| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
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| Outline of Final Research Achievements |
It has been well known that atherosclerosis in diabetic patients is quick in progress, and has a poor prognosis, however, the underlying mechanisms are still unclear. In this study, we examined the mechanism of the development of atherothrombosis in diabetic condition using human atherosclerotic specimens and rabbit atherosclerosis model with or without diabetes mellitus.
The atherosclerotic lesions of rabbit model with diabetes were larger and higher thrombogenic than with non-diabetes, which were similar to those of human lesions. The metabolome analysis identified abount 80 kinds of different metabolites between diabetes and non-diabetes, which were mainly on glucose and amino acid metabolisms. We can expect these metabolites as potential candidates for the new marker of the diabetic atherosclerosis.
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