Mechanisms and applications of SIK2-regulation for neuro-protection

• Project/Area Number: 23390082
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathological medical chemistry
• Research Institution: 独立行政法人医薬基盤研究所
• Principal Investigator: TAKEMORI Hiroshi 独立行政法人医薬基盤研究所, 創薬基盤研究部, プロジェクトリーダー (90273672)
• Co-Investigator(Kenkyū-buntansha): HATANO Osamu 奈良県立医科大学, 医学部, 講師 (40164850) ; KITAGAWA Kazuo 大阪大学, 医学系研究科, 准教授 (70301257) ; NAGAOKA Yasuo 関西大学, 工学部, 教授 (90243039) ; 田端 俊英 富山大学, 大学院理工学研究科, 准教授 (80303270)
• Co-Investigator(Renkei-kenkyūsha): KUMAGAI Ayako 独立行政法人医薬基盤研究所, 創薬基盤研究部, 特任研究員 (20455869)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000); Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
• Keywords: SIK / CREB / 転写 / 神経保護 / フラボノイド / 阻害剤 / CRTC1 / ｃAMPシグナル / 神経 / 化合物 / 活性酸素 / 認知症

Research Abstract

We reported that SIK2-KO mice showed neuro-protective phenotypes after the ischemia-reperfusion operation. In addition, SIK2 regulates hair color by inhibiting melanogenesis. By using these phenotypes, we tried to indentify new compounds that are helpful to care ischemia-reperfusion damage in the brain. We screened compounds by an in vitro kinase assay and identified fisetin as a candidate for the SIK2 inhibitor. However, fisetin did not inhibit SIK2 actions in cultured cells. Interestingly, fisetin changed mouse hair color, and we found methoxy-fisetin in mouse feces. The synthesized methoxy-fisetin (4MF) inhibited SIK2 and acted as a neuro-protector after the glutamate treatment in primary neurons. 4MF-treated mice showed enhanced memory capacity. In addition to 4MF, we obtained some compounds that showed neuro-protective activities in an SIK2 dependent or independent manners.

Research Products

• [Journal Article] Lack of SIK2 prevents the development of cardiac hypertrophy in response to chronic high-salt intake (2014)
  • Author(s): Popov S.*, Takemori H.*, Tokudome T., Mao Y., Otani K., Mochizuki N., Pires N., Pinho M.J., Franco-Cereceda A., Torielli L., Ferrandi M., Hamsten A., Eriksson P., Bertorello A.M., Brion L
  • Journal Title: PLos ONE Volume: 9
  • Peer Reviewed
• [Journal Article] Prostaglandin E promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase (2013)
  • Author(s): Yao C, Hirata T, Soontrapa K, Ma X, Takemori H, Narumiya S
  • Journal Title: Nat Commun Volume: 4 Pages: 1685-1685
• [Journal Article] LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription (2013)
  • Author(s): Tang HM, Gao WW, Chan CP, Siu YT, Wong CM, Kok KH, Ching YP, Takemori H, Jin DY
  • Journal Title: Retrovirology Volume: 10 Pages: 40-40
• [Journal Article] Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells (2013)
  • Author(s): Horibe I, Satoh Y, Shiota Y, Kumagai A, Horike N, Takemori H, Uesato S, Sugie S, Obata K, Kawahara H, Nagaoka Y
  • Journal Title: J Nat Med Volume: 67 Pages: 705-10
• [Journal Article] Salt-inducible kinase 1 is involved in high glucose-induced mesangial cell proliferation mediated by the ALK5 signaling pathway (2013)
  • Author(s): Yu J, Hu X, Yang Z, Takemori H, Li Y, Zheng H, Hong S, Liao Q, Wen X
  • Journal Title: Int J Mol Med Volume: 32 Pages: 151-157
• [Journal Article] 注目される病態関連分子 AMPK 分子脳血管学 (2013)
  • Author(s): 伊東祐美, 竹森 洋
  • Volume: 12
  • Pages: 54-58
• [Journal Article] LKB1 tumor suppressor and salt-inducible kinases negatively regulate human T-cell leukemia virus type 1 transcription. (2013)
  • Author(s): Tang H.M., Gao W.W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Takemori H., Jin D.Y.
