医師のための基礎知識― (2014)
  • Author(s): 柿田明美
  • Total Pages: 303
  • Publisher: 診断と治療社
• [Patent(Industrial Property Rights)] 抗体及びその利用 (2013)
  • Inventor(s): 星 美奈子, 佐藤 道夫, 井手野 祥次, 内藤 幸嗣, 保理江 智, 野田 宗宏, 堀井 肇
  • Industrial Property Rights Holder: TAOヘルスライフファーマ株式会社
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-01-25
• [Patent(Industrial Property Rights)] Antibody and use thereof (2013)
  • Inventor(s): HOSHI Minako, SATO Michio, IDENO Shoji, NAITO Koji, HORIE Satoshi, NODA Munehiro, HORII Hajime
  • Industrial Property Rights Holder: TAO Health Life Pharma Co., Ltd.
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-05-21
  • Overseas
• [Patent(Industrial Property Rights)] アミロスフェロイドが結合して成熟神経細胞死を誘発する標的分子,アミロスフェロイドが誘導する神経細胞死を抑制する方法及び物質,及びそれらの利用 (2012)
  • Inventor(s): 星 美奈子
  • Industrial Property Rights Holder: TAOヘルスライフファーマ株式会社
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-12-21
  • Overseas
• [Patent(Industrial Property Rights)] A NEUROTOXIC TARGET FOR AMYLOSPHEROID, A METHOD AND A MATERIAL FOR REDUCING THE NEUROTOXICITY OF AMYLOSPHEROID, AND A USE OF THE SAME (2012)
  • Inventor(s): HOSHI Minako
  • Industrial Property Rights Holder: HOSHI Minako
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-12-28
  • Overseas
• [Patent(Industrial Property Rights)] 合成アミロスフェロイドの製造方法 (2012)
  • Inventor(s): 星 美奈子
  • Industrial Property Rights Holder: TAOヘルスライフファーマ株式会社
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-12-18
  • Overseas
• [Patent(Industrial Property Rights)] Antibody and use thereof (2012)
  • Inventor(s): HOSHI Minako, NAITO Koji, IDENO Shouji
  • Industrial Property Rights Holder: TAO Health Life Pharma Co., Ltd.
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-01-05
  • Overseas
• [Patent(Industrial Property Rights)] 合成アミロスフェロイドの製造方法 (2012)
  • Inventor(s): 星 美奈子
  • Industrial Property Rights Holder: TAOヘルスライフファーマ株式会社
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-12-18
  • Overseas
• [Patent(Industrial Property Rights)] アミロスフェロイドが結合して成熟神経細胞死を誘発する標的分子、アミロスフェロイドが誘導する神経細胞死を抑制する方法及び物質、及びそれらの利用 (2012)
  • Inventor(s): 星 美奈子
  • Industrial Property Rights Holder: TAOヘルスライフファーマ株式会社
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-12-21
  • Overseas
• [Patent(Industrial Property Rights)] A NEUROTOXIC TARGET FOR AMYLOSPHEROID, A METHOD AND A MATERIAL FOR REDUCING THE NEUROTOXICITY OF AMYLOSPHEROID, AND A USE OF THE SAME (2012)
  • Inventor(s): 星 美奈子
  • Industrial Property Rights Holder: TAOヘルスライフファーマ株式会社
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-12-28
  • Overseas
• [Patent(Industrial Property Rights)] アミロスフェロイドが結合して成熟神経細胞死を誘発する標的分子、アミロスフェロイドが誘導する神経細胞死を抑制する方法及び物質、及びそれらの利用 (2012)
  • Inventor(s): 星美奈子
  • Industrial Property Rights Holder: TAOヘルスライフファーマ株式会社
  • Industrial Property Number: 2012-002448
  • Filing Date: 2012-01-10
• [Patent(Industrial Property Rights)] 抗体及びその利用 (2011)
  • Inventor(s): 星 美奈子, 内藤 幸嗣, 井手野 祥次
  • Industrial Property Rights Holder: TAOヘルスライフファーマ株式会社
  • Industrial Property Rights Type: 特許
  • Filing Date: 2011-09-09
• [Patent(Industrial Property Rights)] アミロスフェロイドが結合して成熟神経細胞死を誘発する標的分子、アミロスフェロイドが誘導する神経細胞死を抑制する方法及び物質、及びそれらの利用 (2011)
  • Inventor(s): Hoshi, M.
  • Industrial Property Rights Holder: TAOヘルスライフファーマ株式会社
  • Filing Date: 2011-12-29
  • Overseas
• [Patent(Industrial Property Rights)] 合成アミロスフェロイドの製造方法 (2011)
  • Inventor(s): 星美奈子
  • Industrial Property Rights Holder: TAOヘルスライフファーマ株式会社
  • Industrial Property Number: 2011-281845
  • Filing Date: 2011-12-22
• [Patent(Industrial Property Rights)] 抗体及びその利用 (2005)
  • Inventor(s): Hoshi, M., Naito, K., Ideno, S.
  • Industrial Property Rights Holder: TAOヘルスライフファーマ株式会社
  • Filing Date: 2005-08-11
  • Acquisition Date: 2012-05-01
  • Overseas
• [Patent(Industrial Property Rights)] 抗体及びその利用 (2005)
  • Inventor(s): 星美奈子、内藤幸嗣、井手野祥次
  • Industrial Property Rights Holder: TAOヘルスライフファーマ株式会社
  • Filing Date: 2005-08-11
  • Acquisition Date: 2011-09-09