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The role of innate immune signals in controlling regulatory T cells

Research Project

Project/Area Number 23390088
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Experimental pathology
Research InstitutionNagoya City University (2012-2013)
Dokkyo Medical University (2011)

Principal Investigator

SAYURI Yamazaki  名古屋市立大学, 医学(系)研究科(研究院), 准教授 (70567255)

Research Collaborator SEYA Tsukasa  北海道大学, 大学院・医学研究科免疫学 (10301805)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2013: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2011: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Keywords制御性T細胞 / 樹状細胞 / Foxp3 / toll like receptor / 口腔 / 皮膚 / ホメオスタシス / 自然免疫 / 免疫寛容 / 免疫制御 / 免疫学 / 自己寛容 / TLR
Research Abstract

We showed regulatory T cells that suppress important immune responses are expanded or induced by antigen presenting dendritic cells. Regulatory T cell is a promising therapy for autoimmunity, graft rejection and allergy. To develop an effective regulatory-T cell therapy, we studied followings. 1) What kinds of innate signals keep regulatory T cell survive long in vivo? 2) To suppress only unwanted responses, are there any innate signals that expand regulatory T cells specifically? We have found that TLR 2 signals that activate dendritic cells maintain regulatory T cell survival and function in vivo. We also found that dendritic cells from oral cavity induce regulatory T cells specifically. And, we are currently investigating a dendritic-cell activating signal that expands regulatory T cell up to about 60% of CD4+T cells in the skin.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (45 results)

All 2014 2013 2012 2011 Other

All Journal Article (14 results) (of which Peer Reviewed: 8 results) Presentation (28 results) (of which Invited: 6 results) Remarks (3 results)

  • [Journal Article] Antigen delivery to CD11c^+ CD8^- dendritic cells induces protective immune response against experimental melanoma in mice in vivo2014

    • Author(s)
      Neubert K, Lehmann C, Heger L, Baranska A, Staedtler A, Buchholz V, Yamazaki S, Heidkamp G, Eissing N, Zebroski H, Nussenzweig M, Nimmerjahn F, Dudziak D
    • Journal Title

      J Immunol

      Volume: (in press) Issue: 12 Pages: 5830-5838

    • DOI

      10.4049/jimmunol.1300975

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 自己免疫疾患と制御性 T 細胞接触皮膚炎2014

    • Author(s)
      山崎小百合, 森田明理
    • Journal Title

      Medical Practice

      Pages: 243-245

    • Related Report
      2013 Final Research Report
  • [Journal Article] 接触皮膚炎2014

    • Author(s)
      山崎小百合、森田明理
    • Journal Title

      Medical Practice

      Volume: 臨時増刊号 Pages: 243-245

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Antigen delivery to CD11c+CD8- dendritic cells induces protective immune response against experimental melanoma in mice in vivo2014

    • Author(s)
      Neubert K, Lehmann C, Heger L, Baranska A, Staedtler A, Buchholz V, Yamazaki S, Heidkamp G, Eissing N, Zebroski H, Nussenzweig M, Nimmerjahn F, Dudziak D
    • Journal Title

      J Immunol

      Volume: 192

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dendritic cells in the periphery control antigen-specific Natural and Induced regulatory T cells2013

    • Author(s)
      Yamazaki S#, Morita A(#Corresponding author)
    • Journal Title

      Frontier Immunol

      Volume: 4 Pages: 1-13

    • DOI

      10.3389/fimmu.2013.00151

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photo(chemo)therapy reduces circulating Th17 cells and restores circulating regulatory T cells in psoriasis2013

    • Author(s)
      Furuhashi T, Saito C, Torii K, Nishida E, Yamazaki S, Morita A
    • Journal Title

      PLosOne

      Volume: 8 Issue: 1 Pages: e54895-e54895

    • DOI

      10.1371/journal.pone.0054895

    • Related Report
      2013 Annual Research Report 2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自己免疫疾患と制御性 T 細胞2013