  • Journal Title: Retrovirology Volume: 10 Pages: 40-40
  • Peer Reviewed
• [Journal Article] Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells. (2013)
  • Author(s): Horibe I., Satoh Y., Shiota Y., Kumagai A., Horike N., Takemori H., Uesato S., Sugie S., Obata K., Kawahara H., Nagaoka Y
  • Journal Title: J Nat Med. Volume: 67 Pages: 705-710
  • Peer Reviewed
• [Journal Article] Salt-inducible kinase 1 is involved in high glucose-induced mesangial cell proliferation mediated by the ALK5 signaling pathway. (2013)
  • Author(s): Yu J., Hu X., Yang Z., Takemori H., Li Y., Zheng H., Hong S., Liao Q., Wen X.
  • Journal Title: Int J Mol Med. Volume: 32 Pages: 151-157
  • Peer Reviewed
• [Journal Article] Involvement of SIK3 in glucose and lipid homeostasis in mice (2012)
  • Author(s): Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii E, Aozasa K, Kawamura T, Okumura M, Nakae J, Takikawa H, Fukusato T, Koura M, Nish M, Hamsten A, Silveira A, Bertorello AM, Kitagawa K, Nagaoka Y, Kawahara H, Tomonaga T, Naka T, Ikegawa S, Tsumaki N, Matsuda J, Takemori H
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] Novel repressor regulates insulin sensitivity through interaction with Foxo1 (2012)
  • Author(s): Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi S, Itoh H
  • Journal Title: EMBO J Volume: 31 Pages: 2275-95
• [Journal Article] Increases in intracellular sodium activate transcription and gene expression via the salt-inducible kinase 1 network in an atrial myocyte cell line (2012)
  • Author(s): Popov S, Venetsanou K, Chedrese PJ, Pinto V, Takemori H, Franco-Cereceda A, Eriksson P, Mochizuki N, Soares-da-Silva P, Bertorello AM
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 303
• [Journal Article] SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice (2012)
  • Author(s): Sasagawa S, Takemori H, Uebi T, Ikegami D, Hiramatsu K, Ikegawa S, Yoshikawa H, Tsumaki N
  • Journal Title: Development Volume: 139 Pages: 1153-63
• [Journal Article] Salt-inducible kinase is involved in the regulation of corticotropin-releasing hormone transcription in hypothalamic neurons in rats (2012)
  • Author(s): Liu Y, Poon V, Sanchez-Watts G, Watts AG, Takemori H, Aguilera G
  • Journal Title: Endocrinology Volume: 153 Pages: 223-33
• [Journal Article] Cocaine induces the expression of MEF2C transcription factor in rat striatum through activation of SIK1 and phosphorylation of the histone deacetylase HDAC5 (2012)
  • Author(s): Dietrich JB, Takemori H, Grosch-Dirrig S, Bertorello A, Zwiller J
  • Journal Title: Synapse Volume: 66 Pages: 61-70
• [Journal Article] Involvement of SIK3 in glucose and lipid homeostasis in mice. (2012)
  • Author(s): Uebi T
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] Popov S, Venetsanou K, Chedrese PJ, Pinto V, Takemori H, Franco-Cereceda A, Eriksson P, Mochizuki N, Soares-da-Silva P, Bertorello AM. Increases in intracellular sodium activate transcription and gene expression via the salt-inducible kinase 1 network in an atrial myocyte cell line. (2012)
