Human natural helper cells and its involvement in diseases
Project/Area Number |
23390086
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Human pathology
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Research Institution | Keio University |
Principal Investigator |
YAMADA TAKETO 慶應義塾大学, 医学部, 准教授 (60230463)
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Research Collaborator |
HAYASHI Mutsumi 慶應義塾大学, 医学部, 特任助教 (60327575)
NISHIDA Hiroko 慶應義塾大学, 医学部, 特任助教 (80317130)
|
Project Period (FY) |
2011-04-01 – 2014-03-31
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
|
Keywords | 病理学 / 免疫学 / メタボリック症候群 / 自然免疫 / アレルギー・ぜんそく |
Research Abstract |
Pathophysiological examinations of human innate immunology-related natural helper (NH) cells in fat-associated lymphoid cluster (LALC) were done using autopsy cases. FALCs in adipose tissues of total body were analyzed anatomically and histologically, consequently FALC was dominantly located in mesentery and NH cells were most frequent in mesentery as compared to omentum, fat capsule of kidney, genitalia, and retroperitoneum. Hunan NH cells prepared from human mesentery had the same patterns of gene expressions and similar kinds of cytokine production to murine NH cells. Human NH cells labeled with CSFE were transplanted in NOG mice. As a result human NH cells lodged in murine adipose tissues and produced human IL-5 and IL-13 constitutively. The area of FALC and NH cell number was decreased in mesentery of cases with diabetes mellitus and metabolic syndrome as compared to control cases.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis2013
Author(s)
Sasaki T, Shiohama A, Kubo A, Kawasaki H, Ishida-Yamamoto A, Yamada T, Hachiya T, Shimizu A, Okano H, Kudoh J, Amagai M
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Journal Title
J Allergy Clin Immunol
Volume: 132
Issue: 5
Pages: 1111-1120
DOI
Related Report
Peer Reviewed
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[Journal Article] Desmoglein 3-specific CD4+ T cells induce pemphigus vulgaris and interface dermatitis in mice2011
Author(s)
Takahashi H, Kouno M, Nagao K, Wada N, Hata T, Nishimoto S, Iwakura Y, Yoshimura A, Yamada T, Kuwana M, Fujii Y, Koyasu S, Amagai M
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Journal Title
Journal of Clinical Investigation
Volume: 121
Pages: 3677-3688
Related Report
Peer Reviewed
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[Presentation] A homozygous nonsense mutation of gene for Mattrin , a component of lamellar granule secretory system, produces spontaneous dermatitis in mice2013
Author(s)
Sasaki T, Shiohama A, Kubo A, Kawakami H, Ishida-Yamamoto A, Yamada T, Hachiyama T, Shimizu A, Okano H, Kudoh J, Amagai M
Organizer
International Investigative Dermatology
Place of Presentation
Edinburgh, Scotland
Related Report
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