    • Author(s)
      山崎小百合, 森田明理
    • Journal Title

      医学のあゆみ

      Volume: 246 Pages: 887-892

    • Related Report
      2013 Final Research Report
  • [Journal Article] 医師として研究をつづけ臨床応用を目指せ~ノーベル賞を受賞したボスからのメッセージ2013

    • Author(s)
      山崎小百合
    • Journal Title

      日本皮膚科学会雑誌

      Volume: 123 Pages: 2449-2451

    • Related Report
      2013 Final Research Report
  • [Journal Article] 自己免疫疾患と制御性T細胞2013

    • Author(s)
      山崎小百合、森田明理
    • Journal Title

      医学のあゆみ

      Volume: 246 Pages: 887-892

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 医師として研究をつづけ臨床応用を目指せ~ノーベル賞を受賞したボスからのメッセージ2013

    • Author(s)
      山崎小百合
    • Journal Title

      日本皮膚科学会雑誌

      Volume: 123 Pages: 2449-2451

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Dendritic cells from oral cavity induce Foxp3^+ regulatory T cells upon antigen stimulation2012

    • Author(s)
      Yamazaki S #, Maruyama A, Okada K, Matsumoto M, Morita A, Seya T(#Corresponding author)
    • Journal Title

      PLosOne

      Volume: 7 Issue: 12 Pages: 1-9

    • DOI

      10.1371/journal.pone.0051665

    • NAID

      120005208896

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TLR2-dependent induction of IL-10 and Foxp3+CD25+CD4+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo.2011

    • Author(s)
      Yamazaki, S., K. Okada, A. Maruyama, M. Matsumoto, and T. Seya.
    • Journal Title

      PLoS ONE.

      Volume: 6(4) Issue: 4 Pages: e18833-e18833

    • DOI

      10.1371/journal.pone.0018833

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR22011

    • Author(s)
      Sawahata, R., Shime, H., Yamazaki, S., Inoue, N., Akazawa, T., Fujimoto, Y., Fukase, K., Matsumoto, M. and Seya, T.
    • Journal Title

      Microbes and Infection

      Volume: 13 Issue: 4 Pages: 350-358

    • DOI

      10.1016/j.micinf.2010.12.003

    • NAID

      120002912001

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] TLR2-dependent induction of IL-10 and Foxp3^+CD25^+CD4^+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in_vivo2011

    • Author(s)
      Yamazaki S, Okada K, Maruyama A, Matsumoto M, Yagita H, Seya T
    • Journal Title

      PLoSOne

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] リンパ球の働き, 特に制御性 T 細胞について2014

    • Author(s)
      山崎小百合
    • Organizer
      第113回日本皮膚科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2014-05-31
    • Related Report
      2013 Final Research Report
  • [Presentation] 皮膚における制御性 T 細胞のホメオスタシスの研究2014

    • Author(s)
      山崎小百合, 西岡明子, 粕谷沙織, 田口修, 森田明理
    • Organizer
      第113回日本皮膚科学会総会
    • Place of Presentation
      京都
    • Year and Date
      2014-05-31
    • Related Report
      2013 Final Research Report
  • [Presentation] Homeostasis of thymus-derived Foxp3^+ regulatory T cells is controlled by ultraviolet B exposure in the skin2014

    • Author(s)
      Yamazaki S , Nishioka A, Kasuya S, Taguchi O, Morita A
    • Organizer
      Society for Investigative Dermatology 2014
    • Place of Presentation
      Albuquerque, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Homeostasis of thymus-derived naturally occurring Foxp3+ regulatory T cells is controlled by ultraviolet B exposure in the skin2014

    • Author(s)
      Sayuri Yamazaki, Akiko Nishioka, Saori Kasuya, Osamu Taguchi, Akimichi Morita
    • Organizer
      Society for Investigative Dermatology 2014
    • Place of Presentation
      Albuquerque Convention Center(Albuquerque, USA)
    • Related Report
      2013 Annual Research Report
  • [Presentation] リンパ球の種類と働き、特に制御性T細胞について2014