  • Author(s): Popov S
  • Journal Title: Am J Physiol Heart Circ Physiol. Volume: 303
  • Peer Reviewed
• [Journal Article] Induction of melanogenesis by 4'-O-methylated flavonoids in B16F10 melanoma cells. (2012)
  • Author(s): Horibe I
  • Journal Title: J Nat Med. Volume: 32 Pages: 1-1
  • Peer Reviewed
• [Journal Article] Involvement of SIK3 in glucose and lipid homeostasis in mice (2012)
  • Author(s): Uebi T, Itoh Y, Hatano O, Kumagai A, Sanosaka M, Sasaki T, Sasagawa S, Doi J, Tatsumi K, Mitamura K, Morii M, Aozasa K, Kawamura T, Okumura M, Nakae J, Takikawa H, Fukusato T, Koura M, Nish M, Hamsten A, Silveiral A, Bertorellol AM, Kitagawa K, Nagaoka Y, Kawahara H, Tomonaga T, Naka T, Ikegawa S, Tsumaki N, Matsuda J, Takemori H
  • Journal Title: PLoS ONE Volume: e7(in press)
  • Peer Reviewed
• [Journal Article] Novel repressor regulates insulin sensitivity through interaction with Foxol (2012)
  • Author(s): Nakae J, Cao Y, Hakuno F, Takemori H, Kawano Y, Sekioka R, Abe T, Kiyonari H, Tanaka T, Sakai J, Takahashi SI, Itoh H
  • Journal Title: EMBO J Volume: (in press)
  • Peer Reviewed
• [Journal Article] cAMP stimulation of STAR expression and cholesterol metabolism (2011)
  • Author(s): Jefcoate CR, Lee J, Cherradi N, Takemori H
  • Journal Title: Mol Cell Endocrinol Volume: 336 Pages: 53-62
• [Journal Article] Salt-inducible kinase 1 influences Na(+),K(+)-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure (2011)
  • Author(s): Popov S, Silveira A, Wågsäter D, Takemori H, Oguro R, Matsumoto S, Sugimoto K, Kamide K, Hirose T, Satoh M, Metoki H, Kikuya M, Ohkubo T, Katsuya T, Rakugi H, Imai Y, Sanchez F, Leosdottir M, Syvänen AC, Hamsten A, Melander O, Bertorello AM
  • Journal Title: J Hypertens Volume: 29 Pages: 2395-403
• [Journal Article] A potent inhibitor of SIK2, 3, 3', 7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells (2011)
  • Author(s): Kumagai A, Horike N, Satoh Y, Uebi T, Sasaki T, Itoh Y, Hirata Y, Uchio-Yamada K, Kitagawa K, Uesato S, Kawahara H, Takemori H Nagaoka Y
  • Journal Title: PLoS One Volume: 6
• [Journal Article] Carbohydrate metabolism is perturbed in peroxisome-deficient hepatocytes due to mitochondrial dysfunction, AMP-activated protein kinase (AMPK) activation, and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression (2011)
  • Author(s): Peeters A, Fraisl P, van den Berg S, Ver Loren van Themaat E, Van Kampen A, Rider MH, Takemori H, van Dijk KW, Van Veldhoven PP, Carmeliet P, Baes M
  • Journal Title: J Biol Chem Volume: 286 Pages: 42162-79
• [Journal Article] Salt-inducible kinase 1 is present in lung alveolar epithelial cells and regulates active sodium transport (2011)
  • Author(s): Eneling K, Chen J, Welch LC, Takemori H, Sznajder JI, Bertorello AM
  • Journal Title: Biochem Biophys Res Commun Volume: 409 Pages: 28-33
• [Journal Article] Salt inducible kinase is involved in the regulation of corticotropin releasing hormone transcription in hypothalamic neurons in rats (2011)
  • Author(s): Liu Y, Poon V, Sanchez-Watts G, Watts AG, Takemori H, Aguilera G
