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Human natural helper cells and its involvement in diseases

Research Project

Project/Area Number 23390086
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Human pathology
Research InstitutionKeio University

Principal Investigator

YAMADA TAKETO  慶應義塾大学, 医学部, 准教授 (60230463)

Research Collaborator HAYASHI Mutsumi  慶應義塾大学, 医学部, 特任助教 (60327575)
NISHIDA Hiroko  慶應義塾大学, 医学部, 特任助教 (80317130)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywords病理学 / 免疫学 / メタボリック症候群 / 自然免疫 / アレルギー・ぜんそく
Research Abstract

Pathophysiological examinations of human innate immunology-related natural helper (NH) cells in fat-associated lymphoid cluster (LALC) were done using autopsy cases. FALCs in adipose tissues of total body were analyzed anatomically and histologically, consequently FALC was dominantly located in mesentery and NH cells were most frequent in mesentery as compared to omentum, fat capsule of kidney, genitalia, and retroperitoneum. Hunan NH cells prepared from human mesentery had the same patterns of gene expressions and similar kinds of cytokine production to murine NH cells. Human NH cells labeled with CSFE were transplanted in NOG mice. As a result human NH cells lodged in murine adipose tissues and produced human IL-5 and IL-13 constitutively. The area of FALC and NH cell number was decreased in mesentery of cases with diabetes mellitus and metabolic syndrome as compared to control cases.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (22 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results,  Open Access: 1 results) Presentation (9 results) Remarks (1 results)

  • [Journal Article] Establishment of monoclonal anti-human CD26 antibodies suitable for immunostaining of formalin- fixed tissue2014

    • Author(s)
      Hatano R, Yamada T, Matsuoka S, Iwata S, Yamazaki H, Komiya E, Okamoto T, Dang NH, Ohnuma K, Morimoto C
    • Journal Title

      Diagn Pathol

      Volume: 9 Issue: 1 Pages: 30-30

    • DOI

      10.1186/1746-1596-9-30

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Islet number rather than islet size is a major determinant of beta and alpha cell mass in humans2014

    • Author(s)
      Kou K, Saisho Y, Satoh S, Yamada T, Itoh H
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 99 Issue: 5 Pages: 733-1740

    • DOI

      10.1210/jc.2013-3731

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Islet number rather than islet size is a major determinant of beta and alpha cell mass in humans2014

    • Author(s)
      Kou K, Saisho Y, Satoh S, Yamada T, Itoh H
    • Journal Title

      Journal of Clinical Endocrinology & Metabolism

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Change in beta cell mass in Japanese nondiabetic obese individuals2013

    • Author(s)
      Kou K, Saisho Y, Satoh S, Yamada T, Itoh H
    • Journal Title

      J Clin Endocrinol Metab

      Volume: 98 Issue: 9 Pages: 3724-3730

    • DOI

      10.1210/jc.2013-1373

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis2013

    • Author(s)
      Sasaki T, Shiohama A, Kubo A, Kawasaki H, Ishida-Yamamoto A, Yamada T, Hachiya T, Shimizu A, Okano H, Kudoh J, Amagai M
    • Journal Title

      J Allergy Clin Immunol

      Volume: 132 Issue: 5 Pages: 1111-1120

    • DOI

      10.1016/j.jaci.2013.08.027

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of acute graft-versus-host disease by humanized anti-CD26 monoclonal antibody2013

    • Author(s)
      Hatano R, Ohnuma K, Yamamoto J, Dang NH, Yamada T, Morimoto C
    • Journal Title

      Br J Haematol

      Volume: 162 Issue: 2 Pages: 263-77

    • DOI

      10.1111/bjh.12378

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi-1 expression and nuclear translocation of RORγ2012

    • Author(s)
      Kurebayashi Y. Nagai S. Ikejiri A. Ohtani M. Ichiyama K. Baba Y. Yamada T. Egami S. Hoshii T. Hirao A. Matsuda S. Koyasu S.
    • Journal Title

      Cell Reports

      Volume: 1 Issue: 4 Pages: 360-373

    • DOI

      10.1016/j.celrep.2012.02.007

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice2012

    • Author(s)
      Kawasaki H
    • Journal Title

      J Allergy Clin Immunol

      Volume: (Epub) Issue: 6 Pages: 1538-1546

    • DOI

      10.1016/j.jaci.2012.01.068

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autoimmunity against M(2) muscarinic acetylcholine receptor induces myocarditis and leads to a dilated cardiomyopathy-like phenotype2012

