| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Research Abstract |
Pathophysiological examinations of human innate immunology-related natural helper (NH) cells in fat-associated lymphoid cluster (LALC) were done using autopsy cases. FALCs in adipose tissues of total body were analyzed anatomically and histologically, consequently FALC was dominantly located in mesentery and NH cells were most frequent in mesentery as compared to omentum, fat capsule of kidney, genitalia, and retroperitoneum. Hunan NH cells prepared from human mesentery had the same patterns of gene expressions and similar kinds of cytokine production to murine NH cells. Human NH cells labeled with CSFE were transplanted in NOG mice. As a result human NH cells lodged in murine adipose tissues and produced human IL-5 and IL-13 constitutively. The area of FALC and NH cell number was decreased in mesentery of cases with diabetes mellitus and metabolic syndrome as compared to control cases.
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