    • Author(s)
      山崎小百合
    • Organizer
      第113回日本皮膚科学会総会
    • Place of Presentation
      京都国際会館(京都)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 皮膚における制御性T細胞のホメオスタシスの研究2014

    • Author(s)
      山崎小百合、西岡明子、粕谷沙織、田口修、森田明理
    • Organizer
      第113回日本皮膚科学会総会
    • Place of Presentation
      京都国際会館(京都)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 医師として研究をつづけ臨床応用を目指せ~ノーベル賞を受賞したボスからのメッセージ2013

    • Author(s)
      山崎小百合
    • Organizer
      第112回日本皮膚科学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2013-06-14
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of dendritic cells in regulation of antigen specific Foxp3 + regulatory T cells2013

    • Author(s)
      Yamazaki S
    • Organizer
      岐阜大学大学院医学研究科皮膚科学セミナー
    • Place of Presentation
      岐阜
    • Year and Date
      2013-03-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Antigen-presenting dendritic cells maintain immunological tolerance in the oral cavity by inducing Foxp3^+ regulatory T cells2013

    • Author(s)
      Yamazaki S , Morita A
    • Organizer
      International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh, UK
    • Related Report
      2013 Final Research Report
  • [Presentation] Antigen-presenting dendritic cells maintain immunological tolerance in the oral cavity by inducing Foxp3+ regulatory T cells2013

    • Author(s)
      Yamazaki S, Morita A
    • Organizer
      International Investigative Dermatology 2013
    • Place of Presentation
      Edinburgh Conference Centre(Edinburgh, UK)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 医師として研究をつづけ臨床応用を目指せ~ノーベル賞を受賞したボスからのメッセージ2013

    • Author(s)
      山崎小百合
    • Organizer
      第112回日本皮膚科学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Antigen presenting dendritic cells maintain immunological tolerance in the oral cavity by inducing Foxp3+ regulatory T cells2013

    • Author(s)
      Sayuri Yamazaki
    • Organizer
      International Investigative Dermatology 2013
    • Place of Presentation
      エジンバラ(UK)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 免疫反応の制御で皮膚疾患の治療を目指す~制御性 T 細胞により誘導された制御性 T 細胞の利用2012

    • Author(s)
      山崎小百合
    • Organizer
      第262回日本皮膚科学会東海地方会平成 24年度生涯教育講演会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-12-02
    • Related Report
      2013 Final Research Report
  • [Presentation] 免疫反応の制御で皮膚疾患の治療を目指す~制御性 T 細胞により誘導された制御性 T 細胞の利用2012

    • Author(s)
      山崎小百合
    • Organizer
      認定薬剤師講演会
    • Place of Presentation
      星薬科大学
    • Year and Date
      2012-11-11
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of dendritic cells in regulation of antigen specific Foxp3^+ regulatory T cells2012

    • Author(s)
      Yamazaki S
    • Organizer
      北里大学医学部免疫学第1回免疫学セミナー
    • Place of Presentation
      相模原
    • Year and Date
      2012-02-15
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of dendritic cells in regulation of antigen specific Foxp3^+ regulatory T cells2012

    • Author(s)
      Yamazaki S
    • Organizer
      獨協医科大学解剖学免疫学合同第10回樹状細胞免疫学セミナー
    • Place of Presentation
      栃木
    • Year and Date
      2012-01-25
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of dendritic cells in regulation of antigen specific Foxp3^+ regulatory T cells2012

    • Author(s)
      Yamazaki S
    • Organizer
      Master in Advance Biotechnology for Health and Life Science Laboratory of Immunology and Biotherapy, Department of Human Pathology
    • Place of Presentation
      University of Messina, Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of dendritic cells in regulation of antigen specific Foxp3^+ regulatory T cells2012