  • Journal Title: Endocrinology Volume: 153 Pages: 223-233
  • Peer Reviewed
• [Journal Article] Carbohydrate metabolism is perturbed in peroxisome deficient hepatocytes due to mitochondrial dysfunction, AMP activated protein kinase (AMPK) activation and peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) suppression (2011)
  • Author(s): Peeters A, Fraisl P, Berg S, Themaat E, Kampen A, Rider MH, Takemori H, Dijk K, Veldhoven P, Cameliet P, Baes M
  • Journal Title: J.Biol.Chem. Volume: 268 Pages: 42162-42179
  • Peer Reviewed
• [Journal Article] Salt-inducible kinase 1 influences Na+, K+-ATPase activity in vascular smooth muscle cells and associates with variations in blood pressure (2011)
  • Author(s): Popov S, Silveira A, Wagsater D, Takemori H, Oguro R, Matsumoto S, Sugimoto K, Kamide K, Hirose T, Satoh M, Metoki H, Kikuya M, Ohkubo T, Katsuya T, Rakugi H, Imai Y, Sanchez F, Leosdottir M, Syvanen AC, Hamsten A, Melander O, Bertorello AM
  • Journal Title: J Hypertens Volume: 29 Pages: 2395-2403
  • Peer Reviewed
• [Journal Article] A potent inhibitor of SIK2, 3,3',7-trihydroxy-4'-methoxyflavon (4'-O-methylfisetin), promotes melanogenesis in B16F10 melanoma cells (2011)
  • Author(s): Kumagai A, Horike N, Satoh Y, Uebi T, Sasaki T, Itoh Y, Hirata Y, Uchio-Yamada K, Kitagawa K, Uesato S, Kawahara H, Takemori H, Nagaoka Y
  • Journal Title: PLoS ONE Volume: 6
  • Peer Reviewed
• [Presentation] カルノソール・カルノソール誘導体による酸化ストレスに対する臓器保護 (2013)
  • Author(s): 川村知裕,舟木壮一郎,中桐伴行,新谷康,井上匡美,澤端章好,南 正人,杉村康司,飯田修,渕野裕之,川原信夫,竹森洋,奥村明之進
  • Organizer: 第194回近畿外科学会
  • Place of Presentation: 大阪
  • Year and Date: 2013-11-09
• [Presentation] Effects of Pterosin B from Pteridium Aquilinum on the blood glucose level in db/db mice (2013)
  • Author(s): Ito Y, Sanosaka M, Kumagai A, Takemori H, Fuchino H, Kawahara N, Doi J, Ota M
  • Organizer: The EMBO meeting
  • Place of Presentation: AMSETDAM
  • Year and Date: 2013-09-22
• [Presentation] Effects of Pterosin B from Pteridium Aquilinum on the blood glucose level in db/db mice. (2013)
  • Author(s): Ito Y., Sanosaka M., Kumagai A., Takemori H., Fuchino H., Kawahara N., Doi J., Ota M.
  • Organizer: The EMBO meeting
  • Place of Presentation: Amsterdam
• [Presentation] SIK3 regulates pro-inflammatroy cytokine expression in mouse macrophage. (2013)
  • Author(s): Sanosaka M., Fujimoto M., Ohkawara T., Ito Y., Kumagai A., Naka T., Takemori H.
  • Organizer: 2013 ASCB Annual Meeting
  • Place of Presentation: New Orleans
• [Presentation] Metformin inhibits human T-cell leukemia virus type 1 transcription through activation of LKB1 and salt-inducible kinases (2013)
  • Author(s): Tang H.M., Gao W.W., Chan C.P., Siu Y.T., Wong C.M., Kok K.H., Ching Y.P., Takemori H., Jin D.Y.
  • Organizer: 16th International Conference on Human Retroviruses
  • Place of Presentation: Montreal
• [Presentation] SIK3 によるクラスII-HDAC 制御がコレステロール-胆汁酸代謝へ与える影響 (2012)
  • Author(s): 伊東祐美,佐野坂真人,熊谷彩子,竹森洋
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-16