    • Author(s)
      Yoshizawa, A.
    • Journal Title

      Eur J Immunol

      Volume: 42 Issue: 5 Pages: 1152-1163

    • DOI

      10.1002/eji.201142104

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A mimic of viral dsRNA triggers fulminant type 1 diabetes-like syndrome in regulatory T cell-deficient autoimmune diabetic mouse2011

    • Author(s)
      Tada A, Shimada A, Yamada T, Oikawa Y, Yamada Y, Okubo Y, Irie J, Bluestone JA, Itoh H
    • Journal Title

      Journal of Immunology

      Volume: 187 Pages: 4947-4953

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice2011

    • Author(s)
      Takahashi H, Kouno M, Nagao K, Wada N, Hata T, Nishimoto S, Iwakura Y, Yoshimura A, Yamada T, Kuwana M, Fujii Y, Koyasu S, Amagai M
    • Journal Title

      Journal of Clinical Investigation

      Volume: 121 Pages: 3677-3688

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Augmented cell death with human and mouse Bloom syndrome helicase deficiency2011

    • Author(s)
      Kaneko H, Fukao T, Kasahara K, Yamada T, Kondo N
    • Journal Title

      Molecular Medicine Reports

      Volume: 4 Pages: 607-609

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] The Pathogenesis of pulmonary alveolar proteinosis in PI3K deficient mice2013

    • Author(s)
      Nagai S, Yoshizawa A, Baba Y, Yamada T, Nishimura T, Koyasu S
    • Organizer
      日本免疫学会総会
    • Place of Presentation
      千葉・幕張
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒトにおいてβ細胞量は膵島サイズではなく膵島数と相関する2013

    • Author(s)
      侯金成 税所芳史 佐藤誠治 山田健人, 伊藤裕
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本
    • Related Report
      2013 Final Research Report
  • [Presentation] A homozygous nonsense mutation of gene for Mattrin , a component of lamellar granule secretory system, produces spontaneous dermatitis in mice2013

    • Author(s)
      Sasaki T, Shiohama A, Kubo A, Kawakami H, Ishida-Yamamoto A, Yamada T, Hachiyama T, Shimizu A, Okano H, Kudoh J, Amagai M
    • Organizer
      International Investigative Dermatology
    • Place of Presentation
      Edinburgh, Scotland
    • Related Report
      2013 Final Research Report
  • [Presentation] The Pathogenesis of pulmonary alveolar proteinosis in PI3K deficient mice2013

    • Author(s)
      Nagai S, Yoshizawa A, Baba Y, Yamada T, Nishimura T, Koyasu S
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] A homozygous nonsense mutation in Matted, a novel skin barrier gene associated with lamellar granule secretory system, causes spontaneous dermatitis in mice2013

    • Author(s)
      Sasaki T, Shiohama A, Kubo A, Kawasaki H, Yamada T, Okano H, Amagai M
    • Organizer
      第42回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] CD26 Signaling Involves Human Functional Osteoclast Development2013

    • Author(s)
      Yamada T, Nishida H, Madokoro H
    • Organizer
      第36 回日本分子生物学会年会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Change in beta cell and alpha cell mass in Japanese obese individuals.2012

    • Author(s)
      Kou K
    • Organizer
      48th Annual meeting of the European Associalon forthe Study of Diabetes
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2012 Annual Research Report
  • [Presentation] Impairment of cell growth by down regulation of NCAP2 gene transcription mediated with nuclear transported CD26 using humanized anti-CD26 monoclonal antibody.2012

    • Author(s)
      Yamada T
    • Organizer
      第45回日本発生生物学会・第64回日本細胞生物学会合同大会
    • Place of Presentation
      神戸国際会議場、神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] CD26 Blockade by Humanized Monoclonal Antibody Leads to Prophylaxis and Treatment of Graft-Versus-Host Disease (GVHD) in Hu-PBL-NOG Model Mice2011

    • Author(s)
      Hatano R, Ohnuma K, Yamada T, Ooki T, Yamamoto J, Komoriya K, Iwata Y, Dang NH, Morimoto C
    • Organizer
      The 53rd American Society of Hematology Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.keio-pathology.net/Yamada_gr.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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