    • Author(s)
      Yamazaki S
    • Organizer
      Lecture-Maser in Biotechnology at the University of Messina
    • Place of Presentation
      University of Messina, Italy(招待講演)
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of dendritic cells to control antigen specific Foxp3^+ regulatory T cells2011

    • Author(s)
      Yamazaki S
    • Organizer
      山梨大学第11回山梨皮膚科セミナー
    • Place of Presentation
      甲府
    • Year and Date
      2011-11-30
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of dendritic cells in regulation of antigen specific Foxp3^+ regulatory T cells2011

    • Author(s)
      山崎小百合
    • Organizer
      第11回山梨皮膚科セミナー
    • Place of Presentation
      山梨大学(招待講演)
    • Year and Date
      2011-11-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] TLR2-dependent induction of IL-10 and Foxp3^+CD25^+CD4^+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo2011

    • Author(s)
      Yamazaki S Okada K, Maruyama A, Matsumoto M, Yagita H, Seya T
    • Organizer
      第40回日本免疫学会
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] TLR2-dependent induction of IL-10 and Foxp3^+ CD25^+CD4^+ regulatory T cells prevents effective anti- tumor immunity induced by Pam2 lipopeptides in vivo2011

    • Author(s)
      Yamazaki S
    • Organizer
      東京医科歯科大学第2回上の野山リサーチカンファランス
    • Place of Presentation
      東京
    • Year and Date
      2011-08-06
    • Related Report
      2013 Final Research Report
  • [Presentation] TLR2-dependent induction of IL-10 and Foxp3^+CD25^+CD4^+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo2011

    • Author(s)
      山崎小百合
    • Organizer
      第2回上野の山リサーチカンファランス
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2011-08-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] The role of dendritic cells to control antigen specific Foxp3^+ regulatory T cells2011

    • Author(s)
      Yamazaki S
    • Place of Presentation
      埼玉医科大学膠原病内科
    • Year and Date
      2011-01-21
    • Related Report
      2013 Final Research Report
  • [Presentation] TLR2-dependent induction of IL-10 and Foxp3^+ CD25^+CD4^+ regulatory T cells prevents effective anti-tumor immunity induced by Pam2 lipopeptides in vivo2011

    • Author(s)
      Yamazaki S , Okada K, Maruyama A, Matsumoto M, Yagita H, Seya T
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張
    • Related Report
      2013 Final Research Report
  • [Presentation] 免疫反応の制御で皮膚疾患の治療を目指すー樹状細胞により誘導された制御性T細胞の利用

    • Author(s)
      山崎小百合
    • Organizer
      星薬科大学認定薬剤師研修講演会
    • Place of Presentation
      星薬科大学(東京都)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 免疫反応の制御で皮膚疾患の治療を目指すー樹状細胞により誘導された制御性T細胞の利用

    • Author(s)
      山崎小百合
    • Organizer
      平成24年度日本皮膚科学会東海地方会生涯教育講演会
    • Place of Presentation
      名古屋ルーセントタワー(愛知県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 樹状細胞による抗原特異的制御性T細胞の誘導

    • Author(s)
      山崎小百合
    • Organizer
      岐阜大学皮膚科学リサーチ講演会
    • Place of Presentation
      岐阜大学(岐阜県)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks]

    • URL

      http://www.med.nagoya-cu.ac.jp/derma.dir/index.htm

    • Related Report
      2013 Final Research Report
  • [Remarks] 名古屋市立大学大学院医学研究科加齢環境皮膚科学

    • URL

      http://www.med.nagoya-cu.ac.jp/derma.dir/index.htm

    • Related Report
      2013 Annual Research Report
  • [Remarks] 名古屋市立大学大学院医学研究科加齢環境皮膚科学

    • URL

      http://www.med.nagoya-cu.ac.jp/derma.dir/research/index.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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