• [Presentation] 塩誘導性キナーゼ 2 (SIK2)の新規メラニン合成調節機構について (2012)
  • Author(s): 熊谷彩子,堀家なな緒,伊東祐美,長岡康夫,竹森 洋
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-16
• [Presentation] SIK3 はマクロファージにおける炎症性サイトカインの発現を制御する (2012)
  • Author(s): 佐野坂真人,伊東祐美,藤本穣,大河原知治,仲哲治,竹森 洋
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-16
• [Presentation] ニコチンによる CREB-CRTC 活性化を介した神 経保護機構の検討 (2012)
  • Author(s): 佐々木勉, 竹森 洋,大山直紀,由上登志郎,渡邊彰弘,八木田佳樹,望月秀樹,北川一夫
  • Organizer: 第24回日本脳循環代謝学会
  • Place of Presentation: 広島
  • Year and Date: 2012-11-08
• [Presentation] 新たなエノキ素材による体重減少と胆汁酸代謝亢進作用について (2012)
  • Author(s): 伊東祐美,大西智子,田村淑恵,藤川和平,土居純子,竹森 洋,片倉啓雄,河原秀久
  • Organizer: 第51回日本栄養・食糧学会 近畿支部大会
  • Place of Presentation: 宝塚
  • Year and Date: 2012-10-20
• [Presentation] 植物由来フラボノイド A に新規に見出されたかん細胞優位な放射線増感作用 (2012)
  • Author(s): 坂東真一,秦野 修,竹森 洋,窪田宜夫,大西健
  • Organizer: 第71回日本癌学会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-20
• [Presentation] フ ラ ボ ノ イ ド 3,5,7-Trihydroxy-3,4 ' -Dimethoxyflavone に新規に見出されたがん細胞優位な細胞致死作用 (2012)
  • Author(s): 大西健,坂東真一,秦野 修,竹森 洋,窪田宜夫
  • Organizer: 第71回日本癌学会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-20
• [Presentation] GPCR を介した神経活動依存的な遺伝子発現制御に関する解析 (2012)
  • Author(s): 津田正明,福地守,桑名由紀,井上南,越智雄基,市村美奈,高崎一朗,竹森 洋,田渕明子
  • Organizer: 第35回日本神経科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-18
• [Presentation] ニコチンによる神経保護効果におけるCREB-CRTC シクナルの意義 (2012)
  • Author(s): 佐々木勉,北川一夫,寺崎泰和,大山直紀,杉山幸生,八木田佳樹,竹森 洋,望月秀樹
  • Organizer: 第35回日本神経科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-18
• [Presentation] 塩誘導性キナーセ SIK3 はコレステロール,胆汁酸代謝に重要である (2012)
  • Author(s): 伊東祐美,上尾達也,熊谷彩子,竹森 洋,土居純子
  • Organizer: 第66回日本栄養食料学会
  • Place of Presentation: 仙台
  • Year and Date: 2012-05-19
• [Presentation] SIK3はコレステロール-胆汁酸代謝の制御因子である- (2011)
  • Author(s): 上尾達也, 伊東裕美, 熊谷彩子, 竹森洋
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-12-16
• [Presentation] 塩誘導性キナーゼSIK3-KOマウスに観察される胆汁うっ滞 (2011)
  • Author(s): 竹森洋、上尾達也、伊東祐美、熊谷彩子、佐野坂真人
  • Organizer: 第33回胆汁酸研究会
  • Place of Presentation: 大阪ガーデンパレス(大阪)
  • Year and Date: 2011-11-19
• [Presentation] 塩誘導性キナーゼSIK3はコレステロールのクリアランスを制御する (2011)
  • Author(s): 伊東祐美、上尾達也、熊谷彩子、竹森洋、土居純子
  • Organizer: 第50回日本栄養食糧学会・近畿支部大会
  • Place of Presentation: 近畿大学(奈良)
  • Year and Date: 2011-10-15
• [Presentation] 塩誘導性キナーゼSIK3はコレステロールのクリアランスを制御する (2011)
  • Author(s): 伊東祐美、上尾達也、熊谷彩子、竹森洋
  • Organizer: 第84回日本生化学会
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2011-09-23
• [Presentation] 脳虚血後SIK2-TORC1-CREB経路の動態 (2011)
  • Author(s): 佐々木勉、竹森洋、寺崎泰和、杉山幸生、大山直紀、川村美貴、八木田佳樹、北川一夫
  • Organizer: STROKE 2011
  • Place of Presentation: 国立京都国際会館(京都)
  • Year and Date: 2011-08-01
• [Presentation] トキワムシゴケのアセトン抽出物によるメラニン生成抑制機構の解明 (2011)
  • Author(s): 下野優子、竹森洋、長岡康夫、河原秀久、山原年
  • Organizer: 第10回日本地衣学会
  • Place of Presentation: 神戸薬科大学(兵庫)
  • Year and Date: 2011-07-09
• [Presentation] カルノソール・カルノソール誘導体による酸化ストレスに対する臓器保護
  • Author(s): 川村知裕，舟木壮一郎，中桐伴行，新谷 康，井上匡美，澤端章好，南 正人，杉村康司，飯田修，渕野裕之，川原信夫，竹森 洋，奥村明之進
  • Organizer: 第194回近畿外科学会
  • Place of Presentation: 大阪
• [Presentation] Gタンハク質共役型受容体GPCR活性化によるCa2+/カルシニューリン経路を介した活動依存的な 遺伝子発現制御系に関する解析
  • Author(s): 津田正明、福地守、高崎一朗、竹森 洋、田渕明子
  • Organizer: Neuro 2013
  • Place of Presentation: 京都
• [Presentation] SIK3によるクラスII-HDAC制御がコレステロール-胆汁酸代謝へ与える影響
  • Author(s): 伊東祐美
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡
• [Presentation] 塩誘導性キナーゼ 2 (SIK2)の新規メラニン合成調節機構について
  • Author(s): 熊谷彩子
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡
• [Presentation] SIK3はマクロファージにおける炎症性サイトカインの発現を制御する
  • Author(s): 佐野坂真人
  • Organizer: 第85回日本生化学会
  • Place of Presentation: 福岡
• [Presentation] 新たなエノキ素材による体重減少と胆汁酸代謝亢進作用について
  • Author(s): 伊東祐美
  • Organizer: 第51回 日本栄養·食糧学会 近畿支部大会
  • Place of Presentation: 宝塚
• [Remarks] 医薬基盤研究所
  • URL: http://www.nibio.go.jp/part/project/metabolism_disease/
• [Patent(Industrial Property Rights)] カスパーゼ 1 活性化阻害剤,抗炎症剤,鎮痒剤,及びカスパーゼ1活性化阻害剤の評価方法 (2013)
  • Inventor(s): 竹森 洋, 佐野坂真人, 伊東祐美, 渕野裕之, 川原信夫
  • Industrial Property Rights Holder: 独立行政法人医薬基盤研究所,株式会社桃谷順天館
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-04-30
• [Patent(Industrial Property Rights)] プテロシン誘導体を含む軟骨変性,および/または軟骨菲薄疾患治療剤 (2013)
  • Inventor(s): 妻木範行, 竹森 洋, 渕野裕之, 川原信夫
  • Industrial Property Rights Holder: 国立大学法人京都大学, 独立行政法人医薬基盤研究所
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-06-27
• [Patent(Industrial Property Rights)] カスパーゼ1活性化阻害剤、抗炎症剤、鎮痒剤、及びカスパーゼ１活性化阻害剤の評価方法 (2013)
  • Inventor(s): 竹森 洋、佐野坂真人、伊東祐美、渕野裕之、川原信夫
  • Industrial Property Rights Holder: 独立行政法人医薬基盤研究所、株式会社桃谷順天館
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-094995
  • Filing Date: 2013-04-30
• [Patent(Industrial Property Rights)] プテロシン誘導体を含む軟骨変性、および/または軟骨菲薄疾患治療剤 (2013)
  • Inventor(s): 妻木範行、竹森 洋、渕野裕之、川原信夫
  • Industrial Property Rights Holder: 国立大学法人京都大学、独立行政法人医薬基盤研究所
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-135040
  • Filing Date: 2013-05-30
• [Patent(Industrial Property Rights)] チロシナーゼ誘導抑制剤及びメラニン合成抑制剤 (2012)
  • Inventor(s): 竹森 洋, 熊谷彩子, 森田純子, 渕野裕之, 川原信夫, 飯田 修, 杉村康司, 志賀幸生, 鎌田 文広, 香月茂樹, 河原秀久, 長岡康夫
  • Industrial Property Rights Holder: 株式会社桃谷順天館
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-11-24
• [Patent(Industrial Property Rights)] チロシナーゼ誘導抑制剤及びメラニン合成抑制剤 (2012)
  • Inventor(s): 竹森洋、熊谷彩子、森田純子
  • Industrial Property Rights Holder: 株式会社桃谷順天館
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2012-249917
  • Filing Date: 2012-11-14
• [Patent(Industrial Property Rights)] PPARd 活性化剤および PPARd 活性化剤の製造方法 (2011)
  • Inventor(s): 河原秀久, 長岡康夫, 竹森 洋, 小出芳栄
  • Industrial Property Rights Holder: 学校法人関西大学,独立行政法人医薬基盤研究所,有限会社一栄
  • Industrial Property Rights Type: 特許
  • Filing Date: 2011-11-16
• [Patent(Industrial Property Rights)] 軟骨疾患治療薬のスクリーニング方法および軟骨疾患治療用改変細胞 (2011)
  • Inventor(s): 妻木範行、竹森洋
  • Industrial Property Rights Holder: 国立大学法人大阪大学、独立行政法人医薬基盤研究所
  • Industrial Property Number: 2011-121788
  • Filing Date: 2011-05-31
• [Patent(Industrial Property Rights)] PPARd活性化剤およびPPARd活性化剤の製造方法 (2011)
  • Inventor(s): 河原秀久、長岡康夫、竹森洋、小出芳栄
  • Industrial Property Rights Holder: 学校法人関西大学、独立行政法人医薬基盤研究所、有限会社一栄
  • Industrial Property Number: 2011-250865
  • Filing Date: 2011-11-26